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Items: 1 to 50 of 149

1.

Structural basis for ATP-dependent chromatin remodelling by the INO80 complex.

Eustermann S, Schall K, Kostrewa D, Lakomek K, Strauss M, Moldt M, Hopfner KP.

Nature. 2018 Apr;556(7701):386-390. doi: 10.1038/s41586-018-0029-y. Epub 2018 Apr 11.

PMID:
29643509
2.

Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy.

Kotlarz D, Marquardt B, Barøy T, Lee WS, Konnikova L, Hollizeck S, Magg T, Lehle AS, Walz C, Borggraefe I, Hauck F, Bufler P, Conca R, Wall SM, Schumacher EM, Misceo D, Frengen E, Bentsen BS, Uhlig HH, Hopfner KP, Muise AM, Snapper SB, Strømme P, Klein C.

Nat Genet. 2018 Mar;50(3):344-348. doi: 10.1038/s41588-018-0063-6. Epub 2018 Feb 26.

PMID:
29483653
3.

Single-molecule nucleosome remodeling by INO80 and effects of histone tails.

Schwarz M, Schall K, Kallis E, Eustermann S, Guariento M, Moldt M, Hopfner KP, Michaelis J.

FEBS Lett. 2018 Feb;592(3):318-331. doi: 10.1002/1873-3468.12973. Epub 2018 Jan 26.

PMID:
29331030
4.

Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I-mediated immunity.

Chiang JJ, Sparrer KMJ, van Gent M, Lässig C, Huang T, Osterrieder N, Hopfner KP, Gack MU.

Nat Immunol. 2018 Jan;19(1):53-62. doi: 10.1038/s41590-017-0005-y. Epub 2017 Nov 27.

PMID:
29180807
5.

Mechanistic insight into the assembly of the HerA-NurA helicase-nuclease DNA end resection complex.

Ahdash Z, Lau AM, Byrne RT, Lammens K, Stüetzer A, Urlaub H, Booth PJ, Reading E, Hopfner KP, Politis A.

Nucleic Acids Res. 2017 Nov 16;45(20):12025-12038. doi: 10.1093/nar/gkx890.

6.

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein-DNA ladders.

Andreeva L, Hiller B, Kostrewa D, Lässig C, de Oliveira Mann CC, Jan Drexler D, Maiser A, Gaidt M, Leonhardt H, Hornung V, Hopfner KP.

Nature. 2017 Sep 21;549(7672):394-398. doi: 10.1038/nature23890. Epub 2017 Sep 13.

PMID:
28902841
7.

Discrimination of cytosolic self and non-self RNA by RIG-I-like receptors.

Lässig C, Hopfner KP.

J Biol Chem. 2017 Jun 2;292(22):9000-9009. doi: 10.1074/jbc.R117.788398. Epub 2017 Apr 14. Review.

PMID:
28411239
8.

SIRPα-antibody fusion proteins stimulate phagocytosis and promote elimination of acute myeloid leukemia cells.

Ponce LP, Fenn NC, Moritz N, Krupka C, Kozik JH, Lauber K, Subklewe M, Hopfner KP.

Oncotarget. 2017 Feb 14;8(7):11284-11301. doi: 10.18632/oncotarget.14500.

9.

RPA Mediates Recruitment of MRX to Forks and Double-Strand Breaks to Hold Sister Chromatids Together.

Seeber A, Hegnauer AM, Hustedt N, Deshpande I, Poli J, Eglinger J, Pasero P, Gut H, Shinohara M, Hopfner KP, Shimada K, Gasser SM.

Mol Cell. 2016 Dec 1;64(5):951-966. doi: 10.1016/j.molcel.2016.10.032. Epub 2016 Nov 23.

10.

CD19-specific triplebody SPM-1 engages NK and γδ T cells for rapid and efficient lysis of malignant B-lymphoid cells.

Schiller CB, Braciak TA, Fenn NC, Seidel UJ, Roskopf CC, Wildenhain S, Honegger A, Schubert IA, Schele A, Lämmermann K, Fey GH, Jacob U, Lang P, Hopfner KP, Oduncu FS.

Oncotarget. 2016 Dec 13;7(50):83392-83408. doi: 10.18632/oncotarget.13110.

11.

Impact of Heterogeneity and Lattice Bond Strength on DNA Triangle Crystal Growth.

Stahl E, Praetorius F, de Oliveira Mann CC, Hopfner KP, Dietz H.

ACS Nano. 2016 Sep 7. [Epub ahead of print]

PMID:
27583560
12.

Structural and biochemical characterization of the cell fate determining nucleotidyltransferase fold protein MAB21L1.

de Oliveira Mann CC, Kiefersauer R, Witte G, Hopfner KP.

Sci Rep. 2016 Jun 8;6:27498. doi: 10.1038/srep27498.

13.

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.

Hartmann L, Dutta S, Opatz S, Vosberg S, Reiter K, Leubolt G, Metzeler KH, Herold T, Bamopoulos SA, Bräundl K, Zellmeier E, Ksienzyk B, Konstandin NP, Schneider S, Hopfner KP, Graf A, Krebs S, Blum H, Middeke JM, Stölzel F, Thiede C, Wolf S, Bohlander SK, Preiss C, Chen-Wichmann L, Wichmann C, Sauerland MC, Büchner T, Berdel WE, Wörmann BJ, Braess J, Hiddemann W, Spiekermann K, Greif PA.

Nat Commun. 2016 Jun 2;7:11733. doi: 10.1038/ncomms11733.

14.

RIG-I-Like Receptors: One STrEP Forward.

Lässig C, Hopfner KP.

Trends Microbiol. 2016 Jul;24(7):517-519. doi: 10.1016/j.tim.2016.05.001. Epub 2016 May 25.

PMID:
27236860
15.

Invited review: Architectures and mechanisms of ATP binding cassette proteins.

Hopfner KP.

Biopolymers. 2016 Aug;105(8):492-504. doi: 10.1002/bip.22843. Review.

PMID:
27037766
16.

Editorial overview: Macromolecular machines and assemblies.

Barford D, Hopfner KP.

Curr Opin Struct Biol. 2016 Apr;37:vi-viii. doi: 10.1016/j.sbi.2016.03.002. Epub 2016 Mar 16. No abstract available.

PMID:
26994942
17.

Dual-targeting triplebody 33-3-19 mediates selective lysis of biphenotypic CD19+ CD33+ leukemia cells.

Roskopf CC, Braciak TA, Fenn NC, Kobold S, Fey GH, Hopfner KP, Oduncu FS.

Oncotarget. 2016 Apr 19;7(16):22579-89. doi: 10.18632/oncotarget.8022.

18.

Chip-based platform for dynamic analysis of NK cell cytolysis mediated by a triplebody.

Chatzopoulou EI, Roskopf CC, Sekhavati F, Braciak TA, Fenn NC, Hopfner KP, Oduncu FS, Fey GH, Rädler JO.

Analyst. 2016 Apr 7;141(7):2284-95. doi: 10.1039/c5an02585k.

PMID:
26958659
19.

Correction: ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.

Elife. 2016 Mar 2;5. pii: e14954. doi: 10.7554/eLife.14954. No abstract available.

20.

Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.

Seifert FU, Lammens K, Stoehr G, Kessler B, Hopfner KP.

EMBO J. 2016 Apr 1;35(7):759-72. doi: 10.15252/embj.201592934. Epub 2016 Feb 19.

21.

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress.

Poli J, Gerhold CB, Tosi A, Hustedt N, Seeber A, Sack R, Herzog F, Pasero P, Shimada K, Hopfner KP, Gasser SM.

Genes Dev. 2016 Feb 1;30(3):337-54. doi: 10.1101/gad.273813.115. Epub 2016 Jan 21.

22.

ATP hydrolysis by the viral RNA sensor RIG-I prevents unintentional recognition of self-RNA.

Lässig C, Matheisl S, Sparrer KM, de Oliveira Mann CC, Moldt M, Patel JR, Goldeck M, Hartmann G, García-Sastre A, Hornung V, Conzelmann KK, Beckmann R, Hopfner KP.

Elife. 2015 Nov 26;4. pii: e10859. doi: 10.7554/eLife.10859. Erratum in: Elife. 2016;5. pii: e14954. doi: 10.7554/eLife.14954.

23.

Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA.

Herzner AM, Hagmann CA, Goldeck M, Wolter S, Kübler K, Wittmann S, Gramberg T, Andreeva L, Hopfner KP, Mertens C, Zillinger T, Jin T, Xiao TS, Bartok E, Coch C, Ackermann D, Hornung V, Ludwig J, Barchet W, Hartmann G, Schlee M.

Nat Immunol. 2015 Oct;16(10):1025-33. doi: 10.1038/ni.3267. Epub 2015 Sep 7.

24.

Structural basis for recognition and remodeling of the TBP:DNA:NC2 complex by Mot1.

Butryn A, Schuller JM, Stoehr G, Runge-Wollmann P, Förster F, Auble DT, Hopfner KP.

Elife. 2015 Aug 10;4. doi: 10.7554/eLife.07432.

25.

Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.

Seifert FU, Lammens K, Hopfner KP.

Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):752-7. doi: 10.1107/S2053230X15007566. Epub 2015 May 22.

26.

Structural analysis of the diadenylate cyclase reaction of DNA-integrity scanning protein A (DisA) and its inhibition by 3'-dATP.

Müller M, Deimling T, Hopfner KP, Witte G.

Biochem J. 2015 Aug 1;469(3):367-74. doi: 10.1042/BJ20150373. Epub 2015 May 27.

PMID:
26014055
27.

Serendipitous crystallization and structure determination of cyanase (CynS) from Serratia proteamaculans.

Butryn A, Stoehr G, Linke-Winnebeck C, Hopfner KP.

Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):471-6. doi: 10.1107/S2053230X15004902. Epub 2015 Mar 21.

28.

Structural basis for dodecameric assembly states and conformational plasticity of the full-length AAA+ ATPases Rvb1 · Rvb2.

Lakomek K, Stoehr G, Tosi A, Schmailzl M, Hopfner KP.

Structure. 2015 Mar 3;23(3):483-495. doi: 10.1016/j.str.2014.12.015. Epub 2015 Feb 5.

29.

Activity-based probes for detection of active MALT1 paracaspase in immune cells and lymphomas.

Eitelhuber AC, Vosyka O, Nagel D, Bognar M, Lenze D, Lammens K, Schlauderer F, Hlahla D, Hopfner KP, Lenz G, Hummel M, Verhelst SH, Krappmann D.

Chem Biol. 2015 Jan 22;22(1):129-38. doi: 10.1016/j.chembiol.2014.10.021. Epub 2014 Dec 31.

30.

Molecular architecture of the HerA-NurA DNA double-strand break resection complex.

Byrne RT, Schuller JM, Unverdorben P, Förster F, Hopfner KP.

FEBS Lett. 2014 Dec 20;588(24):4637-44. doi: 10.1016/j.febslet.2014.10.035. Epub 2014 Nov 11.

31.

c-di-AMP recognition by Staphylococcus aureus PstA.

Müller M, Hopfner KP, Witte G.

FEBS Lett. 2015 Jan 2;589(1):45-51. doi: 10.1016/j.febslet.2014.11.022. Epub 2014 Nov 28.

32.

Cytosolic RNA:DNA hybrids activate the cGAS-STING axis.

Mankan AK, Schmidt T, Chauhan D, Goldeck M, Höning K, Gaidt M, Kubarenko AV, Andreeva L, Hopfner KP, Hornung V.

EMBO J. 2014 Dec 17;33(24):2937-46. doi: 10.15252/embj.201488726. Epub 2014 Nov 25.

33.

Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.

Rojowska A, Lammens K, Seifert FU, Direnberger C, Feldmann H, Hopfner KP.

EMBO J. 2014 Dec 1;33(23):2847-59. doi: 10.15252/embj.201488889. Epub 2014 Oct 27.

34.
35.

RIG-I holds the CARDs in a game of self versus nonself.

Hopfner KP.

Mol Cell. 2014 Aug 21;55(4):505-7. doi: 10.1016/j.molcel.2014.08.009.

36.

T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell.

Roskopf CC, Schiller CB, Braciak TA, Kobold S, Schubert IA, Fey GH, Hopfner KP, Oduncu FS.

Oncotarget. 2014 Aug 15;5(15):6466-83.

37.

Crystal and solution structure of the human RIG-I SF2 domain.

Deimling T, Cui S, Lammens K, Hopfner KP, Witte G.

Acta Crystallogr F Struct Biol Commun. 2014 Aug;70(Pt 8):1027-31. doi: 10.1107/S2053230X14012230. Epub 2014 Jul 23.

38.

Structural studies of DNA end detection and resection in homologous recombination.

Schiller CB, Seifert FU, Linke-Winnebeck C, Hopfner KP.

Cold Spring Harb Perspect Biol. 2014 Jul 31;6(10):a017962. doi: 10.1101/cshperspect.a017962. Review.

39.

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids.

Hornung V, Hartmann R, Ablasser A, Hopfner KP.

Nat Rev Immunol. 2014 Aug;14(8):521-8. doi: 10.1038/nri3719. Epub 2014 Jul 18. Review.

PMID:
25033909
40.

Common variants in the HLA-DQ region confer susceptibility to idiopathic achalasia.

Gockel I, Becker J, Wouters MM, Niebisch S, Gockel HR, Hess T, Ramonet D, Zimmermann J, Vigo AG, Trynka G, de León AR, de la Serna JP, Urcelay E, Kumar V, Franke L, Westra HJ, Drescher D, Kneist W, Marquardt JU, Galle PR, Mattheisen M, Annese V, Latiano A, Fumagalli U, Laghi L, Cuomo R, Sarnelli G, Müller M, Eckardt AJ, Tack J, Hoffmann P, Herms S, Mangold E, Heilmann S, Kiesslich R, von Rahden BH, Allescher HD, Schulz HG, Wijmenga C, Heneka MT, Lang H, Hopfner KP, Nöthen MM, Boeckxstaens GE, de Bakker PI, Knapp M, Schumacher J.

Nat Genet. 2014 Aug;46(8):901-4. doi: 10.1038/ng.3029. Epub 2014 Jul 6.

PMID:
24997987
41.

Crystallization of mouse RIG-I ATPase domain: in situ proteolysis.

Civril F, Hopfner KP.

Methods Mol Biol. 2014;1169:27-35. doi: 10.1007/978-1-4939-0882-0_3.

PMID:
24957226
42.

Single-molecule choreography between telomere proteins and G quadruplexes.

Hopfner KP.

Structure. 2014 Jun 10;22(6):801-2. doi: 10.1016/j.str.2014.05.011.

43.

Editorial overview: Theory and simulation: Macromolecular machines.

Hopfner KP, Smith TJ.

Curr Opin Struct Biol. 2014 Apr;25:vi-viii. doi: 10.1016/j.sbi.2014.04.005. Epub 2014 May 12. No abstract available.

PMID:
24833484
44.

Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production.

Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H, Ruland J.

Nat Immunol. 2014 Jun;15(6):538-45. doi: 10.1038/ni.2888. Epub 2014 Apr 28.

45.

In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.

Runge S, Sparrer KM, Lässig C, Hembach K, Baum A, García-Sastre A, Söding J, Conzelmann KK, Hopfner KP.

PLoS Pathog. 2014 Apr 17;10(4):e1004081. doi: 10.1371/journal.ppat.1004081. eCollection 2014 Apr.

46.

Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.

Janke H, Pastore F, Schumacher D, Herold T, Hopfner KP, Schneider S, Berdel WE, Büchner T, Woermann BJ, Subklewe M, Bohlander SK, Hiddemann W, Spiekermann K, Polzer H.

PLoS One. 2014 Mar 7;9(3):e89560. doi: 10.1371/journal.pone.0089560. eCollection 2014.

47.

Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses.

Liang Q, Seo GJ, Choi YJ, Kwak MJ, Ge J, Rodgers MA, Shi M, Leslie BJ, Hopfner KP, Ha T, Oh BH, Jung JU.

Cell Host Microbe. 2014 Feb 12;15(2):228-38. doi: 10.1016/j.chom.2014.01.009.

48.

NK cells from an AML patient have recovered in remission and reached comparable cytolytic activity to that of a healthy monozygotic twin mediated by the single-chain triplebody SPM-2.

Braciak TA, Wildenhain S, Roskopf CC, Schubert IA, Fey GH, Jacob U, Hopfner KP, Oduncu FS.

J Transl Med. 2013 Nov 16;11:289. doi: 10.1186/1479-5876-11-289.

49.

Structure and subunit topology of the INO80 chromatin remodeler and its nucleosome complex.

Tosi A, Haas C, Herzog F, Gilmozzi A, Berninghausen O, Ungewickell C, Gerhold CB, Lakomek K, Aebersold R, Beckmann R, Hopfner KP.

Cell. 2013 Sep 12;154(6):1207-19. doi: 10.1016/j.cell.2013.08.016.

50.

Structural analysis of phenothiazine derivatives as allosteric inhibitors of the MALT1 paracaspase.

Schlauderer F, Lammens K, Nagel D, Vincendeau M, Eitelhuber AC, Verhelst SH, Kling D, Chrusciel A, Ruland J, Krappmann D, Hopfner KP.

Angew Chem Int Ed Engl. 2013 Sep 23;52(39):10384-7. doi: 10.1002/anie.201304290. Epub 2013 Aug 14. No abstract available.

PMID:
23946259

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