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Items: 22

1.

INPP5E regulates phosphoinositide-dependent cilia transition zone function.

Dyson JM, Conduit SE, Feeney SJ, Hakim S, DiTommaso T, Fulcher AJ, Sriratana A, Ramm G, Horan KA, Gurung R, Wicking C, Smyth I, Mitchell CA.

J Cell Biol. 2017 Jan 2;216(1):247-263. doi: 10.1083/jcb.201511055. Epub 2016 Dec 20.

2.

Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection.

Sun C, Schattgen SA, Pisitkun P, Jorgensen JP, Hilterbrand AT, Wang LJ, West JA, Hansen K, Horan KA, Jakobsen MR, O'Hare P, Adler H, Sun R, Ploegh HL, Damania B, Upton JW, Fitzgerald KA, Paludan SR.

J Immunol. 2015 Feb 15;194(4):1819-31. doi: 10.4049/jimmunol.1402495. Epub 2015 Jan 16.

3.

Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway.

Hansen K, Prabakaran T, Laustsen A, Jørgensen SE, Rahbæk SH, Jensen SB, Nielsen R, Leber JH, Decker T, Horan KA, Jakobsen MR, Paludan SR.

EMBO J. 2014 Aug 1;33(15):1654-66. doi: 10.15252/embj.201488029. Epub 2014 Jun 26.

4.

Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells.

Layton MJ, Rynkiewicz NK, Ivetac I, Horan KA, Mitchell CA, Phillips WA.

Biosci Rep. 2014 Apr 1;34(2). pii: e00104. Print 2014 Apr 1.

5.

Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors.

Horan KA, Hansen K, Jakobsen MR, Holm CK, Søby S, Unterholzner L, Thompson M, West JA, Iversen MB, Rasmussen SB, Ellermann-Eriksen S, Kurt-Jones E, Landolfo S, Damania B, Melchjorsen J, Bowie AG, Fitzgerald KA, Paludan SR.

J Immunol. 2013 Mar 1;190(5):2311-9. doi: 10.4049/jimmunol.1202749. Epub 2013 Jan 23.

6.

Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.

Holm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR.

Nat Immunol. 2012 Jun 17;13(8):737-43. doi: 10.1038/ni.2350.

7.

TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice.

Reinert LS, Harder L, Holm CK, Iversen MB, Horan KA, Dagnæs-Hansen F, Ulhøi BP, Holm TH, Mogensen TH, Owens T, Nyengaard JR, Thomsen AR, Paludan SR.

J Clin Invest. 2012 Apr;122(4):1368-76. doi: 10.1172/JCI60893. Epub 2012 Mar 19.

8.

Mitochondria-derived reactive oxygen species negatively regulates immune innate signaling pathways triggered by a DNA virus, but not by an RNA virus.

Gonzalez-Dosal R, Horan KA, Paludan SR.

Biochem Biophys Res Commun. 2012 Feb 24;418(4):806-10. doi: 10.1016/j.bbrc.2012.01.108. Epub 2012 Jan 28.

PMID:
22310710
9.

Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA.

Berg RK, Melchjorsen J, Rintahaka J, Diget E, Søby S, Horan KA, Gorelick RJ, Matikainen S, Larsen CS, Ostergaard L, Paludan SR, Mogensen TH.

PLoS One. 2012;7(1):e29291. doi: 10.1371/journal.pone.0029291. Epub 2012 Jan 3.

10.

Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes.

Rasmussen SB, Horan KA, Holm CK, Stranks AJ, Mettenleiter TC, Simon AK, Jensen SB, Rixon FJ, He B, Paludan SR.

J Immunol. 2011 Nov 15;187(10):5268-76. doi: 10.4049/jimmunol.1100949. Epub 2011 Oct 12.

11.

HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6.

Gonzalez-Dosal R, Horan KA, Rahbek SH, Ichijo H, Chen ZJ, Mieyal JJ, Hartmann R, Paludan SR.

PLoS Pathog. 2011 Sep;7(9):e1002250. doi: 10.1371/journal.ppat.1002250. Epub 2011 Sep 15.

12.

Recognition of herpesviruses by the innate immune system.

Paludan SR, Bowie AG, Horan KA, Fitzgerald KA.

Nat Rev Immunol. 2011 Feb;11(2):143-54. doi: 10.1038/nri2937. Review. Erratum in: Nat Rev Immunol. 2013 Aug;13(8):614.

13.

IFI16 is an innate immune sensor for intracellular DNA.

Unterholzner L, Keating SE, Baran M, Horan KA, Jensen SB, Sharma S, Sirois CM, Jin T, Latz E, Xiao TS, Fitzgerald KA, Paludan SR, Bowie AG.

Nat Immunol. 2010 Nov;11(11):997-1004. doi: 10.1038/ni.1932. Epub 2010 Oct 3.

14.

Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity.

Kristiansen H, Scherer CA, McVean M, Iadonato SP, Vends S, Thavachelvam K, Steffensen TB, Horan KA, Kuri T, Weber F, Paludan SR, Hartmann R.

J Virol. 2010 Nov;84(22):11898-904. doi: 10.1128/JVI.01003-10. Epub 2010 Sep 15.

15.

Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways.

Melchjorsen J, Rintahaka J, Søby S, Horan KA, Poltajainen A, Østergaard L, Paludan SR, Matikainen S.

J Virol. 2010 Nov;84(21):11350-8. doi: 10.1128/JVI.01106-10. Epub 2010 Aug 25.

16.

Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.

Ivetac I, Gurung R, Hakim S, Horan KA, Sheffield DA, Binge LC, Majerus PW, Tiganis T, Mitchell CA.

EMBO Rep. 2009 May;10(5):487-93. doi: 10.1038/embor.2009.28. Epub 2009 Mar 27.

17.

The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease.

Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, Mitchell CA.

Biochem J. 2009 Apr 1;419(1):29-49. doi: 10.1042/BJ20081673. Review.

PMID:
19272022
19.

The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?

Astle MV, Horan KA, Ooms LM, Mitchell CA.

Biochem Soc Symp. 2007;(74):161-81. Review.

PMID:
17233589
20.

Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.

Kong AM, Horan KA, Sriratana A, Bailey CG, Collyer LJ, Nandurkar HH, Shisheva A, Layton MJ, Rasko JE, Rowe T, Mitchell CA.

Mol Cell Biol. 2006 Aug;26(16):6065-81.

21.

Effect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavir.

Culm-Merdek KE, von Moltke LL, Gan L, Horan KA, Reynolds R, Harmatz JS, Court MH, Greenblatt DJ.

Clin Pharmacol Ther. 2006 Mar;79(3):243-54. Epub 2006 Feb 7.

PMID:
16513448
22.

Ginkgo biloba does not alter clearance of flurbiprofen, a cytochrome P450-2C9 substrate.

Greenblatt DJ, von Moltke LL, Luo Y, Perloff ES, Horan KA, Bruce A, Reynolds RC, Harmatz JS, Avula B, Khan IA, Goldman P.

J Clin Pharmacol. 2006 Feb;46(2):214-21.

PMID:
16432273

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