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Items: 11

1.

2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.

Kassick AJ, Jiang J, Bunda J, Wilson D, Bao J, Lu H, Lin P, Ball RG, Doss GA, Tong X, Tsao KL, Wang H, Chicchi G, Karanam B, Tschirret-Guth R, Samuel K, Hora DF, Kumar S, Madeira M, Eng W, Hargreaves R, Purcell M, Gantert L, Cook J, DeVita RJ, Mills SG.

J Med Chem. 2013 Jul 25;56(14):5940-8. doi: 10.1021/jm400751p. Epub 2013 Jul 9.

PMID:
23808489
2.

1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.

Vachal P, Fletcher JM, Fong TM, Huang CC, Lao J, Xiao JC, Shen CP, Strack AM, Shearman L, Stribling S, Chen RZ, Frassetto A, Tong X, Wang J, Ball RG, Tsou NN, Hickey GJ, Thompson DF, Faidley TD, Nicolich S, Achanfuo-Yeboah J, Hora DF, Hale JJ, Hagmann WK.

J Med Chem. 2009 Apr 23;52(8):2550-8. doi: 10.1021/jm900063x.

PMID:
19320488
3.

Disposition of the dipeptidyl peptidase 4 inhibitor sitagliptin in rats and dogs.

Beconi MG, Reed JR, Teffera Y, Xia YQ, Kochansky CJ, Liu DQ, Xu S, Elmore CS, Ciccotto S, Hora DF, Stearns RA, Vincent SH.

Drug Metab Dispos. 2007 Apr;35(4):525-32. Epub 2007 Jan 12.

4.

In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in cats with lipopolysaccharide-induced pyrexia.

McCann ME, Rickes EL, Hora DF, Cunningham PK, Zhang D, Brideau C, Black WC, Hickey GJ.

Am J Vet Res. 2005 Jul;66(7):1278-84.

PMID:
16111170
5.

Brain penetration of aprepitant, a substance P receptor antagonist, in ferrets.

Huskey SE, Dean BJ, Bakhtiar R, Sanchez RI, Tattersall FD, Rycroft W, Hargreaves R, Watt AP, Chicchi GG, Keohane C, Hora DF, Chiu SH.

Drug Metab Dispos. 2003 Jun;31(6):785-91.

6.

Identification of novel metabolites of pioglitazone in rat and dog.

Shen Z, Reed JR, Creighton M, Liu DQ, Tang YS, Hora DF, Feeney W, Szewczyk J, Bakhtiar R, Franklin RB, Vincent SH.

Xenobiotica. 2003 May;33(5):499-509.

PMID:
12746106
7.

Administration of a nonpeptidyl growth hormone secretagogue, L-163, 255, changes somatostatin pattern, but has no effect on patterns of growth hormone-releasing factor in the hypophyseal-portal circulation of the conscious pig.

Drisko JE, Faidley TD, Zhang D, McDonald TJ, Nicolich S, Hora DF, Cunningham P, Li C, Rickes E, McNamara L, Chang C, Smith RG, Hickey GJ.

Proc Soc Exp Biol Med. 1999 Oct;222(1):70-7.

PMID:
10510248
8.

Synthesis and biological activities of phenyl piperazine-based peptidomimetic growth hormone secretagogues.

Barakat KJ, Cheng K, Chan WW, Butler BS, Jacks TM, Schleim KD, Hora DF Jr, Hickey GJ, Smith RG, Patchett AA, Nargund RP.

Bioorg Med Chem Lett. 1998 Jun 2;8(11):1431-6.

PMID:
9871779
9.

Hypophyseal-portal concentrations of growth hormone-releasing factor and somatostatin in conscious pigs: relationship to production of spontaneous growth hormone pulses.

Drisko JE, Faidley TD, Chang CH, Zhang D, Nicolich S, Hora DF Jr, McNamara L, Rickes E, Abribat T, Smith RG, Hickey GJ.

Proc Soc Exp Biol Med. 1998 Feb;217(2):188-96.

PMID:
9452143
10.

Transorbital approach to the porcine pituitary.

Drisko JE, Faidley TD, Hora DF Jr, Niebauer GW, Feeney WP, Friscino BH, Hickey GJ.

J Invest Surg. 1996 Jul-Aug;9(4):305-11.

PMID:
8887068
11.

Indomethacin attenuates exercise-induced proteinuria in hypertensive miniature swine.

O'Hagan KP, Hora DF Jr, Zambraski EJ.

Am J Physiol. 1992 Oct;263(4 Pt 2):R954-61.

PMID:
1415809

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