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Items: 34

1.

Chemistry and Biology of Cylindrols: Novel Inhibitors of Ras Farnesyl-Protein Transferase from Cylindrocarpon lucidum.

Singh SB, Ball RG, Bills GF, Cascales C, Gibbs JB, Goetz MA, Hoogsteen K, Jenkins RG, Liesch JM, Lingham RB, Silverman KC, Zink DL.

J Org Chem. 1996 Nov 1;61(22):7727-7737.

PMID:
11667727
2.

Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.

Hutchinson JH, Charleson S, Evans JF, Falgueyret JP, Hoogsteen K, Jones TR, Kargman S, Macdonald D, McFarlane CS, Nicholson DW, et al.

J Med Chem. 1995 Oct 27;38(22):4538-47.

PMID:
7473582
3.

Tryptophan-derived NK1 antagonists: conformationally constrained heterocyclic bioisosteres of the ester linkage.

Lewis RT, Macleod AM, Merchant KJ, Kelleher F, Sanderson I, Herbert RH, Cascieri MA, Sadowski S, Ball RG, Hoogsteen K.

J Med Chem. 1995 Mar 17;38(6):923-33.

PMID:
7699709
4.

Synthesis and in vitro biological profile of all four isomers of the potent muscarinic agonist 3-(3-methyl-1,2,4-oxadiazol-5-yl)-1-azabicyclo[2.2.1]heptane.

Showell GA, Baker R, Davis J, Hargreaves R, Freedman SB, Hoogsteen K, Patel S, Snow RJ.

J Med Chem. 1992 Mar 6;35(5):911-6.

PMID:
1548680
5.

1-(substituted)benzyl-5-aminoimidazole-4-carboxamides are potent orally active inhibitors of Trypanosoma cruzi in mice.

Chabala JC, Waits VB, Ikeler T, Patchett AA, Payne L, Peterson LH, Reamer RA, Hoogsteen K, Wyvratt M, Hanson WL, et al.

Experientia. 1991 Jan 15;47(1):51-3.

PMID:
1900244
7.

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

Navia MA, McKeever BM, Springer JP, Lin TY, Williams HR, Fluder EM, Dorn CP, Hoogsteen K.

Proc Natl Acad Sci U S A. 1989 Jan;86(1):7-11.

8.

Crystallization of human neutrophil elastase.

Williams HR, Lin TY, Navia MA, Springer JP, McKeever BM, Hoogsteen K, Dorn CP Jr.

J Biol Chem. 1987 Dec 15;262(35):17178-81.

9.

Crystallographic study of a beta-lactam inhibitor complex with elastase at 1.84 A resolution.

Navia MA, Springer JP, Lin TY, Williams HR, Firestone RA, Pisano JM, Doherty JB, Finke PE, Hoogsteen K.

Nature. 1987 May 7-13;327(6117):79-82.

PMID:
3646481
10.

Pig pancreatic anhydro-elastase. Role of the serine-195 hydroxy group in the binding of inhibitors and substrate.

Williams HR, Lin TY, Navia MA, Springer JP, Hoogsteen K.

Biochem J. 1987 Feb 15;242(1):267-73.

11.

Preliminary X-ray crystallographic data on mouse submaxillary gland renin and renin-inhibitor complexes.

Navia MA, Springer JP, Poe M, Boger J, Hoogsteen K.

J Biol Chem. 1984 Oct 25;259(20):12714-7.

13.
14.

Purification and properties of renin and gamma-renin from the mouse submaxillary gland.

Poe M, Wu JK, Florance JR, Rodkey JA, Bennett CD, Hoogsteen K.

J Biol Chem. 1983 Feb 25;258(4):2209-16. No abstract available.

15.
16.

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

Alberts AW, Chen J, Kuron G, Hunt V, Huff J, Hoffman C, Rothrock J, Lopez M, Joshua H, Harris E, Patchett A, Monaghan R, Currie S, Stapley E, Albers-Schonberg G, Hensens O, Hirshfield J, Hoogsteen K, Liesch J, Springer J.

Proc Natl Acad Sci U S A. 1980 Jul;77(7):3957-61.

17.

5-Methyl-5,6,7,8-tetrahydrofolic acid. Conformation of the tetrahydropyrazine ring.

Poe M, Hensens OD, Hoogsteen K.

J Biol Chem. 1979 Nov 10;254(21):10881-4. No abstract available.

18.

Synthesis, assignment of absolute configuration, and receptor binding studies relevant to the neuroleptic activities of a series of chiral 3-substituted cyproheptadine atropisomers.

Randall WC, Anderson PS, Cresson EL, Hunt CA, Lyon TF, Rittle KE, Remy DC, Springer JP, Hirshfield JM, Hoogsteen K, Williams M, Risley EA, Totaro JA.

J Med Chem. 1979 Oct;22(10):1222-30. No abstract available.

PMID:
41950
20.

Dihydrofolate reductase from trimethoprim-resistant Escherichia coli MB 3746 and MB 3747. Purification, amino acid composition, and some kinetic properties.

Poe M, Breeze AS, Wu JK, Short CR Jr, Hoogsteen K.

J Biol Chem. 1979 Mar 25;254(6):1799-805. No abstract available.

21.

5,6,7,8-Tetrahydrofolic acid. Conformation of the tetrahydropyrazine ring.

Poe M, Hoogsteen K.

J Biol Chem. 1978 Jan 25;253(2):543-6.

22.
23.

Dihydrofolate reductase: x-ray structure of the binary complex with methotrexate.

Matthews DA, Alden RA, Bolin JT, Freer ST, Hamlin R, Xuong N, Kraut J, Poe M, Williams M, Hoogsteen K.

Science. 1977 Jul 29;197(4302):452-5.

PMID:
17920
24.

Dihydrofolate reductase from a methotrexate-resistant Escherichia coli: proton magnetic resonance studies of complexes with folate and methotrexate.

Poe M, Williams MN, Greenfield NJ, Hoogsteen K.

Biochem Biophys Res Commun. 1975 Nov 3;67(1):240-7. No abstract available.

PMID:
1012
25.

Drug-induced suppression of phospholipid synthesis in HeLa cells by inhibition of choline uptake.

Shigeura HT, Hen AC, Hoogsteen K.

Biochim Biophys Acta. 1975 May 22;388(2):180-7.

PMID:
1138894
26.

Metabolic studies on diphenylsulfone derivatives in chick macrophages.

Shigeura HT, Hen AC, Burg RW, Skelly BJ, Hoogsteen K.

Biochem Pharmacol. 1975 Mar 15;24(6):687-91. No abstract available.

PMID:
1125069
27.

Proton NMR studies of E. coli MB 1428 dihydrofolate reductase.

Poe M, Greenfield NJ, Williams MN, Hoogsteen K.

Ann N Y Acad Sci. 1973 Dec 31;222:722-3. No abstract available.

PMID:
4594298
28.
29.

Methotrexate binding to dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli.

Williams MN, Poe M, Greenfield NJ, Hirshfield JM, Hoogsteen K.

J Biol Chem. 1973 Sep 25;248(18):6375-9. No abstract available.

30.

Circular dichroism studies of dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli.

Greenfield NJ, Williams MN, Poe M, Hoogsteen K.

Biochemistry. 1972 Dec 5;11(25):4706-11. No abstract available.

PMID:
4144060
31.

Dihydrofolate reductase. Purification and characterization of the enzyme from an amethopterin-resistant mutant of Escherichia coli.

Poe M, Greenfield NJ, Hirshfield JM, Williams MN, Hoogsteen K.

Biochemistry. 1972 Mar 14;11(6):1023-30. No abstract available.

PMID:
4401227
32.
33.

The structure and conformation of the cis and trans isomers of 1-(p-chlorobenzylidene)-2-methyl-5-methoxyindenylacetic acid.

Hoogsteen K, Trenner NR.

J Org Chem. 1970 Feb;35(2):521-3. No abstract available.

PMID:
5412142
34.

Unit-cell dimensions and space group of 6-mercaptopurine monohydrate.

HOOGSTEEN K.

Nature. 1956 Aug 18;178(4529):379. No abstract available.

PMID:
13358755

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