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Items: 1 to 50 of 147

1.

Credibility, Replicability, and Reproducibility in Simulation for Biomedicine and Clinical Applications in Neuroscience.

Mulugeta L, Drach A, Erdemir A, Hunt CA, Horner M, Ku JP, Myers JG Jr, Vadigepalli R, Lytton WW.

Front Neuroinform. 2018 Apr 16;12:18. doi: 10.3389/fninf.2018.00018. eCollection 2018. Review.

2.

A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation.

Smith AK, Xu Y, Ropella GEP, Hunt CA.

J Pharmacol Exp Ther. 2018 Apr;365(1):127-138. doi: 10.1124/jpet.117.245019. Epub 2018 Feb 6.

PMID:
29434053
3.

Simulation enabled search for explanatory mechanisms of the fracture healing process.

Kennedy RC, Marmor M, Marcucio R, Hunt CA.

PLoS Comput Biol. 2018 Feb 2;14(2):e1005980. doi: 10.1371/journal.pcbi.1005980. eCollection 2018 Feb.

4.

Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments.

Smith AK, Petersen BK, Ropella GE, Kennedy RC, Kaplowitz N, Ookhtens M, Hunt CA.

PLoS Comput Biol. 2016 Dec 16;12(12):e1005253. doi: 10.1371/journal.pcbi.1005253. eCollection 2016 Dec.

5.

Virtual Experiments Enable Exploring and Challenging Explanatory Mechanisms of Immune-Mediated P450 Down-Regulation.

Petersen BK, Ropella GE, Hunt CA.

PLoS One. 2016 May 26;11(5):e0155855. doi: 10.1371/journal.pone.0155855. eCollection 2016.

6.

A cell-centered, agent-based framework that enables flexible environment granularities.

Kennedy RC, Ropella GE, Hunt CA.

Theor Biol Med Model. 2016 Feb 2;13:4. doi: 10.1186/s12976-016-0030-9.

7.

In silico, experimental, mechanistic model for extended-release felodipine disposition exhibiting complex absorption and a highly variable food interaction.

Kim SH, Jackson AJ, Hunt CA.

PLoS One. 2014 Sep 30;9(9):e108392. doi: 10.1371/journal.pone.0108392. eCollection 2014.

8.

Toward modular biological models: defining analog modules based on referent physiological mechanisms.

Petersen BK, Ropella GE, Hunt CA.

BMC Syst Biol. 2014 Aug 16;8:95. doi: 10.1186/s12918-014-0095-1.

9.

Cerebral cortical activity associated with non-experts' most accurate motor performance.

Dyke F, Godwin MM, Goel P, Rehm J, Rietschel JC, Hunt CA, Miller MW.

Hum Mov Sci. 2014 Oct;37:21-31. doi: 10.1016/j.humov.2014.06.008. Epub 2014 Jul 21.

PMID:
25058623
10.

Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models.

Kirschner DE, Hunt CA, Marino S, Fallahi-Sichani M, Linderman JJ.

Wiley Interdiscip Rev Syst Biol Med. 2014 Jul-Aug;6(4):289-309. doi: 10.1002/wsbm.1270. Epub 2014 May 9. Review.

11.

Self-inflicted burns: a systematic review of the literature.

Hahn AP, Jochai D, Caufield-Noll CP, Hunt CA, Allen LE, Rios R, Cordts GA.

J Burn Care Res. 2014 Jan-Feb;35(1):102-19. doi: 10.1097/BCR.0b013e31828b0a46. Review.

PMID:
24165664
12.

Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity.

Hunt CA, Kennedy RC, Kim SH, Ropella GE.

Wiley Interdiscip Rev Syst Biol Med. 2013 Jul-Aug;5(4):461-80. doi: 10.1002/wsbm.1222. Epub 2013 Jun 4. Review.

13.

Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products.

Kim SH, Jackson AJ, Hur R, Hunt CA.

Theor Biol Med Model. 2012 Aug 31;9:39. doi: 10.1186/1742-4682-9-39.

14.

Relational grounding facilitates development of scientifically useful multiscale models.

Hunt CA, Ropella GE, Lam Tn, Gewitz AD.

Theor Biol Med Model. 2011 Sep 27;8:35. doi: 10.1186/1742-4682-8-35. Review.

15.

Enabling clearance predictions to emerge from in silico actions of quasi-autonomous hepatocyte components.

Sheikh-Bahaei S, Hunt CA.

Drug Metab Dispos. 2011 Oct;39(10):1910-20. doi: 10.1124/dmd.111.038703. Epub 2011 Jul 18.

16.

MDCK cystogenesis driven by cell stabilization within computational analogues.

Engelberg JA, Datta A, Mostov KE, Hunt CA.

PLoS Comput Biol. 2011 Apr;7(4):e1002030. doi: 10.1371/journal.pcbi.1002030. Epub 2011 Apr 7.

17.

Cloud computing and validation of expandable in silico livers.

Ropella GE, Hunt CA.

BMC Syst Biol. 2010 Dec 3;4:168. doi: 10.1186/1752-0509-4-168.

18.

Tracing multiscale mechanisms of drug disposition in normal and diseased livers.

Park S, Kim SH, Ropella GE, Roberts MS, Hunt CA.

J Pharmacol Exp Ther. 2010 Jul;334(1):124-36. doi: 10.1124/jpet.110.168526. Epub 2010 Apr 20.

19.

Simulation of lung alveolar epithelial wound healing in vitro.

Kim SH, Matthay MA, Mostov K, Hunt CA.

J R Soc Interface. 2010 Aug 6;7(49):1157-70. doi: 10.1098/rsif.2010.0041. Epub 2010 Mar 17.

20.

Identifying the rules of engagement enabling leukocyte rolling, activation, and adhesion.

Tang J, Hunt CA.

PLoS Comput Biol. 2010 Feb 19;6(2):e1000681. doi: 10.1371/journal.pcbi.1000681.

21.

A computational approach to resolve cell level contributions to early glandular epithelial cancer progression.

Kim SH, Debnath J, Mostov K, Park S, Hunt CA.

BMC Syst Biol. 2009 Dec 31;3:122. doi: 10.1186/1752-0509-3-122.

22.

Mechanistic insight from in silico pharmacokinetic experiments: roles of P-glycoprotein, Cyp3A4 enzymes, and microenvironments.

Lam TN, Hunt CA.

J Pharmacol Exp Ther. 2010 Feb;332(2):398-412. doi: 10.1124/jpet.109.160739. Epub 2009 Oct 28.

23.

At the biological modeling and simulation frontier.

Hunt CA, Ropella GE, Lam TN, Tang J, Kim SH, Engelberg JA, Sheikh-Bahaei S.

Pharm Res. 2009 Nov;26(11):2369-400. doi: 10.1007/s11095-009-9958-3. Epub 2009 Sep 9. Review.

24.

Computational investigation of epithelial cell dynamic phenotype in vitro.

Kim SH, Park S, Mostov K, Debnath J, Hunt CA.

Theor Biol Med Model. 2009 May 28;6:8. doi: 10.1186/1742-4682-6-8.

25.

A computational approach to understand in vitro alveolar morphogenesis.

Kim SH, Yu W, Mostov K, Matthay MA, Hunt CA.

PLoS One. 2009;4(3):e4819. doi: 10.1371/journal.pone.0004819. Epub 2009 Mar 13.

26.

Mechanistic simulations explain paradoxical saquinavir metabolism during in vitro vectorial transport study.

Lam TN, Hunt CA.

Conf Proc IEEE Eng Med Biol Soc. 2008;2008:5462-5. doi: 10.1109/IEMBS.2008.4650450.

PMID:
19163953
27.

In silico simulation of epithelial cell tubulogenesis.

Engelberg JA, Kim M, Mostov KE, Hunt CA.

Conf Proc IEEE Eng Med Biol Soc. 2008;2008:1036-9. doi: 10.1109/IEMBS.2008.4649336.

PMID:
19162839
28.

Essential operating principles for tumor spheroid growth.

Engelberg JA, Ropella GE, Hunt CA.

BMC Syst Biol. 2008 Dec 23;2:110. doi: 10.1186/1752-0509-2-110.

29.

Computational strategies unravel and trace how liver disease changes hepatic drug disposition.

Park S, Ropella GE, Kim SH, Roberts MS, Hunt CA.

J Pharmacol Exp Ther. 2009 Jan;328(1):294-305. doi: 10.1124/jpet.108.142497. Epub 2008 Oct 23.

30.

Discovering plausible mechanistic details of hepatic drug interactions.

Lam TN, Hunt CA.

Drug Metab Dispos. 2009 Jan;37(1):237-46. doi: 10.1124/dmd.108.023820. Epub 2008 Oct 20.

31.

Dichotomies between computational and mathematical models.

Hunt CA, Ropella GE, Park S, Engelberg J.

Nat Biotechnol. 2008 Jul;26(7):737-8; author reply 738-9. doi: 10.1038/nbt0708-737. No abstract available.

PMID:
18612289
32.

In silico methods for unraveling the mechanistic complexities of intestinal absorption: metabolism-efflux transport interactions.

Garmire LX, Hunt CA.

Drug Metab Dispos. 2008 Jul;36(7):1414-24. doi: 10.1124/dmd.107.020164. Epub 2008 Apr 24.

33.

Predictions of hepatic disposition properties using a mechanistically realistic, physiologically based model.

Yan L, Sheihk-Bahaei S, Park S, Ropella GE, Hunt CA.

Drug Metab Dispos. 2008 Apr;36(4):759-68. doi: 10.1124/dmd.107.019067. Epub 2008 Jan 28.

34.

A framework and mechanistically focused, in silico method for enabling rational translational research.

Hunt CA, Baranzini S, Matthay MA, Park S.

Summit Transl Bioinform. 2008 Mar 1;2008:46-50.

35.

Modeling and simulation of hepatic drug disposition using a physiologically based, multi-agent in silico liver.

Yan L, Ropella GE, Park S, Roberts MS, Hunt CA.

Pharm Res. 2008 May;25(5):1023-36. Epub 2007 Nov 28.

PMID:
18044012
36.

Synthetic nano-LDL with paclitaxel oleate as a targeted drug delivery vehicle for glioblastoma multiforme.

Nikanjam M, Gibbs AR, Hunt CA, Budinger TF, Forte TM.

J Control Release. 2007 Dec 20;124(3):163-71. Epub 2007 Sep 26.

PMID:
17964677
37.

An in silico transwell device for the study of drug transport and drug-drug interactions.

Garmire LX, Garmire DG, Hunt CA.

Pharm Res. 2007 Dec;24(12):2171-86. Epub 2007 Aug 17.

PMID:
17703347
38.

The effect of regional variations of the trabecular bone properties on the compressive strength of human vertebral bodies.

Kim DG, Hunt CA, Zauel R, Fyhrie DP, Yeni YN.

Ann Biomed Eng. 2007 Nov;35(11):1907-13. Epub 2007 Aug 10.

PMID:
17690983
39.
40.

Dynamics of in silico leukocyte rolling, activation, and adhesion.

Tang J, Ley KF, Hunt CA.

BMC Syst Biol. 2007 Feb 19;1:14.

41.

Evidence-based modeling of critical illness: an initial consensus from the Society for Complexity in Acute Illness.

Vodovotz Y, Clermont G, Hunt CA, Lefering R, Bartels J, Seydel R, Hotchkiss J, Ta'asan S, Neugebauer E, An G.

J Crit Care. 2007 Mar;22(1):77-84.

42.

Simulating in vitro epithelial morphogenesis in multiple environments.

Grant MR, Kim SH, Hunt CA.

Comput Syst Bioinformatics Conf. 2006:381-4.

43.

Evaluation of postinjury hepatocyte function by central amino acid clearance.

Maull KI, Long CL, Wagner DA, Hunt CA, Scanlon PH, Laws HL.

J Invest Surg. 2007 Jan-Feb;20(1):35-40.

PMID:
17365405
44.

Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.

Yu W, Fang X, Ewald A, Wong K, Hunt CA, Werb Z, Matthay MA, Mostov K.

Mol Biol Cell. 2007 May;18(5):1693-700. Epub 2007 Mar 1.

45.

In silico representation of the liver-connecting function to anatomy, physiology and heterogeneous microenvironments.

Yan L, Hunt CA, Ropella GE, Roberts MS.

Conf Proc IEEE Eng Med Biol Soc. 2004;2:853-6.

PMID:
17271811
46.

Modeling transport kinetics with StarLogo.

Wong DY, Qutub A, Hunt CA.

Conf Proc IEEE Eng Med Biol Soc. 2004;2:845-8.

PMID:
17271809
47.

Representing intestinal drug transport in silico: an agent-oriented approach.

Liu Y, Hunt CA.

Conf Proc IEEE Eng Med Biol Soc. 2004;1:770-3.

PMID:
17271791
48.

An agent-based computational approach for representing aspects of in vitro multi-cellular tumor spheroid growth.

Chen S, Ganguli S, Hunt CA.

Conf Proc IEEE Eng Med Biol Soc. 2004;1:691-4.

PMID:
17271771
49.

Modeling mammary gland morphogenesis as a reaction-diffusion process.

Grant MR, Hunt CA, Xia L, Fata JE, Bissell MJ.

Conf Proc IEEE Eng Med Biol Soc. 2004;1:679-82.

PMID:
17271768
50.

The necessity of a theory of biology for tissue engineering: metabolism-repair systems.

Ganguli S, Hunt CA.

Conf Proc IEEE Eng Med Biol Soc. 2004;7:5031-4.

PMID:
17271446

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