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Methods for the Detection, Study, and Dynamic Profiling of O-GlcNAc Glycosylation.

Thompson JW, Griffin ME, Hsieh-Wilson LC.

Methods Enzymol. 2018;598:101-135. doi: 10.1016/bs.mie.2017.06.009. Epub 2017 Aug 7.


Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth.

Griffith AR, Rogers CJ, Miller GM, Abrol R, Hsieh-Wilson LC, Goddard WA 3rd.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13697-13702. doi: 10.1073/pnas.1715093115. Epub 2017 Dec 11.


Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.

Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Bitra A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE Jr, Zajonc DM.

J Biol Chem. 2018 Jan 5;293(1):390-401. doi: 10.1074/jbc.M117.814541. Epub 2017 Nov 9.


Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation.

Cheung ST, Miller MS, Pacoma R, Roland J, Liu J, Schumacher AM, Hsieh-Wilson LC.

ACS Chem Biol. 2017 Dec 15;12(12):3126-3133. doi: 10.1021/acschembio.7b00885. Epub 2017 Nov 29.


Loss of O-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegeneration.

Wang AC, Jensen EH, Rexach JE, Vinters HV, Hsieh-Wilson LC.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):15120-15125. doi: 10.1073/pnas.1606899113. Epub 2016 Dec 12.


Comprehensive mapping of O-GlcNAc modification sites using a chemically cleavable tag.

Griffin ME, Jensen EH, Mason DE, Jenkins CL, Stone SE, Peters EC, Hsieh-Wilson LC.

Mol Biosyst. 2016 May 24;12(6):1756-9. doi: 10.1039/c6mb00138f.


Glycan Engineering for Cell and Developmental Biology.

Griffin ME, Hsieh-Wilson LC.

Cell Chem Biol. 2016 Jan 21;23(1):108-121. doi: 10.1016/j.chembiol.2015.12.007. Review.


Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans.

Miller GM, Hsieh-Wilson LC.

Exp Neurol. 2015 Dec;274(Pt B):115-25. doi: 10.1016/j.expneurol.2015.08.015. Epub 2015 Aug 24.


Long-lived engineering of glycans to direct stem cell fate.

Pulsipher A, Griffin ME, Stone SE, Hsieh-Wilson LC.

Angew Chem Int Ed Engl. 2015 Jan 26;54(5):1466-70. doi: 10.1002/anie.201409258. Epub 2014 Dec 4.


Murine anti-vaccinia virus D8 antibodies target different epitopes and differ in their ability to block D8 binding to CS-E.

Matho MH, de Val N, Miller GM, Brown J, Schlossman A, Meng X, Crotty S, Peters B, Xiang Y, Hsieh-Wilson LC, Ward AB, Zajonc DM.

PLoS Pathog. 2014 Dec 4;10(12):e1004495. doi: 10.1371/journal.ppat.1004495. eCollection 2014 Dec.


Photoactivatable glycopolymers for the proteome-wide identification of fucose-α(1-2)-galactose binding proteins.

Wibowo A, Peters EC, Hsieh-Wilson LC.

J Am Chem Soc. 2014 Jul 9;136(27):9528-31. doi: 10.1021/ja502482a. Epub 2014 Jun 25.


Directing neuronal signaling through cell-surface glycan engineering.

Pulsipher A, Griffin ME, Stone SE, Brown JM, Hsieh-Wilson LC.

J Am Chem Soc. 2014 May 14;136(19):6794-7. doi: 10.1021/ja5005174. Epub 2014 Apr 30.


Visualization of O-GlcNAc glycosylation stoichiometry and dynamics using resolvable poly(ethylene glycol) mass tags.

Clark PM, Rexach JE, Hsieh-Wilson LC.

Curr Protoc Chem Biol. 2013;5(4):281-302. doi: 10.1002/9780470559277.ch130153.


Chemistry. Improving biologic drugs via total chemical synthesis.

Hsieh-Wilson LC, Griffin ME.

Science. 2013 Dec 13;342(6164):1332-3. doi: 10.1126/science.1247615. No abstract available.


Synthetic probes of glycosaminoglycan function.

Griffin ME, Hsieh-Wilson LC.

Curr Opin Chem Biol. 2013 Dec;17(6):1014-22. doi: 10.1016/j.cbpa.2013.09.015. Epub 2013 Oct 20. Review.


Tailored glycopolymers as anticoagulant heparin mimetics.

Oh YI, Sheng GJ, Chang SK, Hsieh-Wilson LC.

Angew Chem Int Ed Engl. 2013 Nov 4;52(45):11796-9. doi: 10.1002/anie.201306968. Epub 2013 Oct 9. No abstract available.


Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation.

Ramakrishnan P, Clark PM, Mason DE, Peters EC, Hsieh-Wilson LC, Baltimore D.

Sci Signal. 2013 Aug 27;6(290):ra75. doi: 10.1126/scisignal.2004097. Erratum in: Sci Signal. 2014 Apr 29;7(323):er3.


Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains.

Dick G, Tan CL, Alves JN, Ehlert EM, Miller GM, Hsieh-Wilson LC, Sugahara K, Oosterhof A, van Kuppevelt TH, Verhaagen J, Fawcett JW, Kwok JC.

J Biol Chem. 2013 Sep 20;288(38):27384-95. doi: 10.1074/jbc.M111.310029. Epub 2013 Aug 12.


Tunable heparan sulfate mimetics for modulating chemokine activity.

Sheng GJ, Oh YI, Chang SK, Hsieh-Wilson LC.

J Am Chem Soc. 2013 Jul 31;135(30):10898-901. doi: 10.1021/ja4027727. Epub 2013 Jul 23.


Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.

Yi W, Clark PM, Mason DE, Keenan MC, Hill C, Goddard WA 3rd, Peters EC, Driggers EM, Hsieh-Wilson LC.

Science. 2012 Aug 24;337(6097):975-80. doi: 10.1126/science.1222278.


A sulfated carbohydrate epitope inhibits axon regeneration after injury.

Brown JM, Xia J, Zhuang B, Cho KS, Rogers CJ, Gama CI, Rawat M, Tully SE, Uetani N, Mason DE, Tremblay ML, Peters EC, Habuchi O, Chen DF, Hsieh-Wilson LC.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4768-73. doi: 10.1073/pnas.1121318109. Epub 2012 Mar 12.


Chemoenzymatic probes for detecting and imaging fucose-α(1-2)-galactose glycan biomarkers.

Chaubard JL, Krishnamurthy C, Yi W, Smith DF, Hsieh-Wilson LC.

J Am Chem Soc. 2012 Mar 14;134(10):4489-92. doi: 10.1021/ja211312u. Epub 2012 Feb 29.


Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation.

Rexach JE, Clark PM, Mason DE, Neve RL, Peters EC, Hsieh-Wilson LC.

Nat Chem Biol. 2012 Jan 22;8(3):253-61. doi: 10.1038/nchembio.770.


Microarray method for the rapid detection of glycosaminoglycan-protein interactions.

Rogers CJ, Hsieh-Wilson LC.

Methods Mol Biol. 2012;808:321-36. doi: 10.1007/978-1-61779-373-8_22.


Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches.

Rogers CJ, Clark PM, Tully SE, Abrol R, Garcia KC, Goddard WA 3rd, Hsieh-Wilson LC.

Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9747-52. doi: 10.1073/pnas.1102962108. Epub 2011 May 31.


End-functionalized glycopolymers as mimetics of chondroitin sulfate proteoglycans.

Lee SG, Brown JM, Rogers CJ, Matson JB, Krishnamurthy C, Rawat M, Hsieh-Wilson LC.

Chem Sci. 2010 Sep 1;1(3):322-325.


Quantification of O-glycosylation stoichiometry and dynamics using resolvable mass tags.

Rexach JE, Rogers CJ, Yu SH, Tao J, Sun YE, Hsieh-Wilson LC.

Nat Chem Biol. 2010 Sep;6(9):645-51. doi: 10.1038/nchembio.412. Epub 2010 Jul 25.


Identification of the plasticity-relevant fucose-alpha(1-2)-galactose proteome from the mouse olfactory bulb.

Murrey HE, Ficarro SB, Krishnamurthy C, Domino SE, Peters EC, Hsieh-Wilson LC.

Biochemistry. 2009 Aug 4;48(30):7261-70. doi: 10.1021/bi900640x.


Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes.

Wang Z, Park K, Comer F, Hsieh-Wilson LC, Saudek CD, Hart GW.

Diabetes. 2009 Feb;58(2):309-17. doi: 10.2337/db08-0994. Epub 2008 Nov 4.


Direct in-gel fluorescence detection and cellular imaging of O-GlcNAc-modified proteins.

Clark PM, Dweck JF, Mason DE, Hart CR, Buck SB, Peters EC, Agnew BJ, Hsieh-Wilson LC.

J Am Chem Soc. 2008 Sep 3;130(35):11576-7. doi: 10.1021/ja8030467. Epub 2008 Aug 7.


The chemical neurobiology of carbohydrates.

Murrey HE, Hsieh-Wilson LC.

Chem Rev. 2008 May;108(5):1708-31. doi: 10.1021/cr078215f. Epub 2008 May 2. Review. No abstract available.


Neuroactive chondroitin sulfate glycomimetics.

Rawat M, Gama CI, Matson JB, Hsieh-Wilson LC.

J Am Chem Soc. 2008 Mar 12;130(10):2959-61. doi: 10.1021/ja709993p. Epub 2008 Feb 15. No abstract available.


Chemical approaches to understanding O-GlcNAc glycosylation in the brain.

Rexach JE, Clark PM, Hsieh-Wilson LC.

Nat Chem Biol. 2008 Feb;4(2):97-106. doi: 10.1038/nchembio.68. Review.


Activation of phospholipase C pathways by a synthetic chondroitin sulfate-E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons.

Sotogaku N, Tully SE, Gama CI, Higashi H, Tanaka M, Hsieh-Wilson LC, Nishi A.

J Neurochem. 2007 Oct;103(2):749-60. Epub 2007 Aug 6.


Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics.

Khidekel N, Ficarro SB, Clark PM, Bryan MC, Swaney DL, Rexach JE, Sun YE, Coon JJ, Peters EC, Hsieh-Wilson LC.

Nat Chem Biol. 2007 Jun;3(6):339-48. Epub 2007 May 13.


Direct identification of nonreducing GlcNAc residues on N-glycans of glycoproteins using a novel chemoenzymatic method.

Boeggeman E, Ramakrishnan B, Kilgore C, Khidekel N, Hsieh-Wilson LC, Simpson JT, Qasba PK.

Bioconjug Chem. 2007 May-Jun;18(3):806-14. Epub 2007 Mar 20.


Bioorganic chemistry: a sweet synthesis.

Hsieh-Wilson LC.

Nature. 2007 Jan 4;445(7123):31-3. No abstract available.


Sulfation patterns of glycosaminoglycans encode molecular recognition and activity.

Gama CI, Tully SE, Sotogaku N, Clark PM, Rawat M, Vaidehi N, Goddard WA 3rd, Nishi A, Hsieh-Wilson LC.

Nat Chem Biol. 2006 Sep;2(9):467-73. Epub 2006 Jul 30.


Discovery of a TNF-alpha antagonist using chondroitin sulfate microarrays.

Tully SE, Rawat M, Hsieh-Wilson LC.

J Am Chem Soc. 2006 Jun 21;128(24):7740-1.


Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons.

Murrey HE, Gama CI, Kalovidouris SA, Luo WI, Driggers EM, Porton B, Hsieh-Wilson LC.

Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):21-6. Epub 2005 Dec 22.


Regulation of spinophilin Ser94 phosphorylation in neostriatal neurons involves both DARPP-32-dependent and independent pathways.

Uematsu K, Futter M, Hsieh-Wilson LC, Higashi H, Maeda H, Nairn AC, Greengard P, Nishi A.

J Neurochem. 2005 Dec;95(6):1642-52. Epub 2005 Nov 21.


Chemical approaches to deciphering the glycosaminoglycan code.

Gama CI, Hsieh-Wilson LC.

Curr Opin Chem Biol. 2005 Dec;9(6):609-19. Epub 2005 Oct 18. Review.


A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth.

Kalovidouris SA, Gama CI, Lee LW, Hsieh-Wilson LC.

J Am Chem Soc. 2005 Feb 9;127(5):1340-1.


Tailor-made glycoproteins.

Hsieh-Wilson LC.

Trends Biotechnol. 2004 Oct;22(10):489-91. Review.


Exploring the O-GlcNAc proteome: direct identification of O-GlcNAc-modified proteins from the brain.

Khidekel N, Ficarro SB, Peters EC, Hsieh-Wilson LC.

Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13132-7. Epub 2004 Aug 30.


Parallel identification of O-GlcNAc-modified proteins from cell lysates.

Tai HC, Khidekel N, Ficarro SB, Peters EC, Hsieh-Wilson LC.

J Am Chem Soc. 2004 Sep 1;126(34):10500-1.


Spinophilin is phosphorylated by Ca2+/calmodulin-dependent protein kinase II resulting in regulation of its binding to F-actin.

Grossman SD, Futter M, Snyder GL, Allen PB, Nairn AC, Greengard P, Hsieh-Wilson LC.

J Neurochem. 2004 Jul;90(2):317-24.


A chondroitin sulfate small molecule that stimulates neuronal growth.

Tully SE, Mabon R, Gama CI, Tsai SM, Liu X, Hsieh-Wilson LC.

J Am Chem Soc. 2004 Jun 30;126(25):7736-7.


A 'molecular switchboard'--covalent modifications to proteins and their impact on transcription.

Khidekel N, Hsieh-Wilson LC.

Org Biomol Chem. 2004 Jan 7;2(1):1-7. Epub 2003 Dec 2. Review.


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