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Items: 47

1.

Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver.

Hassani-Nezhad-Gashti F, Rysä J, Kummu O, Näpänkangas J, Buler M, Karpale M, Hukkanen J, Hakkola J.

Biochem Pharmacol. 2018 Feb;148:253-264. doi: 10.1016/j.bcp.2018.01.001. Epub 2018 Jan 5.

PMID:
29309761
2.

Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study.

Leder L, Kolehmainen M, Narverud I, Dahlman I, Myhrstad MC, de Mello VD, Paananen J, Carlberg C, Schwab U, Herzig KH, Cloetens L, Storm MU, Hukkanen J, Savolainen MJ, Rosqvist F, Hermansen K, Dragsted LO, Gunnarsdottir I, Thorsdottir I, Risérus U, Åkesson B, Thoresen M, Arner P, Poutanen KS, Uusitupa M, Holven KB, Ulven SM.

Genes Nutr. 2016 Mar 17;11:3. doi: 10.1186/s12263-016-0521-4. eCollection 2016.

3.

Regulation of hepatic energy metabolism by the nuclear receptor PXR.

Hakkola J, Rysä J, Hukkanen J.

Biochim Biophys Acta. 2016 Sep;1859(9):1072-1082. doi: 10.1016/j.bbagrm.2016.03.012. Epub 2016 Apr 8. Review.

PMID:
27041449
4.

A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention.

Lankinen M, Schwab U, Kolehmainen M, Paananen J, Nygren H, Seppänen-Laakso T, Poutanen K, Hyötyläinen T, Risérus U, Savolainen MJ, Hukkanen J, Brader L, Marklund M, Rosqvist F, Hermansen K, Cloetens L, Önning G, Thorsdottir I, Gunnarsdottir I, Åkesson B, Dragsted LO, Uusitupa M, Orešič M.

J Nutr. 2016 Mar 9. pii: jn220459. [Epub ahead of print]

PMID:
26962194
5.

The effect of pregnane X receptor agonists on postprandial incretin hormone secretion in rats and humans.

Hukkanen J, Rysa J, Makela KA, Herzig KH, Hakkola J, Savolainen MJ.

J Physiol Pharmacol. 2015 Dec;66(6):831-9.

6.

The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity.

Hukkanen J, Puurunen J, Hyötyläinen T, Savolainen MJ, Ruokonen A, Morin-Papunen L, Orešič M, Piltonen T, Tapanainen JS.

Br J Clin Pharmacol. 2015 Sep;80(3):473-9. doi: 10.1111/bcp.12701. Epub 2015 Jul 22.

7.

Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome.

Kolehmainen M, Ulven SM, Paananen J, de Mello V, Schwab U, Carlberg C, Myhrstad M, Pihlajamäki J, Dungner E, Sjölin E, Gunnarsdottir I, Cloetens L, Landin-Olsson M, Akesson B, Rosqvist F, Hukkanen J, Herzig KH, Dragsted LO, Savolainen MJ, Brader L, Hermansen K, Risérus U, Thorsdottir I, Poutanen KS, Uusitupa M, Arner P, Dahlman I.

Am J Clin Nutr. 2015 Jan;101(1):228-39. doi: 10.3945/ajcn.114.092783. Epub 2014 Nov 19.

PMID:
25527767
8.

Whole grain rye intake, reflected by a biomarker, is associated with favorable blood lipid outcomes in subjects with the metabolic syndrome--a randomized study.

Magnusdottir OK, Landberg R, Gunnarsdottir I, Cloetens L, Åkesson B, Rosqvist F, Schwab U, Herzig KH, Hukkanen J, Savolainen MJ, Brader L, Hermansen K, Kolehmainen M, Poutanen K, Uusitupa M, Risérus U, Thorsdottir I.

PLoS One. 2014 Oct 23;9(10):e110827. doi: 10.1371/journal.pone.0110827. eCollection 2014.

9.

A dietary biomarker approach captures compliance and cardiometabolic effects of a healthy Nordic diet in individuals with metabolic syndrome.

Marklund M, Magnusdottir OK, Rosqvist F, Cloetens L, Landberg R, Kolehmainen M, Brader L, Hermansen K, Poutanen KS, Herzig KH, Hukkanen J, Savolainen MJ, Dragsted LO, Schwab U, Paananen J, Uusitupa M, Åkesson B, Thorsdottir I, Risérus U.

J Nutr. 2014 Oct;144(10):1642-9. doi: 10.3945/jn.114.193771. Epub 2014 Jul 30.

PMID:
25080537
10.

Adherence to the Nordic Nutrition Recommendations in a Nordic population with metabolic syndrome: high salt consumption and low dietary fibre intake (The SYSDIET study).

Jonsdottir SE, Brader L, Gunnarsdottir I, Kally Magnusdottir O, Schwab U, Kolehmainen M, Risérus U, Herzig KH, Cloetens L, Helgegren H, Johansson-Persson A, Hukkanen J, Poutanen K, Uusitupa M, Hermansen K, Thorsdottir I.

Food Nutr Res. 2013 Dec 16;57. doi: 10.3402/fnr.v57i0.21391. Review.

11.

Pregnane X receptor (PXR)--a contributor to the diabetes epidemic?

Hukkanen J, Hakkola J, Rysä J.

Drug Metabol Drug Interact. 2014;29(1):3-15. doi: 10.1515/dmdi-2013-0036. Review.

PMID:
24166671
12.

Pregnane X receptor agonists impair postprandial glucose tolerance.

Rysä J, Buler M, Savolainen MJ, Ruskoaho H, Hakkola J, Hukkanen J.

Clin Pharmacol Ther. 2013 Jun;93(6):556-63. doi: 10.1038/clpt.2013.48. Epub 2013 Mar 5.

PMID:
23588309
13.

Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome -- a randomized study (SYSDIET).

Uusitupa M, Hermansen K, Savolainen MJ, Schwab U, Kolehmainen M, Brader L, Mortensen LS, Cloetens L, Johansson-Persson A, Onning G, Landin-Olsson M, Herzig KH, Hukkanen J, Rosqvist F, Iggman D, Paananen J, Pulkki KJ, Siloaho M, Dragsted L, Barri T, Overvad K, Bach Knudsen KE, Hedemann MS, Arner P, Dahlman I, Borge GI, Baardseth P, Ulven SM, Gunnarsdottir I, Jónsdóttir S, Thorsdottir I, Orešič M, Poutanen KS, Risérus U, Akesson B.

J Intern Med. 2013 Jul;274(1):52-66. doi: 10.1111/joim.12044. Epub 2013 Mar 2.

14.

Induction of cytochrome P450 enzymes: a view on human in vivo findings.

Hukkanen J.

Expert Rev Clin Pharmacol. 2012 Sep;5(5):569-85. doi: 10.1586/ecp.12.39. Review.

PMID:
23121279
15.

Effect of nicotine on cytochrome P450 1A2 activity.

Hukkanen J, Jacob P 3rd, Peng M, Dempsey D, Benowitz NL.

Br J Clin Pharmacol. 2011 Nov;72(5):836-8. doi: 10.1111/j.1365-2125.2011.04023.x. No abstract available.

16.

Effects of nicotine on cytochrome P450 2A6 and 2E1 activities.

Hukkanen J, Jacob Iii P, Peng M, Dempsey D, Benowitz NL.

Br J Clin Pharmacol. 2010 Feb;69(2):152-9. doi: 10.1111/j.1365-2125.2009.03568.x.

17.

Varenicline and pheochromocytoma.

Hukkanen J, Ukkola O, Benowitz NL.

Ann Intern Med. 2010 Mar 2;152(5):335-6. doi: 10.7326/0003-4819-152-5-201003020-00021. No abstract available.

PMID:
20194248
18.

Effects of low-dose liquorice alone or in combination with hydrochlorothiazide on the plasma potassium in healthy volunteers.

Hukkanen J, Ukkola O, Savolainen MJ.

Blood Press. 2009;18(4):192-5. doi: 10.1080/08037050903072515.

PMID:
19562574
19.

Nicotine chemistry, metabolism, kinetics and biomarkers.

Benowitz NL, Hukkanen J, Jacob P 3rd.

Handb Exp Pharmacol. 2009;(192):29-60. doi: 10.1007/978-3-540-69248-5_2. Review.

20.

Inhibition and induction of human cytochrome P450 enzymes: current status.

Pelkonen O, Turpeinen M, Hakkola J, Honkakoski P, Hukkanen J, Raunio H.

Arch Toxicol. 2008 Oct;82(10):667-715. doi: 10.1007/s00204-008-0332-8. Epub 2008 Jul 11. Review.

PMID:
18618097
21.

Effect of grapefruit juice on cytochrome P450 2A6 and nicotine renal clearance.

Hukkanen J, Jacob P 3rd, Benowitz NL.

Clin Pharmacol Ther. 2006 Nov;80(5):522-30.

PMID:
17112808
22.

Effect of pregnancy on a measure of FMO3 activity.

Hukkanen J, Dempsey D, Jacob P 3rd, Benowitz NL.

Br J Clin Pharmacol. 2005 Aug;60(2):224-6. No abstract available.

23.

Influence of menstrual cycle on cytochrome P450 2A6 activity and cardiovascular effects of nicotine.

Hukkanen J, Gourlay SG, Kenkare S, Benowitz NL.

Clin Pharmacol Ther. 2005 Mar;77(3):159-69.

PMID:
15735610
24.

Metabolism and disposition kinetics of nicotine.

Hukkanen J, Jacob P 3rd, Benowitz NL.

Pharmacol Rev. 2005 Mar;57(1):79-115. Review.

25.

Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells.

Hukkanen J, Väisänen T, Lassila A, Piipari R, Anttila S, Pelkonen O, Raunio H, Hakkola J.

J Pharmacol Exp Ther. 2003 Feb;304(2):745-52.

26.

Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung.

Hukkanen J, Pelkonen O, Hakkola J, Raunio H.

Crit Rev Toxicol. 2002 Sep;32(5):391-411. Review.

PMID:
12389869
27.

In vitro screening of cytochrome P450 induction potential.

Pelkonen O, Hukkanen J, Honkakoski P, Hakkola J, Viitala P, Raunio H.

Ernst Schering Res Found Workshop. 2002;(37):105-37. Review. No abstract available.

PMID:
11975192
28.

Expression of xenobiotic-metabolizing enzymes in human pulmonary tissue: possible role in susceptibility for ILD.

Hukkanen J, Pelkonen O, Raunio H.

Eur Respir J Suppl. 2001 Sep;32:122s-126s. Review.

29.

Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers.

Piipari R, Savela K, Nurminen T, Hukkanen J, Raunio H, Hakkola J, Mäntylä T, Beaune P, Edwards RJ, Boobis AR, Anttila S.

Int J Cancer. 2000 Jun 1;86(5):610-6.

30.

Induction and regulation of xenobiotic-metabolizing cytochrome P450s in the human A549 lung adenocarcinoma cell line.

Hukkanen J, Lassila A, Päivärinta K, Valanne S, Sarpo S, Hakkola J, Pelkonen O, Raunio H.

Am J Respir Cell Mol Biol. 2000 Mar;22(3):360-6.

PMID:
10696073
31.

Expression of xenobiotic-metabolizing CYPs in human pulmonary tissue.

Raunio H, Hakkola J, Hukkanen J, Lassila A, Päivärinta K, Pelkonen O, Anttila S, Piipari R, Boobis A, Edwards RJ.

Exp Toxicol Pathol. 1999 Jul;51(4-5):412-7. Review.

PMID:
10445407
32.

Expression of CYP2A genes in human liver and extrahepatic tissues.

Koskela S, Hakkola J, Hukkanen J, Pelkonen O, Sorri M, Saranen A, Anttila S, Fernandez-Salguero P, Gonzalez F, Raunio H.

Biochem Pharmacol. 1999 Jun 15;57(12):1407-13.

PMID:
10353262
33.

Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium.

Hukkanen J, Mäntylä M, Kangas L, Wirta P, Hakkola J, Paakki P, Evisalmi S, Pelkonen O, Raunio H.

Pharmacol Toxicol. 1998 Feb;82(2):93-7.

PMID:
9498238
34.

Expression of xenobiotic-metabolizing cytochrome P450s in human pulmonary tissues.

Raunio H, Hakkola J, Hukkanen J, Pelkonen O, Edwards R, Boobis A, Anttila S.

Arch Toxicol Suppl. 1998;20:465-9.

PMID:
9442317
35.

Detection of mRNA encoding xenobiotic-metabolizing cytochrome P450s in human bronchoalveolar macrophages and peripheral blood lymphocytes.

Hukkanen J, Hakkola J, Anttila S, Piipari R, Karjalainen A, Pelkonen O, Raunio H.

Mol Carcinog. 1997 Oct;20(2):224-30.

PMID:
9364212
36.

Expression and localization of CYP3A4 and CYP3A5 in human lung.

Anttila S, Hukkanen J, Hakkola J, Stjernvall T, Beaune P, Edwards RJ, Boobis AR, Pelkonen O, Raunio H.

Am J Respir Cell Mol Biol. 1997 Mar;16(3):242-9.

PMID:
9070608
37.

Expression of CYP1B1 in human adult and fetal tissues and differential inducibility of CYP1B1 and CYP1A1 by Ah receptor ligands in human placenta and cultured cells.

Hakkola J, Pasanen M, Pelkonen O, Hukkanen J, Evisalmi S, Anttila S, Rane A, Mäntylä M, Purkunen R, Saarikoski S, Tooming M, Raunio H.

Carcinogenesis. 1997 Feb;18(2):391-7.

PMID:
9054634
38.

Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta.

Hakkola J, Pasanen M, Hukkanen J, Pelkonen O, Mäenpää J, Edwards RJ, Boobis AR, Raunio H.

Biochem Pharmacol. 1996 Feb 23;51(4):403-11.

PMID:
8619884
39.

Protein concentrations have little effect on reabsorption of fluid from isolated rat lungs.

Effros RM, Hacker A, Silverman P, Hukkanen J.

J Appl Physiol (1985). 1991 Jan;70(1):416-22.

PMID:
2010400
40.

Solute concentrations of the pulmonary epithelial lining fluid of anesthetized rats.

Effros RM, Feng NH, Mason G, Sietsema K, Silverman P, Hukkanen J.

J Appl Physiol (1985). 1990 Jan;68(1):275-81.

PMID:
2312470
41.

New evidence for active sodium transport from fluid-filled rat lungs.

Effros RM, Mason GR, Hukkanen J, Silverman P.

J Appl Physiol (1985). 1989 Feb;66(2):906-19.

PMID:
2708220
42.

Pulmonary epithelial sieving of small solutes in rat lungs.

Effros RM, Mason GR, Sietsema K, Hukkanen J, Silverman P.

J Appl Physiol (1985). 1988 Aug;65(2):640-8.

PMID:
3170416
43.

Exchange of labeled bicarbonate and carbon dioxide with erythrocytes suspended in an elutriator.

Effros RM, Taki K, Dodek P, Edwards J, Husczuk A, Silverman P, Hukkanen J.

J Appl Physiol (1985). 1988 Feb;64(2):569-76.

PMID:
3131295
44.

Reabsorption of solutes and water from fluid-filled rabbit lungs.

Effros RM, Mason GR, Hukkanen J, Silverman P.

Am Rev Respir Dis. 1987 Sep;136(3):669-76.

PMID:
2443049
45.

Fluid reabsorption and glucose consumption in edematous rat lungs.

Effros RM, Mason GR, Sietsema K, Silverman P, Hukkanen J.

Circ Res. 1987 May;60(5):708-19.

46.

Movement of ions and small solutes across endothelium and epithelium of perfused rabbit lungs.

Effros RM, Mason GR, Silverman P, Reid E, Hukkanen J.

J Appl Physiol (1985). 1986 Jan;60(1):100-7.

PMID:
3944022
47.

Experimental hematogenous endophthalmitis due to Cryptococcus neoformans.

Fujita NK, Hukkanen J, Edwards JE Jr.

Invest Ophthalmol Vis Sci. 1983 Mar;24(3):368-75.

PMID:
6601086

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