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Host cell cytosolic immune response during Plasmodium liver stage development.

Agop-Nersesian C, Niklaus L, Wacker R, Heussler V.

FEMS Microbiol Rev. 2018 Feb 26. doi: 10.1093/femsre/fuy007. [Epub ahead of print]


BioID Reveals Novel Proteins of the Plasmodium Parasitophorous Vacuole Membrane.

Schnider CB, Bausch-Fluck D, Brühlmann F, Heussler VT, Burda PC.

mSphere. 2018 Jan 24;3(1). pii: e00522-17. doi: 10.1128/mSphere.00522-17. eCollection 2018 Jan-Feb.


Photosensitized INA-Labelled protein 1 (PhIL1) is novel component of the inner membrane complex and is required for Plasmodium parasite development.

Saini E, Zeeshan M, Brady D, Pandey R, Kaiser G, Koreny L, Kumar P, Thakur V, Tatiya S, Katris NJ, Limenitakis RS, Kaur I, Green JL, Bottrill AR, Guttery DS, Waller RF, Heussler V, Holder AA, Mohmmed A, Malhotra P, Tewari R.

Sci Rep. 2017 Nov 14;7(1):15577. doi: 10.1038/s41598-017-15781-z.


A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress.

Pino P, Caldelari R, Mukherjee B, Vahokoski J, Klages N, Maco B, Collins CR, Blackman MJ, Kursula I, Heussler V, Brochet M, Soldati-Favre D.

Science. 2017 Oct 27;358(6362):522-528. doi: 10.1126/science.aaf8675.


Erratum for Huber et al., "The Microtubule-Stabilizing Protein CLASP1 Associates with the Theileria annulata Schizont Surface via Its Kinetochore-Binding Domain".

Huber S, Theiler R, de Quervain D, Wiens O, Karagenc T, Heussler V, Dobbelaere D, Woods K.

mSphere. 2017 Sep 27;2(5). pii: e00413-17. doi: 10.1128/mSphere.00413-17. eCollection 2017 Sep-Oct.


Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites.

Hopp CS, Bennett BL, Mishra S, Lehmann C, Hanson KK, Lin JW, Rousseau K, Carvalho FA, van der Linden WA, Santos NC, Bogyo M, Khan SM, Heussler V, Sinnis P.

PLoS Pathog. 2017 Sep 18;13(9):e1006586. doi: 10.1371/journal.ppat.1006586. eCollection 2017 Sep.


The Microtubule-Stabilizing Protein CLASP1 Associates with the Theileria annulata Schizont Surface via Its Kinetochore-Binding Domain.

Huber S, Theiler R, de Quervain D, Wiens O, Karangenc T, Heussler V, Dobbelaere D, Woods K.

mSphere. 2017 Aug 23;2(4). pii: e00215-17. doi: 10.1128/mSphere.00215-17. eCollection 2017 Jul-Aug. Erratum in: mSphere. 2017 Sep 27;2(5):.


A Plasmodium plasma membrane reporter reveals membrane dynamics by live-cell microscopy.

Burda PC, Schaffner M, Kaiser G, Roques M, Zuber B, Heussler VT.

Sci Rep. 2017 Aug 29;7(1):9740. doi: 10.1038/s41598-017-09569-4.


Inverted recruitment of autophagy proteins to the Plasmodium berghei parasitophorous vacuole membrane.

Schmuckli-Maurer J, Reber V, Wacker R, Bindschedler A, Zakher A, Heussler VT.

PLoS One. 2017 Aug 25;12(8):e0183797. doi: 10.1371/journal.pone.0183797. eCollection 2017.


Generation of transgenic rodent malaria parasites by transfection of cell culture-derived merozoites.

Kaiser G, De Niz M, Burda PC, Niklaus L, Stanway RL, Heussler V.

Malar J. 2017 Aug 1;16(1):305. doi: 10.1186/s12936-017-1949-y.


LC3-association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a noncanonical autophagy pathway.

Wacker R, Eickel N, Schmuckli-Maurer J, Annoura T, Niklaus L, Khan SM, Guan JL, Heussler VT.

Cell Microbiol. 2017 Oct;19(10). doi: 10.1111/cmi.12754. Epub 2017 Jun 19.


Shedding of host autophagic proteins from the parasitophorous vacuolar membrane of Plasmodium berghei.

Agop-Nersesian C, De Niz M, Niklaus L, Prado M, Eickel N, Heussler VT.

Sci Rep. 2017 May 19;7(1):2191. doi: 10.1038/s41598-017-02156-7.


Manipulation of the Host Cell Membrane during Plasmodium Liver Stage Egress.

Burda PC, Caldelari R, Heussler VT.

MBio. 2017 Apr 11;8(2). pii: e00139-17. doi: 10.1128/mBio.00139-17.


Progress in imaging methods: insights gained into Plasmodium biology.

De Niz M, Burda PC, Kaiser G, Del Portillo HA, Spielmann T, Frischknecht F, Heussler VT.

Nat Rev Microbiol. 2017 Jan;15(1):37-54. doi: 10.1038/nrmicro.2016.158. Epub 2016 Nov 28. Review.


High resolution microscopy reveals an unusual architecture of the Plasmodium berghei endoplasmic reticulum.

Kaiser G, De Niz M, Zuber B, Burda PC, Kornmann B, Heussler VT, Stanway RR.

Mol Microbiol. 2016 Dec;102(5):775-791. doi: 10.1111/mmi.13490. Epub 2016 Sep 26.


Protective efficacy and safety of liver stage attenuated malaria parasites.

Kumar H, Sattler JM, Singer M, Heiss K, Reinig M, Hammerschmidt-Kamper C, Heussler V, Mueller AK, Frischknecht F.

Sci Rep. 2016 May 31;6:26824. doi: 10.1038/srep26824.


The machinery underlying malaria parasite virulence is conserved between rodent and human malaria parasites.

De Niz M, Ullrich AK, Heiber A, Blancke Soares A, Pick C, Lyck R, Keller D, Kaiser G, Prado M, Flemming S, Del Portillo H, Janse CJ, Heussler V, Spielmann T.

Nat Commun. 2016 May 26;7:11659. doi: 10.1038/ncomms11659.


An ultrasensitive NanoLuc-based luminescence system for monitoring Plasmodium berghei throughout its life cycle.

De Niz M, Stanway RR, Wacker R, Keller D, Heussler VT.

Malar J. 2016 Apr 21;15:232. doi: 10.1186/s12936-016-1291-9.


Long-term live imaging reveals cytosolic immune responses of host hepatocytes against Plasmodium infection and parasite escape mechanisms.

Prado M, Eickel N, De Niz M, Heitmann A, Agop-Nersesian C, Wacker R, Schmuckli-Maurer J, Caldelari R, Janse CJ, Khan SM, May J, Meyer CG, Heussler VT.

Autophagy. 2015;11(9):1561-79. doi: 10.1080/15548627.2015.1067361.


In vivo and in vitro characterization of a Plasmodium liver stage-specific promoter.

De Niz M, Helm S, Horstmann S, Annoura T, Del Portillo HA, Khan SM, Heussler VT.

PLoS One. 2015 Apr 15;10(4):e0123473. doi: 10.1371/journal.pone.0123473. eCollection 2015.


A Plasmodium phospholipase is involved in disruption of the liver stage parasitophorous vacuole membrane.

Burda PC, Roelli MA, Schaffner M, Khan SM, Janse CJ, Heussler VT.

PLoS Pathog. 2015 Mar 18;11(3):e1004760. doi: 10.1371/journal.ppat.1004760. eCollection 2015 Mar.


A cysteine protease inhibitor of plasmodium berghei is essential for exo-erythrocytic development.

Lehmann C, Heitmann A, Mishra S, Burda PC, Singer M, Prado M, Niklaus L, Lacroix C, Ménard R, Frischknecht F, Stanway R, Sinnis P, Heussler V.

PLoS Pathog. 2014 Aug 28;10(8):e1004336. doi: 10.1371/journal.ppat.1004336. eCollection 2014 Aug.


Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory.

Espinoza Mora MR, Steeg C, Tartz S, Heussler V, Sparwasser T, Link A, Fleischer B, Jacobs T.

PLoS One. 2014 Aug 12;9(8):e104627. doi: 10.1371/journal.pone.0104627. eCollection 2014.


Cell cycle-dependent phosphorylation of Theileria annulata schizont surface proteins.

Wiens O, Xia D, von Schubert C, Wastling JM, Dobbelaere DA, Heussler VT, Woods KL.

PLoS One. 2014 Jul 31;9(7):e103821. doi: 10.1371/journal.pone.0103821. eCollection 2014.


Imaging of the spleen in malaria.

Ferrer M, Martin-Jaular L, De Niz M, Khan SM, Janse CJ, Calvo M, Heussler V, del Portillo HA.

Parasitol Int. 2014 Feb;63(1):195-205. doi: 10.1016/j.parint.2013.08.014. Epub 2013 Aug 31. Review.


Plasmodium berghei MAPK1 displays differential and dynamic subcellular localizations during liver stage development.

Wierk JK, Langbehn A, Kamper M, Richter S, Burda PC, Heussler VT, Deschermeier C.

PLoS One. 2013;8(3):e59755. doi: 10.1371/journal.pone.0059755. Epub 2013 Mar 27.


A new approach to generate a safe double-attenuated Plasmodium liver stage vaccine.

Nagel A, Prado M, Heitmann A, Tartz S, Jacobs T, Deschermeier C, Helm S, Stanway R, Heussler V.

Int J Parasitol. 2013 May;43(6):503-14. doi: 10.1016/j.ijpara.2013.01.010. Epub 2013 Mar 13.


A key role for lipoic acid synthesis during Plasmodium liver stage development.

Falkard B, Kumar TR, Hecht LS, Matthews KA, Henrich PP, Gulati S, Lewis RE, Manary MJ, Winzeler EA, Sinnis P, Prigge ST, Heussler V, Deschermeier C, Fidock D.

Cell Microbiol. 2013 Sep;15(9):1585-604. doi: 10.1111/cmi.12137. Epub 2013 Apr 5.


Features of autophagic cell death in Plasmodium liver-stage parasites.

Eickel N, Kaiser G, Prado M, Burda PC, Roelli M, Stanway RR, Heussler VT.

Autophagy. 2013 Apr;9(4):568-80. doi: 10.4161/auto.23689. Epub 2013 Feb 6.


Plasmodium berghei sporozoite challenge of vaccinated BALB/c mice leads to the induction of humoral immunity and improved function of CD8(+) memory T cells.

Tartz S, Deschermeier C, Retzlaff S, Heussler V, Sebo P, Fleischer B, Jacobs T.

Eur J Immunol. 2013 Mar;43(3):693-704. doi: 10.1002/eji.201142262. Epub 2013 Jan 18.


Analysis of liver stage development in and merozoite release from hepatocytes.

Stanway RR, Schmuckli-Maurer J, Heussler VT.

Methods Mol Biol. 2013;923:411-27.


Evolution and architecture of the inner membrane complex in asexual and sexual stages of the malaria parasite.

Kono M, Herrmann S, Loughran NB, Cabrera A, Engelberg K, Lehmann C, Sinha D, Prinz B, Ruch U, Heussler V, Spielmann T, Parkinson J, Gilberger TW.

Mol Biol Evol. 2012 Sep;29(9):2113-32. doi: 10.1093/molbev/mss081. Epub 2012 Mar 3.


Nematode-induced interference with the anti-Plasmodium CD8+ T-cell response can be overcome by optimizing antigen administration.

Kolbaum J, Tartz S, Hartmann W, Helm S, Nagel A, Heussler V, Sebo P, Fleischer B, Jacobs T, Breloer M.

Eur J Immunol. 2012 Apr;42(4):890-900. doi: 10.1002/eji.201141955. Epub 2012 Jan 19.


Mitochondrial lipoic acid scavenging is essential for Plasmodium berghei liver stage development.

Deschermeier C, Hecht LS, Bach F, Rützel K, Stanway RR, Nagel A, Seeber F, Heussler VT.

Cell Microbiol. 2012 Mar;14(3):416-30. doi: 10.1111/j.1462-5822.2011.01729.x. Epub 2012 Feb 9.


The macromolecular complex of ICP and falcipain-2 from Plasmodium: preparation, crystallization and preliminary X-ray diffraction analysis.

Hansen G, Schwarzloh B, Rennenberg A, Heussler VT, Hilgenfeld R.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1406-10. doi: 10.1107/S1744309111034592. Epub 2011 Oct 27.


Chronicle of a death foretold: Plasmodium liver stage parasites decide on the fate of the host cell.

Graewe S, Stanway RR, Rennenberg A, Heussler VT.

FEMS Microbiol Rev. 2012 Jan;36(1):111-30. doi: 10.1111/j.1574-6976.2011.00297.x. Epub 2011 Aug 9. Review.


Hostile takeover by Plasmodium: reorganization of parasite and host cell membranes during liver stage egress.

Graewe S, Rankin KE, Lehmann C, Deschermeier C, Hecht L, Froehlke U, Stanway RR, Heussler V.

PLoS Pathog. 2011 Sep;7(9):e1002224. doi: 10.1371/journal.ppat.1002224. Epub 2011 Sep 1.


Organelle segregation into Plasmodium liver stage merozoites.

Stanway RR, Mueller N, Zobiak B, Graewe S, Froehlke U, Zessin PJ, Aepfelbacher M, Heussler VT.

Cell Microbiol. 2011 Nov;13(11):1768-82. doi: 10.1111/j.1462-5822.2011.01657.x. Epub 2011 Aug 31.


Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium.

Hansen G, Heitmann A, Witt T, Li H, Jiang H, Shen X, Heussler VT, Rennenberg A, Hilgenfeld R.

Structure. 2011 Jul 13;19(7):919-29. doi: 10.1016/j.str.2011.03.025.


Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes.

Sicard A, Semblat JP, Doerig C, Hamelin R, Moniatte M, Dorin-Semblat D, Spicer JA, Srivastava A, Retzlaff S, Heussler V, Waters AP, Doerig C.

Cell Microbiol. 2011 Jun;13(6):836-45. doi: 10.1111/j.1462-5822.2011.01582.x. Epub 2011 Mar 4.


Identification and characterization of a liver stage-specific promoter region of the malaria parasite Plasmodium.

Helm S, Lehmann C, Nagel A, Stanway RR, Horstmann S, Llinas M, Heussler VT.

PLoS One. 2010 Oct 27;5(10):e13653. doi: 10.1371/journal.pone.0013653.


Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb/c mice facilitates adherence and spleen macrophage-clearance escape.

Martin-Jaular L, Ferrer M, Calvo M, Rosanas-Urgell A, Kalko S, Graewe S, Soria G, Cortadellas N, Ordi J, Planas A, Burns J, Heussler V, del Portillo HA.

Cell Microbiol. 2011 Jan;13(1):109-22. doi: 10.1111/j.1462-5822.2010.01523.x. Epub 2010 Oct 1.


Programmed cell death in unicellular parasites: a prerequisite for sustained infection?

van Zandbergen G, Lüder CG, Heussler V, Duszenko M.

Trends Parasitol. 2010 Oct;26(10):477-83. doi: 10.1016/ Epub 2010 Jun 28.


Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes.

Rennenberg A, Lehmann C, Heitmann A, Witt T, Hansen G, Nagarajan K, Deschermeier C, Turk V, Hilgenfeld R, Heussler VT.

PLoS Pathog. 2010 Mar 26;6(3):e1000825. doi: 10.1371/journal.ppat.1000825.


Imaging liver-stage malaria parasites.

Rankin KE, Graewe S, Heussler VT, Stanway RR.

Cell Microbiol. 2010 May 1;12(5):569-79. doi: 10.1111/j.1462-5822.2010.01454.x. Epub 2010 Feb 19. Review.


The Plasmodium serine-type SERA proteases display distinct expression patterns and non-essential in vivo roles during life cycle progression of the malaria parasite.

Putrianti ED, Schmidt-Christensen A, Arnold I, Heussler VT, Matuschewski K, Silvie O.

Cell Microbiol. 2010 Jun;12(6):725-39. doi: 10.1111/j.1462-5822.2009.01419.x. Epub 2009 Dec 21.


Host cell death induced by the egress of intracellular Plasmodium parasites.

Heussler V, Rennenberg A, Stanway R.

Apoptosis. 2010 Mar;15(3):376-85. doi: 10.1007/s10495-009-0435-6. Review.


Signalling in malaria parasites. The MALSIG consortium.

Doerig C, Baker D, Billker O, Blackman MJ, Chitnis C, Dhar Kumar S, Heussler V, Holder AA, Kocken C, Krishna S, Langsley G, Lasonder E, Menard R, Meissner M, Pradel G, Ranford-Cartwright L, Sharma A, Sharma P, Tardieux T, Tatu U, Alano P.

Parasite. 2009 Sep;16(3):169-82. Review.


Highly efficient subcloning of rodent malaria parasites by injection of single merosomes or detached cells.

Stanway RR, Graewe S, Rennenberg A, Helm S, Heussler VT.

Nat Protoc. 2009;4(10):1433-9. doi: 10.1038/nprot.2009.172. Epub 2009 Sep 10.


Going live: a comparative analysis of the suitability of the RFP derivatives RedStar, mCherry and tdTomato for intravital and in vitro live imaging of Plasmodium parasites.

Graewe S, Retzlaff S, Struck N, Janse CJ, Heussler VT.

Biotechnol J. 2009 Jun;4(6):895-902. doi: 10.1002/biot.200900035.


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