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Urinary Peptides As a Novel Source of T Cell Allergen Epitopes.

da Silva Antunes R, Pham J, McMurtrey C, Hildebrand WH, Phillips E, Mallal S, Sidney J, Busse P, Peters B, Schulten V, Sette A.

Front Immunol. 2018 Apr 26;9:886. doi: 10.3389/fimmu.2018.00886. eCollection 2018.


NetH2pan: A Computational Tool to Guide MHC Peptide Prediction on Murine Tumors.

DeVette CI, Andreatta M, Bardet W, Cate SJ, Jurtz VI, Jackson KW, Welm AL, Nielsen M, Hildebrand WH.

Cancer Immunol Res. 2018 Apr 3. doi: 10.1158/2326-6066.CIR-17-0298. [Epub ahead of print]


MHC-I Genotype Restricts the Oncogenic Mutational Landscape.

Marty R, Kaabinejadian S, Rossell D, Slifker MJ, van de Haar J, Engin HB, de Prisco N, Ideker T, Hildebrand WH, Font-Burgada J, Carter H.

Cell. 2017 Nov 30;171(6):1272-1283.e15. doi: 10.1016/j.cell.2017.09.050. Epub 2017 Oct 26.


Erratum: T cells from patients with Parkinson's disease recognize α-synuclein peptides.

Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Arlehamn CSL, Sette A.

Nature. 2017 Sep 13;549(7671):292. doi: 10.1038/nature23896.


Human Leukocyte Antigen F Presents Peptides and Regulates Immunity through Interactions with NK Cell Receptors.

Dulberger CL, McMurtrey CP, Hölzemer A, Neu KE, Liu V, Steinbach AM, Garcia-Beltran WF, Sulak M, Jabri B, Lynch VJ, Altfeld M, Hildebrand WH, Adams EJ.

Immunity. 2017 Jun 20;46(6):1018-1029.e7. doi: 10.1016/j.immuni.2017.06.002.


T cells from patients with Parkinson's disease recognize α-synuclein peptides.

Sulzer D, Alcalay RN, Garretti F, Cote L, Kanter E, Agin-Liebes J, Liong C, McMurtrey C, Hildebrand WH, Mao X, Dawson VL, Dawson TM, Oseroff C, Pham J, Sidney J, Dillon MB, Carpenter C, Weiskopf D, Phillips E, Mallal S, Peters B, Frazier A, Lindestam Arlehamn CS, Sette A.

Nature. 2017 Jun 29;546(7660):656-661. doi: 10.1038/nature22815. Epub 2017 Jun 21. Erratum in: Nature. 2017 Sep 13;549(7671):292.


The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands.

Hilton HG, McMurtrey CP, Han AS, Djaoud Z, Guethlein LA, Blokhuis JH, Pugh JL, Goyos A, Horowitz A, Buchli R, Jackson KW, Bardet W, Bushnell DA, Robinson PJ, Mendoza JL, Birnbaum ME, Nielsen M, Garcia KC, Hildebrand WH, Parham P.

Cell Rep. 2017 May 16;19(7):1394-1405. doi: 10.1016/j.celrep.2017.04.059.


Immunodominant West Nile Virus T Cell Epitopes Are Fewer in Number and Fashionably Late.

Kaabinejadian S, McMurtrey CP, Kim S, Jain R, Bardet W, Schafer FB, Davenport JL, Martin AD, Diamond MS, Weidanz JA, Hansen TH, Hildebrand WH.

J Immunol. 2016 May 15;196(10):4263-73. doi: 10.4049/jimmunol.1501821. Epub 2016 Apr 20.


The Length Distribution of Class I-Restricted T Cell Epitopes Is Determined by Both Peptide Supply and MHC Allele-Specific Binding Preference.

Trolle T, McMurtrey CP, Sidney J, Bardet W, Osborn SC, Kaever T, Sette A, Hildebrand WH, Nielsen M, Peters B.

J Immunol. 2016 Feb 15;196(4):1480-7. doi: 10.4049/jimmunol.1501721. Epub 2016 Jan 18.


Human Leukocyte Antigen-Presented Macrophage Migration Inhibitory Factor Is a Surface Biomarker and Potential Therapeutic Target for Ovarian Cancer.

Patterson AM, Kaabinejadian S, McMurtrey CP, Bardet W, Jackson KW, Zuna RE, Husain S, Adams GP, MacDonald G, Dillon RL, Ames H, Buchli R, Hawkins OE, Weidanz JA, Hildebrand WH.

Mol Cancer Ther. 2016 Feb;15(2):313-22. doi: 10.1158/1535-7163.MCT-15-0658. Epub 2015 Dec 30.


Enhanced Direct Major Histocompatibility Complex Class I Self-Antigen Presentation Induced by Chlamydia Infection.

Cram ED, Simmons RS, Palmer AL, Hildebrand WH, Rockey DD, Dolan BP.

Infect Immun. 2015 Nov 23;84(2):480-90. doi: 10.1128/IAI.01254-15. Print 2016 Feb.


Complementary IMAC enrichment methods for HLA-associated phosphopeptide identification by mass spectrometry.

Abelin JG, Trantham PD, Penny SA, Patterson AM, Ward ST, Hildebrand WH, Cobbold M, Bai DL, Shabanowitz J, Hunt DF.

Nat Protoc. 2015 Sep;10(9):1308-18. doi: 10.1038/nprot.2015.086. Epub 2015 Aug 6.


Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells.

Carreno BM, Magrini V, Becker-Hapak M, Kaabinejadian S, Hundal J, Petti AA, Ly A, Lie WR, Hildebrand WH, Mardis ER, Linette GP.

Science. 2015 May 15;348(6236):803-8. doi: 10.1126/science.aaa3828. Epub 2015 Apr 2.


Direct interrogation of viral peptides presented by the class I HLA of HIV-infected T cells.

Yaciuk JC, Skaley M, Bardet W, Schafer F, Mojsilovic D, Cate S, Stewart CJ, McMurtrey C, Jackson KW, Buchli R, Olvera A, Cedeño S, Plana M, Mothe B, Brander C, West JT, Hildebrand WH.

J Virol. 2014 Nov;88(22):12992-3004. doi: 10.1128/JVI.01914-14. Epub 2014 Aug 27.


Dengue virus-infected human dendritic cells reveal hierarchies of naturally expressed novel NS3 CD8 T cell epitopes.

Piazza P, Campbell D, Marques E, Hildebrand WH, Buchli R, Mailliard R, Rinaldo CR.

Clin Exp Immunol. 2014 Sep;177(3):696-702. doi: 10.1111/cei.12373.


A novel T-cell receptor mimic defines dendritic cells that present an immunodominant West Nile virus epitope in mice.

Kim S, Pinto AK, Myers NB, Hawkins O, Doll K, Kaabinejadian S, Netland J, Bevan MJ, Weidanz JA, Hildebrand WH, Diamond MS, Hansen TH.

Eur J Immunol. 2014 Jul;44(7):1936-46. doi: 10.1002/eji.201444450. Epub 2014 May 3.


Human herpesvirus 7 U21 tetramerizes to associate with class I major histocompatibility complex molecules.

May NA, Wang Q, Balbo A, Konrad SL, Buchli R, Hildebrand WH, Schuck P, Hudson AW.

J Virol. 2014 Mar;88(6):3298-308. doi: 10.1128/JVI.02639-13. Epub 2014 Jan 3.


The Human Proteome Organization Chromosome 6 Consortium: integrating chromosome-centric and biology/disease driven strategies.

Borchers CH, Kast J, Foster LJ, Siu KW, Overall CM, Binkowski TA, Hildebrand WH, Scherer A, Mansoor M, Keown PA; Human Proteome Organization Chromosome 6 Consortium.

J Proteomics. 2014 Apr 4;100:60-7. doi: 10.1016/j.jprot.2013.08.001. Epub 2013 Aug 8.


Identification of class I HLA T cell control epitopes for West Nile virus.

Kaabinejadian S, Piazza PA, McMurtrey CP, Vernon SR, Cate SJ, Bardet W, Schafer FB, Jackson KW, Campbell DM, Buchli R, Rinaldo CR, Hildebrand WH.

PLoS One. 2013 Jun 10;8(6):e66298. doi: 10.1371/journal.pone.0066298. Print 2013.


Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity.

Norcross MA, Luo S, Lu L, Boyne MT, Gomarteli M, Rennels AD, Woodcock J, Margulies DH, McMurtrey C, Vernon S, Hildebrand WH, Buchli R.

AIDS. 2012 Jul 17;26(11):F21-9. doi: 10.1097/QAD.0b013e328355fe8f.


Proteome sampling by the HLA class I antigen processing pathway.

Hoof I, van Baarle D, Hildebrand WH, Keşmir C.

PLoS Comput Biol. 2012;8(5):e1002517. doi: 10.1371/journal.pcbi.1002517. Epub 2012 May 17.


A shared MHC supertype motif emerges by convergent evolution in macaques and mice, but is totally absent in human MHC molecules.

Sette A, Sidney J, Southwood S, Moore C, Berry J, Dow C, Bradley K, Hoof I, Lewis MG, Hildebrand WH, McMurtrey CP, Wilson NA, Watkins DI, Mothé BR.

Immunogenetics. 2012 Jun;64(6):421-34. doi: 10.1007/s00251-011-0598-5. Epub 2012 Feb 10.


Definition of the viral targets of protective HIV-1-specific T cell responses.

Mothe B, Llano A, Ibarrondo J, Daniels M, Miranda C, Zamarreño J, Bach V, Zuniga R, Pérez-Álvarez S, Berger CT, Puertas MC, Martinez-Picado J, Rolland M, Farfan M, Szinger JJ, Hildebrand WH, Yang OO, Sanchez-Merino V, Brumme CJ, Brumme ZL, Heckerman D, Allen TM, Mullins JI, Gómez G, Goulder PJ, Walker BD, Gatell JM, Clotet B, Korber BT, Sanchez J, Brander C.

J Transl Med. 2011 Dec 7;9:208. doi: 10.1186/1479-5876-9-208.


TCR-like biomolecules target peptide/MHC Class I complexes on the surface of infected and cancerous cells.

Weidanz JA, Hawkins O, Verma B, Hildebrand WH.

Int Rev Immunol. 2011 Oct-Dec;30(5-6):328-40. doi: 10.3109/08830185.2011.604880. Review.


Expanding the targets available to therapeutic antibodies via novel disease-specific markers.

Weidanz JA, Hildebrand WH.

Int Rev Immunol. 2011 Oct-Dec;30(5-6):312-27. doi: 10.3109/08830185.2011.608136. Review.


A novel immunodominant CD8+ T cell response restricted by a common HLA-C allele targets a conserved region of Gag HIV-1 clade CRF01_AE infected Thais.

Buranapraditkun S, Hempel U, Pitakpolrat P, Allgaier RL, Thantivorasit P, Lorenzen SI, Sirivichayakul S, Hildebrand WH, Altfeld M, Brander C, Walker BD, Phanuphak P, Hansasuta P, Rowland-Jones SL, Allen TM, Ruxrungtham K.

PLoS One. 2011;6(8):e23603. doi: 10.1371/journal.pone.0023603. Epub 2011 Aug 22.


Differential MHC class I expression in distinct leukocyte subsets.

Greene JM, Wiseman RW, Lank SM, Bimber BN, Karl JA, Burwitz BJ, Lhost JJ, Hawkins OE, Kunstman KJ, Broman KW, Wolinsky SM, Hildebrand WH, O'Connor DH.

BMC Immunol. 2011 Jul 15;12:39. doi: 10.1186/1471-2172-12-39.


The role of MHC class I allele Mamu-A*07 during SIV(mac)239 infection.

Reed JS, Sidney J, Piaskowski SM, Glidden CE, León EJ, Burwitz BJ, Kolar HL, Eernisse CM, Furlott JR, Maness NJ, Walsh AD, Rudersdorf RA, Bardet W, McMurtrey CP, O'Connor DH, Hildebrand WH, Sette A, Watkins DI, Wilson NA.

Immunogenetics. 2011 Dec;63(12):789-807. doi: 10.1007/s00251-011-0541-9. Epub 2011 Jul 6.


Association of HLA alleles with Plasmodium falciparum severity in Malian children.

Lyke KE, Fernández-Viňa MA, Cao K, Hollenbach J, Coulibaly D, Kone AK, Guindo A, Burdett LA, Hartzman RJ, Wahl AR, Hildebrand WH, Doumbo OK, Plowe CV, Sztein MB.

Tissue Antigens. 2011 Jun;77(6):562-71. doi: 10.1111/j.1399-0039.2011.01661.x. Epub 2011 Mar 30.


Although divergent in residues of the peptide binding site, conserved chimpanzee Patr-AL and polymorphic human HLA-A*02 have overlapping peptide-binding repertoires.

Gleimer M, Wahl AR, Hickman HD, Abi-Rached L, Norman PJ, Guethlein LA, Hammond JA, Draghi M, Adams EJ, Juo S, Jalili R, Gharizadeh B, Ronaghi M, Garcia KC, Hildebrand WH, Parham P.

J Immunol. 2011 Feb 1;186(3):1575-88. doi: 10.4049/jimmunol.1002990. Epub 2011 Jan 5.


Surface phenotype and functionality of WNV specific T cells differ with age and disease severity.

Piazza P, McMurtrey CP, Lelic A, Cook RL, Hess R, Yablonsky E, Borowski L, Loeb MB, Bramson JL, Hildebrand WH, Rinaldo CR.

PLoS One. 2010 Dec 13;5(12):e15343. doi: 10.1371/journal.pone.0015343.


NIAID workshop on Flavivirus immunity.

Augustine AD, Cassetti MC, Ennis FA, Harris E, Hildebrand WH, Repik PM.

Viral Immunol. 2010 Jun;23(3):235-40. doi: 10.1089/vim.2009.0114.


Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity.

Wang S, Buchli R, Schiller J, Gao J, VanGundy RS, Hildebrand WH, Eckels DD.

World J Gastroenterol. 2010 Apr 28;16(16):1953-69.


Single-chain HLA-A2 MHC trimers that incorporate an immundominant peptide elicit protective T cell immunity against lethal West Nile virus infection.

Kim S, Li L, McMurtrey CP, Hildebrand WH, Weidanz JA, Gillanders WE, Diamond MS, Hansen TH.

J Immunol. 2010 Apr 15;184(8):4423-30. doi: 10.4049/jimmunol.0903955. Epub 2010 Mar 8.


Recognition of lyso-phospholipids by human natural killer T lymphocytes.

Fox LM, Cox DG, Lockridge JL, Wang X, Chen X, Scharf L, Trott DL, Ndonye RM, Veerapen N, Besra GS, Howell AR, Cook ME, Adams EJ, Hildebrand WH, Gumperz JE.

PLoS Biol. 2009 Oct;7(10):e1000228. doi: 10.1371/journal.pbio.1000228. Epub 2009 Oct 27.


Direct discovery and validation of a peptide/MHC epitope expressed in primary human breast cancer cells using a TCRm monoclonal antibody with profound antitumor properties.

Verma B, Hawkins OE, Neethling FA, Caseltine SL, Largo SR, Hildebrand WH, Weidanz JA.

Cancer Immunol Immunother. 2010 Apr;59(4):563-73. doi: 10.1007/s00262-009-0774-8. Epub 2009 Sep 25.


HLA class I molecules reflect an altered host proteome after influenza virus infection.

Wahl A, Schafer F, Bardet W, Hildebrand WH.

Hum Immunol. 2010 Jan;71(1):14-22. doi: 10.1016/j.humimm.2009.08.012.


T-cell tolerance for variability in an HLA class I-presented influenza A virus epitope.

Wahl A, McCoy W, Schafer F, Bardet W, Buchli R, Fremont DH, Hildebrand WH.

J Virol. 2009 Sep;83(18):9206-14. doi: 10.1128/JVI.00932-09. Epub 2009 Jun 24.


Two MHC class I molecules associated with elite control of immunodeficiency virus replication, Mamu-B*08 and HLA-B*2705, bind peptides with sequence similarity.

Loffredo JT, Sidney J, Bean AT, Beal DR, Bardet W, Wahl A, Hawkins OE, Piaskowski S, Wilson NA, Hildebrand WH, Watkins DI, Sette A.

J Immunol. 2009 Jun 15;182(12):7763-75. doi: 10.4049/jimmunol.0900111.


Amyloid precursor-like protein 2 association with HLA class I molecules.

Tuli A, Sharma M, Wang X, Simone LC, Capek HL, Cate S, Hildebrand WH, Naslavsky N, Caplan S, Solheim JC.

Cancer Immunol Immunother. 2009 Sep;58(9):1419-31. doi: 10.1007/s00262-009-0657-z. Epub 2009 Jan 31. Erratum in: Cancer Immunol Immunother. 2010 Feb;59(2):339.


HLA class I molecules consistently present internal influenza epitopes.

Wahl A, Schafer F, Bardet W, Buchli R, Air GM, Hildebrand WH.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):540-5. doi: 10.1073/pnas.0811271106. Epub 2009 Jan 2.


Identification of breast cancer peptide epitopes presented by HLA-A*0201.

Hawkins OE, Vangundy RS, Eckerd AM, Bardet W, Buchli R, Weidanz JA, Hildebrand WH.

J Proteome Res. 2008 Apr;7(4):1445-57. doi: 10.1021/pr700761w. Epub 2008 Mar 18.


Epitope discovery in West Nile virus infection: Identification and immune recognition of viral epitopes.

McMurtrey CP, Lelic A, Piazza P, Chakrabarti AK, Yablonsky EJ, Wahl A, Bardet W, Eckerd A, Cook RL, Hess R, Buchli R, Loeb M, Rinaldo CR, Bramson J, Hildebrand WH.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2981-6. doi: 10.1073/pnas.0711874105. Epub 2008 Feb 25.


A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs.

Hurley CK, Fernandez-Vina M, Hildebrand WH, Noreen HJ, Trachtenberg E, Williams TM, Baxter-Lowe LA, Begovich AB, Petersdorf E, Selvakumar A, Stastny P, Hegland J, Hartzman RJ, Carston M, Gandham S, Kollman C, Nelson G, Spellman S, Setterholm M.

Hum Immunol. 2007 Jan;68(1):30-40. Epub 2006 Oct 25.


Development and implementation of a direct detection, quantitation and validation system for class I MHC self-peptide epitopes.

Weidanz JA, Piazza P, Hickman-Miller H, Woodburn D, Nguyen T, Wahl A, Neethling F, Chiriva-Internati M, Rinaldo CR, Hildebrand WH.

J Immunol Methods. 2007 Jan 10;318(1-2):47-58. Epub 2006 Oct 25.


Levels of specific peptide-HLA class I complex predicts tumor cell susceptibility to CTL killing.

Weidanz JA, Nguyen T, Woodburn T, Neethling FA, Chiriva-Internati M, Hildebrand WH, Lustgarten J.

J Immunol. 2006 Oct 15;177(8):5088-97.


Critical factors in the development of fluorescence polarization-based peptide binding assays: an equilibrium study monitoring specific peptide binding to soluble HLA-A*0201.

Buchli R, Vangundy RS, Giberson CF, Hildebrand WH.

J Immunol Methods. 2006 Jul 31;314(1-2):38-53. Epub 2006 Jun 21.


The high frequency Indian rhesus macaque MHC class I molecule, Mamu-B*01, does not appear to be involved in CD8+ T lymphocyte responses to SIVmac239.

Loffredo JT, Sidney J, Piaskowski S, Szymanski A, Furlott J, Rudersdorf R, Reed J, Peters B, Hickman-Miller HD, Bardet W, Rehrauer WM, O'Connor DH, Wilson NA, Hildebrand WH, Sette A, Watkins DI.

J Immunol. 2005 Nov 1;175(9):5986-97.


Markov model recognition and classification of DNA/protein sequences within large text databases.

Wren JD, Hildebrand WH, Chandrasekaran S, Melcher U.

Bioinformatics. 2005 Nov 1;21(21):4046-53. Epub 2005 Sep 13.


Development and validation of a fluorescence polarization-based competitive peptide-binding assay for HLA-A*0201--a new tool for epitope discovery.

Buchli R, VanGundy RS, Hickman-Miller HD, Giberson CF, Bardet W, Hildebrand WH.

Biochemistry. 2005 Sep 20;44(37):12491-507.


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