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Identification and Analysis of Host Proteins that Interact with the 3'-Untranslated Region of Tick-Borne Encephalitis Virus Genomic RNA.

Muto M, Kamitani W, Sakai M, Hirano M, Kobayashi S, Kariwa H, Yoshii K.

Virus Res. 2018 Mar 12. pii: S0168-1702(18)30022-4. doi: 10.1016/j.virusres.2018.03.006. [Epub ahead of print]


Differing effects of an immersive virtual reality programme on unilateral spatial neglect on activities of daily living.

Yasuda K, Muroi D, Hirano M, Saichi K, Iwata H.

BMJ Case Rep. 2018 Mar 9;2018. pii: bcr-2017-222860. doi: 10.1136/bcr-2017-222860.


Traumatic Globe Luxation with Complete Optic Nerve Transection Caused by Heavy Object Compression.

Kosaki Y, Yumoto T, Naito H, Tsuboi N, Kameda M, Hirano M, Morizane Y, Senoo T, Tokuyama E, Nakao A.

Acta Med Okayama. 2018 Feb;72(1):85-88. doi: 10.18926/AMO/55669.


Results of a Treat-and-Eextend Regimen of Intravitreal Ranibizumab Injection for Macular Edema due to Branch Retinal Vein Occlusion.

Hosogi M, Morizane Y, Shiode Y, Doi S, Kumase F, Kimura S, Hosokawa M, Hirano M, Toshima S, Takahashi K, Fujiwara A, Shiraga F.

Acta Med Okayama. 2018 Feb;72(1):39-45. doi: 10.18926/AMO/55661.


A novel high-sensitivity assay to detect a small fraction of mutant IDH1 using droplet digital PCR.

Hirano M, Ohka F, Maeda S, Chalise L, Yamamichi A, Aoki K, Kato A, Tanahashi K, Motomura K, Nishimura Y, Hara M, Shinjo K, Kondo Y, Wakabayashi T, Natsume A.

Brain Tumor Pathol. 2018 Feb 19. doi: 10.1007/s10014-018-0310-7. [Epub ahead of print]


Brentuximab vedotin is effective for rheumatoid arthritis in a patient with relapsed methotrexate-associated Hodgkin lymphoma.

Nakazato T, Takanashi S, Hirano M, Ito C, Fujita Y, Osada Y, Aisa Y, Mori T.

Ann Hematol. 2018 Feb 17. doi: 10.1007/s00277-018-3279-8. [Epub ahead of print] No abstract available.


Promotion of bone regeneration on titanium implants through a chemical treatment process using calcium phosphate slurry: Microscopic analysis, cellular response, and animal experiment.

Ito T, Ohtsu N, Tomozawa M, Hirano M, Takita H, Iizuka T, Yokoyama A.

J Biomed Mater Res B Appl Biomater. 2018 Feb 16. doi: 10.1002/jbm.b.34089. [Epub ahead of print]


A gold nano-electrode for single ion channel recordings.

Okuno D, Hirano M, Yokota H, Ichinose J, Kira T, Hijiya T, Uozumi C, Yamakami M, Ide T.

Nanoscale. 2018 Feb 22;10(8):4036-4040. doi: 10.1039/c7nr08098k.


Subcellular storage and release mode of the novel 18F-labeled sympathetic nerve PET tracer LMI1195.

Chen X, Werner RA, Lapa C, Nose N, Hirano M, Javadi MS, Robinson S, Higuchi T.

EJNMMI Res. 2018 Feb 6;8(1):12. doi: 10.1186/s13550-018-0365-9.


Comprehensive Treatment Using Cytoreductive Surgery Combined with Perioperative Chemotherapy Improved Outcome of Colorectal Cancer Patients with Metachronous Peritoneal Metastasis.

Yonemura Y, Canbay E, Sako S, Wakama S, Ishibashi H, Hirano M, Mizumoto A, Takao N, Ichinose M, Noguchi K, Motoi S, Liu Y, Li Y, Taniguchi K.

Gan To Kagaku Ryoho. 2017 Nov;44(12):1939-1942.


Normal/high-fat milk consumption is associated with higher lean body and muscle mass in Japanese women aged between 40 and 60 years: a cross-sectional study.

Sukenobe Y, Terauchi M, Hirose A, Hirano M, Akiyoshi M, Kato K, Miyasaka N.

BMC Womens Health. 2018 Feb 2;18(1):32. doi: 10.1186/s12905-018-0525-0.


Endogenous Hydrogen Sulfide Contributes to Tone Generation in Porcine Lower Esophageal Sphincter Via Na+/Ca2+ Exchanger.

Bai X, Ihara E, Hirano K, Tanaka Y, Nakano K, Kita S, Iwamoto T, Ogino H, Hirano M, Oda Y, Nakamura K, Ogawa Y.

Cell Mol Gastroenterol Hepatol. 2017 Nov 22;5(3):209-221. doi: 10.1016/j.jcmgh.2017.11.004. eCollection 2018 Mar.


Assessment of lamellar macular hole and macular pseudohole with a combination of en face and radial B-scan optical coherence tomography imaging.

Hirano M, Morizane Y, Kimura S, Hosokawa M, Shiode Y, Doi S, Toshima S, Takahashi K, Hosogi M, Fujiwara A, Takasu I, Okanouchi T, Kawabata M, Shiraga F.

Am J Ophthalmol. 2018 Jan 19. pii: S0002-9394(18)30022-9. doi: 10.1016/j.ajo.2018.01.016. [Epub ahead of print]


Cerebral Mitochondrial Microangiopathy Leads to Leukoencephalopathy in Mitochondrial Neurogastrointestinal Encephalopathy.

Gramegna LL, Pisano A, Testa C, Manners DN, D'Angelo R, Boschetti E, Giancola F, Pironi L, Caporali L, Capristo M, Valentino ML, Plazzi G, Casali C, Dotti MT, Cenacchi G, Hirano M, Giordano C, Parchi P, Rinaldi R, De Giorgio R, Lodi R, Carelli V, Tonon C.

AJNR Am J Neuroradiol. 2018 Jan 18. doi: 10.3174/ajnr.A5507. [Epub ahead of print]


[Autologous peripheral blood stem cell transplantation for double-refractory myeloma with K-RAS and N-RAS mutations].

Jimbo K, Yokoyama K, Ogawa M, Hirano M, Ochi K, Kobayashi M, Yusa N, Shimizu E, Kawamata T, Yasui H, Ohno N, Yamaguchi R, Imoto S, Furukawa Y, Miyano S, Imai Y, Tojo A.

Rinsho Ketsueki. 2017;58(12):2380-2385. doi: 10.11406/rinketsu.58.2380. Japanese.


Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration.

Kosmidou C, Efstathiou NE, Hoang MV, Notomi S, Konstantinou EK, Hirano M, Takahashi K, Maidana DE, Tsoka P, Young L, Gragoudas ES, Olsen TW, Morizane Y, Miller JW, Vavvas DG.

Sci Rep. 2018 Jan 11;8(1):461. doi: 10.1038/s41598-017-17634-1.


Long-Term Sustained Effect of Liver-Targeted Adeno-Associated Virus Gene Therapy for Mitochondrial Neurogastrointestinal Encephalomyopathy.

Torres-Torronteras J, Cabrera-Pérez R, Vila-Julià F, Viscomi C, Cámara Y, Hirano M, Zeviani M, Martí R.

Hum Gene Ther. 2018 Feb 26. doi: 10.1089/hum.2017.133. [Epub ahead of print]


A novel cell exclusion zone assay with a barrier made from room temperature vulcanizing silicone rubber.

Shiode Y, Morizane Y, Matoba R, Hirano M, Doi S, Toshima S, Araki R, Hosogi M, Takahashi K, Kanzaki Y, Yonezawa T, Shiraga F.

PLoS One. 2017 Dec 21;12(12):e0190198. doi: 10.1371/journal.pone.0190198. eCollection 2017.


Different clonal dynamics of chronic myeloid leukaemia between bone marrow and the central nervous system.

Ogawa M, Yokoyama K, Hirano M, Jimbo K, Ochi K, Kawamata T, Ohno N, Shimizu E, Yokoyama N, Yamaguchi R, Imoto S, Uchimaru K, Takahashi N, Miyano S, Imai Y, Tojo A.

Br J Haematol. 2017 Dec 19. doi: 10.1111/bjh.15065. [Epub ahead of print] No abstract available.


Novel functional renal imaging with 18F-FDS PET in rat models of kidney diseases.

Werner R, Wakabayashi H, Chen X, Hirano M, Shinaji T, Lapa C, Rowe SP, Javadi MS, Higuchi T.

J Nucl Med. 2017 Dec 14. pii: jnumed.117.203828. doi: 10.2967/jnumed.117.203828. [Epub ahead of print]


Comparative Effectiveness of Routine Invasive Coronary Angiography for Managing Unstable Angina.

Oshima Y, Morishima Y, Ono K, Hirano M, Suzuki K.

Ann Intern Med. 2017 Dec 5;167(11):836. doi: 10.7326/L17-0521. No abstract available.


Factors affecting foveal avascular zone in healthy eyes: An examination using swept-source optical coherence tomography angiography.

Fujiwara A, Morizane Y, Hosokawa M, Kimura S, Shiode Y, Hirano M, Doi S, Toshima S, Takahashi K, Hosogi M, Shiraga F.

PLoS One. 2017 Nov 27;12(11):e0188572. doi: 10.1371/journal.pone.0188572. eCollection 2017.


Evolution of Alternative Adaptive Immune Systems in Vertebrates.

Boehm T, Hirano M, Holland SJ, Das S, Schorpp M, Cooper MD.

Annu Rev Immunol. 2017 Nov 16. doi: 10.1146/annurev-immunol-042617-053028. [Epub ahead of print]


Acquisition of skilled finger movements is accompanied by reorganization of the corticospinal system.

Hirano M, Kubota S, Furuya S, Koizume Y, Tanaka S, Funase K.

J Neurophysiol. 2018 Feb 1;119(2):573-584. doi: 10.1152/jn.00667.2017. Epub 2017 Nov 15.


Ir4(CO)12-Catalyzed Benzylic C(sp3)-H Silylation of 2-Alkylpyridines with Hydrosilanes Leading to 2-(1-Silylalkyl)pyridines.

Fukumoto Y, Hirano M, Matsubara N, Chatani N.

J Org Chem. 2017 Dec 15;82(24):13649-13655. doi: 10.1021/acs.joc.7b02375. Epub 2017 Nov 30.


International Workshop:: Outcome measures and clinical trial readiness in primary mitochondrial myopathies in children and adults. Consensus recommendations. 16-18 November 2016, Rome, Italy.

Mancuso M, McFarland R, Klopstock T, Hirano M; consortium on Trial Readiness in Mitochondrial Myopathies.

Neuromuscul Disord. 2017 Dec;27(12):1126-1137. doi: 10.1016/j.nmd.2017.08.006. Epub 2017 Sep 8. No abstract available.


Inflammatory myofibroblastic tumors of the breast with simultaneous intracranial, lung, and pancreas involvement: ultrasonographic findings and a review of the literature.

Inoue M, Ohta T, Shioya H, Sato S, Takahashi H, Nakata N, Taniguchi C, Hirano M, Nishioka M, Yamakawa H.

J Med Ultrason (2001). 2017 Oct 12. doi: 10.1007/s10396-017-0829-y. [Epub ahead of print]


Development of a novel shock wave catheter ablation system-A validation study in pigs in vivo.

Hirano M, Yamamoto H, Hasebe Y, Fukuda K, Morosawa S, Amamizu H, Ohyama K, Uzuka H, Takayama K, Shimokawa H.

Europace. 2017 Aug 2. doi: 10.1093/europace/eux244. [Epub ahead of print]


Activation of Nrf2 might reduce oxidative stress in human granulosa cells.

Akino N, Wada-Hiraike O, Terao H, Honjoh H, Isono W, Fu H, Hirano M, Miyamoto Y, Tanikawa M, Harada M, Hirata T, Hirota Y, Koga K, Oda K, Kawana K, Fujii T, Osuga Y.

Mol Cell Endocrinol. 2017 Oct 4. pii: S0303-7207(17)30522-1. doi: 10.1016/j.mce.2017.10.002. [Epub ahead of print]


Is the eCura system useful for selecting patients who require radical surgery after noncurative endoscopic submucosal dissection for early gastric cancer? A comparative study.

Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Ohnita K, Yamanouchi K, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Hayashi Y, Nakamura T, Nakaya N, Shimosegawa T.

Gastric Cancer. 2017 Oct 5. doi: 10.1007/s10120-017-0769-7. [Epub ahead of print]


The Role of Inverted Internal Limiting Membrane Flap in Macular Hole Closure.

Shiode Y, Morizane Y, Matoba R, Hirano M, Doi S, Toshima S, Takahashi K, Araki R, Kanzaki Y, Hosogi M, Yonezawa T, Yoshida A, Shiraga F.

Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4847-4855. doi: 10.1167/iovs.17-21756.


Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome.

Siegmund SE, Yang H, Sharma R, Javors M, Skinner O, Mootha V, Hirano M, Schon EA.

Hum Mol Genet. 2017 Dec 1;26(23):4588-4605. doi: 10.1093/hmg/ddx341.


Phenotypic differentiation of the Solidago virgaurea complex along an elevational gradient: Insights from a common garden experiment and population genetics.

Hirano M, Sakaguchi S, Takahashi K.

Ecol Evol. 2017 Jul 28;7(17):6949-6962. doi: 10.1002/ece3.3252. eCollection 2017 Sep.


Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function.

Joseph LC, Kokkinaki D, Valenti MC, Kim GJ, Barca E, Tomar D, Hoffman NE, Subramanyam P, Colecraft HM, Hirano M, Ratner AJ, Madesh M, Drosatos K, Morrow JP.

JCI Insight. 2017 Sep 7;2(17). pii: 94248. doi: 10.1172/jci.insight.94248. [Epub ahead of print]


Assessment of tilt and decentration of crystalline lens and intraocular lens relative to the corneal topographic axis using anterior segment optical coherence tomography.

Kimura S, Morizane Y, Shiode Y, Hirano M, Doi S, Toshima S, Fujiwara A, Shiraga F.

PLoS One. 2017 Sep 1;12(9):e0184066. doi: 10.1371/journal.pone.0184066. eCollection 2017.


Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease.

Hirano M, Muto M, Sakai M, Kondo H, Kobayashi S, Kariwa H, Yoshii K.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9960-9965. doi: 10.1073/pnas.1704454114. Epub 2017 Aug 28.


Retinal sensitivity after displacement of submacular hemorrhage due to polypoidal choroidal vasculopathy: effectiveness and safety of subretinal tissue plasminogen activator.

Kimura S, Morizane Y, Matoba R, Hosokawa M, Shiode Y, Hirano M, Doi S, Toshima S, Takahashi K, Hosogi M, Fujiwara A, Shiraga F.

Jpn J Ophthalmol. 2017 Nov;61(6):472-478. doi: 10.1007/s10384-017-0530-0. Epub 2017 Aug 23.


Peptide Specificity Analysis of Peptide: N-glycanases Using Synthetic Chitobiose-pentapeptides.

Kuribara T, Ishihara T, Kudo T, Hirano M, Totani K.

Protein Pept Lett. 2017;24(8):723-728. doi: 10.2174/0929866524666170818160159.


Renal Denervation Suppresses Coronary Hyperconstricting Responses After Drug-Eluting Stent Implantation in Pigs In Vivo Through the Kidney-Brain-Heart Axis.

Uzuka H, Matsumoto Y, Nishimiya K, Ohyama K, Suzuki H, Amamizu H, Morosawa S, Hirano M, Shindo T, Kikuchi Y, Hao K, Shiroto T, Ito K, Takahashi J, Fukuda K, Miyata S, Funaki Y, Ishibashi-Ueda H, Yasuda S, Shimokawa H.

Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1869-1880. doi: 10.1161/ATVBAHA.117.309777. Epub 2017 Aug 17.


Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness.

Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D.

J Virol. 2017 Aug 16. pii: JVI.01028-17. doi: 10.1128/JVI.01028-17. [Epub ahead of print]


Survival Benefit of Additional Surgery After Non-curative Endoscopic Submucosal Dissection for Early Gastric Cancer: A Propensity Score Matching Analysis.

Suzuki S, Gotoda T, Hatta W, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Ohnita K, Yamanouchi K, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Hayashi Y, Shimosegawa T.

Ann Surg Oncol. 2017 Oct;24(11):3353-3360. doi: 10.1245/s10434-017-6039-4. Epub 2017 Aug 9.


Anatomical Study of the Cervical and Interosseous Talocalcaneal Ligaments of the Foot with Surgical Relevance.

Poonja AJ, Hirano M, Khakimov D, Ojumah N, Tubbs RS, Loukas M, Kozlowski PB, Khan KH, DiLandro AC, D'Antoni AV.

Cureus. 2017 Jun 22;9(6):e1382. doi: 10.7759/cureus.1382.


Association of Coronary Perivascular Adipose Tissue Inflammation and Drug-Eluting Stent-Induced Coronary Hyperconstricting Responses in Pigs: 18F-Fluorodeoxyglucose Positron Emission Tomography Imaging Study.

Ohyama K, Matsumoto Y, Amamizu H, Uzuka H, Nishimiya K, Morosawa S, Hirano M, Watabe H, Funaki Y, Miyata S, Takahashi J, Ito K, Shimokawa H.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1757-1764. doi: 10.1161/ATVBAHA.117.309843. Epub 2017 Jul 27.


Time Course of Radiological Imaging and Variable Interindividual Symptoms in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Associated with p.Arg487His Mutation in the VCP Gene.

Hirano M, Yamagishi Y, Yanagimoto S, Saigoh K, Nakamura Y, Kusunoki S.

Eur Neurol. 2017;78(1-2):78-83. doi: 10.1159/000478906. Epub 2017 Jul 24.


Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells.

Matoba R, Morizane Y, Shiode Y, Hirano M, Doi S, Toshima S, Araki R, Hosogi M, Yonezawa T, Shiraga F.

PLoS One. 2017 Jul 18;12(7):e0181481. doi: 10.1371/journal.pone.0181481. eCollection 2017.


Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein.

Yamagishi Y, Saigoh K, Saito Y, Ogawa I, Mitsui Y, Hamada Y, Samukawa M, Suzuki H, Kuwahara M, Hirano M, Noguchi N, Kusunoki S.

Neurosci Res. 2018 Mar;128:58-62. doi: 10.1016/j.neures.2017.06.008. Epub 2017 Jul 10.


Adult T-cell leukemia cell-induced uveitis: rapid increase in adult T-cell leukemia cells disrupts the blood-ocular barrier.

Hirano M, Ohno N, Tanosaki R, Mochizuki M, Ohno-Matsui K, Uchimaru K, Tojo A, Kamoi K.

Int J Hematol. 2017 Dec;106(6):842-846. doi: 10.1007/s12185-017-2293-2. Epub 2017 Jul 4.


Clinical characteristics of methotrexate-associated lymphoproliferative disorders: relationship between absolute lymphocyte count recovery and spontaneous regression.

Takanashi S, Aisa Y, Ito C, Arakaki H, Osada Y, Amano Y, Hirano M, Nakazato T.

Rheumatol Int. 2017 Oct;37(10):1629-1633. doi: 10.1007/s00296-017-3764-8. Epub 2017 Jul 5.


Homozygous alpha-synuclein p.A53V in familial Parkinson's disease.

Yoshino H, Hirano M, Stoessl AJ, Imamichi Y, Ikeda A, Li Y, Funayama M, Yamada I, Nakamura Y, Sossi V, Farrer MJ, Nishioka K, Hattori N.

Neurobiol Aging. 2017 Sep;57:248.e7-248.e12. doi: 10.1016/j.neurobiolaging.2017.05.022. Epub 2017 Jun 27.


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