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Items: 38


Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics.

Robertson J, Humphries JD, Paul NR, Warwood S, Knight D, Byron A, Humphries MJ.

Methods Mol Biol. 2017;1636:235-251. doi: 10.1007/978-1-4939-7154-1_15.


The integrin adhesome network at a glance.

Horton ER, Humphries JD, James J, Jones MC, Askari JA, Humphries MJ.

J Cell Sci. 2016 Nov 15;129(22):4159-4163. Epub 2016 Oct 31. Review.


Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition.

Horton ER, Humphries JD, Stutchbury B, Jacquemet G, Ballestrem C, Barry ST, Humphries MJ.

J Cell Biol. 2016 Feb 1;212(3):349-64. doi: 10.1083/jcb.201508080.


Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome.

Horton ER, Astudillo P, Humphries MJ, Humphries JD.

Exp Cell Res. 2016 Apr 10;343(1):7-13. doi: 10.1016/j.yexcr.2015.10.025. Epub 2015 Oct 26. Review.


Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly.

Horton ER, Byron A, Askari JA, Ng DHJ, Millon-Frémillon A, Robertson J, Koper EJ, Paul NR, Warwood S, Knight D, Humphries JD, Humphries MJ.

Nat Cell Biol. 2015 Dec;17(12):1577-1587. doi: 10.1038/ncb3257. Epub 2015 Oct 19.


Proteomic analysis of integrin-associated complexes from mesenchymal stem cells.

Ajeian JN, Horton ER, Astudillo P, Byron A, Askari JA, Millon-Frémillon A, Knight D, Kimber SJ, Humphries MJ, Humphries JD.

Proteomics Clin Appl. 2016 Jan;10(1):51-7. doi: 10.1002/prca.201500033. Epub 2015 Sep 17.


Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.

Randles MJ, Woolf AS, Huang JL, Byron A, Humphries JD, Price KL, Kolatsi-Joannou M, Collinson S, Denny T, Knight D, Mironov A, Starborg T, Korstanje R, Humphries MJ, Long DA, Lennon R.

J Am Soc Nephrol. 2015 Dec;26(12):3021-34. doi: 10.1681/ASN.2014040419. Epub 2015 Apr 20.


Emerging properties of adhesion complexes: what are they and what do they do?

Humphries JD, Paul NR, Humphries MJ, Morgan MR.

Trends Cell Biol. 2015 Jul;25(7):388-97. doi: 10.1016/j.tcb.2015.02.008. Epub 2015 Mar 27. Review.


Isolation of integrin-based adhesion complexes.

Jones MC, Humphries JD, Byron A, Millon-Frémillon A, Robertson J, Paul NR, Ng DH, Askari JA, Humphries MJ.

Curr Protoc Cell Biol. 2015 Mar 2;66:9.8.1-15. doi: 10.1002/0471143030.cb0908s66.


Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling.

Robertson J, Jacquemet G, Byron A, Jones MC, Warwood S, Selley JN, Knight D, Humphries JD, Humphries MJ.

Nat Commun. 2015 Feb 13;6:6265. doi: 10.1038/ncomms7265.


A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting.

Byron A, Askari JA, Humphries JD, Jacquemet G, Koper EJ, Warwood S, Choi CK, Stroud MJ, Chen CS, Knight D, Humphries MJ.

Nat Commun. 2015 Jan 22;6:6135. doi: 10.1038/ncomms7135.


Microtubule-dependent modulation of adhesion complex composition.

Ng DH, Humphries JD, Byron A, Millon-Frémillon A, Humphries MJ.

PLoS One. 2014 Dec 19;9(12):e115213. doi: 10.1371/journal.pone.0115213. eCollection 2014.


Glomerular cell cross-talk influences composition and assembly of extracellular matrix.

Byron A, Randles MJ, Humphries JD, Mironov A, Hamidi H, Harris S, Mathieson PW, Saleem MA, Satchell SC, Zent R, Humphries MJ, Lennon R.

J Am Soc Nephrol. 2014 May;25(5):953-66. doi: 10.1681/ASN.2013070795. Epub 2014 Jan 16.


Global analysis reveals the complexity of the human glomerular extracellular matrix.

Lennon R, Byron A, Humphries JD, Randles MJ, Carisey A, Murphy S, Knight D, Brenchley PE, Zent R, Humphries MJ.

J Am Soc Nephrol. 2014 May;25(5):939-51. doi: 10.1681/ASN.2013030233. Epub 2014 Jan 16.


Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway.

Jacquemet G, Morgan MR, Byron A, Humphries JD, Choi CK, Chen CS, Caswell PT, Humphries MJ.

J Cell Sci. 2013 Sep 15;126(Pt 18):4121-35. doi: 10.1242/jcs.121988. Epub 2013 Jul 10.


Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.

Soteriou D, Iskender B, Byron A, Humphries JD, Borg-Bartolo S, Haddock MC, Baxter MA, Knight D, Humphries MJ, Kimber SJ.

J Biol Chem. 2013 Jun 28;288(26):18716-31. doi: 10.1074/jbc.M113.463372. Epub 2013 May 8.


Defining the extracellular matrix using proteomics.

Byron A, Humphries JD, Humphries MJ.

Int J Exp Pathol. 2013 Apr;94(2):75-92. doi: 10.1111/iep.12011. Epub 2013 Feb 19. Review.


Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver.

Rashid ST, Humphries JD, Byron A, Dhar A, Askari JA, Selley JN, Knight D, Goldin RD, Thursz M, Humphries MJ.

J Proteome Res. 2012 Aug 3;11(8):4052-64. doi: 10.1021/pr3000927. Epub 2012 Jun 28.


Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment.

Byron A, Humphries JD, Craig SE, Knight D, Humphries MJ.

Proteomics. 2012 Jul;12(13):2107-14. doi: 10.1002/pmic.201100487.


Alternative cellular roles for proteins identified using proteomics.

Byron A, Humphries JD, Humphries MJ.

J Proteomics. 2012 Jul 16;75(13):4184-5. doi: 10.1016/j.jprot.2012.04.049. Epub 2012 May 9. No abstract available.


A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis.

Bass MD, Williamson RC, Nunan RD, Humphries JD, Byron A, Morgan MR, Martin P, Humphries MJ.

Dev Cell. 2011 Oct 18;21(4):681-93. doi: 10.1016/j.devcel.2011.08.007. Epub 2011 Oct 6. Erratum in: Dev Cell. 2012 Nov 13;23(5):1081-2.


Proteomic analysis of integrin adhesion complexes.

Byron A, Humphries JD, Bass MD, Knight D, Humphries MJ.

Sci Signal. 2011 Apr 5;4(167):pt2. doi: 10.1126/scisignal.2001827.


Anti-integrin monoclonal antibodies.

Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ.

J Cell Sci. 2009 Nov 15;122(Pt 22):4009-11. doi: 10.1242/jcs.056770. Review. No abstract available.


Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.

Humphries JD, Byron A, Bass MD, Craig SE, Pinney JW, Knight D, Humphries MJ.

Sci Signal. 2009 Sep 8;2(87):ra51. doi: 10.1126/scisignal.2000396.


Inhospitable night.

Humphries JD.

Creat Nurs. 2009;15(3):121-3. No abstract available.


Workplace debt: sleep loss.

Humphries JD.

Creat Nurs. 2009;15(1):23-7.


Sleep disruption in hospitalized adults.

Humphries JD.

Medsurg Nurs. 2008 Dec;17(6):391-5.


Quantification of integrin receptor agonism by fluorescence lifetime imaging.

Parsons M, Messent AJ, Humphries JD, Deakin NO, Humphries MJ.

J Cell Sci. 2008 Feb 1;121(Pt 3):265-71. doi: 10.1242/jcs.018440.


Vinculin controls focal adhesion formation by direct interactions with talin and actin.

Humphries JD, Wang P, Streuli C, Geiger B, Humphries MJ, Ballestrem C.

J Cell Biol. 2007 Dec 3;179(5):1043-57.


The alternatively spliced type III connecting segment of fibronectin is a zinc-binding module.

Askari JA, Thornton DJ, Humphries JD, Buckley PA, Humphries MJ.

Matrix Biol. 2007 Jul;26(6):485-93. Epub 2007 Apr 6.


CD14 is a ligand for the integrin alpha4beta1.

Humphries JD, Humphries MJ.

FEBS Lett. 2007 Feb 20;581(4):757-63. Epub 2007 Jan 25.


Integrin ligands at a glance.

Humphries JD, Byron A, Humphries MJ.

J Cell Sci. 2006 Oct 1;119(Pt 19):3901-3. Review. No abstract available.


A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity.

Gläsner J, Blum H, Wehner V, Stilz HU, Humphries JD, Curley GP, Mould AP, Humphries MJ, Hallmann R, Röllinghoff M, Gessner A.

J Immunol. 2005 Oct 1;175(7):4724-34.


Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors.

Humphries JD, Schofield NR, Mostafavi-Pour Z, Green LJ, Garratt AN, Mould AP, Humphries MJ.

J Biol Chem. 2005 Mar 18;280(11):10234-43. Epub 2005 Jan 4.


An unraveling tale of how integrins are activated from within.

Travis MA, Humphries JD, Humphries MJ.

Trends Pharmacol Sci. 2003 Apr;24(4):192-7. Review.


Molecular basis of ligand recognition by integrin alpha5beta 1. II. Specificity of arg-gly-Asp binding is determined by Trp157 OF THE alpha subunit.

Humphries JD, Askari JA, Zhang XP, Takada Y, Humphries MJ, Mould AP.

J Biol Chem. 2000 Jul 7;275(27):20337-45.


All-trans retinoic acid compromises desmosome expression in human epidermis.

Humphries JD, Parry EJ, Watson RE, Garrod DR, Griffiths CE.

Br J Dermatol. 1998 Oct;139(4):577-84.


Fibrillin microfibrils are reduced in skin exhibiting striae distensae.

Watson RE, Parry EJ, Humphries JD, Jones CJ, Polson DW, Kielty CM, Griffiths CE.

Br J Dermatol. 1998 Jun;138(6):931-7.


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