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Items: 49

1.

Maspin is a deoxycholate-inducible, anti-apoptotic stress-response protein differentially expressed during colon carcinogenesis.

Payne CM, Holubec H, Crowley-Skillicorn C, Nguyen H, Bernstein H, Wilcox G, Bernstein C.

Clin Exp Gastroenterol. 2011;4:239-53. doi: 10.2147/CEG.S24093. Epub 2011 Oct 3.

2.

Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.

Payne CM, Crowley-Skillicorn C, Bernstein C, Holubec H, Bernstein H.

Clin Exp Gastroenterol. 2011;4:75-119. doi: 10.2147/CEG.S17114. Epub 2011 May 3.

3.

Carcinogenicity of deoxycholate, a secondary bile acid.

Bernstein C, Holubec H, Bhattacharyya AK, Nguyen H, Payne CM, Zaitlin B, Bernstein H.

Arch Toxicol. 2011 Aug;85(8):863-71. doi: 10.1007/s00204-011-0648-7. Epub 2011 Jan 26.

4.

Hydrophobic bile acid-induced micronuclei formation, mitotic perturbations, and decreases in spindle checkpoint proteins: relevance to genomic instability in colon carcinogenesis.

Payne CM, Crowley-Skillicorn C, Bernstein C, Holubec H, Moyer MP, Bernstein H.

Nutr Cancer. 2010;62(6):825-40. doi: 10.1080/01635581003695756.

PMID:
20661832
5.

Exposure of mouse colon to dietary bile acid supplement induces sessile adenomas.

Payne CM, Holubec H, Bhattacharyya AK, Bernstein C, Bernstein H.

Inflamm Bowel Dis. 2010 May;16(5):729-30. doi: 10.1002/ibd.21079. No abstract available.

PMID:
20135625
6.

Deoxycholate, an endogenous cytotoxin/genotoxin, induces the autophagic stress-survival pathway: implications for colon carcinogenesis.

Payne CM, Crowley-Skillicorn C, Holubec H, Dvorak K, Bernstein C, Moyer MP, Garewal H, Bernstein H.

J Toxicol. 2009;2009:785907. doi: 10.1155/2009/785907. Epub 2009 May 10.

7.

Expression of bile acid transporting proteins in Barrett's esophagus and esophageal adenocarcinoma.

Dvorak K, Watts GS, Ramsey L, Holubec H, Payne CM, Bernstein C, Jenkins GJ, Sampliner RE, Prasad A, Garewal HS, Bernstein H.

Am J Gastroenterol. 2009 Feb;104(2):302-9. doi: 10.1038/ajg.2008.85. Epub 2009 Jan 27.

8.

A novel dietary-related model of esophagitis and Barrett's esophagus, a premalignant lesion.

Guy NC, Garewal H, Holubec H, Bernstein H, Payne CM, Bernstein C, Bhattacharyya AK, Dvorak K.

Nutr Cancer. 2007;59(2):217-27.

PMID:
18001217
9.

Activation of the interleukin-6/STAT3 antiapoptotic pathway in esophageal cells by bile acids and low pH: relevance to barrett's esophagus.

Dvorak K, Chavarria M, Payne CM, Ramsey L, Crowley-Weber C, Dvorakova B, Dvorak B, Bernstein H, Holubec H, Sampliner RE, Bernstein C, Prasad A, Green SB, Garewal H.

Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5305-13.

10.

Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice.

Chandramouli A, Shi J, Feng Y, Holubec H, Shanas RM, Bhattacharyya AK, Zheng W, Nelson MA.

Carcinogenesis. 2007 Sep;28(9):2028-35. Epub 2007 Mar 26.

PMID:
17389615
11.

Deoxycholate-induced colitis is markedly attenuated in Nos2 knockout mice in association with modulation of gene expression profiles.

Bernstein H, Holubec H, Bernstein C, Ignatenko NA, Gerner E, Dvorak K, Besselsen D, Blohm-Mangone KA, Padilla-Torres J, Dvorakova B, Garewal H, Payne CM.

Dig Dis Sci. 2007 Mar;52(3):628-42.

PMID:
17253130
12.

Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: relevance to the pathogenesis of Barrett's oesophagus.

Dvorak K, Payne CM, Chavarria M, Ramsey L, Dvorakova B, Bernstein H, Holubec H, Sampliner RE, Guy N, Condon A, Bernstein C, Green SB, Prasad A, Garewal HS.

Gut. 2007 Jun;56(6):763-71. Epub 2006 Dec 4.

13.

Role of c-Myc in intestinal tumorigenesis of the ApcMin/+ mouse.

Ignatenko NA, Holubec H, Besselsen DG, Blohm-Mangone KA, Padilla-Torres JL, Nagle RB, de Alboránç IM, Guillen-R JM, Gerner EW.

Cancer Biol Ther. 2006 Dec;5(12):1658-64. Epub 2006 Dec 7.

PMID:
17106247
14.

Deoxycholate induces mitochondrial oxidative stress and activates NF-kappaB through multiple mechanisms in HCT-116 colon epithelial cells.

Payne CM, Weber C, Crowley-Skillicorn C, Dvorak K, Bernstein H, Bernstein C, Holubec H, Dvorakova B, Garewal H.

Carcinogenesis. 2007 Jan;28(1):215-22. Epub 2006 Aug 3.

PMID:
16887864
15.

Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment.

Clark JA, Doelle SM, Halpern MD, Saunders TA, Holubec H, Dvorak K, Boitano SA, Dvorak B.

Am J Physiol Gastrointest Liver Physiol. 2006 Nov;291(5):G938-49. Epub 2006 Jun 22.

16.

Reduced Pms2 expression in non-neoplastic flat mucosa from patients with colon cancer correlates with reduced apoptosis competence.

Bernstein H, Prasad A, Holubec H, Bernstein C, Payne CM, Ramsey L, Dvorakova K, Wilson M, Warneke JA, Garewal H.

Appl Immunohistochem Mol Morphol. 2006 Jun;14(2):166-72.

PMID:
16785784
17.

Role of polyamines in arginine-dependent colon carcinogenesis in Apc(Min) (/+) mice.

Yerushalmi HF, Besselsen DG, Ignatenko NA, Blohm-Mangone KA, Padilla-Torres JL, Stringer DE, Guillen JM, Holubec H, Payne CM, Gerner EW.

Mol Carcinog. 2006 Oct;45(10):764-73.

PMID:
16705737
18.

Unique dietary-related mouse model of colitis.

Bernstein H, Holubec H, Bernstein C, Ignatenko N, Gerner E, Dvorak K, Besselsen D, Ramsey L, Dall'Agnol M, Blohm-Mangone KA, Padilla-Torres J, Cui H, Garewal H, Payne CM.

Inflamm Bowel Dis. 2006 Apr;12(4):278-93.

PMID:
16633050
19.

Bile acids induce ileal damage during experimental necrotizing enterocolitis.

Halpern MD, Holubec H, Saunders TA, Dvorak K, Clark JA, Doelle SM, Ballatori N, Dvorak B.

Gastroenterology. 2006 Feb;130(2):359-72.

20.

The role of NO synthases in arginine-dependent small intestinal and colonic carcinogenesis.

Yerushalmi HF, Besselsen DG, Ignatenko NA, Blohm-Mangone KA, Padilla-Torres JL, Stringer DE, Cui H, Holubec H, Payne CM, Gerner EW.

Mol Carcinog. 2006 Feb;45(2):93-105.

PMID:
16329147
21.

Mitochondrial perturbation attenuates bile acid-induced cytotoxicity.

Payne CM, Crowley-Weber CL, Dvorak K, Bernstein C, Bernstein H, Holubec H, Crowley C, Garewal H.

Cell Biol Toxicol. 2005 Sep-Nov;21(5-6):215-31.

PMID:
16323058
22.

Epidermal growth factor reduces hepatic sequelae in experimental necrotizing enterocolitis.

Halpern MD, Holubec H, Clark JA, Saunders TA, Williams CS, Dvorak K, Dvorak B.

Biol Neonate. 2006;89(4):227-35. Epub 2005 Nov 29.

PMID:
16319449
23.

Crypt-restricted loss and decreased protein expression of cytochrome C oxidase subunit I as potential hypothesis-driven biomarkers of colon cancer risk.

Payne CM, Holubec H, Bernstein C, Bernstein H, Dvorak K, Green SB, Wilson M, Dall'Agnol M, Dvorakova B, Warneke J, Garewal H.

Cancer Epidemiol Biomarkers Prev. 2005 Sep;14(9):2066-75.

24.

Assessment of apoptosis by immunohistochemical markers compared to cellular morphology in ex vivo-stressed colonic mucosa.

Holubec H, Payne CM, Bernstein H, Dvorakova K, Bernstein C, Waltmire CN, Warneke JA, Garewal H.

J Histochem Cytochem. 2005 Feb;53(2):229-35.

PMID:
15684335
25.

Apoptosis resistance in Barrett's esophagus: ex vivo bioassay of live stressed tissues.

Dvorakova K, Payne CM, Ramsey L, Bernstein H, Holubec H, Chavarria M, Bernstein C, Sampliner RE, Riley C, Prasad A, Garewal H.

Am J Gastroenterol. 2005 Feb;100(2):424-31.

PMID:
15667503
26.

Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis.

Clark JA, Lane RH, Maclennan NK, Holubec H, Dvorakova K, Halpern MD, Williams CS, Payne CM, Dvorak B.

Am J Physiol Gastrointest Liver Physiol. 2005 Apr;288(4):G755-62. Epub 2004 Nov 4.

27.

Rat milk decreases necrotizing enterocolitis in a rat model.

Dvorak B, Halpern MD, Holubec H, Dvorakova K, Dominguez JA, Williams CS, Meza YG.

Adv Exp Med Biol. 2004;554:471-3. No abstract available.

PMID:
15384627
28.

Increased expression and secretion of interleukin-6 in patients with Barrett's esophagus.

Dvorakova K, Payne CM, Ramsey L, Holubec H, Sampliner R, Dominguez J, Dvorak B, Bernstein H, Bernstein C, Prasad A, Fass R, Cui H, Garewal H.

Clin Cancer Res. 2004 Mar 15;10(6):2020-8.

29.

Caspase-6 mediated cleavage of guanylate cyclase alpha 1 during deoxycholate-induced apoptosis: protective role of the nitric oxide signaling module.

Payne CM, Waltmire CN, Crowley C, Crowley-Weber CL, Dvorakova K, Bernstein H, Bernstein C, Holubec H, Garewal H.

Cell Biol Toxicol. 2003 Nov;19(6):373-92.

PMID:
15015762
30.

A proteomic study of resistance to deoxycholate-induced apoptosis.

Bernstein H, Payne CM, Kunke K, Crowley-Weber CL, Waltmire CN, Dvorakova K, Holubec H, Bernstein C, Vaillancourt RR, Raynes DA, Guerriero V, Garewal H.

Carcinogenesis. 2004 May;25(5):681-92. Epub 2004 Jan 16.

PMID:
14729586
31.

Deoxycholate, an endogenous tumor promoter and DNA damaging agent, modulates BRCA-1 expression in apoptosis-sensitive epithelial cells: loss of BRCA-1 expression in colonic adenocarcinomas.

Romagnolo DF, Chirnomas RB, Ku J, Jeffy BD, Payne CM, Holubec H, Ramsey L, Bernstein H, Bernstein C, Kunke K, Bhattacharyya A, Warneke J, Garewal H.

Nutr Cancer. 2003;46(1):82-92.

PMID:
12925308
32.

Maternal milk reduces severity of necrotizing enterocolitis and increases intestinal IL-10 in a neonatal rat model.

Dvorak B, Halpern MD, Holubec H, Dvorakova K, Dominguez JA, Williams CS, Meza YG, Kozakova H, McCuskey RS.

Pediatr Res. 2003 Mar;53(3):426-33.

PMID:
12595590
33.

Hepatic inflammatory mediators contribute to intestinal damage in necrotizing enterocolitis.

Halpern MD, Holubec H, Dominguez JA, Meza YG, Williams CS, Ruth MC, McCuskey RS, Dvorak B.

Am J Physiol Gastrointest Liver Physiol. 2003 Apr;284(4):G695-702. Epub 2003 Jan 15.

34.

Ileal cytokine dysregulation in experimental necrotizing enterocolitis is reduced by epidermal growth factor.

Halpern MD, Dominguez JA, Dvorakova K, Holubec H, Williams CS, Meza YG, Ruth MC, Dvorak B.

J Pediatr Gastroenterol Nutr. 2003 Jan;36(1):126-33.

PMID:
12500008
35.

Patchy field defects of apoptosis resistance and dedifferentiation in flat mucosa of colon resections from colon cancer patients.

Bernstein H, Holubec H, Warneke JA, Garewal H, Earnest DL, Payne CM, Roe DJ, Cui H, Jacobson EL, Bernstein C.

Ann Surg Oncol. 2002 Jun;9(5):505-17.

PMID:
12052764
36.

Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis.

Halpern MD, Holubec H, Dominguez JA, Williams CS, Meza YG, McWilliam DL, Payne CM, McCuskey RS, Besselsen DG, Dvorak B.

Pediatr Res. 2002 Jun;51(6):733-9.

PMID:
12032269
37.

Epidermal growth factor reduces the development of necrotizing enterocolitis in a neonatal rat model.

Dvorak B, Halpern MD, Holubec H, Williams CS, McWilliam DL, Dominguez JA, Stepankova R, Payne CM, McCuskey RS.

Am J Physiol Gastrointest Liver Physiol. 2002 Jan;282(1):G156-64.

38.

The effects of dietary selenomethionine on polyamines and azoxymethane-induced aberrant crypts.

Baines AT, Holubec H, Basye JL, Thorne P, Bhattacharyya AK, Spallholz J, Shriver B, Cui H, Roe D, Clark LC, Earnest DL, Nelson MA.

Cancer Lett. 2000 Nov 28;160(2):193-8.

PMID:
11053649
39.

APC-dependent changes in expression of genes influencing polyamine metabolism, and consequences for gastrointestinal carcinogenesis, in the Min mouse.

Erdman SH, Ignatenko NA, Powell MB, Blohm-Mangone KA, Holubec H, Guillén-Rodriguez JM, Gerner EW.

Carcinogenesis. 1999 Sep;20(9):1709-13.

PMID:
10469614
40.

The stress-response proteins poly(ADP-ribose) polymerase and NF-kappaB protect against bile salt-induced apoptosis.

Payne CM, Crowley C, Washo-Stultz D, Briehl M, Bernstein H, Bernstein C, Beard S, Holubec H, Warneke J.

Cell Death Differ. 1998 Jul;5(7):623-36.

41.

Enrichment of the more hydrophilic bile acid ursodeoxycholic acid in the fecal water-soluble fraction after feeding to rats with colon polyps.

Batta AK, Salen G, Holubec H, Brasitus TA, Alberts D, Earnest DL.

Cancer Res. 1998 Apr 15;58(8):1684-7.

42.

Insulin-like growth factor-I (IGF-I) mRNA in the small intestine of suckling and adult rats.

Dvorák B, Stephana AL, Holubec H, Williams CS, Philipps AF, Koldovskoý O.

FEBS Lett. 1996 Jun 17;388(2-3):155-60.

43.

Cellular origin and rate of endothelial cell coverage of PTFE grafts.

Bull DA, Hunter GC, Holubec H, Aguirre ML, Rappaport WD, Putnam CW.

J Surg Res. 1995 Jan;58(1):58-68.

PMID:
7830407
44.

Epidermal growth factor and transforming growth factor-alpha mRNA in rat small intestine: in situ hybridization study.

Dvorák B, Holubec H, LeBouton AV, Wilson JM, Koldovský O.

FEBS Lett. 1994 Oct 3;352(3):291-5.

45.

Chemoprevention of azoxymethane-induced colonic carcinogenesis by supplemental dietary ursodeoxycholic acid.

Earnest DL, Holubec H, Wali RK, Jolley CS, Bissonette M, Bhattacharyya AK, Roy H, Khare S, Brasitus TA.

Cancer Res. 1994 Oct 1;54(19):5071-4.

46.

Collagen fibers as a temporary scaffold for replacement of ACL in goats.

Chvapil M, Speer DP, Holubec H, Chvapil TA, King DH.

J Biomed Mater Res. 1993 Mar;27(3):313-25.

PMID:
8360201
47.

Effect of surgical manipulation of polytetrafluoroethylene grafts on microstructural properties and healing characteristics.

Holubec H, Hunter GC, Putnam CW, Bull DA, Rappaport WD, Chvapil M.

Am J Surg. 1992 Nov;164(5):512-6.

PMID:
1443379
48.

Inert wound dressing is not desirable.

Chvapil M, Holubec H, Chvapil T.

J Surg Res. 1991 Sep;51(3):245-52.

PMID:
1881139
49.

Increased fibronectin production by cell lines from hypertrophic scar and keloid.

Kischer CW, Wagner HN Jr, Pindur J, Holubec H, Jones M, Ulreich JB, Scuderi P.

Connect Tissue Res. 1989;23(4):279-88.

PMID:
2630174

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