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Items: 1 to 50 of 388

1.

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress.

El-Daly M, Venu VKP, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD.

Vascul Pharmacol. 2018 Jun 13. pii: S1537-1891(18)30057-0. doi: 10.1016/j.vph.2018.06.006. [Epub ahead of print]

PMID:
29908295
2.

Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.

Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD.

Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. doi: 10.1167/iovs.17-22562.

PMID:
29860464
3.

Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation.

Darby WG, Potocnik S, Ramachandran R, Hollenberg MD, Woodman OL, McIntyre P.

Pharmacol Res. 2018 May 19;133:152-159. doi: 10.1016/j.phrs.2018.05.009. [Epub ahead of print]

PMID:
29787869
4.

Functional Proteomic Profiling of Secreted Serine Proteases in Health and Inflammatory Bowel Disease.

Denadai-Souza A, Bonnart C, Tapias NS, Marcellin M, Gilmore B, Alric L, Bonnet D, Burlet-Schiltz O, Hollenberg MD, Vergnolle N, Deraison C.

Sci Rep. 2018 May 18;8(1):7834. doi: 10.1038/s41598-018-26282-y.

5.
6.

Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition.

Pulakazhi Venu VK, Saifeddine M, Mihara K, El-Daly M, Belke D, Dean JLE, O'Brien ER, Hirota SA, Hollenberg MD.

Br J Pharmacol. 2018 Jun;175(11):2063-2076. doi: 10.1111/bph.14200. Epub 2018 Apr 25.

PMID:
29532457
7.

Proteinases and their receptors in inflammatory arthritis: an overview.

Oikonomopoulou K, Diamandis EP, Hollenberg MD, Chandran V.

Nat Rev Rheumatol. 2018 Mar;14(3):170-180. doi: 10.1038/nrrheum.2018.17. Epub 2018 Feb 8. Review.

PMID:
29416136
8.

Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia.

van den Boogaard FE, Brands X, Duitman J, de Stoppelaar SF, Borensztajn KS, Roelofs JJTH, Hollenberg MD, Spek CA, Schultz MJ, van 't Veer C, van der Poll T.

J Infect Dis. 2018 Apr 11;217(9):1462-1471. doi: 10.1093/infdis/jiy010.

PMID:
29415278
9.

Tumor necrosis factor α decreases aquaporin 3 expression in intestinal epithelial cells through inhibition of constitutive transcription.

Peplowski MA, Vegso AJ, Iablokov V, Dicay M, Zaheer RS, Renaux B, Proud D, Hollenberg MD, Beck PL, MacNaughton WK.

Physiol Rep. 2017 Oct;5(19). pii: e13451. doi: 10.14814/phy2.13451. Epub 2017 Oct 16.

10.

Granulocyte-colony-stimulating factor (G-CSF) signaling in spinal microglia drives visceral sensitization following colitis.

Basso L, Lapointe TK, Iftinca M, Marsters C, Hollenberg MD, Kurrasch DM, Altier C.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11235-11240. doi: 10.1073/pnas.1706053114. Epub 2017 Oct 2.

11.

Transforming Growth Factor-β1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated Gq-Calcium Signaling.

Ungefroren H, Witte D, Mihara K, Rauch BH, Henklein P, Jöhren O, Bonni S, Settmacher U, Lehnert H, Hollenberg MD, Kaufmann R, Gieseler F.

Mol Pharmacol. 2017 Nov;92(5):519-532. doi: 10.1124/mol.117.109017. Epub 2017 Aug 25.

PMID:
28842394
12.

Career and research outcomes of the physician-scientist training program at the University of Calgary: a retrospective cohort study.

Bau JT, Frolkis AD, Nathoo N, Yipp BG, Hollenberg MD, Beck PL.

CMAJ Open. 2017 May 15;5(2):E395-E401. doi: 10.9778/cmajo.20160103. Epub 2017 May 15.

13.

Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2.

Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg MD.

Clin Exp Allergy. 2017 Jul;47(7):946-960. doi: 10.1111/cea.12921. Epub 2017 Apr 27.

PMID:
28317204
14.

Insights into cellular signalling by G protein coupled receptor transactivation of cell surface protein kinase receptors.

Chaplin R, Thach L, Hollenberg MD, Cao Y, Little PJ, Kamato D.

J Cell Commun Signal. 2017 Jun;11(2):117-125. doi: 10.1007/s12079-017-0375-9. Epub 2017 Feb 6. Review.

15.

Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function.

Ramachandran R, Mihara K, Thibeault P, Vanderboor CM, Petri B, Saifeddine M, Bouvier M, Hollenberg MD.

Mol Pharmacol. 2017 Apr;91(4):287-295. doi: 10.1124/mol.116.106526. Epub 2017 Jan 26.

16.

Proteinases, Their Extracellular Targets, and Inflammatory Signaling.

Ramachandran R, Altier C, Oikonomopoulou K, Hollenberg MD.

Pharmacol Rev. 2016 Oct;68(4):1110-1142. Review.

17.

Thrombin Cleavage of Plasmodium falciparum Erythrocyte Membrane Protein 1 Inhibits Cytoadherence.

Gillrie MR, Renaux B, Russell-Goldman E, Avril M, Brazier AJ, Mihara K, Di Cera E, Milner DA Jr, Hollenberg MD, Smith JD, Ho M.

MBio. 2016 Sep 13;7(5). pii: e01120-16. doi: 10.1128/mBio.01120-16.

18.

Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5.

Zeeh F, Witte D, Gädeken T, Rauch BH, Grage-Griebenow E, Leinung N, Fromm SJ, Stölting S, Mihara K, Kaufmann R, Settmacher U, Lehnert H, Hollenberg MD, Ungefroren H.

Oncotarget. 2016 Jul 5;7(27):41095-41109. doi: 10.18632/oncotarget.9600.

19.

Lost: Young Canadian physician-scientists need a map.

Lewinson RT, Keough MB, Beck PL, Hollenberg MD, Yipp BG.

Sci Transl Med. 2016 Mar 9;8(329):329fs6. doi: 10.1126/scitranslmed.aad4355. Review.

PMID:
26962153
20.

Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling.

Mihara K, Ramachandran R, Saifeddine M, Hansen KK, Renaux B, Polley D, Gibson S, Vanderboor C, Hollenberg MD.

Mol Pharmacol. 2016 May;89(5):606-14. doi: 10.1124/mol.115.102723. Epub 2016 Mar 8.

21.

Proceedings from the 6th Annual University of Calgary Leaders in Medicine Research Symposium.

Roberts JI, Beatty JK, Peplowski MA, Keough MB, Yipp BG, Hollenberg MD, Beck PL.

Clin Invest Med. 2015 Dec 4;38(6):E318-50.

PMID:
26654516
22.

Highlights from the 6th Annual University of Calgary Leaders in Medicine Research Symposium and the Keynote Address by Dr. Danuta Skowronski.

Roberts JI, Beatty JK, Peplowski MA, Keough MB, Yipp BG, Hollenberg MD, Beck PL.

Clin Invest Med. 2015 Dec 4;38(6):E314-7.

PMID:
26654515
23.

Integrating the GPCR transactivation-dependent and biased signalling paradigms in the context of PAR1 signalling.

Little PJ, Hollenberg MD, Kamato D, Thomas W, Chen J, Wang T, Zheng W, Osman N.

Br J Pharmacol. 2016 Oct;173(20):2992-3000. doi: 10.1111/bph.13398. Epub 2016 Feb 16. Review.

24.

Protease activated receptor-1 mediated dual kinase receptor transactivation stimulates the expression of glycosaminoglycan synthesizing genes.

Kamato D, Thach L, Getachew R, Burch M, Hollenberg MD, Zheng W, Little PJ, Osman N.

Cell Signal. 2016 Jan;28(1):110-9. doi: 10.1016/j.cellsig.2015.11.003. Epub 2015 Nov 5.

PMID:
26548632
25.

Functional inhibition of PAR2 alleviates allergen-induced airway hyperresponsiveness and inflammation.

Asaduzzaman M, Nadeem A, Arizmendi N, Davidson C, Nichols HL, Abel M, Ionescu LI, Puttagunta L, Thebaud B, Gordon J, DeFea K, Hollenberg MD, Vliagoftis H.

Clin Exp Allergy. 2015 Dec;45(12):1844-55. doi: 10.1111/cea.12628.

PMID:
26312432
26.

Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.

Kim W, Zekas E, Lodge R, Susan-Resiga D, Marcinkiewicz E, Essalmani R, Mihara K, Ramachandran R, Asahchop E, Gelman B, Cohen ÉA, Power C, Hollenberg MD, Seidah NG.

Mol Cell Biol. 2015 Nov;35(21):3684-700. doi: 10.1128/MCB.00764-15. Epub 2015 Aug 17.

27.

Vitamin D, the autonomic nervous system, and cardiovascular risk.

Mann MC, Hollenberg MD, Hanley DA, Ahmed SB.

Physiol Rep. 2015 Apr;3(4). pii: e12349. doi: 10.14814/phy2.12349. No abstract available.

28.

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature.

Saifeddine M, El-Daly M, Mihara K, Bunnett NW, McIntyre P, Altier C, Hollenberg MD, Ramachandran R.

Br J Pharmacol. 2015 May;172(10):2493-506. doi: 10.1111/bph.13072. Epub 2015 Mar 18.

29.

Proteinases, their receptors and inflammatory signalling: the Oxford South Parks Road connection.

Hollenberg MD.

Br J Pharmacol. 2015 Jul;172(13):3196-211. doi: 10.1111/bph.13041. Epub 2015 Mar 17. Review.

30.

Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells.

Iablokov V, Hirota CL, Peplowski MA, Ramachandran R, Mihara K, Hollenberg MD, MacNaughton WK.

J Biol Chem. 2014 Dec 5;289(49):34366-77. doi: 10.1074/jbc.M114.610485. Epub 2014 Oct 20.

31.

KLKs and their hormone-like signaling actions: a new life for the PSA-KLK family.

Hollenberg MD.

Biol Chem. 2014 Sep;395(9):915-29. doi: 10.1515/hsz-2014-0123. Review.

PMID:
25153380
32.

Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites.

Haerteis S, Krappitz A, Krappitz M, Murphy JE, Bertog M, Krueger B, Nacken R, Chung H, Hollenberg MD, Knecht W, Bunnett NW, Korbmacher C.

J Biol Chem. 2014 Jul 4;289(27):19067-78. doi: 10.1074/jbc.M113.538470. Epub 2014 May 19.

33.

Tulathromycin exerts proresolving effects in bovine neutrophils by inhibiting phospholipases and altering leukotriene B4, prostaglandin E2, and lipoxin A4 production.

Fischer CD, Duquette SC, Renaux BS, Feener TD, Morck DW, Hollenberg MD, Lucas MJ, Buret AG.

Antimicrob Agents Chemother. 2014 Aug;58(8):4298-307. doi: 10.1128/AAC.02813-14. Epub 2014 May 12.

34.

Hypothetical structure of prostate-specific antigen.

Hollenberg MD.

Clin Chem. 2014 Apr;60(4):702. doi: 10.1373/clinchem.2014.221457. No abstract available.

35.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

36.

Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways.

El-Daly M, Saifeddine M, Mihara K, Ramachandran R, Triggle CR, Hollenberg MD.

Br J Pharmacol. 2014 May;171(9):2413-25. doi: 10.1111/bph.12593.

37.

Proteinase-activated receptor-1 and immunomodulatory effects of a PAR1-activating peptide in a mouse model of prostatitis.

Stanton MM, Nelson LK, Benediktsson H, Hollenberg MD, Buret AG, Ceri H.

Mediators Inflamm. 2013;2013:748395. doi: 10.1155/2013/748395. Epub 2013 Dec 29.

38.

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease.

Hollenberg MD, Mihara K, Polley D, Suen JY, Han A, Fairlie DP, Ramachandran R.

Br J Pharmacol. 2014 Mar;171(5):1180-94. doi: 10.1111/bph.12544. Review.

39.

Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-β receptor signaling pathways contributes to renal fibrosis.

Chung H, Ramachandran R, Hollenberg MD, Muruve DA.

J Biol Chem. 2013 Dec 27;288(52):37319-31. doi: 10.1074/jbc.M113.492793. Epub 2013 Nov 19.

40.

Implantation serine proteinase 2 is a monomeric enzyme with mixed serine proteolytic activity and can silence signalling via proteinase activated receptors.

Sharma N, Fahr J, Renaux B, Saifeddine M, Kumar R, Nishikawa S, Mihara K, Ramachandran R, Hollenberg MD, Rancourt DE.

Biochem Cell Biol. 2013 Dec;91(6):487-97. doi: 10.1139/bcb-2013-0006. Epub 2013 Aug 6.

PMID:
24219291
41.

Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impact.

Gieseler F, Ungefroren H, Settmacher U, Hollenberg MD, Kaufmann R.

Cell Commun Signal. 2013 Nov 11;11:86. doi: 10.1186/1478-811X-11-86. Review.

42.

Proteinase-activated receptor-2 activation participates in allergic sensitization to house dust mite allergens in a murine model.

Davidson CE, Asaduzzaman M, Arizmendi NG, Polley D, Wu Y, Gordon JR, Hollenberg MD, Cameron L, Vliagoftis H.

Clin Exp Allergy. 2013 Nov;43(11):1274-85. doi: 10.1111/cea.12185.

PMID:
24152160
43.

Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).

Mihara K, Ramachandran R, Renaux B, Saifeddine M, Hollenberg MD.

J Biol Chem. 2013 Nov 15;288(46):32979-90. doi: 10.1074/jbc.M113.483123. Epub 2013 Sep 19.

44.

Induction of complement C3a receptor responses by kallikrein-related peptidase 14.

Oikonomopoulou K, DeAngelis RA, Chen H, Diamandis EP, Hollenberg MD, Ricklin D, Lambris JD.

J Immunol. 2013 Oct 1;191(7):3858-66. doi: 10.4049/jimmunol.1202999. Epub 2013 Sep 6.

45.

TRPM8 activation attenuates inflammatory responses in mouse models of colitis.

Ramachandran R, Hyun E, Zhao L, Lapointe TK, Chapman K, Hirota CL, Ghosh S, McKemy DD, Vergnolle N, Beck PL, Altier C, Hollenberg MD.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7476-81. doi: 10.1073/pnas.1217431110. Epub 2013 Apr 17.

46.

PAR-2-mediated control of barrier function and motility differs between early and late phases of postinfectious gut dysfunction in the rat.

Fernández-Blanco JA, Hollenberg MD, Martínez V, Vergara P.

Am J Physiol Gastrointest Liver Physiol. 2013 Feb 15;304(4):G390-400. doi: 10.1152/ajpgi.00387.2012. Epub 2012 Dec 13. Erratum in: Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15;304(12):G1136. Fernández-Blanco, Juan A [corrected to Fernández-Blanco, Joan Antoni].

48.

β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway.

Nichols HL, Saffeddine M, Theriot BS, Hegde A, Polley D, El-Mays T, Vliagoftis H, Hollenberg MD, Wilson EH, Walker JK, DeFea KA.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16660-5. doi: 10.1073/pnas.1208881109. Epub 2012 Sep 25.

49.

The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells.

Jijon HB, Buret A, Hirota CL, Hollenberg MD, Beck PL.

Mediators Inflamm. 2012;2012:207398. doi: 10.1155/2012/207398. Epub 2012 Sep 5.

50.

Activation of PAR(2) receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint.

Russell FA, Schuelert N, Veldhoen VE, Hollenberg MD, McDougall JJ.

Br J Pharmacol. 2012 Dec;167(8):1665-78. doi: 10.1111/j.1476-5381.2012.02120.x.

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