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Items: 1 to 50 of 138


AutismKB 2.0: a knowledgebase for the genetic evidence of autism spectrum disorder.

Yang C, Li J, Wu Q, Yang X, Huang AY, Zhang J, Ye AY, Dou Y, Yan L, Zhou WZ, Kong L, Wang M, Ai C, Yang D, Wei L.

Database (Oxford). 2018 Jan 1;2018. doi: 10.1093/database/bay106.


Real-Time Blood Pressure Estimation From Force-Measured Ultrasound.

Zakrzewski AM, Huang AY, Zubajlo R, Anthony BW.

IEEE Trans Biomed Eng. 2018 Nov;65(11):2405-2416. doi: 10.1109/TBME.2018.2873297. Epub 2018 Oct 1.


MiR-490-3p inhibits osteogenic differentiation in thoracic ligamentum flavum cells by targeting FOXO1.

Yang X, Qu X, Meng X, Li M, Fan D, Fan T, Huang AY, Chen Z, Zhang C.

Int J Biol Sci. 2018 Aug 6;14(11):1457-1465. doi: 10.7150/ijbs.26686. eCollection 2018.


De Novo Sequence and Copy Number Variants Are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis.

Wang S, Mandell JD, Kumar Y, Sun N, Morris MT, Arbelaez J, Nasello C, Dong S, Duhn C, Zhao X, Yang Z, Padmanabhuni SS, Yu D, King RA, Dietrich A, Khalifa N, Dahl N, Huang AY, Neale BM, Coppola G, Mathews CA, Scharf JM; Tourette International Collaborative Genetics Study (TIC Genetics); Tourette Syndrome Genetics Southern and Eastern Europe Initiative (TSGENESEE); Tourette Association of America International Consortium for Genetics (TAAICG), Fernandez TV, Buxbaum JD, De Rubeis S, Grice DE, Xing J, Heiman GA, Tischfield JA, Paschou P, Willsey AJ, State MW.

Cell Rep. 2018 Sep 25;24(13):3441-3454.e12. doi: 10.1016/j.celrep.2018.08.082.


Multifactorial regulators of tumor programmed death-ligand 1 (PD-L1) response.

Dorand RD, Petrosiute A, Huang AY.

Transl Cancer Res. 2017 Dec;6(Suppl 9):S1451-S1454. doi: 10.21037/tcr.2017.11.08. No abstract available.


Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis.

Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW.

Sci Immunol. 2018 Aug 24;3(26). pii: eaat2738. doi: 10.1126/sciimmunol.aat2738.


Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases.

Chen JA, Chen Z, Won H, Huang AY, Lowe JK, Wojta K, Yokoyama JS, Bensimon G, Leigh PN, Payan C, Shatunov A, Jones AR, Lewis CM, Deloukas P, Amouyel P, Tzourio C, Dartigues JF, Ludolph A, Boxer AL, Bronstein JM, Al-Chalabi A, Geschwind DH, Coppola G.

Mol Neurodegener. 2018 Aug 8;13(1):41. doi: 10.1186/s13024-018-0270-8.


Inhibiting Notch1 enhances immunotherapy efficacy in melanoma by preventing Notch1 dependent immune suppressive properties.

Qiu H, Zmina PM, Huang AY, Askew D, Bedogni B.

Cancer Lett. 2018 Oct 10;434:144-151. doi: 10.1016/j.canlet.2018.07.024. Epub 2018 Jul 21.


Biomimetic post-capillary venule expansions for leukocyte adhesion studies.

Benson BL, Li L, Myers JT, Dorand RD, Gurkan UA, Huang AY, Ransohoff RM.

Sci Rep. 2018 Jun 19;8(1):9328. doi: 10.1038/s41598-018-27566-z.


A model for postzygotic mosaicisms quantifies the allele fraction drift, mutation rate, and contribution to de novo mutations.

Ye AY, Dou Y, Yang X, Wang S, Huang AY, Wei L.

Genome Res. 2018 Jul;28(7):943-951. doi: 10.1101/gr.230003.117. Epub 2018 Jun 6.


Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery.

Borton AH, Benson BL, Neilson LE, Saunders A, Alaiti MA, Huang AY, Jain MK, Proweller A, Ramirez-Bergeron DL.

J Am Heart Assoc. 2018 Jun 1;7(11). pii: e009205. doi: 10.1161/JAHA.118.009205.


Distinctive types of postzygotic single-nucleotide mosaicisms in healthy individuals revealed by genome-wide profiling of multiple organs.

Huang AY, Yang X, Wang S, Zheng X, Wu Q, Ye AY, Wei L.

PLoS Genet. 2018 May 15;14(5):e1007395. doi: 10.1371/journal.pgen.1007395. eCollection 2018 May.


Foxp3 expression in induced T regulatory cells derived from human umbilical cord blood vs. adult peripheral blood.

Do JS, Zhong F, Huang AY, Van't Hof WJ, Finney M, Laughlin MJ.

Bone Marrow Transplant. 2018 May 9. doi: 10.1038/s41409-018-0205-6. [Epub ahead of print]


Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.

Morrow JJ, Bayles I, Funnell APW, Miller TE, Saiakhova A, Lizardo MM, Bartels CF, Kapteijn MY, Hung S, Mendoza A, Dhillon G, Chee DR, Myers JT, Allen F, Gambarotti M, Righi A, DiFeo A, Rubin BP, Huang AY, Meltzer PS, Helman LJ, Picci P, Versteeg HH, Stamatoyannopoulos JA, Khanna C, Scacheri PC.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525c.


Optimizing Tumor Microenvironment for Cancer Immunotherapy: β-Glucan-Based Nanoparticles.

Zhang M, Kim JA, Huang AY.

Front Immunol. 2018 Feb 26;9:341. doi: 10.3389/fimmu.2018.00341. eCollection 2018. Review.


Posttransplant Intramuscular Injection of PLX-R18 Mesenchymal-Like Adherent Stromal Cells Improves Human Hematopoietic Engraftment in A Murine Transplant Model.

Metheny L, Eid S, Lingas K, Ofir R, Pinzur L, Meyerson H, Lazarus HM, Huang AY.

Front Med (Lausanne). 2018 Feb 22;5:37. doi: 10.3389/fmed.2018.00037. eCollection 2018.


CCL3 augments tumor rejection and enhances CD8+ T cell infiltration through NK and CD103+ dendritic cell recruitment via IFNγ.

Allen F, Bobanga ID, Rauhe P, Barkauskas D, Teich N, Tong C, Myers J, Huang AY.

Oncoimmunology. 2017 Nov 20;7(3):e1393598. doi: 10.1080/2162402X.2017.1393598. eCollection 2018.


Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.

Morrow JJ, Bayles I, Funnell APW, Miller TE, Saiakhova A, Lizardo MM, Bartels CF, Kapteijn MY, Hung S, Mendoza A, Dhillon G, Chee DR, Myers JT, Allen F, Gambarotti M, Righi A, DiFeo A, Rubin BP, Huang AY, Meltzer PS, Helman LJ, Picci P, Versteeg HH, Stamatoyannopoulos JA, Khanna C, Scacheri PC.

Nat Med. 2018 Feb;24(2):176-185. doi: 10.1038/nm.4475. Epub 2018 Jan 15. Erratum in: Nat Med. 2018 Apr 10;24(4):525.


Substance P as a putative efferent transmitter mediates GABAergic inhibition in mouse taste buds.

Huang AY, Wu SY.

Br J Pharmacol. 2018 Apr;175(7):1039-1053. doi: 10.1111/bph.14142. Epub 2018 Feb 23.


Systemic administration of β-glucan of 200 kDa modulates melanoma microenvironment and suppresses metastatic cancer.

Zhang M, Chun L, Sandoval V, Graor H, Myers J, Nthale J, Rauhe P, Senders Z, Choong K, Huang AY, Kim J.

Oncoimmunology. 2017 Oct 30;7(2):e1387347. doi: 10.1080/2162402X.2017.1387347. eCollection 2018.


Causal somatic mutations in urine DNA from persons with the CLOVES subgroup of the PIK3CA-related overgrowth spectrum.

Michel ME, Konczyk DJ, Yeung KS, Murillo R, Vivero MP, Hall AM, Zurakowski D, Adams D, Gupta A, Huang AY, Chung BHY, Warman ML.

Clin Genet. 2018 May;93(5):1075-1080. doi: 10.1111/cge.13195. Epub 2018 Jan 25.


Genomic mosaicism in paternal sperm and multiple parental tissues in a Dravet syndrome cohort.

Yang X, Liu A, Xu X, Yang X, Zeng Q, Ye AY, Yu Z, Wang S, Huang AY, Wu X, Wu Q, Wei L, Zhang Y.

Sci Rep. 2017 Nov 15;7(1):15677. doi: 10.1038/s41598-017-15814-7.


CCL3 Enhances Antitumor Immune Priming in the Lymph Node via IFNγ with Dependency on Natural Killer Cells.

Allen F, Rauhe P, Askew D, Tong AA, Nthale J, Eid S, Myers JT, Tong C, Huang AY.

Front Immunol. 2017 Oct 23;8:1390. doi: 10.3389/fimmu.2017.01390. eCollection 2017.


A method for going from 2D laparoscope to 3D acquisition of surface landmarks by a novel computer vision approach.

Garbey M, Nguyen TB, Huang AY, Fikfak V, Dunkin BJ.

Int J Comput Assist Radiol Surg. 2018 Feb;13(2):267-280. doi: 10.1007/s11548-017-1655-9. Epub 2017 Aug 31.


In vivo cloning of up to 16 kb plasmids in E. coli is as simple as PCR.

Huang F, Spangler JR, Huang AY.

PLoS One. 2017 Aug 24;12(8):e0183974. doi: 10.1371/journal.pone.0183974. eCollection 2017.


Notch2 blockade enhances hematopoietic stem cell mobilization and homing.

Wang W, Yu S, Myers J, Wang Y, Xin WW, Albakri M, Xin AW, Li M, Huang AY, Xin W, Siebel CW, Lazarus HM, Zhou L.

Haematologica. 2017 Oct;102(10):1785-1795. doi: 10.3324/haematol.2017.168674. Epub 2017 Jul 20.


Live-cell visualization of gasdermin D-driven pyroptotic cell death.

Rathkey JK, Benson BL, Chirieleison SM, Yang J, Xiao TS, Dubyak GR, Huang AY, Abbott DW.

J Biol Chem. 2017 Sep 1;292(35):14649-14658. doi: 10.1074/jbc.M117.797217. Epub 2017 Jul 18.


Rare Copy Number Variants in NRXN1 and CNTN6 Increase Risk for Tourette Syndrome.

Huang AY, Yu D, Davis LK, Sul JH, Tsetsos F, Ramensky V, Zelaya I, Ramos EM, Osiecki L, Chen JA, McGrath LM, Illmann C, Sandor P, Barr CL, Grados M, Singer HS, Nöthen MM, Hebebrand J, King RA, Dion Y, Rouleau G, Budman CL, Depienne C, Worbe Y, Hartmann A, Müller-Vahl KR, Stuhrmann M, Aschauer H, Stamenkovic M, Schloegelhofer M, Konstantinidis A, Lyon GJ, McMahon WM, Barta C, Tarnok Z, Nagy P, Batterson JR, Rizzo R, Cath DC, Wolanczyk T, Berlin C, Malaty IA, Okun MS, Woods DW, Rees E, Pato CN, Pato MT, Knowles JA, Posthuma D, Pauls DL, Cox NJ, Neale BM, Freimer NB, Paschou P, Mathews CA, Scharf JM, Coppola G; Tourette Syndrome Association International Consortium for Genetics (TSAICG); Gilles de la Tourette Syndrome GWAS Replication Initiative (GGRI).

Neuron. 2017 Jun 21;94(6):1101-1111.e7. doi: 10.1016/j.neuron.2017.06.010.


Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing sarcoma.

Tong AA, Hashem H, Eid S, Allen F, Kingsley D, Huang AY.

Oncoimmunology. 2017 Mar 16;6(4):e1303586. doi: 10.1080/2162402X.2017.1303586. eCollection 2017.


Postzygotic single-nucleotide mosaicisms contribute to the etiology of autism spectrum disorder and autistic traits and the origin of mutations.

Dou Y, Yang X, Li Z, Wang S, Zhang Z, Ye AY, Yan L, Yang C, Wu Q, Li J, Zhao B, Huang AY, Wei L.

Hum Mutat. 2017 Aug;38(8):1002-1013. doi: 10.1002/humu.23255. Epub 2017 May 30.


De Novo Coding Variants Are Strongly Associated with Tourette Disorder.

Willsey AJ, Fernandez TV, Yu D, King RA, Dietrich A, Xing J, Sanders SJ, Mandell JD, Huang AY, Richer P, Smith L, Dong S, Samocha KE; Tourette International Collaborative Genetics (TIC Genetics); Tourette Syndrome Association International Consortium for Genetics (TSAICG), Neale BM, Coppola G, Mathews CA, Tischfield JA, Scharf JM, State MW, Heiman GA.

Neuron. 2017 May 3;94(3):486-499.e9. doi: 10.1016/j.neuron.2017.04.024.


Solid-Phase Synthesis of a Seventh-Generation Inverse Poly(amidoamine) Dendrimer: Importance of the Loading Ratio on the Resin.

Kao CL, Huang AY, Chen HT.

Macromol Rapid Commun. 2017 Jun;38(12). doi: 10.1002/marc.201700062. Epub 2017 Apr 20.


Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands.

Chung J, Ebens CL, Perkey E, Radojcic V, Koch U, Scarpellino L, Tong A, Allen F, Wood S, Feng J, Friedman A, Granadier D, Tran IT, Chai Q, Onder L, Yan M, Reddy P, Blazar BR, Huang AY, Brennan TV, Bishop DK, Ludewig B, Siebel CW, Radtke F, Luther SA, Maillard I.

J Clin Invest. 2017 Apr 3;127(4):1574-1588. doi: 10.1172/JCI89535. Epub 2017 Mar 20.


Confocal imaging of mouse mandibular condyle cartilage.

He Y, Zhang M, Huang AY, Cui Y, Bai D, Warman ML.

Sci Rep. 2017 Mar 7;7:43848. doi: 10.1038/srep43848.


The SmartOR: a distributed sensor network to improve operating room efficiency.

Huang AY, Joerger G, Fikfak V, Salmon R, Dunkin BJ, Bass BL, Garbey M.

Surg Endosc. 2017 Sep;31(9):3590-3595. doi: 10.1007/s00464-016-5390-z. Epub 2017 Feb 24.


Somatic MAP2K1 Mutations Are Associated with Extracranial Arteriovenous Malformation.

Couto JA, Huang AY, Konczyk DJ, Goss JA, Fishman SJ, Mulliken JB, Warman ML, Greene AK.

Am J Hum Genet. 2017 Mar 2;100(3):546-554. doi: 10.1016/j.ajhg.2017.01.018. Epub 2017 Feb 9.


MosaicHunter: accurate detection of postzygotic single-nucleotide mosaicism through next-generation sequencing of unpaired, trio, and paired samples.

Huang AY, Zhang Z, Ye AY, Dou Y, Yan L, Yang X, Zhang Y, Wei L.

Nucleic Acids Res. 2017 Jun 2;45(10):e76. doi: 10.1093/nar/gkx024.


A somatic GNA11 mutation is associated with extremity capillary malformation and overgrowth.

Couto JA, Ayturk UM, Konczyk DJ, Goss JA, Huang AY, Hann S, Reeve JL, Liang MG, Bischoff J, Warman ML, Greene AK.

Angiogenesis. 2017 Aug;20(3):303-306. doi: 10.1007/s10456-016-9538-1. Epub 2017 Jan 24.


Cyclin-dependent kinase 5 activity is required for allogeneic T-cell responses after hematopoietic cell transplantation in mice.

Askew D, Pareek TK, Eid S, Ganguly S, Tyler M, Huang AY, Letterio JJ, Cooke KR.

Blood. 2017 Jan 12;129(2):246-256. doi: 10.1182/blood-2016-05-702738. Epub 2016 Nov 14.


Plant viral nanoparticles-based HER2 vaccine: Immune response influenced by differential transport, localization and cellular interactions of particulate carriers.

Shukla S, Myers JT, Woods SE, Gong X, Czapar AE, Commandeur U, Huang AY, Levine AD, Steinmetz NF.

Biomaterials. 2017 Mar;121:15-27. doi: 10.1016/j.biomaterials.2016.12.030. Epub 2016 Dec 27.


Intra-osseous Co-transplantation of CD34-selected Umbilical Cord Blood and Mesenchymal Stromal Cells.

Metheny L 3rd, Eid S, Lingas K, Reese J, Meyerson H, Tong A, de Lima M, Huang AY.

Hematol Med Oncol. 2016;1(1):25-29. Epub 2016 Oct 20.


Nanoparticle Systems Modulating Myeloid-Derived Suppressor Cells for Cancer Immunotherapy.

Wilkerson A, Kim J, Huang AY, Zhang M.

Curr Top Med Chem. 2017;17(16):1843-1857. doi: 10.2174/1568026617666161122121412. Review.


The effect of imiquimod on taste bud calcium transients and transmitter secretion.

Huang AY, Wu SY.

Br J Pharmacol. 2016 Nov;173(21):3121-3133. doi: 10.1111/bph.13567. Epub 2016 Sep 6.


Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity.

Dorand RD, Nthale J, Myers JT, Barkauskas DS, Avril S, Chirieleison SM, Pareek TK, Abbott DW, Stearns DS, Letterio JJ, Huang AY, Petrosiute A.

Science. 2016 Jul 22;353(6297):399-403. doi: 10.1126/science.aae0477. Epub 2016 Jul 21.


Image-guided simulation of tissue deformation using a mechanical model on a surgical application.

Nguyen TB, Huang AY, Fikfak V, Dunkin BJ, Garbey M.

Comput Methods Biomech Biomed Engin. 2017 Feb;20(2):206-214. Epub 2016 Jul 25.


Unique Transcompartmental Bridge: Antigen-Presenting Cells Sampling across Endothelial and Mucosal Barriers.

Allen F, Tong AA, Huang AY.

Front Immunol. 2016 Jun 10;7:231. doi: 10.3389/fimmu.2016.00231. eCollection 2016. Review.


Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma.

Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HPW, Bischoff J, Greene AK, Warman ML.

Am J Hum Genet. 2016 Jun 2;98(6):1271. doi: 10.1016/j.ajhg.2016.05.010. Epub 2016 Jun 2. No abstract available.


Multiple Administrations of Viral Nanoparticles Alter in Vivo Behavior-Insights from Intravital Microscopy.

Shukla S, Dorand RD, Myers JT, Woods SE, Gulati NM, Stewart PL, Commandeur U, Huang AY, Steinmetz NF.

ACS Biomater Sci Eng. 2016 May 9;2(5):829-837. doi: 10.1021/acsbiomaterials.6b00060. Epub 2016 Mar 30.


Collaboration Platforms in China for Translational and Clinical Research: The Partnership Between Peking University Health Science Center and the University of Michigan Medical School.

Kolars JC, Fang W, Zheng K, Huang AY, Sun Q, Wang Y, Woolliscroft JO, Ke Y.

Acad Med. 2017 Mar;92(3):370-373. doi: 10.1097/ACM.0000000000001202.


Autophagic down-regulation in motor neurons remarkably prolongs the survival of ALS mice.

Hsueh KW, Chiou TW, Chiang SF, Yamashita T, Abe K, Borlongan CV, Sanberg PR, Huang AY, Lin SZ, Harn HJ.

Neuropharmacology. 2016 Sep;108:152-60. doi: 10.1016/j.neuropharm.2016.03.035. Epub 2016 Apr 6.


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