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Items: 13


Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations.

Holler CJ, Taylor G, Deng Q, Kukar T.

eNeuro. 2017 Aug 18;4(4). pii: ENEURO.0100-17.2017. doi: 10.1523/ENEURO.0100-17.2017. eCollection 2017 Jul-Aug.


Disulfide bonds and disorder in granulin-3: An unusual handshake between structural stability and plasticity.

Ghag G, Holler CJ, Taylor G, Kukar TL, Uversky VN, Rangachari V.

Protein Sci. 2017 Sep;26(9):1759-1772. doi: 10.1002/pro.3212. Epub 2017 Jun 22.


Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia.

Holler CJ, Taylor G, McEachin ZT, Deng Q, Watkins WJ, Hudson K, Easley CA, Hu WT, Hales CM, Rossoll W, Bassell GJ, Kukar T.

Mol Neurodegener. 2016 Jun 24;11(1):46. doi: 10.1186/s13024-016-0114-3.


Bridging integrator 1 (BIN1) protein expression increases in the Alzheimer's disease brain and correlates with neurofibrillary tangle pathology.

Holler CJ, Davis PR, Beckett TL, Platt TL, Webb RL, Head E, Murphy MP.

J Alzheimers Dis. 2014;42(4):1221-7. doi: 10.3233/JAD-132450.


FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.

Deng Q, Holler CJ, Taylor G, Hudson KF, Watkins W, Gearing M, Ito D, Murray ME, Dickson DW, Seyfried NT, Kukar T.

J Neurosci. 2014 Jun 4;34(23):7802-13. doi: 10.1523/JNEUROSCI.0172-14.2014.


Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression.

Beckett TL, Webb RL, Niedowicz DM, Holler CJ, Matveev S, Baig I, LeVine H 3rd, Keller JN, Murphy MP.

J Alzheimers Dis. 2012;32(1):127-38.


BACE2 expression increases in human neurodegenerative disease.

Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP.

Am J Pathol. 2012 Jan;180(1):337-50. doi: 10.1016/j.ajpath.2011.09.034. Epub 2011 Nov 7.


APP(DeltaNL695) expression in murine tissue downregulates CNBP expression.

Niedowicz DM, Beckett TL, Holler CJ, Weidner AM, Murphy MP.

Neurosci Lett. 2010 Sep 20;482(1):57-61. doi: 10.1016/j.neulet.2010.07.006. Epub 2010 Jul 16.


Effects of nonsteroidal anti-inflammatory drugs on amyloid-beta pathology in mouse skeletal muscle.

Beckett TL, Niedowicz DM, Studzinski CM, Weidner AM, Webb RL, Holler CJ, Ahmed RR, LeVine H 3rd, Murphy MP.

Neurobiol Dis. 2010 Sep;39(3):449-56. doi: 10.1016/j.nbd.2010.05.018. Epub 2010 May 20.


The interaction of rare earth chlorides with 4,4'-bipyridine for the reversible formation of template based luminescent Ln-N-MOFs.

Höller CJ, Mai M, Feldmann C, Müller-Buschbaum K.

Dalton Trans. 2010 Jan 14;(2):461-8. doi: 10.1039/b911460b. Epub 2009 Sep 14.


BACE1 and BACE2 enzymatic activities in Alzheimer's disease.

Ahmed RR, Holler CJ, Webb RL, Li F, Beckett TL, Murphy MP.

J Neurochem. 2010 Feb;112(4):1045-53. doi: 10.1111/j.1471-4159.2009.06528.x. Epub 2009 Dec 4.


STI571 sensitizes breast cancer cells to 5-fluorouracil, cisplatin and camptothecin in a cell type-specific manner.

Sims JT, Ganguly S, Fiore LS, Holler CJ, Park ES, Plattner R.

Biochem Pharmacol. 2009 Aug 1;78(3):249-60. doi: 10.1016/j.bcp.2009.04.007. Epub 2009 Apr 14.

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