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Items: 1 to 50 of 283

1.

Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism.

Özer Ö, Bhowmick R, Liu Y, Hickson ID.

Oncotarget. 2018 Mar 23;9(22):15836-15846. doi: 10.18632/oncotarget.24745. eCollection 2018 Mar 23.

2.

Anaphase: a fortune-teller of genomic instability.

Bizard AH, Hickson ID.

Curr Opin Cell Biol. 2018 Mar 8;52:112-119. doi: 10.1016/j.ceb.2018.02.012. [Epub ahead of print] Review.

PMID:
29525475
3.

Inducing and Detecting Mitotic DNA Synthesis at Difficult-to-Replicate Loci.

Garribba L, Wu W, Özer Ö, Bhowmick R, Hickson ID, Liu Y.

Methods Enzymol. 2018;601:45-58. doi: 10.1016/bs.mie.2017.11.025. Epub 2018 Feb 3.

PMID:
29523241
4.

Erratum to: Detection of Ultrafine Anaphase Bridges.

Bizard AH, Nielsen CF, Hickson ID.

Methods Mol Biol. 2018;1672:E1. doi: 10.1007/978-1-4939-7306-4_43. No abstract available.

PMID:
29340994
5.

Knotty Problems during Mitosis: Mechanistic Insight into the Processing of Ultrafine DNA Bridges in Anaphase.

Sarlós K, Biebricher A, Petermann EJG, Wuite GJL, Hickson ID.

Cold Spring Harb Symp Quant Biol. 2017 Nov 22. pii: 033647. doi: 10.1101/sqb.2017.82.033647. [Epub ahead of print]

PMID:
29167280
6.

Detection of Ultrafine Anaphase Bridges.

Bizard AH, Nielsen CF, Hickson ID.

Methods Mol Biol. 2018;1672:495-508. doi: 10.1007/978-1-4939-7306-4_33.

PMID:
29043644
7.

The Detection and Analysis of Chromosome Fragile Sites.

Bjerregaard VA, Özer Ö, Hickson ID, Liu Y.

Methods Mol Biol. 2018;1672:471-482. doi: 10.1007/978-1-4939-7306-4_31.

PMID:
29043642
8.

A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation.

Larsen NB, Hickson ID, Mankouri HW.

Methods Mol Biol. 2018;1672:295-309. doi: 10.1007/978-1-4939-7306-4_20.

PMID:
29043631
9.

A novel TPR-BEN domain interaction mediates PICH-BEND3 association.

Pitchai GP, Kaulich M, Bizard AH, Mesa P, Yao Q, Sarlos K, Streicher WW, Nigg EA, Montoya G, Hickson ID.

Nucleic Acids Res. 2017 Nov 2;45(19):11413-11424. doi: 10.1093/nar/gkx792.

10.

Stalled replication forks generate a distinct mutational signature in yeast.

Larsen NB, Liberti SE, Vogel I, Jørgensen SW, Hickson ID, Mankouri HW.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9665-9670. doi: 10.1073/pnas.1706640114. Epub 2017 Aug 21.

11.

The "enemies within": regions of the genome that are inherently difficult to replicate.

Bhowmick R, Hickson ID.

F1000Res. 2017 May 12;6:666. doi: 10.12688/f1000research.11024.1. eCollection 2017. Review.

12.

RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis.

Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, Sedlackova H, Langhoff J, Surendranath K, Hühn D, Bhowmick R, Marini V, Ferrari S, Hickson ID, Krejci L, Janscak P.

Mol Cell. 2017 Jun 1;66(5):658-671.e8. doi: 10.1016/j.molcel.2017.05.006.

PMID:
28575661
13.

Acute inactivation of the replicative helicase in human cells triggers MCM8-9-dependent DNA synthesis.

Natsume T, Nishimura K, Minocherhomji S, Bhowmick R, Hickson ID, Kanemaki MT.

Genes Dev. 2017 Apr 15;31(8):816-829. doi: 10.1101/gad.297663.117. Epub 2017 May 9.

14.

Potential biomarkers of DNA replication stress in cancer.

Ren L, Chen L, Wu W, Garribba L, Tian H, Liu Z, Vogel I, Li C, Hickson ID, Liu Y.

Oncotarget. 2017 Jun 6;8(23):36996-37008. doi: 10.18632/oncotarget.16940. Review.

15.

RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress.

Bhowmick R, Minocherhomji S, Hickson ID.

Mol Cell. 2016 Dec 15;64(6):1117-1126. doi: 10.1016/j.molcel.2016.10.037.

16.

Biochemical and Mass Spectrometry-Based Approaches to Profile SUMOylation in Human Cells.

Kessler BM, Bursomanno S, McGouran JF, Hickson ID, Liu Y.

Methods Mol Biol. 2017;1491:131-144. Review.

PMID:
27778286
17.

PICH promotes mitotic chromosome segregation: Identification of a novel role in rDNA disjunction.

Nielsen CF, Hickson ID.

Cell Cycle. 2016 Oct 17;15(20):2704-11. doi: 10.1080/15384101.2016.1222336. Epub 2016 Aug 26.

18.

Characterization of the NTPR and BD1 interacting domains of the human PICH-BEND3 complex.

Pitchai GP, Hickson ID, Streicher W, Montoya G, Mesa P.

Acta Crystallogr F Struct Biol Commun. 2016 Aug;72(Pt 8):646-51. doi: 10.1107/S2053230X16010724. Epub 2016 Jul 27.

PMID:
27487930
19.

The fluorescent two-hybrid assay for live-cell profiling of androgen receptor modulators.

Bogner J, Zolghadr K, Hickson I, Romer T, Yurlova L.

J Steroid Biochem Mol Biol. 2017 Feb;166:45-53. doi: 10.1016/j.jsbmb.2016.05.005. Epub 2016 May 9.

PMID:
27174722
20.

LIFESTAT - Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction.

Christensen CL, Wulff Helge J, Krasnik A, Kriegbaum M, Rasmussen LJ, Hickson ID, Liisberg KB, Oxlund B, Bruun B, Lau SR, Olsen MN, Andersen JS, Heltberg AS, Kuhlman AB, Morville TH, Dohlmann TL, Larsen S, Dela F.

Scand J Public Health. 2016 Jul;44(5):534-9. doi: 10.1177/1403494816636304. Epub 2016 Mar 3.

PMID:
26939591
21.

A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells.

Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M.

Nat Commun. 2016 Feb 15;7:10660. doi: 10.1038/ncomms10660.

22.

Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.

Ghamrasni SE, Cardoso R, Li L, Guturi KK, Bjerregaard VA, Liu Y, Venkatesan S, Hande MP, Henderson JT, Sanchez O, Hickson ID, Hakem A, Hakem R.

Oncogene. 2016 Sep 15;35(37):4836-45. doi: 10.1038/onc.2016.16. Epub 2016 Feb 15.

PMID:
26876210
23.

PICH promotes sister chromatid disjunction and co-operates with topoisomerase II in mitosis.

Nielsen CF, Huttner D, Bizard AH, Hirano S, Li TN, Palmai-Pallag T, Bjerregaard VA, Liu Y, Nigg EA, Wang LH, Hickson ID.

Nat Commun. 2015 Dec 8;6:8962. doi: 10.1038/ncomms9962.

24.

Replication stress activates DNA repair synthesis in mitosis.

Minocherhomji S, Ying S, Bjerregaard VA, Bursomanno S, Aleliunaite A, Wu W, Mankouri HW, Shen H, Liu Y, Hickson ID.

Nature. 2015 Dec 10;528(7581):286-90. doi: 10.1038/nature16139. Epub 2015 Dec 2.

PMID:
26633632
25.

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells.

Kliszczak M, Sedlackova H, Pitchai GP, Streicher WW, Krejci L, Hickson ID.

Oncotarget. 2015 Dec 1;6(38):40464-79. doi: 10.18632/oncotarget.6342.

26.

Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.

Xing M, Wang X, Palmai-Pallag T, Shen H, Helleday T, Hickson ID, Ying S.

Oncotarget. 2015 Nov 10;6(35):37638-46. doi: 10.18632/oncotarget.5497.

27.

Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes.

Newman JA, Savitsky P, Allerston CK, Bizard AH, Özer Ö, Sarlós K, Liu Y, Pardon E, Steyaert J, Hickson ID, Gileadi O.

Nucleic Acids Res. 2015 May 26;43(10):5221-35. doi: 10.1093/nar/gkv373. Epub 2015 Apr 21.

28.

FBH1 Catalyzes Regression of Stalled Replication Forks.

Fugger K, Mistrik M, Neelsen KJ, Yao Q, Zellweger R, Kousholt AN, Haahr P, Chu WK, Bartek J, Lopes M, Hickson ID, Sørensen CS.

Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00174-6. doi: 10.1016/j.celrep.2015.02.028. [Epub ahead of print]

PMID:
25772361
Free Article
29.

Regulation of SUMO2 target proteins by the proteasome in human cells exposed to replication stress.

Bursomanno S, McGouran JF, Kessler BM, Hickson ID, Liu Y.

J Proteome Res. 2015 Apr 3;14(4):1687-99. doi: 10.1021/pr500997p. Epub 2015 Mar 19.

PMID:
25748227
30.

FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.

Chu WK, Payne MJ, Beli P, Hanada K, Choudhary C, Hickson ID.

Nat Commun. 2015 Jan 14;6:5931. doi: 10.1038/ncomms6931.

PMID:
25585578
31.

USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses.

Perez-Oliva AB, Lachaud C, Szyniarowski P, Muñoz I, Macartney T, Hickson I, Rouse J, Alessi DR.

EMBO J. 2015 Feb 3;34(3):326-43. doi: 10.15252/embj.201489184. Epub 2014 Dec 23.

32.

Proteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells.

Bursomanno S, Beli P, Khan AM, Minocherhomji S, Wagner SA, Bekker-Jensen S, Mailand N, Choudhary C, Hickson ID, Liu Y.

DNA Repair (Amst). 2015 Jan;25:84-96. doi: 10.1016/j.dnarep.2014.10.011. Epub 2014 Nov 25.

PMID:
25497329
33.

Tus-Ter as a tool to study site-specific DNA replication perturbation in eukaryotes.

Larsen NB, Hickson ID, Mankouri HW.

Cell Cycle. 2014;13(19):2994-8. doi: 10.4161/15384101.2014.958912. Review.

34.

Mechanistic insight into the interaction of BLM helicase with intra-strand G-quadruplex structures.

Chatterjee S, Zagelbaum J, Savitsky P, Sturzenegger A, Huttner D, Janscak P, Hickson ID, Gileadi O, Rothenberg E.

Nat Commun. 2014 Nov 24;5:5556. doi: 10.1038/ncomms6556.

35.

The dissolution of double Holliday junctions.

Bizard AH, Hickson ID.

Cold Spring Harb Perspect Biol. 2014 Jul 1;6(7):a016477. doi: 10.1101/cshperspect.a016477. Review.

36.

Regulation of gene expression by the BLM helicase correlates with the presence of G-quadruplex DNA motifs.

Nguyen GH, Tang W, Robles AI, Beyer RP, Gray LT, Welsh JA, Schetter AJ, Kumamoto K, Wang XW, Hickson ID, Maizels N, Monnat RJ Jr, Harris CC.

Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9905-10. doi: 10.1073/pnas.1404807111. Epub 2014 Jun 23.

37.

The origins and processing of ultra fine anaphase DNA bridges.

Liu Y, Nielsen CF, Yao Q, Hickson ID.

Curr Opin Genet Dev. 2014 Jun;26:1-5. doi: 10.1016/j.gde.2014.03.003. Epub 2014 May 8. Review.

PMID:
24795279
38.

The Escherichia coli Tus-Ter replication fork barrier causes site-specific DNA replication perturbation in yeast.

Larsen NB, Sass E, Suski C, Mankouri HW, Hickson ID.

Nat Commun. 2014 Apr 7;5:3574. doi: 10.1038/ncomms4574.

PMID:
24705096
39.

Overexpression of DNA ligase III in mitochondria protects cells against oxidative stress and improves mitochondrial DNA base excision repair.

Akbari M, Keijzers G, Maynard S, Scheibye-Knudsen M, Desler C, Hickson ID, Bohr VA.

DNA Repair (Amst). 2014 Apr;16:44-53. doi: 10.1016/j.dnarep.2014.01.015. Epub 2014 Feb 27.

40.

Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIα and RMI1.

Bocquet N, Bizard AH, Abdulrahman W, Larsen NB, Faty M, Cavadini S, Bunker RD, Kowalczykowski SC, Cejka P, Hickson ID, Thomä NH.

Nat Struct Mol Biol. 2014 Mar;21(3):261-8. doi: 10.1038/nsmb.2775. Epub 2014 Feb 9.

41.

The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4.

Yurlova L, Derks M, Buchfellner A, Hickson I, Janssen M, Morrison D, Stansfield I, Brown CJ, Ghadessy FJ, Lane DP, Rothbauer U, Zolghadr K, Krausz E.

J Biomol Screen. 2014 Apr;19(4):516-25. doi: 10.1177/1087057113518067. Epub 2014 Jan 29.

PMID:
24476585
42.

Structure-specific endonucleases: guardians of fragile site stability.

Minocherhomji S, Hickson ID.

Trends Cell Biol. 2014 May;24(5):321-7. doi: 10.1016/j.tcb.2013.11.007. Epub 2013 Dec 19. Review.

PMID:
24361091
43.

FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells.

Simandlova J, Zagelbaum J, Payne MJ, Chu WK, Shevelev I, Hanada K, Chatterjee S, Reid DA, Liu Y, Janscak P, Rothenberg E, Hickson ID.

J Biol Chem. 2013 Nov 22;288(47):34168-80. doi: 10.1074/jbc.M113.484493. Epub 2013 Oct 9.

44.

A role for BLM in double-strand break repair pathway choice: prevention of CtIP/Mre11-mediated alternative nonhomologous end-joining.

Grabarz A, Guirouilh-Barbat J, Barascu A, Pennarun G, Genet D, Rass E, Germann SM, Bertrand P, Hickson ID, Lopez BS.

Cell Rep. 2013 Oct 17;5(1):21-8. doi: 10.1016/j.celrep.2013.08.034. Epub 2013 Oct 3.

45.

How unfinished business from S-phase affects mitosis and beyond.

Mankouri HW, Huttner D, Hickson ID.

EMBO J. 2013 Oct 16;32(20):2661-71. doi: 10.1038/emboj.2013.211. Epub 2013 Sep 24. Review.

46.

Initial testing (stage 1) of the histone deacetylase inhibitor, quisinostat (JNJ-26481585), by the Pediatric Preclinical Testing Program.

Carol H, Gorlick R, Kolb EA, Morton CL, Manesh DM, Keir ST, Reynolds CP, Kang MH, Maris JM, Wozniak A, Hickson I, Lyalin D, Kurmasheva RT, Houghton PJ, Smith MA, Lock R.

Pediatr Blood Cancer. 2014 Feb;61(2):245-52. doi: 10.1002/pbc.24724. Epub 2013 Sep 4.

47.

Discovery of ML216, a Small Molecule Inhibitor of Bloom (BLM) Helicase.

Rosenthal AS, Dexheimer TS, Nguyen G, Gileadi O, Vindigni A, Simeonov A, Jadhav A, Hickson I, Maloney DJ.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Apr 15 [updated 2013 Feb 28].

48.

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase.

Rosenthal AS, Dexheimer TS, Gileadi O, Nguyen GH, Chu WK, Hickson ID, Jadhav A, Simeonov A, Maloney DJ.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5660-6. doi: 10.1016/j.bmcl.2013.08.025. Epub 2013 Aug 13.

49.

PICH: a DNA translocase specially adapted for processing anaphase bridge DNA.

Biebricher A, Hirano S, Enzlin JH, Wiechens N, Streicher WW, Huttner D, Wang LH, Nigg EA, Owen-Hughes T, Liu Y, Peterman E, Wuite GJL, Hickson ID.

Mol Cell. 2013 Sep 12;51(5):691-701. doi: 10.1016/j.molcel.2013.07.016. Epub 2013 Aug 22.

50.

MUS81 promotes common fragile site expression.

Ying S, Minocherhomji S, Chan KL, Palmai-Pallag T, Chu WK, Wass T, Mankouri HW, Liu Y, Hickson ID.

Nat Cell Biol. 2013 Aug;15(8):1001-7. doi: 10.1038/ncb2773. Epub 2013 Jun 30.

PMID:
23811685

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