Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 65

1.

Controlling of N-alkylpolyamine analogue metabolism by selective deuteration.

Ucal S, Häkkinen MR, Alanne AL, Alhonen L, Vepsäläinen J, Keinänen TA, Hyvönen MT.

Biochem J. 2018 Feb 14;475(3):663-676. doi: 10.1042/BCJ20170887.

PMID:
29301981
2.

Hepatitis C virus alters metabolism of biogenic polyamines by affecting expression of key enzymes of their metabolism.

Smirnova OA, Keinanen TA, Ivanova ON, Hyvonen MT, Khomutov AR, Kochetkov SN, Bartosch B, Ivanov AV.

Biochem Biophys Res Commun. 2017 Feb 5;483(2):904-909. doi: 10.1016/j.bbrc.2017.01.032. Epub 2017 Jan 9.

PMID:
28082202
3.

Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer.

Thomas TJ, Thomas T, John S, Hsu HC, Yang P, Keinänen TA, Hyvönen MT.

Amino Acids. 2016 Oct;48(10):2293-302. doi: 10.1007/s00726-016-2300-6. Epub 2016 Jul 20.

PMID:
27438264
4.

Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation.

Hyvönen MT, Ucal S, Pasanen M, Peräniemi S, Weisell J, Khomutov M, Khomutov AR, Vepsäläinen J, Alhonen L, Keinänen TA.

Biochem J. 2016 May 15;473(10):1433-41. doi: 10.1042/BCJ20160134. Epub 2016 Mar 21.

PMID:
27001865
5.

[Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines].

Khomutov MA, Keinanen TA, Hyvonen MT, Weisell J, Vepsalainen J, Alhonen L, Kochetkov SN, Khomutov AR.

Bioorg Khim. 2015 Sep-Oct;41(5):612-8. Russian.

PMID:
26762100
6.

Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.

Hyvönen MT, Khomutov M, Petit M, Weisell J, Kochetkov SN, Alhonen L, Vepsäläinen J, Khomutov AR, Keinänen TA.

ACS Chem Biol. 2015 Jun 19;10(6):1417-24. doi: 10.1021/cb500938e. Epub 2015 Feb 27.

PMID:
25689365
7.

Maintenance of white adipose tissue in man.

Hyvönen MT, Spalding KL.

Int J Biochem Cell Biol. 2014 Nov;56:123-32. doi: 10.1016/j.biocel.2014.09.013. Epub 2014 Sep 20. Review.

PMID:
25240584
8.

Selective regulation of polyamine metabolism with methylated polyamine analogues.

Keinänen TA, Hyvönen MT, Alhonen L, Vepsäläinen J, Khomutov AR.

Amino Acids. 2014 Mar;46(3):605-20. Epub 2013 Oct 10. Review.

PMID:
24022706
9.

Charge deficient analogues of the natural polyamines.

Weisell J, Hyvönen MT, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR.

Curr Pharm Des. 2014;20(2):262-77. Review.

PMID:
23701551
10.

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A.

Hyvönen MT, Koponen T, Weisell J, Pietilä M, Khomutov AR, Vepsäläinen J, Alhonen L, Keinänen TA.

Biochem J. 2013 Aug 1;453(3):467-74. doi: 10.1042/BJ20130263.

PMID:
23672317
11.

Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.

Hyvönen MT, Weisell J, Khomutov AR, Alhonen L, Vepsäläinen J, Keinänen TA.

Drug Metab Dispos. 2013 Jan;41(1):30-2. doi: 10.1124/dmd.112.047274. Epub 2012 Sep 28.

12.

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells.

Smirnova OA, Isaguliants MG, Hyvonen MT, Keinanen TA, Tunitskaya VL, Vepsalainen J, Alhonen L, Kochetkov SN, Ivanov AV.

Biochimie. 2012 Sep;94(9):1876-83. doi: 10.1016/j.biochi.2012.04.023. Epub 2012 May 8.

PMID:
22579641
13.

Lipid exchange mechanism of the cholesteryl ester transfer protein clarified by atomistic and coarse-grained simulations.

Koivuniemi A, Vuorela T, Kovanen PT, Vattulainen I, Hyvönen MT.

PLoS Comput Biol. 2012 Jan;8(1):e1002299. doi: 10.1371/journal.pcbi.1002299. Epub 2012 Jan 12.

14.

Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine.

Jin HT, Lämsä T, Nordback PH, Hyvönen MT, Grigorenko N, Khomutov AR, Nordback I, Räty S, Pörsti I, Alhonen L, Sand J.

Pharmacol Rep. 2011;63(4):999-1008.

15.

Complex N-acetylation of triethylenetetramine.

Cerrada-Gimenez M, Weisell J, Hyvönen MT, Park MH, Alhonen L, Vepsäläinen J, Keinänen TA.

Drug Metab Dispos. 2011 Dec;39(12):2242-9. doi: 10.1124/dmd.111.041798. Epub 2011 Aug 30.

16.

Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.

Hyvönen MT, Keinänen TA, Khomutov M, Simonian A, Vepsäläinen J, Park JH, Khomutov AR, Alhonen L, Park MH.

Amino Acids. 2012 Feb;42(2-3):685-95. doi: 10.1007/s00726-011-0984-1. Epub 2011 Aug 23.

17.

A potential estrogen mimetic effect of a bis(ethyl)polyamine analogue on estrogen receptor positive MCF-7 breast cancer cells.

Nayvelt I, John S, Hsu HC, Yang P, Liu W, Das G, Hyvönen MT, Alhonen L, Keinänen TA, Shirahata A, Patel R, Thomas T, Thomas TJ.

Amino Acids. 2012 Feb;42(2-3):899-911. doi: 10.1007/s00726-011-1005-0. Epub 2011 Aug 10.

PMID:
21830120
18.

Tissue-specific alternative splicing of spermidine/spermine N1-acetyltransferase.

Hyvönen MT, Uimari A, Vepsäläinen J, Khomutov AR, Keinänen TA, Alhonen L.

Amino Acids. 2012 Feb;42(2-3):485-93. doi: 10.1007/s00726-011-1027-7. Epub 2011 Aug 2.

PMID:
21809078
19.

The use of novel C-methylated spermidine derivatives to investigate the regulation of polyamine metabolism.

Hyvönen MT, Keinänen TA, Khomutov M, Simonian A, Weisell J, Kochetkov SN, Vepsäläinen J, Alhonen L, Khomutov AR.

J Med Chem. 2011 Jul 14;54(13):4611-8. doi: 10.1021/jm200293r. Epub 2011 Jun 3.

PMID:
21639123
20.

Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis.

Jin HT, Lämsä T, Nordback PH, Hyvönen MT, Räty S, Nordback I, Herzig KH, Alhonen L, Sand J.

Pancreatology. 2011;11(2):83-91. doi: 10.1159/000327260. Epub 2011 Apr 27.

PMID:
21525776
21.

A molecular dynamics approach for the association of apolipoproteinB-100 and chondroitin-6-sulfate.

Cilpa G, Koivuniemi A, Hyvönen MT, Riekkola ML.

J Phys Chem B. 2011 Apr 28;115(16):4818-25. doi: 10.1021/jp110987r. Epub 2011 Apr 1.

PMID:
21456564
22.

Methylated polyamines as research tools.

Khomutov AR, Weisell J, Khomutov MA, Grigorenko NA, Simonian AR, Häkkinen MR, Keinänen TA, Hyvönen MT, Alhonen L, Kochetkov SN, Vepsäläinen J.

Methods Mol Biol. 2011;720:449-61. doi: 10.1007/978-1-61779-034-8_29.

PMID:
21318892
23.

Transgenic rodents with altered SSAT expression as models of pancreatitis and altered glucose and lipid metabolism.

Uimari A, Hyvönen MT, Pirinen E, Alhonen L.

Methods Mol Biol. 2011;720:143-58. doi: 10.1007/978-1-61779-034-8_8.

PMID:
21318871
24.

Role of lipids in spheroidal high density lipoproteins.

Vuorela T, Catte A, Niemelä PS, Hall A, Hyvönen MT, Marrink SJ, Karttunen M, Vattulainen I.

PLoS Comput Biol. 2010 Oct 28;6(10):e1000964. doi: 10.1371/journal.pcbi.1000964.

25.

Synthesis and biological characterization of novel charge-deficient spermine analogues.

Weisell J, Hyvönen MT, Häkkinen MR, Grigorenko NA, Pietilä M, Lampinen A, Kochetkov SN, Alhonen L, Vepsäläinen J, Keinänen TA, Khomutov AR.

J Med Chem. 2010 Aug 12;53(15):5738-48. doi: 10.1021/jm100439p.

PMID:
20684609
26.

Continuous oxidative stress due to activation of polyamine catabolism accelerates aging and protects against hepatotoxic insults.

Cerrada-Gimenez M, Pietilä M, Loimas S, Pirinen E, Hyvönen MT, Keinänen TA, Jänne J, Alhonen L.

Transgenic Res. 2011 Apr;20(2):387-96. doi: 10.1007/s11248-010-9422-5. Epub 2010 Jun 25.

PMID:
20577801
27.

Acute pancreatitis induced by activated polyamine catabolism is associated with coagulopathy: effects of alpha-methylated polyamine analogs on hemostasis.

Hyvönen MT, Sinervirta R, Keinänen TA, Fashe T, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L.

Pancreatology. 2010;10(2-3):208-21. doi: 10.1159/000243730. Epub 2010 May 7.

PMID:
20453551
28.

Membrane simulations mimicking acidic pH reveal increased thickness and negative curvature in a bilayer consisting of lysophosphatidylcholines and free fatty acids.

Lähdesmäki K, Ollila OH, Koivuniemi A, Kovanen PT, Hyvönen MT.

Biochim Biophys Acta. 2010 May;1798(5):938-46. doi: 10.1016/j.bbamem.2010.01.020. Epub 2010 Feb 2.

29.

Transgenic animals modelling polyamine metabolism-related diseases.

Alhonen L, Uimari A, Pietilä M, Hyvönen MT, Pirinen E, Keinänen TA.

Essays Biochem. 2009 Nov 4;46:125-44. doi: 10.1042/bse0460009. Review.

PMID:
20095974
30.

Atomistic insight into chondroitin-6-sulfate glycosaminoglycan chain through quantum mechanics calculations and molecular dynamics simulation.

Cilpa G, Hyvönen MT, Koivuniemi A, Riekkola ML.

J Comput Chem. 2010 Jun;31(8):1670-80. doi: 10.1002/jcc.21453.

PMID:
20087899
31.

Metabolism of N-alkylated spermine analogues by polyamine and spermine oxidases.

Häkkinen MR, Hyvönen MT, Auriola S, Casero RA Jr, Vepsäläinen J, Khomutov AR, Alhonen L, Keinänen TA.

Amino Acids. 2010 Feb;38(2):369-81. doi: 10.1007/s00726-009-0429-2. Epub 2009 Dec 10.

32.

alpha-Methylspermidine protects against carbon tetrachloride-induced hepatic and pancreatic damage.

Hyvönen MT, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Keinänen TA, Alhonen L.

Amino Acids. 2010 Feb;38(2):575-81. doi: 10.1007/s00726-009-0418-5. Epub 2009 Dec 3.

PMID:
19956991
33.

Novel isosteric charge-deficient spermine analogue--1,12-diamino-3,6,9-triazadodecane: synthesis, pK(a) measurement and biological activity.

Weisell J, Hyvönen MT, Vepsäläinen J, Alhonen L, Keinänen TA, Khomutov AR, Soininen P.

Amino Acids. 2010 Feb;38(2):501-7. doi: 10.1007/s00726-009-0409-6. Epub 2009 Dec 2.

PMID:
19953281
34.

DNA condensation by chiral alpha-methylated polyamine analogues and protection of cellular DNA from oxidative damage.

Nayvelt I, Hyvönen MT, Alhonen L, Pandya I, Thomas T, Khomutov AR, Vepsäläinen J, Patel R, Keinänen TA, Thomas TJ.

Biomacromolecules. 2010 Jan 11;11(1):97-105. doi: 10.1021/bm900958c.

PMID:
19919070
35.

Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues.

Hyvönen MT, Howard MT, Anderson CB, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J, Keinänen TA.

Biochem J. 2009 Aug 13;422(2):321-8. doi: 10.1042/BJ20090737.

PMID:
19522702
36.

Atomistic simulations of phosphatidylcholines and cholesteryl esters in high-density lipoprotein-sized lipid droplet and trilayer: clues to cholesteryl ester transport and storage.

Koivuniemi A, Heikelä M, Kovanen PT, Vattulainen I, Hyvönen MT.

Biophys J. 2009 May 20;96(10):4099-108. doi: 10.1016/j.bpj.2009.01.058.

37.

[Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism].

Khomutov AR, Keinanen TA, Grigorenko NA, Hyvonen MT, Uimari A, Pietila M, Cerrada-Gimenez M, Simonian AR, Khomutov MA, Verspalainen J, Alhonen L, Janne J.

Mol Biol (Mosk). 2009 Mar-Apr;43(2):274-85. Russian.

PMID:
19425496
38.

Atom-scale molecular interactions in lipid raft mixtures.

Niemelä PS, Hyvönen MT, Vattulainen I.

Biochim Biophys Acta. 2009 Jan;1788(1):122-35. doi: 10.1016/j.bbamem.2008.08.018. Epub 2008 Sep 6. Review.

39.

Molecular dynamics simulations of a lipovitellin-derived amphiphilic beta-sheet homologous to apoB-100 beta-sheets at a hydrophobic decane-water interface.

Koivuniemi A, Kovanen PT, Hyvönen MT.

Biochim Biophys Acta. 2008 Nov;1784(11):1668-75. doi: 10.1016/j.bbapap.2008.06.007. Epub 2008 Jun 19.

PMID:
18619564
40.

A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate.

Jin HT, Lämsä T, Hyvönen MT, Sand J, Räty S, Grigorenko N, Khomutov AR, Herzig KH, Alhonen L, Nordback I.

Surgery. 2008 Jul;144(1):49-56. doi: 10.1016/j.surg.2008.03.029.

PMID:
18571584
41.

Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis.

Jin HT, Lamsa T, Merentie M, Hyvonen MT, Sand J, Raty S, Herzig KH, Alhonen L, Nordback I.

Pancreatology. 2008;8(1):15-24. doi: 10.1159/000114851. Epub 2008 Jan 31.

PMID:
18235212
42.

Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.

Hyvönen MT, Keinänen TA, Cerrada-Gimenez M, Sinervirta R, Grigorenko N, Khomutov AR, Vepsäläinen J, Alhonen L, Jänne J.

J Biol Chem. 2007 Nov 30;282(48):34700-6. Epub 2007 Sep 27.

43.

Alpha-methylated polyamines as potential drugs and experimental tools in enzymology.

Keinänen TA, Järvinen A, Uimari A, Vepsäläinen J, Khomutov AR, Grigorenko NA, Hyvönen MT, Cerrada-Gimenez M, Alhonen L, Jänne J.

Mini Rev Med Chem. 2007 Aug;7(8):813-20. Review.

PMID:
17692042
44.

Polyunsaturation in lipid membranes: dynamic properties and lateral pressure profiles.

Ollila S, Hyvönen MT, Vattulainen I.

J Phys Chem B. 2007 Mar 29;111(12):3139-50. Epub 2007 Mar 3.

PMID:
17388448
45.

Mechanisms of polyamine catabolism-induced acute pancreatitis.

Hyvönen MT, Merentie M, Uimari A, Keinänen TA, Jänne J, Alhonen L.

Biochem Soc Trans. 2007 Apr;35(Pt 2):326-30.

PMID:
17371271
46.

Assessing the nature of lipid raft membranes.

Niemelä PS, Ollila S, Hyvönen MT, Karttunen M, Vattulainen I.

PLoS Comput Biol. 2007 Feb 23;3(2):e34. Epub 2007 Jan 5.

47.

Insight into the putative specific interactions between cholesterol, sphingomyelin, and palmitoyl-oleoyl phosphatidylcholine.

Aittoniemi J, Niemelä PS, Hyvönen MT, Karttunen M, Vattulainen I.

Biophys J. 2007 Feb 15;92(4):1125-37. Epub 2006 Nov 17.

48.

Polyamine-regulated unproductive splicing and translation of spermidine/spermine N1-acetyltransferase.

Hyvönen MT, Uimari A, Keinänen TA, Heikkinen S, Pellinen R, Wahlfors T, Korhonen A, Närvänen A, Wahlfors J, Alhonen L, Jänne J.

RNA. 2006 Aug;12(8):1569-82. Epub 2006 Jun 29.

49.

Genetic manipulation of polyamine catabolism in rodents.

Jänne J, Alhonen L, Pietilä M, Keinänen TA, Uimari A, Hyvönen MT, Pirinen E, Järvinen A.

J Biochem. 2006 Feb;139(2):155-60. Review.

PMID:
16452302
50.

activated polyamine catabolism in acute pancreatitis: alpha-methylated polyamine analogues prevent trypsinogen activation and pancreatitis-associated mortality.

Hyvönen MT, Herzig KH, Sinervirta R, Albrecht E, Nordback I, Sand J, Keinänen TA, Vepsäläinen J, Grigorenko N, Khomutov AR, Krüger B, Jänne J, Alhonen L.

Am J Pathol. 2006 Jan;168(1):115-22.

Supplemental Content

Loading ...
Support Center