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Items: 31

1.

Comprehensive redox profiling of the thiol proteome of Clostridium difficile.

Sievers S, Dittmann S, Jordt T, Otto A, Hochgräfe F, Riedel K.

Mol Cell Proteomics. 2018 Mar 1. pii: mcp.TIR118.000671. doi: 10.1074/mcp.TIR118.000671. [Epub ahead of print]

2.

Staphylococcus aureus α-Toxin Induces Actin Filament Remodeling in Human Airway Epithelial Model Cells.

Ziesemer S, Eiffler I, Schönberg A, Müller C, Hochgräfe F, Beule AG, Hildebrandt JP.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):482-491. doi: 10.1165/rcmb.2016-0207OC.

PMID:
29111771
3.

Modulation of MHC class I surface expression in B16F10 melanoma cells by methylseleninic acid.

Lennicke C, Rahn J, Bukur J, Hochgräfe F, Wessjohann LA, Lichtenfels R, Seliger B.

Oncoimmunology. 2016 Dec 21;6(6):e1259049. doi: 10.1080/2162402X.2016.1259049. eCollection 2017.

4.

Staphylococcus aureus Infection Reduces Nutrition Uptake and Nucleotide Biosynthesis in a Human Airway Epithelial Cell Line.

Gierok P, Harms M, Methling K, Hochgräfe F, Lalk M.

Metabolites. 2016 Nov 9;6(4). pii: E41.

5.

Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus.

Richter E, Harms M, Ventz K, Nölker R, Fraunholz MJ, Mostertz J, Hochgräfe F.

J Proteome Res. 2016 Dec 2;15(12):4369-4386. Epub 2016 Nov 4.

PMID:
27762562
6.

Real-Time Imaging of the Bacillithiol Redox Potential in the Human Pathogen Staphylococcus aureus Using a Genetically Encoded Bacilliredoxin-Fused Redox Biosensor.

Loi VV, Harms M, Müller M, Huyen NTT, Hamilton CJ, Hochgräfe F, Pané-Farré J, Antelmann H.

Antioxid Redox Signal. 2017 May 20;26(15):835-848. doi: 10.1089/ars.2016.6733. Epub 2016 Aug 11.

7.

Redox regulation of mitochondrial proteins and proteomes by cysteine thiol switches.

Nietzel T, Mostertz J, Hochgräfe F, Schwarzländer M.

Mitochondrion. 2017 Mar;33:72-83. doi: 10.1016/j.mito.2016.07.010. Epub 2016 Jul 22. Review.

PMID:
27456428
8.

Proteomic discovery of host kinase signaling in bacterial infections.

Richter E, Mostertz J, Hochgräfe F.

Proteomics Clin Appl. 2016 Oct;10(9-10):994-1010. doi: 10.1002/prca.201600035. Epub 2016 Sep 9. Review.

9.

Resolution of Novel Pancreatic Ductal Adenocarcinoma Subtypes by Global Phosphotyrosine Profiling.

Humphrey ES, Su SP, Nagrial AM, Hochgräfe F, Pajic M, Lehrbach GM, Parton RG, Yap AS, Horvath LG, Chang DK, Biankin AV, Wu J, Daly RJ.

Mol Cell Proteomics. 2016 Aug;15(8):2671-85. doi: 10.1074/mcp.M116.058313. Epub 2016 Jun 3.

10.

Induction of Macrophage Function in Human THP-1 Cells Is Associated with Rewiring of MAPK Signaling and Activation of MAP3K7 (TAK1) Protein Kinase.

Richter E, Ventz K, Harms M, Mostertz J, Hochgräfe F.

Front Cell Dev Biol. 2016 Mar 30;4:21. doi: 10.3389/fcell.2016.00021. eCollection 2016.

11.

Quantitative phosphotyrosine profiling of patient-derived xenografts identifies therapeutic targets in pediatric leukemia.

Dolai S, Sia KC, Robbins AK, Zhong L, Heatley SL, Vincent TL, Hochgräfe F, Sutton R, Kurmasheva RT, Revesz T, White DL, Houghton PJ, Smith MA, Teachey DT, Daly RJ, Raftery MJ, Lock RB.

Cancer Res. 2016 Mar 9. pii: canres.2786.2015. [Epub ahead of print]

PMID:
26960974
12.

A multi-omics approach identifies key hubs associated with cell type-specific responses of airway epithelial cells to staphylococcal alpha-toxin.

Richter E, Harms M, Ventz K, Gierok P, Chilukoti RK, Hildebrandt JP, Mostertz J, Hochgräfe F.

PLoS One. 2015 Mar 27;10(3):e0122089. doi: 10.1371/journal.pone.0122089. eCollection 2015.

13.

Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.

Ali NA, Wu J, Hochgräfe F, Chan H, Nair R, Ye S, Zhang L, Lyons RJ, Pinese M, Lee HC, Armstrong N, Ormandy CJ, Clark SJ, Swarbrick A, Daly RJ.

Breast Cancer Res. 2014 Sep 9;16(5):437. doi: 10.1186/s13058-014-0437-3.

14.

Staphylococcus aureus alpha-toxin mediates general and cell type-specific changes in metabolite concentrations of immortalized human airway epithelial cells.

Gierok P, Harms M, Richter E, Hildebrandt JP, Lalk M, Mostertz J, Hochgräfe F.

PLoS One. 2014 Apr 14;9(4):e94818. doi: 10.1371/journal.pone.0094818. eCollection 2014.

15.

Phosphoproteomic profiling identifies focal adhesion kinase as a mediator of docetaxel resistance in castrate-resistant prostate cancer.

Lee BY, Hochgräfe F, Lin HM, Castillo L, Wu J, Raftery MJ, Martin Shreeve S, Horvath LG, Daly RJ.

Mol Cancer Ther. 2014 Jan;13(1):190-201. doi: 10.1158/1535-7163.MCT-13-0225-T. Epub 2013 Nov 5.

16.

Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.

Sattu K, Hochgräfe F, Wu J, Umapathy G, Schönherr C, Ruuth K, Chand D, Witek B, Fuchs J, Li PK, Hugosson F, Daly RJ, Palmer RH, Hallberg B.

FEBS J. 2013 Nov;280(21):5269-82. doi: 10.1111/febs.12453. Epub 2013 Aug 22.

17.

Global characterization of signalling networks associated with tamoxifen resistance in breast cancer.

Browne BC, Hochgräfe F, Wu J, Millar EK, Barraclough J, Stone A, McCloy RA, Lee CS, Roberts C, Ali NA, Boulghourjian A, Schmich F, Linding R, Farrow L, Gee JM, Nicholson RI, O'Toole SA, Sutherland RL, Musgrove EA, Butt AJ, Daly RJ.

FEBS J. 2013 Nov;280(21):5237-57. doi: 10.1111/febs.12441. Epub 2013 Aug 19.

18.

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.

Zhang L, Holmes IP, Hochgräfe F, Walker SR, Ali NA, Humphrey ES, Wu J, de Silva M, Kersten WJ, Connor T, Falk H, Allan L, Street IP, Bentley JD, Pilling PA, Monahan BJ, Peat TS, Daly RJ.

J Proteome Res. 2013 Jul 5;12(7):3104-16. doi: 10.1021/pr3008495. Epub 2013 Jun 25.

PMID:
23692254
19.

Distribution and infection-related functions of bacillithiol in Staphylococcus aureus.

Pöther DC, Gierok P, Harms M, Mostertz J, Hochgräfe F, Antelmann H, Hamilton CJ, Borovok I, Lalk M, Aharonowitz Y, Hecker M.

Int J Med Microbiol. 2013 Apr;303(3):114-23. doi: 10.1016/j.ijmm.2013.01.003. Epub 2013 Mar 6.

PMID:
23517692
20.

Involvement of Lyn and the atypical kinase SgK269/PEAK1 in a basal breast cancer signaling pathway.

Croucher DR, Hochgräfe F, Zhang L, Liu L, Lyons RJ, Rickwood D, Tactacan CM, Browne BC, Ali N, Chan H, Shearer R, Gallego-Ortega D, Saunders DN, Swarbrick A, Daly RJ.

Cancer Res. 2013 Mar 15;73(6):1969-80. doi: 10.1158/0008-5472.CAN-12-1472. Epub 2013 Feb 1.

21.

Functional characterization of cancer-associated Gab1 mutations.

Ortiz-Padilla C, Gallego-Ortega D, Browne BC, Hochgräfe F, Caldon CE, Lyons RJ, Croucher DR, Rickwood D, Ormandy CJ, Brummer T, Daly RJ.

Oncogene. 2013 May 23;32(21):2696-702. doi: 10.1038/onc.2012.271. Epub 2012 Jul 2.

PMID:
22751113
22.

Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells.

Hochgräfe F, Zhang L, O'Toole SA, Browne BC, Pinese M, Porta Cubas A, Lehrbach GM, Croucher DR, Rickwood D, Boulghourjian A, Shearer R, Nair R, Swarbrick A, Faratian D, Mullen P, Harrison DJ, Biankin AV, Sutherland RL, Raftery MJ, Daly RJ.

Cancer Res. 2010 Nov 15;70(22):9391-401. doi: 10.1158/0008-5472.CAN-10-0911. Epub 2010 Sep 21.

23.

Diamide triggers mainly S Thiolations in the cytoplasmic proteomes of Bacillus subtilis and Staphylococcus aureus.

Pöther DC, Liebeke M, Hochgräfe F, Antelmann H, Becher D, Lalk M, Lindequist U, Borovok I, Cohen G, Aharonowitz Y, Hecker M.

J Bacteriol. 2009 Dec;191(24):7520-30. doi: 10.1128/JB.00937-09. Epub 2009 Oct 16.

24.

Depletion of thiol-containing proteins in response to quinones in Bacillus subtilis.

Liebeke M, Pöther DC, van Duy N, Albrecht D, Becher D, Hochgräfe F, Lalk M, Hecker M, Antelmann H.

Mol Microbiol. 2008 Sep;69(6):1513-29. doi: 10.1111/j.1365-2958.2008.06382.x. Epub 2008 Jul 30.

25.

Proteomic analysis of antioxidant strategies of Staphylococcus aureus: diverse responses to different oxidants.

Wolf C, Hochgräfe F, Kusch H, Albrecht D, Hecker M, Engelmann S.

Proteomics. 2008 Aug;8(15):3139-53. doi: 10.1002/pmic.200701062.

PMID:
18604844
26.

The role of thioredoxin TrxA in Bacillus subtilis: a proteomics and transcriptomics approach.

Mostertz J, Hochgräfe F, Jürgen B, Schweder T, Hecker M.

Proteomics. 2008 Jul;8(13):2676-90. doi: 10.1002/pmic.200701015.

PMID:
18601268
27.

Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus.

Hochgräfe F, Wolf C, Fuchs S, Liebeke M, Lalk M, Engelmann S, Hecker M.

J Bacteriol. 2008 Jul;190(14):4997-5008. doi: 10.1128/JB.01846-07. Epub 2008 May 16.

28.

A proteome map of murine heart and skeletal muscle.

Raddatz K, Albrecht D, Hochgräfe F, Hecker M, Gotthardt M.

Proteomics. 2008 May;8(9):1885-97. doi: 10.1002/pmic.200700902.

PMID:
18398877
29.

S-cysteinylation is a general mechanism for thiol protection of Bacillus subtilis proteins after oxidative stress.

Hochgräfe F, Mostertz J, Pöther DC, Becher D, Helmann JD, Hecker M.

J Biol Chem. 2007 Sep 7;282(36):25981-5. Epub 2007 Jul 4.

30.

Fluorescence thiol modification assay: oxidatively modified proteins in Bacillus subtilis.

Hochgräfe F, Mostertz J, Albrecht D, Hecker M.

Mol Microbiol. 2005 Oct;58(2):409-25.

31.

The role of peptide deformylase in protein biosynthesis: a proteomic study.

Bandow JE, Becher D, Büttner K, Hochgräfe F, Freiberg C, Brötz H, Hecker M.

Proteomics. 2003 Mar;3(3):299-306.

PMID:
12627383

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