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The Dynamics of TGF-β Signaling Are Dictated by Receptor Trafficking via the ESCRT Machinery.

Miller DSJ, Bloxham RD, Jiang M, Gori I, Saunders RE, Das D, Chakravarty P, Howell M, Hill CS.

Cell Rep. 2018 Nov 13;25(7):1841-1855.e5. doi: 10.1016/j.celrep.2018.10.056.


Bridging the Gap: Interdepartmental Quality Improvement and Patient Safety Curriculum Created by Hospital Leaders, Faculty, and Trainees.

Miller ME, Patel A, Schindler N, Hirsch K, Ming M, Weber S, Turner P, Howell MD, Arora VM, Oyler JL.

J Grad Med Educ. 2018 Oct;10(5):566-572. doi: 10.4300/JGME-D-18-00060.1.


Association Between Room Location and Adverse Outcomes in Hospitalized Patients.

Mayampurath A, Ward C, Fahrenbach J, LaFond C, Howell M, Churpek MM.

HERD. 2018 Oct 31:1937586718806702. doi: 10.1177/1937586718806702. [Epub ahead of print]


Visualizing the Invisible: A Guide to Designing, Printing, and Incorporating Dynamic 3D Molecular Models to Teach Structure-Function Relationships.

Howell ME, van Dijk K, Booth CS, Helikar T, Couch BA, Roston RL.

J Microbiol Biol Educ. 2018 Oct 31;19(3). pii: 19.3.100. doi: 10.1128/jmbe.v19i3.1663. eCollection 2018. No abstract available.


Establishing a Core Outcome Measure for Life Participation: a Standardized Outcomes in Nephrology - Kidney Transplantation (SONG-Tx) Consensus Workshop Report.

Ju A, Josephson MA, Butt Z, Jowsey-Gregoire S, Tan J, Taylor Q, Fowler K, Dobbels F, Caskey F, Jha V, Locke J, Knoll G, Ahn C, Hanson CS, Sautenet B, Manera K, Craig JC, Howell M, Rutherford C, Tong A; SONG-Tx Life Participation Workshop Investigators*.

Transplantation. 2018 Oct 8. doi: 10.1097/TP.0000000000002476. [Epub ahead of print]


Mutation pattern analysis reveals polygenic mini-drivers associated with relapse after surgery in lung adenocarcinoma.

Bennett L, Howell M, Memon D, Smowton C, Zhou C, Miller CJ.

Sci Rep. 2018 Oct 4;8(1):14830. doi: 10.1038/s41598-018-33276-3.


Research priorities for childhood chronic conditions: a workshop report.

Lopez-Vargas P, Tong A, Crowe S, Alexander SI, Caldwell PHY, Campbell DE, Couper J, Davidson A, De S, Fitzgerald DA, Haddad S, Hill S, Howell M, Jaffe A, James LJ, Ju A, Manera KE, McKenzie A, Morrow AM, Odgers HL, Pinkerton R, Ralph AF, Richmond P, Shaw PJ, Singh-Grewal D, van Zwieten A, Wake M, Craig JC; Kaleidoscope Project workshop investigators.

Arch Dis Child. 2018 Oct 2. pii: archdischild-2018-315628. doi: 10.1136/archdischild-2018-315628. [Epub ahead of print]


The Impact of Age on Income-Related Health Status Inequalities from Birth to Adolescence: A Systematic Review with Cross-Country Comparisons.

van Zwieten A, Saglimbene V, Teixeira-Pinto A, Howell M, Howard K, Craig JC, Wong G.

J Pediatr. 2018 Sep 25. pii: S0022-3476(18)30935-1. doi: 10.1016/j.jpeds.2018.07.030. [Epub ahead of print]


Integrating the skin and blood transcriptomes and serum proteome in hidradenitis suppurativa reveals complement dysregulation and a plasma cell signature.

Hoffman LK, Tomalin LE, Schultz G, Howell MD, Anandasabapathy N, Alavi A, Suárez-Fariñas M, Lowes MA.

PLoS One. 2018 Sep 28;13(9):e0203672. doi: 10.1371/journal.pone.0203672. eCollection 2018.


Robot-assisted versus laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy: a propensity score-matched comparative analysis using the 2015-2016 MBSAQIP database.

Sebastian R, Howell MH, Chang KH, Adrales G, Magnuson T, Schweitzer M, Nguyen H.

Surg Endosc. 2018 Sep 17. doi: 10.1007/s00464-018-6422-7. [Epub ahead of print]


Switched On: How the Timing of Aversive Content in Traffic Safety Videos Impact Psychophysiological Indicators of Message Processing.

Howell M, Ekman DS, Almond A, Bolls P.

Health Commun. 2018 Sep 12:1-10. doi: 10.1080/10410236.2018.1517706. [Epub ahead of print]


Failures in the Respectful Care of Critically Ill Patients.

Law AC, Roche S, Reichheld A, Folcarelli P, Cocchi MN, Howell MD, Sands K, Stevens JP.

Jt Comm J Qual Patient Saf. 2018 Aug 28. pii: S1553-7250(18)30148-X. doi: 10.1016/j.jcjq.2018.05.008. [Epub ahead of print]


Systematic Reviews and Meta-analyses in Transplantation: Challenges and Pitfalls?

Wong G, Sharma A, Teixeira-Pinto A, Howell M.

Transplantation. 2018 Sep;102(9):1415-1418. doi: 10.1097/TP.0000000000002314.


How did a prosthetic femoral head migrate to the mesorectum?

Howell M, Smith G, Marsh AG.

BMJ Case Rep. 2018 Aug 16;2018. pii: bcr-2018-226248. doi: 10.1136/bcr-2018-226248. No abstract available.


Impact of Traumatic Stress on Sleep and Management Options in Women.

Kobayashi I, Howell MK.

Sleep Med Clin. 2018 Sep;13(3):419-431. doi: 10.1016/j.jsmc.2018.04.009. Epub 2018 Jun 28. Review.


Corrigendum: Multi-modal Brain MRI in Subjects with PD and iRBD.

Mangia S, Svatkova A, Mascali D, Nissi MJ, Burton PC, Bednarik P, Auerbach EJ, Giove F, Eberly LE, Howell MJ, Nestrasil I, Tuite PJ, Michaeli S.

Front Neurosci. 2018 Jun 26;12:446. doi: 10.3389/fnins.2018.00446. eCollection 2018.


Building communities of respect in the intensive care unit.

Brown SM, Talmor D, Howell MD.

Intensive Care Med. 2018 Aug;44(8):1339-1341. doi: 10.1007/s00134-018-5259-9. Epub 2018 Jun 30. No abstract available.


Neuromuscular Adaptations Following Training and Protein Supplementation in a Group of Trained Weightlifters.

Taber C, Carroll K, DeWeese B, Sato K, Stuart C, Howell M, Hall K, Bazyler C, Stone M.

Sports (Basel). 2018 Apr 19;6(2). pii: E37. doi: 10.3390/sports6020037.


Quantitative Analysis Reveals that Actin and Src-Family Kinases Regulate Nuclear YAP1 and Its Export.

Ege N, Dowbaj AM, Jiang M, Howell M, Hooper S, Foster C, Jenkins RP, Sahai E.

Cell Syst. 2018 Jun 27;6(6):692-708.e13. doi: 10.1016/j.cels.2018.05.006. Epub 2018 Jun 18.


Treatment of atopic dermatitis with tralokinumab, an anti-IL-13 mAb.

Wollenberg A, Howell MD, Guttman-Yassky E, Silverberg JI, Kell C, Ranade K, Moate R, van der Merwe R.

J Allergy Clin Immunol. 2018 Jun 12. pii: S0091-6749(18)30850-9. doi: 10.1016/j.jaci.2018.05.029. [Epub ahead of print]


The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma.

Miess H, Dankworth B, Gouw AM, Rosenfeldt M, Schmitz W, Jiang M, Saunders B, Howell M, Downward J, Felsher DW, Peck B, Schulze A.

Oncogene. 2018 Oct;37(40):5435-5450. doi: 10.1038/s41388-018-0315-z. Epub 2018 Jun 5.


Resolving the Productivity Paradox of Health Information Technology: A Time for Optimism.

Wachter RM, Howell MD.

JAMA. 2018 Jul 3;320(1):25-26. doi: 10.1001/jama.2018.5605. No abstract available.


Implications of Centers for Medicare & Medicaid Services Severe Sepsis and Septic Shock Early Management Bundle and Initial Lactate Measurement on the Management of Sepsis.

Han X, Edelson DP, Snyder A, Pettit N, Sokol S, Barc C, Howell MD, Churpek MM.

Chest. 2018 Aug;154(2):302-308. doi: 10.1016/j.chest.2018.03.025. Epub 2018 May 24.


Identifying and integrating patient and caregiver perspectives in clinical practice guidelines for percutaneous renal biopsy.

Gutman T, Lopez-Vargas P, Manera KE, Craig JC, Howell M, Tunnicliffe D, James LJ, MacGinley R, See E, Wong J, Voss D, Saunders J, Menahem S, Jesudason S, Tong A, Champion de Crespigny P.

Nephrology (Carlton). 2018 May 23. doi: 10.1111/nep.13406. [Epub ahead of print]


Predicting Intensive Care Unit Readmission with Machine Learning Using Electronic Health Record Data.

Rojas JC, Carey KA, Edelson DP, Venable LR, Howell MD, Churpek MM.

Ann Am Thorac Soc. 2018 Jul;15(7):846-853. doi: 10.1513/AnnalsATS.201710-787OC.


Less Is More: Learning from Variation in Pulmonary Embolism Care.

Howell MD.

Ann Am Thorac Soc. 2018 May;15(5):554-555. doi: 10.1513/AnnalsATS.201802-113ED. No abstract available.


Absence of the Min System Does Not Cause Major Cell Division Defects in Agrobacterium tumefaciens.

Flores SA, Howell M, Daniel JJ, Piccolo R, Brown PJB.

Front Microbiol. 2018 Apr 9;9:681. doi: 10.3389/fmicb.2018.00681. eCollection 2018.


Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases.

Hudson AM, Stephenson NL, Li C, Trotter E, Fletcher AJ, Katona G, Bieniasz-Krzywiec P, Howell M, Wirth C, Furney S, Miller CJ, Brognard J.

Sci Signal. 2018 Apr 17;11(526). pii: eaan6776. doi: 10.1126/scisignal.aan6776.


Nephrologists' perspectives on cancer screening in patients with chronic kidney disease: an interview study.

James L, Wong G, Craig J, Howard K, Howell M, Tong A.

Nephrology (Carlton). 2018 Apr 6. doi: 10.1111/nep.13269. [Epub ahead of print]


A trial based economic evaluation of occupational therapy discharge planning for older adults: the HOME randomized trial.

Wales K, Salkeld G, Clemson L, Lannin NA, Gitlin L, Rubenstein L, Howard K, Howell M, Cameron ID.

Clin Rehabil. 2018 Jul;32(7):919-929. doi: 10.1177/0269215518764249. Epub 2018 Mar 23.


Repeat associated mechanisms of genome evolution and function revealed by the Mus caroli and Mus pahari genomes.

Thybert D, Roller M, Navarro FCP, Fiddes I, Streeter I, Feig C, Martin-Galvez D, Kolmogorov M, Janoušek V, Akanni W, Aken B, Aldridge S, Chakrapani V, Chow W, Clarke L, Cummins C, Doran A, Dunn M, Goodstadt L, Howe K, Howell M, Josselin AA, Karn RC, Laukaitis CM, Jingtao L, Martin F, Muffato M, Nachtweide S, Quail MA, Sisu C, Stanke M, Stefflova K, Van Oosterhout C, Veyrunes F, Ward B, Yang F, Yazdanifar G, Zadissa A, Adams DJ, Brazma A, Gerstein M, Paten B, Pham S, Keane TM, Odom DT, Flicek P.

Genome Res. 2018 Apr;28(4):448-459. doi: 10.1101/gr.234096.117. Epub 2018 Mar 21.


Implementation of a Rapid, Protocol-based TIA Management Pathway.

Jarhult SJ, Howell ML, Barnaure-Nachbar I, Chang Y, White BA, Amatangelo M, Brown DF, Singhal AB, Schwamm LH, Silverman SB, Goldstein JN.

West J Emerg Med. 2018 Mar;19(2):216-223. doi: 10.5811/westjem.2017.9.35341. Epub 2018 Feb 8.


Establishing a Core Outcome Measure for Fatigue in Patients on Hemodialysis: A Standardized Outcomes in Nephrology-Hemodialysis (SONG-HD) Consensus Workshop Report.

Ju A, Unruh M, Davison S, Dapueto J, Dew MA, Fluck R, Germain M, Jassal SV, Obrador G, O'Donoghue D, Josephson MA, Craig JC, Viecelli A, O'Lone E, Hanson CS, Manns B, Sautenet B, Howell M, Reddy B, Wilkie C, Rutherford C, Tong A; SONG-HD Fatigue Workshop Collaborators.

Am J Kidney Dis. 2018 Jul;72(1):104-112. doi: 10.1053/j.ajkd.2017.12.018. Epub 2018 Mar 16.


Imaging single DNA molecules for high precision NIPT.

Dahl F, Ericsson O, Karlberg O, Karlsson F, Howell M, Persson F, Roos F, Stenberg J, Ahola T, Alftrén I, Andersson B, Barkenäs E, Brandner B, Dahlberg J, Elfman S, Eriksson M, Forsgren PO, Francois N, Gousseva A, Hakamali F, Janfalk-Carlsson Å, Johansson H, Lundgren J, Mohsenchian A, Olausson L, Olofsson S, Qureshi A, Skarpås B, Sävneby A, Åström E, Öhman O, Westgren M, Kopp-Kallner H, Fianu-Jonasson A, Syngelaki A, Nicolaides K.

Sci Rep. 2018 Mar 14;8(1):4549. doi: 10.1038/s41598-018-22606-0.


Survival and Quality of Life Impact of a Risk-based Allocation Algorithm for Deceased Donor Kidney Transplantation.

Calisa V, Craig JC, Howard K, Howell M, Alexander S, Chadban SJ, Clayton P, Lim WH, Kanellis J, Wyburn K, Johnson DW, McDonald SP, Opdam H, Chapman JR, Yang J, Wong G.

Transplantation. 2018 Sep;102(9):1530-1537. doi: 10.1097/TP.0000000000002144.


Report of the Standardized Outcomes in Nephrology-Hemodialysis (SONG-HD) Consensus Workshop on Establishing a Core Outcome Measure for Hemodialysis Vascular Access.

Viecelli AK, Tong A, O'Lone E, Ju A, Hanson CS, Sautenet B, Craig JC, Manns B, Howell M, Chemla E, Hooi LS, Johnson DW, Lee T, Lok CE, Polkinghorne KR, Quinn RR, Vachharajani T, Vanholder R, Zuo L, Hawley CM; SONG-HD Vascular Access Workshop Investigators.

Am J Kidney Dis. 2018 May;71(5):690-700. doi: 10.1053/j.ajkd.2017.12.003. Epub 2018 Feb 23.


Prevalence of Dyspnea Among Hospitalized Patients at the Time of Admission.

Stevens JP, Dechen T, Schwartzstein R, O'Donnell C, Baker K, Howell MD, Banzett RB.

J Pain Symptom Manage. 2018 Jul;56(1):15-22.e2. doi: 10.1016/j.jpainsymman.2018.02.013. Epub 2018 Feb 22.


Neurocognitive and Educational Outcomes in Children and Adolescents with CKD: A Systematic Review and Meta-Analysis.

Chen K, Didsbury M, van Zwieten A, Howell M, Kim S, Tong A, Howard K, Nassar N, Barton B, Lah S, Lorenzo J, Strippoli G, Palmer S, Teixeira-Pinto A, Mackie F, McTaggart S, Walker A, Kara T, Craig JC, Wong G.

Clin J Am Soc Nephrol. 2018 Mar 7;13(3):387-397. doi: 10.2215/CJN.09650917. Epub 2018 Feb 22.


Management of ARDS in Adults.

Howell MD, Davis AM.

JAMA. 2018 Feb 20;319(7):711-712. doi: 10.1001/jama.2018.0307. No abstract available.


LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death.

Wang L, Howell MEA, McPeak B, Riggs K, Kohne C, Yohanon JU, Foxler DE, Sharp TV, Moorman JP, Yao ZQ, Ning S.

Oncotarget. 2017 Dec 26;9(5):6282-6297. doi: 10.18632/oncotarget.23676. eCollection 2018 Jan 19.


A Single-center Experience Examining the Length of Stay and Safety of Early Discharge After Laparoscopic Roux-en-Y Gastric Bypass Surgery.

Howell MH, Praiss A, Podolsky D, Zundel N, Moran-Atkin E, Choi JJ, Camacho DR.

Obes Surg. 2018 May;28(5):1225-1231. doi: 10.1007/s11695-017-2993-y.


JAK/STAT inhibitors and other small molecule cytokine antagonists for the treatment of allergic disease.

Howell MD, Fitzsimons C, Smith PA.

Ann Allergy Asthma Immunol. 2018 Apr;120(4):367-375. doi: 10.1016/j.anai.2018.02.012. Epub 2018 Feb 14. Review.


Using Watershed Boundaries to Map Adverse Health Outcomes: Examples From Nebraska, USA.

Corley B, Bartelt-Hunt S, Rogan E, Coulter D, Sparks J, Baccaglini L, Howell M, Liaquat S, Commack R, Kolok AS.

Environ Health Insights. 2018 Jan 24;12:1178630217751906. doi: 10.1177/1178630217751906. eCollection 2018.


Randomised controlled trial to determine the efficacy and safety of prescribed water intake to prevent kidney failure due to autosomal dominant polycystic kidney disease (PREVENT-ADPKD).

Wong ATY, Mannix C, Grantham JJ, Allman-Farinelli M, Badve SV, Boudville N, Byth K, Chan J, Coulshed S, Edwards ME, Erickson BJ, Fernando M, Foster S, Haloob I, Harris DCH, Hawley CM, Hill J, Howard K, Howell M, Jiang SH, Johnson DW, Kline TL, Kumar K, Lee VW, Lonergan M, Mai J, McCloud P, Peduto A, Rangan A, Roger SD, Sud K, Torres V, Vliayuri E, Rangan GK.

BMJ Open. 2018 Jan 21;8(1):e018794. doi: 10.1136/bmjopen-2017-018794.


The Practice of Respect in the ICU.

Brown SM, Azoulay E, Benoit D, Butler TP, Folcarelli P, Geller G, Rozenblum R, Sands K, Sokol-Hessner L, Talmor D, Turner K, Howell MD.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1389-1395. doi: 10.1164/rccm.201708-1676CP.


Multi-modal Brain MRI in Subjects with PD and iRBD.

Mangia S, Svatkova A, Mascali D, Nissi MJ, Burton PC, Bednarik P, Auerbach EJ, Giove F, Eberly LE, Howell MJ, Nestrasil I, Tuite PJ, Michaeli S.

Front Neurosci. 2017 Dec 19;11:709. doi: 10.3389/fnins.2017.00709. eCollection 2017. Erratum in: Front Neurosci. 2018 Jun 26;12:446.


Live Cell Fluorescence Microscopy to Observe Essential Processes During Microbial Cell Growth.

Howell M, Daniel JJ, Brown PJB.

J Vis Exp. 2017 Nov 24;(129). doi: 10.3791/56497.


Sertoli Cells Loaded with Doxorubicin in Lipid Micelles Reduced Tumor Burden and Dox-Induced Toxicity.

Das M, Howell M, Foran EA, Iyre R, Mohapatra SS, Mohapatra S.

Cell Transplant. 2017 Oct;26(10):1694-1702. doi: 10.1177/0963689717721223.


Test-Retest Reliability of Two Consecutive Mean Sleep Latency Tests in Patients with Hypersomnia.

Kwon Y, Kazaglis L, Cho Y, Howell MJ, Mahowald MW.

Sleep Biol Rhythms. 2017 Oct;15(4):337-339. doi: 10.1007/s41105-017-0116-8. Epub 2017 Aug 16.


Patient-Reported Outcome Measures for Fatigue in Patients on Hemodialysis: A Systematic Review.

Ju A, Unruh ML, Davison SN, Dapueto J, Dew MA, Fluck R, Germain M, Jassal SV, Obrador G, O'Donoghue D, Tugwell P, Craig JC, Ralph AF, Howell M, Tong A.

Am J Kidney Dis. 2018 Mar;71(3):327-343. doi: 10.1053/j.ajkd.2017.08.019. Epub 2017 Dec 1.


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