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Items: 17

1.

Single-Cell Dynamics Determines Response to CDK4/6 Inhibition in Triple-Negative Breast Cancer.

Asghar US, Barr AR, Cutts R, Beaney M, Babina I, Sampath D, Giltnane J, Lacap JA, Crocker L, Young A, Pearson A, Herrera-Abreu MT, Bakal C, Turner NC.

Clin Cancer Res. 2017 Sep 15;23(18):5561-5572. doi: 10.1158/1078-0432.CCR-17-0369. Epub 2017 Jun 12.

PMID:
28606920
2.

High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial.

Pearson A, Smyth E, Babina IS, Herrera-Abreu MT, Tarazona N, Peckitt C, Kilgour E, Smith NR, Geh C, Rooney C, Cutts R, Campbell J, Ning J, Fenwick K, Swain A, Brown G, Chua S, Thomas A, Johnston SRD, Ajaz M, Sumpter K, Gillbanks A, Watkins D, Chau I, Popat S, Cunningham D, Turner NC.

Cancer Discov. 2016 Aug;6(8):838-851. doi: 10.1158/2159-8290.CD-15-1246. Epub 2016 May 13.

3.

Early Adaptation and Acquired Resistance to CDK4/6 Inhibition in Estrogen Receptor-Positive Breast Cancer.

Herrera-Abreu MT, Palafox M, Asghar U, Rivas MA, Cutts RJ, Garcia-Murillas I, Pearson A, Guzman M, Rodriguez O, Grueso J, Bellet M, Cortés J, Elliott R, Pancholi S, Baselga J, Dowsett M, Martin LA, Turner NC, Serra V.

Cancer Res. 2016 Apr 15;76(8):2301-13. doi: 10.1158/0008-5472.CAN-15-0728. Epub 2016 Mar 28. Erratum in: Cancer Res. 2016 Oct 1;76(19):5907.

4.

Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways.

Aarts M, Bajrami I, Herrera-Abreu MT, Elliott R, Brough R, Ashworth A, Lord CJ, Turner NC.

Mol Cancer Ther. 2015 Apr;14(4):865-76. doi: 10.1158/1535-7163.MCT-14-0845. Epub 2015 Feb 11.

5.

Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer.

Herrera-Abreu MT, Pearson A, Campbell J, Shnyder SD, Knowles MA, Ashworth A, Turner NC.

Cancer Discov. 2013 Sep;3(9):1058-71. doi: 10.1158/2159-8290.CD-12-0569. Epub 2013 Jun 6.

6.

Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.

Bai SW, Herrera-Abreu MT, Rohn JL, Racine V, Tajadura V, Suryavanshi N, Bechtel S, Wiemann S, Baum B, Ridley AJ.

BMC Biol. 2011 Aug 11;9:54. doi: 10.1186/1741-7007-9-54.

7.

FGFR signaling promotes the growth of triple-negative and basal-like breast cancer cell lines both in vitro and in vivo.

Sharpe R, Pearson A, Herrera-Abreu MT, Johnson D, Mackay A, Welti JC, Natrajan R, Reynolds AR, Reis-Filho JS, Ashworth A, Turner NC.

Clin Cancer Res. 2011 Aug 15;17(16):5275-86. doi: 10.1158/1078-0432.CCR-10-2727. Epub 2011 Jun 28.

8.

Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation.

Herrera Abreu MT, Hughes WE, Mele K, Lyons RJ, Rickwood D, Browne BC, Bennett HL, Vallotton P, Brummer T, Daly RJ.

Mol Biol Cell. 2011 Jan 1;22(1):105-16. doi: 10.1091/mbc.E10-03-0185. Epub 2010 Nov 30.

9.

Protein-tyrosine phosphatase-alpha and Src functionally link focal adhesions to the endoplasmic reticulum to mediate interleukin-1-induced Ca2+ signaling.

Wang Q, Rajshankar D, Branch DR, Siminovitch KA, Herrera Abreu MT, Downey GP, McCulloch CA.

J Biol Chem. 2009 Jul 31;284(31):20763-72. doi: 10.1074/jbc.M808828200. Epub 2009 Jun 3. Erratum in: J Biol Chem. 2009 Sep 25;284(39):27020.

10.

Experimental ventilator-induced lung injury: exacerbation by positive end-expiratory pressure.

Villar J, Herrera-Abreu MT, Valladares F, Muros M, Pérez-Méndez L, Flores C, Kacmarek RM.

Anesthesiology. 2009 Jun;110(6):1341-7. doi: 10.1097/ALN.0b013e31819fcba9.

PMID:
19417614
11.

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

Brummer T, Larance M, Herrera Abreu MT, Lyons RJ, Timpson P, Emmerich CH, Fleuren ED, Lehrbach GM, Schramek D, Guilhaus M, James DE, Daly RJ.

EMBO J. 2008 Sep 3;27(17):2305-16.

12.

Tyrosine phosphatase PTPalpha regulates focal adhesion remodeling through Rac1 activation.

Herrera Abreu MT, Penton PC, Kwok V, Vachon E, Shalloway D, Vidali L, Lee W, McCulloch CA, Downey GP.

Am J Physiol Cell Physiol. 2008 Apr;294(4):C931-44. doi: 10.1152/ajpcell.00359.2007. Epub 2008 Jan 23.

13.

Phosphorylation of SHP-2 regulates interactions between the endoplasmic reticulum and focal adhesions to restrict interleukin-1-induced Ca2+ signaling.

Wang Q, Herrera Abreu MT, Siminovitch K, Downey GP, McCulloch CA.

J Biol Chem. 2006 Oct 13;281(41):31093-105. Epub 2006 Aug 11.

14.

Tyrosine phosphatase SHP-2 regulates IL-1 signaling in fibroblasts through focal adhesions.

Herrera Abreu MT, Wang Q, Vachon E, Suzuki T, Chow CW, Wang Y, Hong O, Villar J, McCulloch CA, Downey GP.

J Cell Physiol. 2006 Apr;207(1):132-43.

PMID:
16250012
15.

SHP-2 modulates interleukin-1-induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1.

Wang Q, Downey GP, Herrera-Abreu MT, Kapus A, McCulloch CA.

J Biol Chem. 2005 Mar 4;280(9):8397-406. Epub 2004 Nov 24.

16.

Oxidative stress and acute lung injury.

Chow CW, Herrera Abreu MT, Suzuki T, Downey GP.

Am J Respir Cell Mol Biol. 2003 Oct;29(4):427-31. Review. No abstract available.

PMID:
14500253
17.

The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts.

MacGillivray M, Herrera-Abreu MT, Chow CW, Shek C, Wang Q, Vachon E, Feng GS, Siminovitch KA, McCulloch CA, Downey GP.

J Biol Chem. 2003 Jul 18;278(29):27190-8. Epub 2003 Apr 29.

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