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Items: 40


Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise.

Pourteymour S, Hjorth M, Lee S, Holen T, Langleite TM, Jensen J, Birkeland KI, Drevon CA, Eckardt K.

Physiol Rep. 2017 Oct;5(19). pii: e13459. doi: 10.14814/phy2.13459.


Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines.

Pourteymour S, Eckardt K, Holen T, Langleite T, Lee S, Jensen J, Birkeland KI, Drevon CA, Hjorth M.

Mol Metab. 2017 Jan 29;6(4):352-365. doi: 10.1016/j.molmet.2017.01.007. eCollection 2017 Apr.


Interaction between plasma fetuin-A and free fatty acids predicts changes in insulin sensitivity in response to long-term exercise.

Lee S, Norheim F, Gulseth HL, Langleite TM, Kolnes KJ, Tangen DS, Stadheim HK, Gilfillan GD, Holen T, Birkeland KI, Jensen J, Drevon CA.

Physiol Rep. 2017 Mar;5(5). pii: e13183. doi: 10.14814/phy2.13183.


Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging.

Lee S, Norheim F, Langleite TM, Noreng HJ, Storås TH, Afman LA, Frost G, Bell JD, Thomas EL, Kolnes KJ, Tangen DS, Stadheim HK, Gilfillan GD, Gulseth HL, Birkeland KI, Jensen J, Drevon CA, Holen T; NutriTech Consortium.

Physiol Rep. 2016 Nov;4(21). pii: e13019.


Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men.

Langleite TM, Jensen J, Norheim F, Gulseth HL, Tangen DS, Kolnes KJ, Heck A, Storås T, Grøthe G, Dahl MA, Kielland A, Holen T, Noreng HJ, Stadheim HK, Bjørnerud A, Johansen EI, Nellemann B, Birkeland KI, Drevon CA.

Arch Physiol Biochem. 2016 Oct;122(4):167-179. Epub 2016 Jul 31.


Biomarkers for nutrient intake with focus on alternative sampling techniques.

Holen T, Norheim F, Gundersen TE, Mitry P, Linseisen J, Iversen PO, Drevon CA.

Genes Nutr. 2016 Apr 16;11:12. doi: 10.1186/s12263-016-0527-1. eCollection 2016. Review.


A large-scale quantitative EM study on activation of olfactory glands shows no effect of cholinergic agents.

Li Y, Hessvik NP, Danbolt NC, Holen T.

Microscopy (Oxf). 2016 Oct;65(5):438-443. Epub 2016 Jul 26.


Myostatin in relation to physical activity and dysglycaemia and its effect on energy metabolism in human skeletal muscle cells.

Hjorth M, Pourteymour S, Görgens SW, Langleite TM, Lee S, Holen T, Gulseth HL, Birkeland KI, Jensen J, Drevon CA, Norheim F.

Acta Physiol (Oxf). 2016 May;217(1):45-60. doi: 10.1111/apha.12631. Epub 2015 Dec 9.


The exercise-regulated myokine chitinase-3-like protein 1 stimulates human myocyte proliferation.

Görgens SW, Hjorth M, Eckardt K, Wichert S, Norheim F, Holen T, Lee S, Langleite T, Birkeland KI, Stadheim HK, Kolnes KJ, Tangen DS, Kolnes AJ, Jensen J, Drevon CA, Eckel J.

Acta Physiol (Oxf). 2016 Mar;216(3):330-45. doi: 10.1111/apha.12579. Epub 2015 Sep 8.


The effect of acute and long-term physical activity on extracellular matrix and serglycin in human skeletal muscle.

Hjorth M, Norheim F, Meen AJ, Pourteymour S, Lee S, Holen T, Jensen J, Birkeland KI, Martinov VN, Langleite TM, Eckardt K, Drevon CA, Kolset SO.

Physiol Rep. 2015 Aug;3(8). pii: e12473. doi: 10.14814/phy2.12473.


Perilipin 4 in human skeletal muscle: localization and effect of physical activity.

Pourteymour S, Lee S, Langleite TM, Eckardt K, Hjorth M, Bindesbøll C, Dalen KT, Birkeland KI, Drevon CA, Holen T, Norheim F.

Physiol Rep. 2015 Aug;3(8). pii: e12481. doi: 10.14814/phy2.12481.


Irisin - a myth rather than an exercise-inducible myokine.

Albrecht E, Norheim F, Thiede B, Holen T, Ohashi T, Schering L, Lee S, Brenmoehl J, Thomas S, Drevon CA, Erickson HP, Maak S.

Sci Rep. 2015 Mar 9;5:8889. doi: 10.1038/srep08889.


Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention.

Li Y, Lee S, Langleite T, Norheim F, Pourteymour S, Jensen J, Stadheim HK, Storås TH, Davanger S, Gulseth HL, Birkeland KI, Drevon CA, Holen T.

Physiol Rep. 2014 Nov 20;2(11). pii: e12187. doi: 10.14814/phy2.12187. Print 2014 Nov 1.


Regulation of angiopoietin-like protein 4 production during and after exercise.

Norheim F, Hjorth M, Langleite TM, Lee S, Holen T, Bindesbøll C, Stadheim HK, Gulseth HL, Birkeland KI, Kielland A, Jensen J, Dalen KT, Drevon CA.

Physiol Rep. 2014 Aug 19;2(8). pii: e12109. doi: 10.14814/phy2.12109. Print 2014 Aug 1.


The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans.

Norheim F, Langleite TM, Hjorth M, Holen T, Kielland A, Stadheim HK, Gulseth HL, Birkeland KI, Jensen J, Drevon CA.

FEBS J. 2014 Feb;281(3):739-49. doi: 10.1111/febs.12619. Epub 2013 Dec 10.


A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties.

Kazak L, Reyes A, He J, Wood SR, Brea-Calvo G, Holen TT, Holt IJ.

PLoS One. 2013 May 13;8(5):e62340. doi: 10.1371/journal.pone.0062340. Print 2013.


Regulation of AQP4 surface expression via vesicle mobility in astrocytes.

Potokar M, Stenovec M, Jorgačevski J, Holen T, Kreft M, Ottersen OP, Zorec R.

Glia. 2013 Jun;61(6):917-28. doi: 10.1002/glia.22485. Epub 2013 Mar 18.


Molecular nutrition research: the modern way of performing nutritional science.

Norheim F, Gjelstad IM, Hjorth M, Vinknes KJ, Langleite TM, Holen T, Jensen J, Dalen KT, Karlsen AS, Kielland A, Rustan AC, Drevon CA.

Nutrients. 2012 Dec 3;4(12):1898-944. doi: 10.3390/nu4121898. Review.


Small-scale purification and mass spectrometry analysis reveal a third aquaporin-4 protein isoform of 36 kDa in rat brain.

Sørbø JG, Fleckenstein B, Ottersen OP, Holen T.

J Neurosci Methods. 2012 Oct 15;211(1):31-9. doi: 10.1016/j.jneumeth.2012.07.021. Epub 2012 Aug 7.


Aquaporin pathways and mucin secretion of Bowman's glands might protect the olfactory mucosa.

Solbu TT, Holen T.

Chem Senses. 2012 Jan;37(1):35-46. doi: 10.1093/chemse/bjr063. Epub 2011 Jul 10.


The ultrastructure of lamellar stack astrocytes.

Holen T.

Glia. 2011 Jul;59(7):1075-83. doi: 10.1002/glia.21180. Epub 2011 May 4.


Deletion of the betaine-GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice.

Lehre AC, Rowley NM, Zhou Y, Holmseth S, Guo C, Holen T, Hua R, Laake P, Olofsson AM, Poblete-Naredo I, Rusakov DA, Madsen KK, Clausen RP, Schousboe A, White HS, Danbolt NC.

Epilepsy Res. 2011 Jun;95(1-2):70-81. doi: 10.1016/j.eplepsyres.2011.02.014. Epub 2011 Apr 3.


Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema.

Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Rangroo Thrane V, Enger R, Haj-Yasein NN, Skare Ø, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):846-51. doi: 10.1073/pnas.1015217108. Epub 2010 Dec 27.


Differential water permeability and regulation of three aquaporin 4 isoforms.

Fenton RA, Moeller HB, Zelenina M, Snaebjornsson MT, Holen T, MacAulay N.

Cell Mol Life Sci. 2010 Mar;67(5):829-40. doi: 10.1007/s00018-009-0218-9. Epub 2009 Dec 15.


Roles of aquaporin-4 isoforms and amino acids in square array assembly.

Strand L, Moe SE, Solbu TT, Vaadal M, Holen T.

Biochemistry. 2009 Jun 30;48(25):5785-93. doi: 10.1021/bi802231q.


Protein interacting with C kinase 1 (PICK1) and GluR2 are associated with presynaptic plasma membrane and vesicles in hippocampal excitatory synapses.

Haglerød C, Kapic A, Boulland JL, Hussain S, Holen T, Skare O, Laake P, Ottersen OP, Haug FM, Davanger S.

Neuroscience. 2009 Jan 12;158(1):242-52. doi: 10.1016/j.neuroscience.2008.11.029. Epub 2008 Nov 27.


Neuronal enriched endosomal protein of 21 kDa colocalizes with glutamate receptor subunit GLUR2/3 at the postsynaptic membrane.

Utvik JK, Haglerød C, Mylonakou MN, Holen T, Kropf M, Hirling H, Skare O, Laake P, Ottersen OP, Haug FM, Davanger S.

Neuroscience. 2009 Jan 12;158(1):96-104. doi: 10.1016/j.neuroscience.2008.11.030. Epub 2008 Nov 27.


Huntingtin triplet-repeat locus is stable under long-term Fen1 knockdown in human cells.

Moe SE, Sorbo JG, Holen T.

J Neurosci Methods. 2008 Jun 30;171(2):233-8. doi: 10.1016/j.jneumeth.2008.03.012. Epub 2008 Mar 30.


New isoforms of rat Aquaporin-4.

Moe SE, Sorbo JG, Sogaard R, Zeuthen T, Petter Ottersen O, Holen T.

Genomics. 2008 Apr;91(4):367-77. doi: 10.1016/j.ygeno.2007.12.003. Epub 2008 Feb 5.


The molecular composition of square arrays.

Sorbo JG, Moe SE, Ottersen OP, Holen T.

Biochemistry. 2008 Feb 26;47(8):2631-7. doi: 10.1021/bi702146k. Epub 2008 Feb 2.


Ex vivo and in vivo delivery of anti-tissue factor short interfering RNA inhibits mouse pulmonary metastasis of B16 melanoma cells.

Amarzguioui M, Peng Q, Wiiger MT, Vasovic V, Babaie E, Holen T, Nesland JM, Prydz H.

Clin Cancer Res. 2006 Jul 1;12(13):4055-61.


Tolerated wobble mutations in siRNAs decrease specificity, but can enhance activity in vivo.

Holen T, Moe SE, Sørbø JG, Meza TJ, Ottersen OP, Klungland A.

Nucleic Acids Res. 2005 Aug 19;33(15):4704-10. Print 2005.


Mechanisms of RNAi: mRNA cleavage fragments may indicate stalled RISC.

Holen T.

J RNAi Gene Silencing. 2005 Jul 28;1(1):21-5.


Many commonly used siRNAs risk off-target activity.

Snøve O Jr, Holen T.

Biochem Biophys Res Commun. 2004 Jun 18;319(1):256-63.


Lobotomy of genes: use of RNA interference in neuroscience.

Holen T, Mobbs CV.

Neuroscience. 2004;126(1):1-7. Review.


Similar behaviour of single-strand and double-strand siRNAs suggests they act through a common RNAi pathway.

Holen T, Amarzguioui M, Babaie E, Prydz H.

Nucleic Acids Res. 2003 May 1;31(9):2401-7.


Tolerance for mutations and chemical modifications in a siRNA.

Amarzguioui M, Holen T, Babaie E, Prydz H.

Nucleic Acids Res. 2003 Jan 15;31(2):589-95.


Positional effects of short interfering RNAs targeting the human coagulation trigger Tissue Factor.

Holen T, Amarzguioui M, Wiiger MT, Babaie E, Prydz H.

Nucleic Acids Res. 2002 Apr 15;30(8):1757-66.

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