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A novel method for expansion and differentiation of mouse tracheal epithelial cells in culture.

Eenjes E, Mertens TCJ, Buscop-van Kempen MJ, van Wijck Y, Taube C, Rottier RJ, Hiemstra PS.

Sci Rep. 2018 May 9;8(1):7349. doi: 10.1038/s41598-018-25799-6.


Basic and translational research in the European Respiratory Journal.

Farré R, Hiemstra PS, Dinh-Xuan AT.

Eur Respir J. 2018 May 3;51(5). pii: 1800377. doi: 10.1183/13993003.00377-2018. Print 2018 May. No abstract available.


Predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD.

Hartjes FJ, Vonk JM, Faiz A, Hiemstra PS, Lapperre TS, Kerstjens HAM, Postma DS, van den Berge M; and the Groningen and Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) Study Group.

Respirology. 2018 Apr 26. doi: 10.1111/resp.13312. [Epub ahead of print]


Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease.

Amatngalim GD, Hiemstra PS.

Chin Med J (Engl). 2018 May 5;131(9):1099-1107. doi: 10.4103/0366-6999.230743. No abstract available.


Response to Comment on "Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease".

van Wijck Y, Hiemstra PS, Taube C.

J Immunol. 2018 May 1;200(9):3027-3028. doi: 10.4049/jimmunol.1800260. No abstract available.


Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?

Broekman W, Khedoe PPSJ, Schepers K, Roelofs H, Stolk J, Hiemstra PS.

Thorax. 2018 Jun;73(6):565-574. doi: 10.1136/thoraxjnl-2017-210672. Epub 2018 Apr 13.


Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence.

Amatngalim GD, Schrumpf JA, Dishchekenian F, Mertens TCJ, Ninaber DK, van der Linden AC, Pilette C, Taube C, Hiemstra PS, van der Does AM.

Eur Respir J. 2018 Apr 26;51(4). pii: 1701009. doi: 10.1183/13993003.01009-2017. Print 2018 Apr.


Effects of E-cigarette Use on Human Lung Tissue: On Harm Reduction and Causing Harm.

Hiemstra PS, Bals R.

Am J Respir Crit Care Med. 2018 Mar 8. doi: 10.1164/rccm.201802-0299ED. [Epub ahead of print] No abstract available.


Assembly 3: Basic and Translational Sciences.

Greene CM, Hiemstra PS.

Breathe (Sheff). 2018 Mar;14(1):67-68. doi: 10.1183/20734735.020017.


Farm dust reduces viral load in human bronchial epithelial cells by increasing barrier function and antiviral responses.

van der Vlugt LEPM, Eger K, Müller C, Ninaber DK, Zarcone MC, Amatngalim GD, Bracher F, von Mutius E, Smits HH, Hiemstra PS.

J Allergy Clin Immunol. 2018 May;141(5):1949-1952.e8. doi: 10.1016/j.jaci.2018.01.025. Epub 2018 Feb 7. No abstract available.


Effect of diesel exhaust generated by a city bus engine on stress responses and innate immunity in primary bronchial epithelial cell cultures.

Zarcone MC, Duistermaat E, Alblas MJ, van Schadewijk A, Ninaber DK, Clarijs V, Moerman MM, Vaessen D, Hiemstra PS, Kooter IM.

Toxicol In Vitro. 2018 Apr;48:221-231. doi: 10.1016/j.tiv.2018.01.024.


Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease.

van Wijck Y, de Kleijn S, John-Schuster G, Mertens TCJ, Hiemstra PS, Müller A, Smits HH, Taube C.

J Immunol. 2018 Mar 1;200(5):1570-1579. doi: 10.4049/jimmunol.1700987. Epub 2018 Jan 19.


Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population.

Rafiq R, Thijs W, Prein R, de Jongh RT, Taube C, Hiemstra PS, de Mutsert R, den Heijer M.

Nutrients. 2018 Jan 3;10(1). pii: E35. doi: 10.3390/nu10010035.


Pulmonary function, exhaled nitric oxide and symptoms in asthma patients with obesity: a cross-sectional study.

Kasteleyn MJ, Bonten TN, de Mutsert R, Thijs W, Hiemstra PS, le Cessie S, Rosendaal FR, Chavannes NH, Taube C.

Respir Res. 2017 Dec 7;18(1):205. doi: 10.1186/s12931-017-0684-9.


Reprogramming of cellular metabolism: driver for airway remodelling in COPD?

Hiemstra PS, van der Does AM.

Eur Respir J. 2017 Nov 30;50(5). pii: 1702197. doi: 10.1183/13993003.02197-2017. Print 2017 Nov. No abstract available.


Human lung epithelial cell cultures for analysis of inhaled toxicants: Lessons learned and future directions.

Hiemstra PS, Grootaers G, van der Does AM, Krul CAM, Kooter IM.

Toxicol In Vitro. 2018 Mar;47:137-146. doi: 10.1016/j.tiv.2017.11.005. Epub 2017 Nov 15. Review.


High intensity training in obesity: a Meta-analysis.

Türk Y, Theel W, Kasteleyn MJ, Franssen FME, Hiemstra PS, Rudolphus A, Taube C, Braunstahl GJ.

Obes Sci Pract. 2017 May 29;3(3):258-271. doi: 10.1002/osp4.109. eCollection 2017 Sep. Review.


microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach.

Conickx G, Avila Cobos F, van den Berge M, Faiz A, Timens W, Hiemstra PS, Joos GF, Brusselle GG, Mestdagh P, Bracke KR.

Sci Rep. 2017 Oct 9;7(1):12871. doi: 10.1038/s41598-017-13265-8.


Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure.

Aghapour M, Raee P, Moghaddam SJ, Hiemstra PS, Heijink IH.

Am J Respir Cell Mol Biol. 2018 Feb;58(2):157-169. doi: 10.1165/rcmb.2017-0200TR. Review.


Acute and chronic effects of treatment with mesenchymal stromal cells on LPS-induced pulmonary inflammation, emphysema and atherosclerosis development.

Khedoe PPSJ, de Kleijn S, van Oeveren-Rietdijk AM, Plomp JJ, de Boer HC, van Pel M, Rensen PCN, Berbée JFP, Hiemstra PS.

PLoS One. 2017 Sep 14;12(9):e0183741. doi: 10.1371/journal.pone.0183741. eCollection 2017.


Pre-surgical Pulmonary Rehabilitation in Asthma Patients Undergoing Bariatric Surgery.

Türk Y, van Huisstede A, Hiemstra PS, Taube C, Braunstahl GJ.

Obes Surg. 2017 Nov;27(11):3055-3060. doi: 10.1007/s11695-017-2888-y.


The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice.

Hoeke G, Khedoe PPSJ, van Diepen JA, Pike-Overzet K, van de Ven B, Vazirpanah N, Mol I, Hiemstra PS, Staal FJT, Stienstra R, Netea MG, Dinarello CA, Rensen PCN, Berbée JFP.

Int J Mol Sci. 2017 Aug 9;18(8). pii: E1672. doi: 10.3390/ijms18081672.


Bone Morphogenetic Protein 9 Protects against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation.

Chen X, Orriols M, Walther FJ, Laghmani EH, Hoogeboom AM, Hogen-Esch ACB, Hiemstra PS, Folkerts G, Goumans MTH, Ten Dijke P, Morrell NW, Wagenaar GTM.

Front Physiol. 2017 Jul 13;8:486. doi: 10.3389/fphys.2017.00486. eCollection 2017.


Cigarette smoke differentially affects IL-13-induced gene expression in human airway epithelial cells.

Mertens TCJ, van der Does AM, Kistemaker LE, Ninaber DK, Taube C, Hiemstra PS.

Physiol Rep. 2017 Jul;5(13). pii: e13347. doi: 10.14814/phy2.13347. Epub 2017 Jul 11.


The effect of tiotropium in combination with olodaterol on house dust mite-induced allergic airway disease.

John-Schuster G, de Kleijn S, van Wijck Y, Kremer V, Smits HH, Pieper MP, Hiemstra PS, Taube C.

Pulm Pharmacol Ther. 2017 Aug;45:210-217. doi: 10.1016/j.pupt.2017.06.010. Epub 2017 Jul 5.


Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids.

Kunz LIZ, Ten Hacken NH, Lapperre TS, Timens W, Kerstjens HAM, van Schadewijk A, Vonk JM, Sont JK, Snoeck-Stroband JB, Postma DS, Sterk PJ, Hiemstra PS; GLUCOLD Study Group.

Eur Respir J. 2017 Jun 15;49(6). pii: 1700848. doi: 10.1183/13993003.00848-2017. Print 2017 Jun. No abstract available.


Use of airway epithelial cell culture to unravel the pathogenesis and study treatment in obstructive airway diseases.

Mertens TCJ, Karmouty-Quintana H, Taube C, Hiemstra PS.

Pulm Pharmacol Ther. 2017 Aug;45:101-113. doi: 10.1016/j.pupt.2017.05.008. Epub 2017 May 11. Review.


Defining asthma-COPD overlap syndrome: a population-based study.

Bonten TN, Kasteleyn MJ, de Mutsert R, Hiemstra PS, Rosendaal FR, Chavannes NH, Slats AM, Taube C.

Eur Respir J. 2017 May 1;49(5). pii: 1602008. doi: 10.1183/13993003.02008-2016. Print 2017 May.


Aberrant DNA methylation and expression of SPDEF and FOXA2 in airway epithelium of patients with COPD.

Song J, Heijink IH, Kistemaker LEM, Reinders-Luinge M, Kooistra W, Noordhoek JA, Gosens R, Brandsma CA, Timens W, Hiemstra PS, Rots MG, Hylkema MN.

Clin Epigenetics. 2017 Apr 24;9:42. doi: 10.1186/s13148-017-0341-7. eCollection 2017.


Effect of an Outpatient Pulmonary Rehabilitation Program on Exercise Tolerance and Asthma Control in Obese Asthma Patients.

Türk Y, van Huisstede A, Franssen FME, Hiemstra PS, Rudolphus A, Taube C, Braunstahl GJ.

J Cardiopulm Rehabil Prev. 2017 May;37(3):214-222. doi: 10.1097/HCR.0000000000000249.


Antimicrobial peptide levels are linked to airway inflammation, bacterial colonisation and exacerbations in chronic obstructive pulmonary disease.

Persson LJ, Aanerud M, Hardie JA, Miodini Nilsen R, Bakke PS, Eagan TM, Hiemstra PS.

Eur Respir J. 2017 Mar 15;49(3). pii: 1601328. doi: 10.1183/13993003.01328-2016. Print 2017 Mar.


Proinflammatory Cytokines Impair Vitamin D-Induced Host Defense in Cultured Airway Epithelial Cells.

Schrumpf JA, Amatngalim GD, Veldkamp JB, Verhoosel RM, Ninaber DK, Ordonez SR, van der Does AM, Haagsman HP, Hiemstra PS.

Am J Respir Cell Mol Biol. 2017 Jun;56(6):749-761. doi: 10.1165/rcmb.2016-0289OC.


Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus influenzae: Modulation by Cigarette Smoke.

Amatngalim GD, Schrumpf JA, Henic A, Dronkers E, Verhoosel RM, Ordonez SR, Haagsman HP, Fuentes ME, Sridhar S, Aarbiou J, Janssen RAJ, Lekkerkerker AN, Hiemstra PS.

J Innate Immun. 2017;9(4):359-374. doi: 10.1159/000455193. Epub 2017 Feb 8.


Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae.

Zarcone MC, van Schadewijk A, Duistermaat E, Hiemstra PS, Kooter IM.

Respir Res. 2017 Jan 28;18(1):27. doi: 10.1186/s12931-017-0510-4.


Standard radiotherapy but not chemotherapy impairs systemic immunity in non-small cell lung cancer.

Talebian Yazdi M, Schinkelshoek MS, Loof NM, Taube C, Hiemstra PS, Welters MJ, van der Burg SH.

Oncoimmunology. 2016 Nov 8;5(12):e1255393. doi: 10.1080/2162402X.2016.1255393. eCollection 2016.


Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids.

Kunz LI, Ten Hacken NH, Lapperre TS, Timens W, Kerstjens HA, van Schadewijk A, Vonk JM, Sont JK, Snoeck-Stroband JB, Postma DS, Sterk PJ, Hiemstra PS; GLUCOLD Study Group.

Eur Respir J. 2017 Jan 3;49(1). pii: 1600839. doi: 10.1183/13993003.00839-2016. Print 2017 Jan.


Cigarette Smoke Modulates Repair and Innate Immunity following Injury to Airway Epithelial Cells.

Amatngalim GD, Broekman W, Daniel NM, van der Vlugt LE, van Schadewijk A, Taube C, Hiemstra PS.

PLoS One. 2016 Nov 9;11(11):e0166255. doi: 10.1371/journal.pone.0166255. eCollection 2016.


Childhood allergies and asthma: New insights on environmental exposures and local immunity at the lung barrier.

Smits HH, van der Vlugt LE, von Mutius E, Hiemstra PS.

Curr Opin Immunol. 2016 Oct;42:41-47. doi: 10.1016/j.coi.2016.05.009. Epub 2016 May 30. Review.


Xenobiotic metabolism in differentiated human bronchial epithelial cells.

Boei JJWA, Vermeulen S, Klein B, Hiemstra PS, Verhoosel RM, Jennen DGJ, Lahoz A, Gmuender H, Vrieling H.

Arch Toxicol. 2017 May;91(5):2093-2105. doi: 10.1007/s00204-016-1868-7. Epub 2016 Oct 13.


Functional characterisation of bone marrow-derived mesenchymal stromal cells from COPD patients.

Broekman W, Roelofs H, Zarcone MC, Taube C, Stolk J, Hiemstra PS.

ERJ Open Res. 2016 Jun 28;2(2). pii: 00045-2015. eCollection 2016 Apr.


Airway hyperresponsiveness in chronic obstructive pulmonary disease: A marker of asthma-chronic obstructive pulmonary disease overlap syndrome?

Tkacova R, Dai DLY, Vonk JM, Leung JM, Hiemstra PS, van den Berge M, Kunz L, Hollander Z, Tashkin D, Wise R, Connett J, Ng R, McManus B, Paul Man SF, Postma DS, Sin DD.

J Allergy Clin Immunol. 2016 Dec;138(6):1571-1579.e10. doi: 10.1016/j.jaci.2016.04.022. Epub 2016 May 24.


The Dutch National Program for Respiratory Research.

Postma DS, Wijkstra PJ, Hiemstra PS, Melgert BN, Braunstahl GJ, Hylkema MN, Sterk PJ.

Lancet Respir Med. 2016 May;4(5):356-7. doi: 10.1016/S2213-2600(16)30035-2. Review. No abstract available.


Azithromycin differentially affects the IL-13-induced expression profile in human bronchial epithelial cells.

Mertens TC, Hiemstra PS, Taube C.

Pulm Pharmacol Ther. 2016 Aug;39:14-20. doi: 10.1016/j.pupt.2016.05.005. Epub 2016 May 28.


Lung function decline in asthma patients with elevated bronchial CD8, CD4 and CD3 cells.

den Otter I, Willems LN, van Schadewijk A, van Wijngaarden S, Janssen K, de Jeu RC, Sont JK, Sterk PJ, Hiemstra PS.

Eur Respir J. 2016 Aug;48(2):393-402. doi: 10.1183/13993003.01525-2015. Epub 2016 May 26.


Cellular response of mucociliary differentiated primary bronchial epithelial cells to diesel exhaust.

Zarcone MC, Duistermaat E, van Schadewijk A, Jedynska A, Hiemstra PS, Kooter IM.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L111-23. doi: 10.1152/ajplung.00064.2016. Epub 2016 May 17.


Microarray Gene Expression Analysis to Evaluate Cell Type Specific Expression of Targets Relevant for Immunotherapy of Hematological Malignancies.

Pont MJ, Honders MW, Kremer AN, van Kooten C, Out C, Hiemstra PS, de Boer HC, Jager MJ, Schmelzer E, Vries RG, Al Hinai AS, Kroes WG, Monajemi R, Goeman JJ, Böhringer S, Marijt WA, Falkenburg JH, Griffioen M.

PLoS One. 2016 May 12;11(5):e0155165. doi: 10.1371/journal.pone.0155165. eCollection 2016.


Anti-carbamylated protein antibodies: a specific hallmark for rheumatoid arthritis. Comparison to conditions known for enhanced carbamylation; renal failure, smoking and chronic inflammation.

Verheul MK, van Erp SJ, van der Woude D, Levarht EW, Mallat MJ, Verspaget HW, Stolk J, Toes RE, van der Meulen-de Jong AE, Hiemstra PS, van Kooten C, Trouw LA.

Ann Rheum Dis. 2016 Aug;75(8):1575-6. doi: 10.1136/annrheumdis-2016-209248. Epub 2016 Apr 29. No abstract available.


Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus aureus from Cultured Skin and Airway Epithelial Surfaces.

Haisma EM, Göblyös A, Ravensbergen B, Adriaans AE, Cordfunke RA, Schrumpf J, Limpens RW, Schimmel KJ, den Hartigh J, Hiemstra PS, Drijfhout JW, El Ghalbzouri A, Nibbering PH.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4063-72. doi: 10.1128/AAC.03001-15. Print 2016 Jul.

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