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Lipophilicity of the Cystic Fibrosis drug, Ivacaftor, and its destabilizing effect on the major CF-causing mutation: F508del.

Chin S, Hung M, Won A, Wu YS, Ahmadi S, Yang D, Elmallah S, Toutah K, Hamilton CM, Young RN, Viirre RD, Yip CM, Bear CE.

Mol Pharmacol. 2018 Jun 14. pii: mol.118.112177. doi: 10.1124/mol.118.112177. [Epub ahead of print]


Orofacial strength, dysarthria, and dysphagia in Congenital Myotonic Dystrophy.

Berggren KN, Hung M, Dixon MM, Bounsanga J, Crockett B, Foye MD, Gu Y, Campbell C, Butterfield RJ, Johnson NE.

Muscle Nerve. 2018 Jun 14. doi: 10.1002/mus.26176. [Epub ahead of print]


A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues.

Chou CK, Huang PJ, Tsou PH, Wei Y, Lee HH, Wang YN, Liu YL, Shi C, Yeh HC, Kameoka J, Hung MC.

Biosens Bioelectron. 2018 May 29;117:97-103. doi: 10.1016/j.bios.2018.05.053. [Epub ahead of print]


Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.

Nature. 2018 Jun 6. doi: 10.1038/s41586-018-0198-8. [Epub ahead of print]


The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion.

Sing TL, Hung MP, Ohnuki S, Suzuki G, San Luis BJ, McClain M, Unruh JR, Yu Z, Ou J, Marshall-Sheppard J, Huh WK, Costanzo M, Boone C, Ohya Y, Jaspersen SL, Brown GW.

J Cell Biol. 2018 Jun 6. pii: jcb.201709009. doi: 10.1083/jcb.201709009. [Epub ahead of print]


Reduction of Myocardial Ischemia-Reperfusion Injury by Inactivating Oxidized Phospholipids.

Yeang C, Hasanally D, Que X, Hung MY, Stemankovic A, Chan D, Chaudhary R, Margulets V, Edel AL, Hoshijima M, Gu Y, Bradford W, Dalton N, Miu P, Cheung DYC, Jassal DS, Pierce GN, Peterson KL, Kirshenbaum LA, Witztum JL, Tsimikas S, Ravandi A.

Cardiovasc Res. 2018 May 30. doi: 10.1093/cvr/cvy136. [Epub ahead of print]


Effect of intraoperative hyperoxia on the incidence of surgical site infections: a meta-analysis.

Cohen B, Schacham YN, Ruetzler K, Ahuja S, Yang D, Mascha EJ, Barclay AB, Hung MH, Sessler DI.

Br J Anaesth. 2018 Jun;120(6):1176-1186. doi: 10.1016/j.bja.2018.02.027. Epub 2018 Apr 5. Review.


Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression.

Yang WH, Cha JH, Xia W, Lee HH, Chan LC, Wang YN, Hsu JL, Ren G, Hung MC.

Cancer Res. 2018 May 22. pii: canres.0040.2018. doi: 10.1158/0008-5472.CAN-18-0040. [Epub ahead of print]


STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion.

Hsu JM, Xia W, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, Khoo KH, Hsu JL, Li CW, Lim SO, Chang SS, Chen YC, Ren GX, Hung MC.

Nat Commun. 2018 May 15;9(1):1908. doi: 10.1038/s41467-018-04313-6.


Distinct heat shock factors and chromatin modifications mediate the organ-autonomous transcriptional memory of heat stress.

Liu HC, Lämke J, Lin SY, Hung MJ, Liu KM, Charng YY, Bäurle I.

Plant J. 2018 May 11. doi: 10.1111/tpj.13958. [Epub ahead of print]


Pyogenic hepatic abscess induced secondary to toothpick penetration of stomach.

Chou DA, Hung MC, Lai JC, Huang WS.

Turk J Gastroenterol. 2018 Mar;29(2):241-242. doi: 10.5152/tjg.2018.17346. No abstract available.


Corrigendum to "Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation" [Lung Cancer 112 (October) (2017) 81-89].

Hsieh FS, Hung MH, Wang CY, Chen YL, Hsiao YJ, Tsai MH, Li JR, Chen LJ, Shih CT, Chao TI, Chen KF.

Lung Cancer. 2018 Jul;121:105-106. doi: 10.1016/j.lungcan.2018.04.021. Epub 2018 May 3. No abstract available.


Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing.

Xu A, Zhou R, Tu J, Huo Z, Zhu D, Wang D, Gingold JA, Mata H, Rao PH, Liu M, Mohamed AMT, Kong CSL, Jewell BE, Xia W, Zhao R, Hung MC, Lee DF.

Stem Cell Res. 2018 May;29:215-219. doi: 10.1016/j.scr.2018.04.013. Epub 2018 Apr 27.


17β-Estradiol and/or estrogen receptor alpha signaling blocks protein phosphatase 1 mediated ISO induced cardiac hypertrophy.

Fang HY, Hung MY, Lin YM, Pandey S, Chang CC, Lin KH, Shen CY, Viswanadha VP, Kuo WW, Huang CY.

PLoS One. 2018 May 3;13(5):e0196569. doi: 10.1371/journal.pone.0196569. eCollection 2018.


GABA tea attenuates cardiac apoptosis in spontaneously hypertensive rats (SHR) by enhancing PI3K/Akt-mediated survival pathway and suppressing Bax/Bak dependent apoptotic pathway.

Chen BC, Hung MY, Wang HF, Yeh LJ, Pandey S, Chen RJ, Chang RL, Viswanadha VP, Lin KH, Huang CY.

Environ Toxicol. 2018 Apr 30. doi: 10.1002/tox.22565. [Epub ahead of print]


ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer.

Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN, Su X, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G, Sood AK, Chen J, You MJ, Sun SC, Liang H, Huang Y, Yang X, Sun D, Sun Y, Hung MC, Ma L.

Cell Rep. 2018 Apr 17;23(3):823-837. doi: 10.1016/j.celrep.2018.03.078.


YY1 and HDAC9c transcriptionally regulate p38-mediated mesenchymal stem cell differentiation into osteoblasts.

Chen YH, Chung CC, Liu YC, Lai WC, Lin ZS, Chen TM, Li LY, Hung MC.

Am J Cancer Res. 2018 Mar 1;8(3):514-525. eCollection 2018.


Validation and Generalizability of Preoperative PROMIS Scores to Predict Postoperative Success in Foot and Ankle Patients.

Anderson MR, Houck JR, Saltzman CL, Hung M, Nickisch F, Barg A, Beals T, Baumhauer JF.

Foot Ankle Int. 2018 Apr 1:1071100718765225. doi: 10.1177/1071100718765225. [Epub ahead of print]


Activation of the monocytic α7 nicotinic acetylcholine receptor modulates oxidative stress and inflammation-associated development of coronary artery spasm via a p38 MAP-kinase signaling-dependent pathway.

Hung MY, Wu YH, Bamodu OA, Chen X, Lin YK, Hu P, Chang NC, Pang JS, Yeh CT.

Free Radic Biol Med. 2018 May 20;120:266-276. doi: 10.1016/j.freeradbiomed.2018.03.050. Epub 2018 Mar 31.


Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.

Wang YN, Lee HH, Chou CK, Yang WH, Wei Y, Chen CT, Yao J, Hsu JL, Zhu C, Ying H, Ye Y, Wang WJ, Lim SO, Xia W, Ko HW, Liu X, Liu CG, Wu X, Wang H, Li D, Prakash LR, Katz MH, Kang Y, Kim M, Fleming JB, Fogelman D, Javle M, Maitra A, Hung MC.

Cancer Cell. 2018 Apr 9;33(4):752-769.e8. doi: 10.1016/j.ccell.2018.02.012. Epub 2018 Mar 29.


The association between red blood cell transfusion and outcomes in patients with upper gastrointestinal bleeding.

Chen YC, Hsiao CT, Lin LC, Hsiao KY, Hung MS.

Clin Transl Gastroenterol. 2018 Mar 29;9(3):138. doi: 10.1038/s41424-018-0004-9.


Corrigendum to "Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation" [Lung Cancer 112, (October) (2017) 81-89].

Hsieh FS, Hung MH, Wang CY, Chen YL, Hsiao YJ, Tsai MH, Li JR, Chen LJ, Shih CT, Chao TI, Chen KF.

Lung Cancer. 2018 May;119:127-128. doi: 10.1016/j.lungcan.2018.03.012. Epub 2018 Mar 19. No abstract available.


A large pseudoaneurysm of the superficial femoral artery in a patient with SLE with Salmonella group D infection.

Liu CW, Hung ML, Liao HT, Tsai CY.

BMJ Case Rep. 2018 Mar 20;2018. pii: bcr-2017-222393. doi: 10.1136/bcr-2017-222393.


The association of emergency department administration of sodium bicarbonate after out of hospital cardiac arrest with outcomes.

Chen YC, Hung MS, Liu CY, Hsiao CT, Yang YH.

Am J Emerg Med. 2018 Mar 5. pii: S0735-6757(18)30187-6. doi: 10.1016/j.ajem.2018.03.010. [Epub ahead of print]


4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy.

Lin SY, Yeh TK, Song JS, Hung MS, Cheng MF, Liao FY, Li AS, Cheng SY, Lin LM, Chiu CH, Wu MH, Lin YJ, Hsiao W, Sun M, Wang YH, Huang CH, Tang YC, Chang HH, Huang ZT, Chao YS, Shih C, Pan SL, Wu SY, Kuo CC, Ueng SH.

Bioorg Chem. 2018 Apr;77:600-607. doi: 10.1016/j.bioorg.2018.02.010. Epub 2018 Feb 12.


Survival-associated factors of first-line EGFR-tyrosine kinase inhibitor responders and non-responders in lung adenocarcinoma patients with common EGFR mutations.

Hung MS, Fang YH, Lin YC, Lung JH, Hsieh MJ, Tsai YH.

Mol Clin Oncol. 2018 Mar;8(3):421-428. doi: 10.3892/mco.2018.1550. Epub 2018 Jan 10.


Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1.

Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, Khoo KH, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Huang TH, Sahin AA, Hortobagyi GN, Yoo SS, Hung MC.

Cancer Cell. 2018 Feb 12;33(2):187-201.e10. doi: 10.1016/j.ccell.2018.01.009.


Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation.

Weng FJ, Garcia RI, Lutzu S, Alviña K, Zhang Y, Dushko M, Ku T, Zemoura K, Rich D, Garcia-Dominguez D, Hung M, Yelhekar TD, Sørensen AT, Xu W, Chung K, Castillo PE, Lin Y.

Neuron. 2018 Mar 7;97(5):1137-1152.e5. doi: 10.1016/j.neuron.2018.01.026. Epub 2018 Feb 8.


Single oral dose acute and subacute toxicity of a c-MET tyrosine kinase inhibitor and CDK 4/6 inhibitor combination drug therapy.

Smith B, Hsu YH, Flores R, Gagea M, Craig S, Hung MC.

Am J Cancer Res. 2018 Jan 1;8(1):183-191. eCollection 2018.


A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing.

Zhou R, Xu A, Wang D, Zhu D, Mata H, Huo Z, Tu J, Liu M, Mohamed AMT, Jewell BE, Gingold J, Xia W, Rao PH, Hung MC, Zhao R, Lee DF.

Stem Cell Res. 2018 Mar;27:131-135. doi: 10.1016/j.scr.2018.01.035. Epub 2018 Jan 28.


Enrichment of Extracellular Vesicle Subpopulations Via Affinity Chromatography.

Hung ME, Lenzini SB, Stranford DM, Leonard JN.

Methods Mol Biol. 2018;1740:109-124. doi: 10.1007/978-1-4939-7652-2_9.


Identification of the benefits, enablers and barriers to integrating junior pharmacists into the ward team within one UK-based hospital.

Hung MY, Wright DJ, Blacklock J, Needle RJ.

Integr Pharm Res Pract. 2017 Nov 13;6:181-190. doi: 10.2147/IPRP.S146630. eCollection 2017.


Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function.

Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M, Hung MC, Wei W.

Mol Cell. 2018 Jan 18;69(2):279-291.e5. doi: 10.1016/j.molcel.2017.12.024.


Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment.

Korphaisarn K, Chou CK, Xia WY, Clarke CN, Katkhuda R, Davis JS, Raghav KP, Liao HW, Wu JY, Menter DG, Maru DM, Hung MC, Kopetz S.

Am J Cancer Res. 2017 Dec 1;7(12):2587-2599. eCollection 2017.


Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).

Koltun DO, Parkhill EQ, Kalla R, Perry TD, Elzein E, Li X, Simonovich SP, Ziebenhaus C, Hansen TR, Marchand B, Hung WK, Lagpacan L, Hung M, Aoyama RG, Murray BP, Perry JK, Somoza JR, Villaseñor AG, Pagratis N, Zablocki JA.

Bioorg Med Chem Lett. 2017 Oct 20. pii: S0960-894X(17)31034-X. doi: 10.1016/j.bmcl.2017.10.040. [Epub ahead of print]


Nasal high-flow oxygen therapy improves arterial oxygenation during one-lung ventilation in non-intubated thoracoscopic surgery.

Wang ML, Hung MH, Chen JS, Hsu HH, Cheng YJ.

Eur J Cardiothorac Surg. 2018 May 1;53(5):1001-1006. doi: 10.1093/ejcts/ezx450.


HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis.

Lai HH, Li JN, Wang MY, Huang HY, Croce CM, Sun HL, Lyu YJ, Kang JW, Chiu CF, Hung MC, Suzuki HI, Chen PS.

J Clin Invest. 2018 Feb 1;128(2):625-643. doi: 10.1172/JCI89212. Epub 2017 Dec 18.


Pneumatically Actuated Soft Micromold Device for Fabricating Collagen and Matrigel Microparticles.

Huang PJ, Chou CK, Chen CT, Yamaguchi H, Qu J, Muliana A, Hung MC, Kameoka J.

Soft Robot. 2017 Dec;4(4):390-399. doi: 10.1089/soro.2016.0073. Epub 2017 Jun 27.


The Relationship of PROMIS Pain Interference and Physical Function Scales.

Kendall R, Wagner B, Brodke D, Bounsanga J, Voss M, Gu Y, Spiker R, Lawrence B, Hung M.

Pain Med. 2017 Dec 7. doi: 10.1093/pm/pnx310. [Epub ahead of print]


Nurses' preparedness for infectious disease outbreaks: A literature review and narrative synthesis of qualitative evidence.

Lam SKK, Kwong EWY, Hung MSY, Pang SMC, Chiang VCL.

J Clin Nurs. 2018 Apr;27(7-8):e1244-e1255. doi: 10.1111/jocn.14210. Epub 2018 Jan 11. Review.


Inhibition of protein phosphatase 5 suppresses non-small cell lung cancer through AMP-activated kinase activation.

Hsieh FS, Hung MH, Wang CY, Chen YL, Hsiao YJ, Tsai MH, Li JR, Chen LJ, Shih CT, Chao TI, Chen KF.

Lung Cancer. 2017 Oct;112:81-89. doi: 10.1016/j.lungcan.2017.07.040. Epub 2017 Aug 5. Erratum in: Lung Cancer. 2018 Mar 19;:. Lung Cancer. 2018 May 3;:.


Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly.

Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X.

Theranostics. 2017 Oct 17;7(19):4805-4824. doi: 10.7150/thno.20771. eCollection 2017.


In silico-based identification of human α-enolase inhibitors to block cancer cell growth metabolically.

Lung J, Chen KL, Hung CH, Chen CC, Hung MS, Lin YC, Wu CY, Lee KD, Shih NY, Tsai YH.

Drug Des Devel Ther. 2017 Nov 16;11:3281-3290. doi: 10.2147/DDDT.S149214. eCollection 2017.


Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice.

Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Chai SP, Wei Y, Wang H, Hung MC, Hsieh SY.

Hepatology. 2018 Jun;67(6):2226-2243. doi: 10.1002/hep.29678. Epub 2018 Apr 19.


JAK2-binding long noncoding RNA promotes breast cancer brain metastasis.

Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C.

J Clin Invest. 2017 Dec 1;127(12):4498-4515. doi: 10.1172/JCI91553. Epub 2017 Nov 13.


Rational combination of immunotherapy for triple negative breast cancer treatment.

Li CW, Lim SO, Hsu JL, Hung MC.

Chin Clin Oncol. 2017 Oct;6(5):54. doi: :10.21037/cco.2017.08.04.


Impact of hypertrophic pulmonary osteoarthropathy on patients with lung cancer.

Fang YH, Hsu CC, Hsieh MJ, Hung MS, Tsai YH, Lin YC.

Onco Targets Ther. 2017 Oct 25;10:5173-5177. doi: 10.2147/OTT.S139558. eCollection 2017.


Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers.

Nilsson MB, Sun H, Diao L, Tong P, Liu D, Li L, Fan Y, Poteete A, Lim SO, Howells K, Haddad V, Gomez D, Tran H, Pena GA, Sequist LV, Yang JC, Wang J, Kim ES, Herbst R, Lee JJ, Hong WK, Wistuba I, Hung MC, Sood AK, Heymach JV.

Sci Transl Med. 2017 Nov 8;9(415). pii: eaao4307. doi: 10.1126/scitranslmed.aao4307.

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