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Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.

Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaao1313. doi: 10.1126/scitranslmed.aao1313.


Poly(lactic-co-glycolic) Acid as a Slow-Release Drug-Carrying Matrix for Methotrexate Coated onto Intraocular Lenses to Conquer Posterior Capsule Opacification.

Kassumeh SA, Wertheimer CM, von Studnitz A, Hillenmayer A, Priglinger C, Wolf A, Mayer WJ, Teupser D, Holdt LM, Priglinger SG, Eibl-Lindner KH.

Curr Eye Res. 2018 Feb 16:1-7. doi: 10.1080/02713683.2018.1437455. [Epub ahead of print]


The ADAM17 Metalloproteinase Maintains Arterial Elasticity.

Nicolaou A, Northoff BH, Zhao Z, Kohlmaier A, Sass K, Rose-John S, Steffens S, Weber C, Teupser D, Holdt LM.

Thromb Haemost. 2018 Jan;118(1):210-213. doi: 10.1160/TH17-07-0494. Epub 2018 Jan 5. No abstract available.


Molecular Fingerprint for Terminal Abdominal Aortic Aneurysm Disease.

Gäbel G, Northoff BH, Weinzierl I, Ludwig S, Hinterseher I, Wilfert W, Teupser D, Doderer SA, Bergert H, Schönleben F, Lindeman JHN, Holdt LM.

J Am Heart Assoc. 2017 Nov 30;6(12). pii: e006798. doi: 10.1161/JAHA.117.006798.


Molecular roles and function of circular RNAs in eukaryotic cells.

Holdt LM, Kohlmaier A, Teupser D.

Cell Mol Life Sci. 2018 Mar;75(6):1071-1098. doi: 10.1007/s00018-017-2688-5. Epub 2017 Nov 7. Review.


CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice.

Winkels H, Meiler S, Lievens D, Engel D, Spitz C, Bürger C, Beckers L, Dandl A, Reim S, Ahmadsei M, Hartwig H, Holdt LM, Hristov M, Megens RTA, Schmitt MM, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N.

Eur Heart J. 2017 Dec 21;38(48):3590-3599. doi: 10.1093/eurheartj/ehx517.


Revisiting biomarker discovery by plasma proteomics.

Geyer PE, Holdt LM, Teupser D, Mann M.

Mol Syst Biol. 2017 Sep 26;13(9):942. doi: 10.15252/msb.20156297. Review.


Quantitative trait locus mapping in mice identifies phospholipase Pla2g12a as novel atherosclerosis modifier.

Nicolaou A, Northoff BH, Sass K, Ernst J, Kohlmaier A, Krohn K, Wolfrum C, Teupser D, Holdt LM.

Atherosclerosis. 2017 Oct;265:197-206. doi: 10.1016/j.atherosclerosis.2017.08.030. Epub 2017 Sep 4.


Adventitial adipogenic degeneration is an unidentified contributor to aortic wall weakening in the abdominal aortic aneurysm.

Doderer SA, Gäbel G, Kokje VBC, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN.

J Vasc Surg. 2017 Sep 11. pii: S0741-5214(17)31601-4. doi: 10.1016/j.jvs.2017.05.088. [Epub ahead of print]


Comprehensive Analytics of Actovegin® and Its Effect on Muscle Cells.

Reichl FX, Holdt LM, Teupser D, Schütze G, Metcalfe AJ, Hickel R, Högg C, Bloch W.

Int J Sports Med. 2017 Oct;38(11):809-818. doi: 10.1055/s-0043-115738. Epub 2017 Sep 11.


Modulation of Glutathione Hemostasis by Inhibition of 12/15-Lipoxygenase Prevents ROS-Mediated Cell Death after Hepatic Ischemia and Reperfusion.

Drefs M, Thomas MN, Guba M, Angele MK, Werner J, Conrad M, Steib CJ, Holdt LM, Andrassy J, Khandoga A, Rentsch M.

Oxid Med Cell Longev. 2017;2017:8325754. doi: 10.1155/2017/8325754. Epub 2017 Jul 24.


RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke.

Tiedt S, Prestel M, Malik R, Schieferdecker N, Duering M, Kautzky V, Stoycheva I, Böck J, Northoff BH, Klein M, Dorn F, Krohn K, Teupser D, Liesz A, Plesnila N, Holdt LM, Dichgans M.

Circ Res. 2017 Sep 29;121(8):970-980. doi: 10.1161/CIRCRESAHA.117.311572. Epub 2017 Jul 19.


Cathepsin S increases tau oligomer formation through limited cleavage, but only IL-6, not cathespin S serum levels correlate with disease severity in the neurodegenerative tauopathy progressive supranuclear palsy.

Nübling G, Schuberth M, Feldmer K, Giese A, Holdt LM, Teupser D, Lorenzl S.

Exp Brain Res. 2017 Aug;235(8):2407-2412. doi: 10.1007/s00221-017-4978-4. Epub 2017 May 10.


Vascular CXCR4 Limits Atherosclerosis by Maintaining Arterial Integrity: Evidence From Mouse and Human Studies.

Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C.

Circulation. 2017 Jul 25;136(4):388-403. doi: 10.1161/CIRCULATIONAHA.117.027646. Epub 2017 Apr 27.


Whole genome sequencing of Brucella melitensis isolated from 57 patients in Germany reveals high diversity in strains from Middle East.

Georgi E, Walter MC, Pfalzgraf MT, Northoff BH, Holdt LM, Scholz HC, Zoeller L, Zange S, Antwerpen MH.

PLoS One. 2017 Apr 7;12(4):e0175425. doi: 10.1371/journal.pone.0175425. eCollection 2017.


Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery.

Pott J, Burkhardt R, Beutner F, Horn K, Teren A, Kirsten H, Holdt LM, Schuler G, Teupser D, Loeffler M, Thiery J, Scholz M.

Atherosclerosis. 2017 Apr;259:32-40. doi: 10.1016/j.atherosclerosis.2017.02.018. Epub 2017 Feb 24.


Alteration of Multiple Leukocyte Gene Expression Networks is Linked with Magnetic Resonance Markers of Prognosis After Acute ST-Elevation Myocardial Infarction.

Teren A, Kirsten H, Beutner F, Scholz M, Holdt LM, Teupser D, Gutberlet M, Thiery J, Schuler G, Eitel I.

Sci Rep. 2017 Feb 3;7:41705. doi: 10.1038/srep41705.


Methylated free-circulating HPP1 DNA is an early response marker in patients with metastatic colorectal cancer.

Herbst A, Vdovin N, Gacesa S, Philipp A, Nagel D, Holdt LM, Op den Winkel M, Heinemann V, Stieber P, Graeven U, Reinacher-Schick A, Arnold D, Ricard I, Mansmann U, Hegewisch-Becker S, Kolligs FT.

Int J Cancer. 2017 May 1;140(9):2134-2144. doi: 10.1002/ijc.30625. Epub 2017 Feb 22. Erratum in: Int J Cancer. 2018 Feb 1;142(3):E1.


Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice.

Nicolaou A, Zhao Z, Northoff BH, Sass K, Herbst A, Kohlmaier A, Chalaris A, Wolfrum C, Weber C, Steffens S, Rose-John S, Teupser D, Holdt LM.

Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):247-257. doi: 10.1161/ATVBAHA.116.308682. Epub 2016 Dec 22.


Contrasting effects of myeloid and endothelial ADAM17 on atherosclerosis development.

van der Vorst EP, Zhao Z, Rami M, Holdt LM, Teupser D, Steffens S, Weber C.

Thromb Haemost. 2017 Feb 28;117(3):644-646. doi: 10.1160/TH16-09-0674. Epub 2016 Dec 22. No abstract available.


Exploring an association between hostility and serum concentrations of TNF-α and its soluble receptors.

Himmerich H, Wesemann U, Dalton B, Holdt LM, Teupser D, Willmund GD.

J Psychosom Res. 2016 Dec;91:87-88. doi: 10.1016/j.jpsychores.2016.11.001. Epub 2016 Nov 6. No abstract available.


Changes of bivalent chromatin coincide with increased expression of developmental genes in cancer.

Bernhart SH, Kretzmer H, Holdt LM, Jühling F, Ammerpohl O, Bergmann AK, Northoff BH, Doose G, Siebert R, Stadler PF, Hoffmann S.

Sci Rep. 2016 Nov 23;6:37393. doi: 10.1038/srep37393.


Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues.

Marzi C, Holdt LM, Fiorito G, Tsai PC, Kretschmer A, Wahl S, Guarrera S, Teupser D, Spector TD, Iacoviello L, Sacerdote C, Strauch K, Lee S, Thasler WE, Peters A, Thorand B, Wolf P, Prokisch H, Tumino R, Gieger C, Krogh V, Panico S, Bell JT, Matullo G, Waldenberger M, Grallert H, Koenig W.

PLoS One. 2016 Nov 8;11(11):e0166015. doi: 10.1371/journal.pone.0166015. eCollection 2016.


CD70 limits atherosclerosis and promotes macrophage function.

Winkels H, Meiler S, Smeets E, Lievens D, Engel D, Spitz C, Bürger C, Rinne P, Beckers L, Dandl A, Reim S, Ahmadsei M, Van den Bossche J, Holdt LM, Megens RT, Schmitt M, de Winther M, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N.

Thromb Haemost. 2017 Jan 5;117(1):164-175. doi: 10.1160/TH16-04-0318. Epub 2016 Oct 27.


Impact of vitamin E-blended UHMWPE wear particles on the osseous microenvironment in polyethylene particle-induced osteolysis.

Neuerburg C, Loer T, Mittlmeier L, Polan C, Farkas Z, Holdt LM, Utzschneider S, Schwiesau J, Grupp TM, Böcker W, Aszodi A, Wedemeyer C, Kammerlander C.

Int J Mol Med. 2016 Dec;38(6):1652-1660. doi: 10.3892/ijmm.2016.2780. Epub 2016 Oct 18.


Serum concentrations of TNF-α and its soluble receptors during psychotherapy in German soldiers suffering from combat-related PTSD.

Himmerich H, Willmund GD, Zimmermann P, Wolf JE, Bühler AH, Kirkby KC, Dalton B, Holdt LM, Teupser D, Wesemann U.

Psychiatr Danub. 2016 Sep;28(3):293-298.


Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.

Holdt LM, Stahringer A, Sass K, Pichler G, Kulak NA, Wilfert W, Kohlmaier A, Herbst A, Northoff BH, Nicolaou A, Gäbel G, Beutner F, Scholz M, Thiery J, Musunuru K, Krohn K, Mann M, Teupser D.

Nat Commun. 2016 Aug 19;7:12429. doi: 10.1038/ncomms12429.


Predictors of Inadequate Linezolid Concentrations after Standard Dosing in Critically Ill Patients.

Taubert M, Zoller M, Maier B, Frechen S, Scharf C, Holdt LM, Frey L, Vogeser M, Fuhr U, Zander J.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5254-61. doi: 10.1128/AAC.00356-16. Print 2016 Sep.


IL-6: A Janus-like factor in abdominal aortic aneurysm disease.

Kokje VBC, Gäbel G, Koole D, Northoff BH, Holdt LM, Hamming JF, Lindeman JHN.

Atherosclerosis. 2016 Aug;251:139-146. doi: 10.1016/j.atherosclerosis.2016.06.021. Epub 2016 Jun 11.


Thyroid Hormones and Vitamin D in Patients with Breast Cancer with Mutations in BRCA1 or BRCA2 Genes.

Kolben T, Hary T, Holdt LM, Schwarz TM, Goess C, Wuerstlein R, Gallwas J, Toth B, Weissenbacher T, Jeschke U, Harbeck N, Ditsch N.

Anticancer Res. 2016 Jun;36(6):3185-90.


Pro- and anti-inflammatory cytokines, but not CRP, are inversely correlated with severity and symptoms of major depression.

Schmidt FM, Schröder T, Kirkby KC, Sander C, Suslow T, Holdt LM, Teupser D, Hegerl U, Himmerich H.

Psychiatry Res. 2016 May 30;239:85-91. doi: 10.1016/j.psychres.2016.02.052. Epub 2016 Feb 23.


Plasma Proteome Profiling to Assess Human Health and Disease.

Geyer PE, Kulak NA, Pichler G, Holdt LM, Teupser D, Mann M.

Cell Syst. 2016 Mar 23;2(3):185-95. doi: 10.1016/j.cels.2016.02.015. Epub 2016 Mar 23.


Ferromagnetic particles as a rapid and robust sample preparation for the absolute quantification of seven eicosanoids in human plasma by UHPLC-MS/MS.

Suhr AC, Bruegel M, Maier B, Holdt LM, Kleinhempel A, Teupser D, Grimm SH, Vogeser M.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 1;1022:173-182. doi: 10.1016/j.jchromb.2016.03.022. Epub 2016 Mar 21.


Serum Concentrations of Tumor Necrosis Factor-α and its Soluble Receptors in Soldiers with and Without Combat-related Posttraumatic Stress Disorder: Influence of Age and Body Mass Index.

Himmerich H, Wolf JE, Zimmermann P, Bühler AH, Holdt LM, Teupser D, Kirkby KC, Willmund GD, Wesemann U.

Chin Med J (Engl). 2016 Mar 20;129(6):751-2. doi: 10.4103/0366-6999.178039. No abstract available.


miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux.

Ouimet M, Hennessy EJ, van Solingen C, Koelwyn GJ, Hussein MA, Ramkhelawon B, Rayner KJ, Temel RE, Perisic L, Hedin U, Maegdefessel L, Garabedian MJ, Holdt LM, Teupser D, Moore KJ.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):942-951. doi: 10.1161/ATVBAHA.116.307282. Epub 2016 Mar 3.


Non-invasive detection of iron deficiency by fluorescence measurement of erythrocyte zinc protoporphyrin in the lip.

Hennig G, Homann C, Teksan I, Hasbargen U, Hasmüller S, Holdt LM, Khaled N, Sroka R, Stauch T, Stepp H, Vogeser M, Brittenham GM.

Nat Commun. 2016 Feb 17;7:10776. doi: 10.1038/ncomms10776.


Serum concentrations of TNF-α, sTNF-R p55 and p75 and post-traumatic stress in German soldiers.

Himmerich H, Willmund GD, Zimmermann P, Wolf JE, Bühler AH, Holdt LM, Teupser D, Kirkby KC, Wesemann U.

Eur Cytokine Netw. 2015 Sep;26(3):57-60. doi: 10.1684/ecn.2015.0366.


Impact of Serum Cytokine Levels on EEG-Measured Arousal Regulation in Patients with Major Depressive Disorder and Healthy Controls.

Schmidt FM, Pschiebl A, Sander C, Kirkby KC, Thormann J, Minkwitz J, Chittka T, Weschenfelder J, Holdt LM, Teupser D, Hegerl U, Himmerich H.

Neuropsychobiology. 2016;73(1):1-9. doi: 10.1159/000441190. Epub 2016 Jan 27.


Preanalytical Conditions and DNA Isolation Methods Affect Telomere Length Quantification in Whole Blood.

Tolios A, Teupser D, Holdt LM.

PLoS One. 2015 Dec 4;10(12):e0143889. doi: 10.1371/journal.pone.0143889. eCollection 2015.


Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood.

Burkhardt R, Kirsten H, Beutner F, Holdt LM, Gross A, Teren A, Tönjes A, Becker S, Krohn K, Kovacs P, Stumvoll M, Teupser D, Thiery J, Ceglarek U, Scholz M.

PLoS Genet. 2015 Sep 24;11(9):e1005510. doi: 10.1371/journal.pgen.1005510. eCollection 2015 Sep.


Identification of a novel SERPINA-1 mutation causing alpha-1 antitrypsin deficiency in a patient with severe bronchiectasis and pulmonary embolism.

Milger K, Holdt LM, Teupser D, Huber RM, Behr J, Kneidinger N.

Int J Chron Obstruct Pulmon Dis. 2015 May 7;10:891-7. doi: 10.2147/COPD.S80173. eCollection 2015.


Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease.

Biros E, Gäbel G, Moran CS, Schreurs C, Lindeman JH, Walker PJ, Nataatmadja M, West M, Holdt LM, Hinterseher I, Pilarsky C, Golledge J.

Oncotarget. 2015 May 30;6(15):12984-96.


Inflammatory cytokines in general and central obesity and modulating effects of physical activity.

Schmidt FM, Weschenfelder J, Sander C, Minkwitz J, Thormann J, Chittka T, Mergl R, Kirkby KC, Faßhauer M, Stumvoll M, Holdt LM, Teupser D, Hegerl U, Himmerich H.

PLoS One. 2015 Mar 17;10(3):e0121971. doi: 10.1371/journal.pone.0121971. eCollection 2015.


DNA methylation of lipid-related genes affects blood lipid levels.

Pfeiffer L, Wahl S, Pilling LC, Reischl E, Sandling JK, Kunze S, Holdt LM, Kretschmer A, Schramm K, Adamski J, Klopp N, Illig T, Hedman ÅK, Roden M, Hernandez DG, Singleton AB, Thasler WE, Grallert H, Gieger C, Herder C, Teupser D, Meisinger C, Spector TD, Kronenberg F, Prokisch H, Melzer D, Peters A, Deloukas P, Ferrucci L, Waldenberger M.

Circ Cardiovasc Genet. 2015 Apr;8(2):334-42. doi: 10.1161/CIRCGENETICS.114.000804. Epub 2015 Jan 12.


Long noncoding RNA-MicroRNA pathway controlling nuclear factor IA, a novel atherosclerosis modifier gene.

Holdt LM, Teupser D.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):7-8. doi: 10.1161/ATVBAHA.114.304485. No abstract available.


Comparison of whole blood RNA preservation tubes and novel generation RNA extraction kits for analysis of mRNA and MiRNA profiles.

Häntzsch M, Tolios A, Beutner F, Nagel D, Thiery J, Teupser D, Holdt LM.

PLoS One. 2014 Dec 3;9(12):e113298. doi: 10.1371/journal.pone.0113298. eCollection 2014.


High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.

Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C.

Nat Commun. 2014 Aug 21;5:4699. doi: 10.1038/ncomms5699.


Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study.

Zoller M, Maier B, Hornuss C, Neugebauer C, Döbbeler G, Nagel D, Holdt LM, Bruegel M, Weig T, Grabein B, Frey L, Teupser D, Vogeser M, Zander J.

Crit Care. 2014 Jul 10;18(4):R148. doi: 10.1186/cc13984.


Cytokine levels in depressed and non-depressed subjects, and masking effects of obesity.

Schmidt FM, Lichtblau N, Minkwitz J, Chittka T, Thormann J, Kirkby KC, Sander C, Mergl R, Faßhauer M, Stumvoll M, Holdt LM, Teupser D, Hegerl U, Himmerich H.

J Psychiatr Res. 2014 Aug;55:29-34. doi: 10.1016/j.jpsychires.2014.04.021. Epub 2014 May 8.


β-catenin regulates NF-κB activity via TNFRSF19 in colorectal cancer cells.

Schön S, Flierman I, Ofner A, Stahringer A, Holdt LM, Kolligs FT, Herbst A.

Int J Cancer. 2014 Oct 15;135(8):1800-11. doi: 10.1002/ijc.28839. Epub 2014 Apr 1.

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