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Items: 1 to 50 of 135

1.

Regulation of age-associated B cells by IRF5 in systemic autoimmunity.

Manni M, Gupta S, Ricker E, Chinenov Y, Park SH, Shi M, Pannellini T, Jessberger R, Ivashkiv LB, Pernis AB.

Nat Immunol. 2018 Apr;19(4):407-419. doi: 10.1038/s41590-018-0056-8. Epub 2018 Feb 26.

PMID:
29483597
2.

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.

Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB.

Nat Commun. 2018 Feb 23;9(1):789. doi: 10.1038/s41467-018-02892-y.

3.

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation.

Stephenson W, Donlin LT, Butler A, Rozo C, Bracken B, Rashidfarrokhi A, Goodman SM, Ivashkiv LB, Bykerk VP, Orange DE, Darnell RB, Swerdlow HP, Satija R.

Nat Commun. 2018 Feb 23;9(1):791. doi: 10.1038/s41467-017-02659-x.

4.

Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data.

Orange DE, Agius P, DiCarlo EF, Robine N, Geiger H, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, Figgie M, Ivashkiv LB, Pernis AB, Jiang CS, Frank MO, Darnell RB, Lingampali N, Robinson WH, Gravallese E; Accelerating Medicines Partnership in Rheumatoid Arthritis and Lupus Network, Bykerk VP, Goodman SM, Donlin LT.

Arthritis Rheumatol. 2018 May;70(5):690-701. doi: 10.1002/art.40428. Epub 2018 Apr 2.

PMID:
29468833
5.

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.

Sokhi UK, Liber MP, Frye L, Park S, Kang K, Pannellini T, Zhao B, Norinsky R, Ivashkiv LB, Gong S.

Nat Commun. 2018 Feb 13;9(1):658. doi: 10.1038/s41467-018-03081-7.

6.

Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation.

Park SH, Kang K, Giannopoulou E, Qiao Y, Kang K, Kim G, Park-Min KH, Ivashkiv LB.

Nat Immunol. 2017 Oct;18(10):1104-1116. doi: 10.1038/ni.3818. Epub 2017 Aug 21.

7.

Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF.

Kang K, Park SH, Chen J, Qiao Y, Giannopoulou E, Berg K, Hanidu A, Li J, Nabozny G, Kang K, Park-Min KH, Ivashkiv LB.

Immunity. 2017 Aug 15;47(2):235-250.e4. doi: 10.1016/j.immuni.2017.07.017.

PMID:
28813657
8.

Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.

Murata K, Fang C, Terao C, Giannopoulou EG, Lee YJ, Lee MJ, Mun SH, Bae S, Qiao Y, Yuan R, Furu M, Ito H, Ohmura K, Matsuda S, Mimori T, Matsuda F, Park-Min KH, Ivashkiv LB.

Immunity. 2017 Jul 18;47(1):66-79.e5. doi: 10.1016/j.immuni.2017.06.018.

PMID:
28723554
9.

Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes.

Loupasakis K, Kuo D, Sokhi UK, Sohn C, Syracuse B, Giannopoulou EG, Park SH, Kang H, Rätsch G, Ivashkiv LB, Kalliolias GD.

PLoS One. 2017 Jul 14;12(7):e0179762. doi: 10.1371/journal.pone.0179762. eCollection 2017.

10.

Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption.

Binder N, Miller C, Yoshida M, Inoue K, Nakano S, Hu X, Ivashkiv LB, Schett G, Pernis A, Goldring SR, Ross FP, Zhao B.

J Immunol. 2017 May 1;198(9):3436-3447. doi: 10.4049/jimmunol.1601716. Epub 2017 Mar 17.

11.

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis.

Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB.

Nature. 2017 Feb 1;542(7639):110-114. doi: 10.1038/nature20810.

12.

IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages.

Qiao Y, Kang K, Giannopoulou E, Fang C, Ivashkiv LB.

Cell Rep. 2016 Sep 20;16(12):3121-3129. doi: 10.1016/j.celrep.2016.08.051.

13.

Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.

Huynh L, Kusnadi A, Park SH, Murata K, Park-Min KH, Ivashkiv LB.

Sci Rep. 2016 Aug 25;6:31959. doi: 10.1038/srep31959.

14.

Epigenetic Regulation of Myeloid Cells.

Ivashkiv LB, Park SH.

Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.MCHD-0010-2015. Review.

15.

RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis.

Miller CH, Smith SM, Elguindy M, Zhang T, Xiang JZ, Hu X, Ivashkiv LB, Zhao B.

J Immunol. 2016 Jun 15;196(12):4977-86. doi: 10.4049/jimmunol.1502044. Epub 2016 May 9.

16.

Cutting Edge: EZH2 Promotes Osteoclastogenesis by Epigenetic Silencing of the Negative Regulator IRF8.

Fang C, Qiao Y, Mun SH, Lee MJ, Murata K, Bae S, Zhao B, Park-Min KH, Ivashkiv LB.

J Immunol. 2016 Jun 1;196(11):4452-4456. doi: 10.4049/jimmunol.1501466. Epub 2016 Apr 29.

17.

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes.

Foldi J, Shang Y, Zhao B, Ivashkiv LB, Hu X.

Protein Cell. 2016 Mar;7(3):201-9. doi: 10.1007/s13238-016-0248-7. Epub 2016 Feb 13.

18.

TNF biology, pathogenic mechanisms and emerging therapeutic strategies.

Kalliolias GD, Ivashkiv LB.

Nat Rev Rheumatol. 2016 Jan;12(1):49-62. doi: 10.1038/nrrheum.2015.169. Epub 2015 Dec 10. Review.

19.

Intravenous Immunoglobulin (IVIG) Attenuates TNF-Induced Pathologic Bone Resorption and Suppresses Osteoclastogenesis by Inducing A20 Expression.

Lee MJ, Lim E, Mun S, Bae S, Murata K, Ivashkiv LB, Park-Min KH.

J Cell Physiol. 2016 Feb;231(2):449-458. doi: 10.1002/jcp.25091.

20.

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation.

Su X, Yu Y, Zhong Y, Giannopoulou EG, Hu X, Liu H, Cross JR, Rätsch G, Rice CM, Ivashkiv LB.

Nat Immunol. 2015 Aug;16(8):838-849. doi: 10.1038/ni.3205. Epub 2015 Jun 29.

21.

Use of RNA sequencing to evaluate rheumatic disease patients.

Giannopoulou EG, Elemento O, Ivashkiv LB.

Arthritis Res Ther. 2015 Jul 1;17:167. doi: 10.1186/s13075-015-0677-3. Review.

22.

Metabolic-epigenetic coupling in osteoclast differentiation.

Ivashkiv LB.

Nat Med. 2015 Mar;21(3):212-3. doi: 10.1038/nm.3815. No abstract available.

23.

Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation.

Park-Min KH, Lim E, Lee MJ, Park SH, Giannopoulou E, Yarilina A, van der Meulen M, Zhao B, Smithers N, Witherington J, Lee K, Tak PP, Prinjha RK, Ivashkiv LB.

Nat Commun. 2014 Nov 13;5:5418. doi: 10.1038/ncomms6418.

24.

BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes.

Chan CH, Fang C, Yarilina A, Prinjha RK, Qiao Y, Ivashkiv LB.

Eur J Immunol. 2015 Jan;45(1):287-297. doi: 10.1002/eji.201444862. Epub 2014 Dec 1.

25.

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis.

Li S, Miller CH, Giannopoulou E, Hu X, Ivashkiv LB, Zhao B.

J Clin Invest. 2014 Nov;124(11):5057-73. doi: 10.1172/JCI71882. Epub 2014 Oct 20.

26.

Prolonged tumor necrosis factor α primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin.

Sohn C, Lee A, Qiao Y, Loupasakis K, Ivashkiv LB, Kalliolias GD.

Arthritis Rheumatol. 2015 Jan;67(1):86-95. doi: 10.1002/art.38871.

27.

Modulation of TNF-induced macrophage polarization by synovial fibroblasts.

Donlin LT, Jayatilleke A, Giannopoulou EG, Kalliolias GD, Ivashkiv LB.

J Immunol. 2014 Sep 1;193(5):2373-83. doi: 10.4049/jimmunol.1400486. Epub 2014 Jul 23.

28.

Macrophage activation and polarization: nomenclature and experimental guidelines.

Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, Gordon S, Hamilton JA, Ivashkiv LB, Lawrence T, Locati M, Mantovani A, Martinez FO, Mege JL, Mosser DM, Natoli G, Saeij JP, Schultze JL, Shirey KA, Sica A, Suttles J, Udalova I, van Ginderachter JA, Vogel SN, Wynn TA.

Immunity. 2014 Jul 17;41(1):14-20. doi: 10.1016/j.immuni.2014.06.008.

29.

Regulation of type I interferon responses.

Ivashkiv LB, Donlin LT.

Nat Rev Immunol. 2014 Jan;14(1):36-49. doi: 10.1038/nri3581. Review.

30.

Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.

Qiao Y, Giannopoulou EG, Chan CH, Park SH, Gong S, Chen J, Hu X, Elemento O, Ivashkiv LB.

Immunity. 2013 Sep 19;39(3):454-69. doi: 10.1016/j.immuni.2013.08.009. Epub 2013 Sep 5.

31.

PTPN22 in autoimmunity: different cell and different way.

Ivashkiv LB.

Immunity. 2013 Jul 25;39(1):91-3. doi: 10.1016/j.immuni.2013.07.007.

32.

Kinase inhibitors: a new tool for the treatment of rheumatoid arthritis.

Chakravarty SD, Poulikakos PI, Ivashkiv LB, Salmon JE, Kalliolias GD.

Clin Immunol. 2013 Jul;148(1):66-78. doi: 10.1016/j.clim.2013.04.007. Epub 2013 Apr 17. Review.

PMID:
23651870
33.

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.

Issuree PD, Maretzky T, McIlwain DR, Monette S, Qing X, Lang PA, Swendeman SL, Park-Min KH, Binder N, Kalliolias GD, Yarilina A, Horiuchi K, Ivashkiv LB, Mak TW, Salmon JE, Blobel CP.

J Clin Invest. 2013 Feb;123(2):928-32. doi: 10.1172/JCI66168. Epub 2013 Jan 25.

34.

Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts.

Lee A, Qiao Y, Grigoriev G, Chen J, Park-Min KH, Park SH, Ivashkiv LB, Kalliolias GD.

Arthritis Rheum. 2013 Apr;65(4):928-38. doi: 10.1002/art.37853.

35.

Epigenetic regulation of macrophage polarization and function.

Ivashkiv LB.

Trends Immunol. 2013 May;34(5):216-23. doi: 10.1016/j.it.2012.11.001. Epub 2012 Dec 4. Review.

36.

Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors.

Yarilina A, Xu K, Chan C, Ivashkiv LB.

Arthritis Rheum. 2012 Dec;64(12):3856-66. doi: 10.1002/art.37691.

37.

Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling.

Park-Min KH, Lee EY, Moskowitz NK, Lim E, Lee SK, Lorenzo JA, Huang C, Melnick AM, Purdue PE, Goldring SR, Ivashkiv LB.

J Bone Miner Res. 2013 Jan;28(1):135-49. doi: 10.1002/jbmr.1739.

38.
39.

Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.

Xu H, Zhu J, Smith S, Foldi J, Zhao B, Chung AY, Outtz H, Kitajewski J, Shi C, Weber S, Saftig P, Li Y, Ozato K, Blobel CP, Ivashkiv LB, Hu X.

Nat Immunol. 2012 May 20;13(7):642-50. doi: 10.1038/ni.2304.

40.

ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes.

Huynh L, Wang L, Shi C, Park-Min KH, Ivashkiv LB.

J Immunol. 2012 Apr 1;188(7):3447-57. doi: 10.4049/jimmunol.1102211. Epub 2012 Feb 24.

41.

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.

Zhao B, Grimes SN, Li S, Hu X, Ivashkiv LB.

J Exp Med. 2012 Feb 13;209(2):319-34. doi: 10.1084/jem.20111566. Epub 2012 Jan 16.

42.

Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8.

Ivashkiv LB, Zhao B, Park-Min KH, Takami M.

Ann N Y Acad Sci. 2011 Nov;1237:88-94. doi: 10.1111/j.1749-6632.2011.06217.x. Review.

43.

Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states.

Ivashkiv LB.

Eur J Immunol. 2011 Sep;41(9):2477-81. doi: 10.1002/eji.201141783. Review.

44.

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors.

Zhao B, Ivashkiv LB.

Arthritis Res Ther. 2011 Jul 28;13(4):234. doi: 10.1186/ar3379. Review.

45.

Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages.

Park SH, Park-Min KH, Chen J, Hu X, Ivashkiv LB.

Nat Immunol. 2011 May 22;12(7):607-15. doi: 10.1038/ni.2043.

46.

How ITAMs inhibit signaling.

Ivashkiv LB.

Sci Signal. 2011 Apr 19;4(169):pe20. doi: 10.1126/scisignal.2001917.

47.

Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway.

Antoniv TT, Ivashkiv LB.

Immunology. 2011 Apr;132(4):567-77. doi: 10.1111/j.1365-2567.2010.03402.x. Epub 2011 Jan 24.

48.

TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages.

Yarilina A, Xu K, Chen J, Ivashkiv LB.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1573-8. doi: 10.1073/pnas.1010030108. Epub 2011 Jan 10.

49.

IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling.

Chen J, Ivashkiv LB.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19438-43. doi: 10.1073/pnas.1007816107. Epub 2010 Oct 25.

50.

Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27.

Kalliolias GD, Gordon RA, Ivashkiv LB.

J Immunol. 2010 Dec 1;185(11):7047-56. doi: 10.4049/jimmunol.1001290. Epub 2010 Oct 22.

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