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Items: 13

1.

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels.

Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD.

Cell Rep. 2017 Oct 31;21(5):1331-1346. doi: 10.1016/j.celrep.2017.10.029.

2.

Corrigendum: Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.

Heintz C, Doktor TK, Lanjuin A, Escoubas CC, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB.

Nature. 2017 Jul 27;547(7664):476. doi: 10.1038/nature23313. Epub 2017 Jul 12.

PMID:
28700577
3.

Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.

Howell JJ, Hellberg K, Turner M, Talbott G, Kolar MJ, Ross DS, Hoxhaj G, Saghatelian A, Shaw RJ, Manning BD.

Cell Metab. 2017 Feb 7;25(2):463-471. doi: 10.1016/j.cmet.2016.12.009. Epub 2017 Jan 12.

4.

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.

Heintz C, Doktor TK, Lanjuin A, Escoubas C, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB.

Nature. 2017 Jan 5;541(7635):102-106. doi: 10.1038/nature20789. Epub 2016 Dec 5. Erratum in: Nature. 2017 Jul 27;547(7664):476.

5.

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.

Hoxhaj G, Caddye E, Najafov A, Houde VP, Johnson C, Dissanayake K, Toth R, Campbell DG, Prescott AR, MacKintosh C.

Elife. 2016 Apr 22;5. pii: e12278. doi: 10.7554/eLife.12278.

6.

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle.

Ben-Sahra I, Hoxhaj G, Ricoult SJH, Asara JM, Manning BD.

Science. 2016 Feb 12;351(6274):728-733. doi: 10.1126/science.aad0489.

7.

Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome.

Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD.

Cell. 2014 Feb 13;156(4):771-85. doi: 10.1016/j.cell.2013.11.049.

8.

ANIA: ANnotation and Integrated Analysis of the 14-3-3 interactome.

Tinti M, Madeira F, Murugesan G, Hoxhaj G, Toth R, Mackintosh C.

Database (Oxford). 2014 Feb 5;2014:bat085. doi: 10.1093/database/bat085. Print 2014.

9.

Effect of IRS4 levels on PI 3-kinase signalling.

Hoxhaj G, Dissanayake K, MacKintosh C.

PLoS One. 2013 Sep 10;8(9):e73327. doi: 10.1371/journal.pone.0073327. eCollection 2013.

10.

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.

Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR, MacKintosh C.

J Cell Sci. 2012 Oct 1;125(Pt 19):4662-75. doi: 10.1242/jcs.110296. Epub 2012 Jul 13.

11.

MENA is a transcriptional target of the Wnt/beta-catenin pathway.

Najafov A, Seker T, Even I, Hoxhaj G, Selvi O, Ozel DE, Koman A, Birgül-İyison N.

PLoS One. 2012;7(5):e37013. doi: 10.1371/journal.pone.0037013. Epub 2012 May 17.

12.

Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets.

Kavak E, Najafov A, Ozturk N, Seker T, Cavusoglu K, Aslan T, Duru AD, Saygili T, Hoxhaj G, Hiz MC, Unal DO, Birgül-Iyison N, Ozturk M, Koman A.

Cell Signal. 2010 Oct;22(10):1523-35. doi: 10.1016/j.cellsig.2010.05.021. Epub 2010 Jun 9.

PMID:
20538055
13.

An erythropoietin autocrine/paracrine axis modulates the growth and survival of human prostate cancer cells.

Jeong JY, Hoxhaj G, Socha AL, Sytkowski AJ, Feldman L.

Mol Cancer Res. 2009 Jul;7(7):1150-7. doi: 10.1158/1541-7786.MCR-08-0243. Epub 2009 Jun 30.

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