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Transforming Growth Factor-β1/Activin Receptor-like Kinase 5-Mediated Cell Migration is Dependent on the Protein Proteinase-Activated Receptor 2 but not on Proteinase-Activated Receptor 2-Stimulated Gq-Calcium Signaling.

Ungefroren H, Witte D, Mihara K, Rauch BH, Henklein P, Jöhren O, Bonni S, Settmacher U, Lehnert H, Hollenberg MD, Kaufmann R, Gieseler F.

Mol Pharmacol. 2017 Nov;92(5):519-532. doi: 10.1124/mol.117.109017. Epub 2017 Aug 25.


Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection.

Platteel ACM, Liepe J, Textoris-Taube K, Keller C, Henklein P, Schalkwijk HH, Cardoso R, Kloetzel PM, Mishto M, Sijts AJAM.

Cell Rep. 2017 Aug 1;20(5):1242-1253. doi: 10.1016/j.celrep.2017.07.026.


Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner.

Hahn F, Schmalen A, Setz C, Friedrich M, Schlößer S, Kölle J, Spranger R, Rauch P, Fraedrich K, Reif T, Karius-Fischer J, Balasubramanyam A, Henklein P, Fossen T, Schubert U.

PLoS One. 2017 Apr 7;12(4):e0174254. doi: 10.1371/journal.pone.0174254. eCollection 2017.


Proteinase-activated receptor 2 (PAR2) in hepatic stellate cells - evidence for a role in hepatocellular carcinoma growth in vivo.

Mußbach F, Ungefroren H, Günther B, Katenkamp K, Henklein P, Westermann M, Settmacher U, Lenk L, Sebens S, Müller JP, Böhmer FD, Kaufmann R.

Mol Cancer. 2016 Jul 29;15(1):54. doi: 10.1186/s12943-016-0538-y.


Glutamic Acid Residues in HIV-1 p6 Regulate Virus Budding and Membrane Association of Gag.

Friedrich M, Setz C, Hahn F, Matthaei A, Fraedrich K, Rauch P, Henklein P, Traxdorf M, Fossen T, Schubert U.

Viruses. 2016 Apr 25;8(4):117. doi: 10.3390/v8040117.


Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.

Ebstein F, Textoris-Taube K, Keller C, Golnik R, Vigneron N, Van den Eynde BJ, Schuler-Thurner B, Schadendorf D, Lorenz FK, Uckert W, Urban S, Lehmann A, Albrecht-Koepke N, Janek K, Henklein P, Niewienda A, Kloetzel PM, Mishto M.

Sci Rep. 2016 Apr 6;6:24032. doi: 10.1038/srep24032.


The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing.

Textoris-Taube K, Keller C, Liepe J, Henklein P, Sidney J, Sette A, Kloetzel PM, Mishto M.

J Biol Chem. 2015 Dec 18;290(51):30417-28. doi: 10.1074/jbc.M115.695189. Epub 2015 Oct 27.


The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.

Keller M, Ebstein F, Bürger E, Textoris-Taube K, Gorny X, Urban S, Zhao F, Dannenberg T, Sucker A, Keller C, Saveanu L, Krüger E, Rothkötter HJ, Dahlmann B, Henklein P, Voigt A, Kuckelkorn U, Paschen A, Kloetzel PM, Seifert U.

Eur J Immunol. 2015 Dec;45(12):3257-68. doi: 10.1002/eji.201445243. Epub 2015 Oct 19.


The native structure of annexin A2 peptides in hydrophilic environment determines their anti-angiogenic effects.

Raddum AM, Hollås H, Shumilin IA, Henklein P, Kretsinger R, Fossen T, Vedeler A.

Biochem Pharmacol. 2015 May 1;95(1):1-15. doi: 10.1016/j.bcp.2015.02.013. Epub 2015 Mar 13.


Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model.

Mlynarczuk-Bialy I, Doeppner TR, Golab J, Nowis D, Wilczynski GM, Parobczak K, Wigand ME, Hajdamowicz M, Biały LP, Aniolek O, Henklein P, Bähr M, Schmidt B, Kuckelkorn U, Kloetzel PM.

Transl Oncol. 2014 Oct 24;7(5):570-9. doi: 10.1016/j.tranon.2014.07.002. eCollection 2014 Oct.


Proteinase-activated receptor 1- and 4-promoted migration of Hep3B hepatocellular carcinoma cells depends on ROS formation and RTK transactivation.

Mußbach F, Henklein P, Westermann M, Settmacher U, Böhmer FD, Kaufmann R.

J Cancer Res Clin Oncol. 2015 May;141(5):813-25. doi: 10.1007/s00432-014-1863-4. Epub 2014 Nov 6.


Development of peptidyl lysine dendrons: 1,3-dipolar cycloaddition for peptide coupling and antibody recognition.

Hüttl C, Hettrich C, Riedel M, Henklein P, Rawel H, Bier FF.

Chem Biol Drug Des. 2015 May;85(5):565-73. doi: 10.1111/cbdd.12444. Epub 2014 Oct 28.


Mutation of the highly conserved Ser-40 of the HIV-1 p6 gag protein to Phe causes the formation of a hydrophobic patch, enhances membrane association, and polyubiquitination of Gag.

Hahn F, Setz C, Friedrich M, Rauch P, Solbak SM, Frøystein NA, Henklein P, Votteler J, Fossen T, Schubert U.

Viruses. 2014 Oct 2;6(10):3738-65. doi: 10.3390/v6103738.


Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation.

Mishto M, Liepe J, Textoris-Taube K, Keller C, Henklein P, Weberruß M, Dahlmann B, Enenkel C, Voigt A, Kuckelkorn U, Stumpf MP, Kloetzel PM.

Eur J Immunol. 2014 Dec;44(12):3508-21. doi: 10.1002/eji.201444902. Epub 2014 Nov 20.


Therapeutic potential of larval excretory/secretory proteins of the pig whipworm Trichuris suis in allergic disease.

Ebner F, Hepworth MR, Rausch S, Janek K, Niewienda A, Kühl A, Henklein P, Lucius R, Hamelmann E, Hartmann S.

Allergy. 2014 Nov;69(11):1489-97. doi: 10.1111/all.12496. Epub 2014 Sep 6.


Inhibition of Helicobacter pylori urease activity in vivo by the synthetic nickel binding protein Hpn.

Heyl KA, Fischer A, Göbel UB, Henklein P, Heimesaat MM, Bereswill S.

Eur J Microbiol Immunol (Bp). 2013 Mar;3(1):77-80. doi: 10.1556/EuJMI.3.2013.1.11. Epub 2013 Mar 13.


Self-assembled peptide amphiphiles function as multivalent binder with increased hemagglutinin affinity.

Hüttl C, Hettrich C, Miller R, Paulke BR, Henklein P, Rawel H, Bier FF.

BMC Biotechnol. 2013 Jun 18;13:51. doi: 10.1186/1472-6750-13-51.


Assembling an ion channel: ORF 3a from SARS-CoV.

Chien TH, Chiang YL, Chen CP, Henklein P, Hänel K, Hwang IS, Willbold D, Fischer WB.

Biopolymers. 2013 Sep;99(9):628-35. doi: 10.1002/bip.22230.


Influenza A virus protein PB1-F2 from different strains shows distinct structural signatures.

Solbak SM, Sharma A, Bruns K, Röder R, Mitzner D, Hahn F, Niebert R, Vedeler A, Henklein P, Henklein P, Schubert U, Wray V, Fossen T.

Biochim Biophys Acta. 2013 Feb;1834(2):568-82. doi: 10.1016/j.bbapap.2012.11.009. Epub 2012 Dec 7.


HIV-1 p6 - a structured to flexible multifunctional membrane-interacting protein.

Solbak SM, Reksten TR, Hahn F, Wray V, Henklein P, Henklein P, Halskau Ø, Schubert U, Fossen T.

Biochim Biophys Acta. 2013 Feb;1828(2):816-23. doi: 10.1016/j.bbamem.2012.11.010. Epub 2012 Nov 19.


Facile synthesis of colorimetric histone deacetylase substrates.

Dose A, Jost JO, Spieß AC, Henklein P, Beyermann M, Schwarzer D.

Chem Commun (Camb). 2012 Oct 4;48(76):9525-7. doi: 10.1039/c2cc34422j.


Proteinase-activated receptor 2 (PAR(2)) in cholangiocarcinoma (CCA) cells: effects on signaling and cellular level.

Kaufmann R, Hascher A, Mussbach F, Henklein P, Katenkamp K, Westermann M, Settmacher U.

Histochem Cell Biol. 2012 Dec;138(6):913-24. doi: 10.1007/s00418-012-1006-4. Epub 2012 Aug 15.


Driving forces of proteasome-catalyzed peptide splicing in yeast and humans.

Mishto M, Goede A, Taube KT, Keller C, Janek K, Henklein P, Niewienda A, Kloss A, Gohlke S, Dahlmann B, Enenkel C, Kloetzel PM.

Mol Cell Proteomics. 2012 Oct;11(10):1008-23. Epub 2012 Jul 20.


The efficiency of human cytomegalovirus pp65(495-503) CD8+ T cell epitope generation is determined by the balanced activities of cytosolic and endoplasmic reticulum-resident peptidases.

Urban S, Textoris-Taube K, Reimann B, Janek K, Dannenberg T, Ebstein F, Seifert C, Zhao F, Kessler JH, Halenius A, Henklein P, Paschke J, Cadel S, Bernhard H, Ossendorp F, Foulon T, Schadendorf D, Paschen A, Seifert U.

J Immunol. 2012 Jul 15;189(2):529-38. doi: 10.4049/jimmunol.1101886. Epub 2012 Jun 15.


Mapping of O-GlcNAc sites of 20 S proteasome subunits and Hsp90 by a novel biotin-cystamine tag.

Overath T, Kuckelkorn U, Henklein P, Strehl B, Bonar D, Kloss A, Siele D, Kloetzel PM, Janek K.

Mol Cell Proteomics. 2012 Aug;11(8):467-77. doi: 10.1074/mcp.M111.015966. Epub 2012 May 3.


HIV-1 p6-Another viral interaction partner to the host cellular protein cyclophilin A.

Solbak SM, Reksten TR, Röder R, Wray V, Horvli O, Raae AJ, Henklein P, Henklein P, Fossen T.

Biochim Biophys Acta. 2012 Apr;1824(4):667-78. doi: 10.1016/j.bbapap.2012.02.002. Epub 2012 Feb 9.


The host-pathogen interaction of human cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains.

Solbak SM, Wray V, Horvli O, Raae AJ, Flydal MI, Henklein P, Henklein P, Nimtz M, Schubert U, Fossen T.

BMC Struct Biol. 2011 Dec 20;11:49. doi: 10.1186/1472-6807-11-49.


An optimized MM/PBSA virtual screening approach applied to an HIV-1 gp41 fusion peptide inhibitor.

Venken T, Krnavek D, Münch J, Kirchhoff F, Henklein P, De Maeyer M, Voet A.

Proteins. 2011 Nov;79(11):3221-35. doi: 10.1002/prot.23158. Epub 2011 Aug 30.


Highly conserved serine residue 40 in HIV-1 p6 regulates capsid processing and virus core assembly.

Votteler J, Neumann L, Hahn S, Hahn F, Rauch P, Schmidt K, Studtrucker N, Solbak SM, Fossen T, Henklein P, Ott DE, Holland G, Bannert N, Schubert U.

Retrovirology. 2011 Feb 16;8:11. doi: 10.1186/1742-4690-8-11.


Proteinase-activated receptor 2-mediated calcium signaling in hepatocellular carcinoma cells.

Kaufmann R, Mussbach F, Henklein P, Settmacher U.

J Cancer Res Clin Oncol. 2011 Jun;137(6):965-73. doi: 10.1007/s00432-010-0961-1. Epub 2010 Dec 2.


The intriguing cyclophilin A-HIV-1 Vpr interaction: prolyl cis/trans isomerisation catalysis and specific binding.

Solbak SM, Reksten TR, Wray V, Bruns K, Horvli O, Raae AJ, Henklein P, Henklein P, Röder R, Mitzner D, Schubert U, Fossen T.

BMC Struct Biol. 2010 Oct 4;10:31. doi: 10.1186/1472-6807-10-31.


ORF8a of SARS-CoV forms an ion channel: experiments and molecular dynamics simulations.

Chen CC, Krüger J, Sramala I, Hsu HJ, Henklein P, Chen YM, Fischer WB.

Biochim Biophys Acta. 2011 Feb;1808(2):572-9. doi: 10.1016/j.bbamem.2010.08.004. Epub 2010 Aug 12.


The 20S proteasome splicing activity discovered by SpliceMet.

Liepe J, Mishto M, Textoris-Taube K, Janek K, Keller C, Henklein P, Kloetzel PM, Zaikin A.

PLoS Comput Biol. 2010 Jun 24;6(6):e1000830. doi: 10.1371/journal.pcbi.1000830.


Easy strategy to protect antimicrobial peptides from fast degradation in serum.

Knappe D, Henklein P, Hoffmann R, Hilpert K.

Antimicrob Agents Chemother. 2010 Sep;54(9):4003-5. doi: 10.1128/AAC.00300-10. Epub 2010 Jun 28.


The proapoptotic influenza A virus protein PB1-F2 forms a nonselective ion channel.

Henkel M, Mitzner D, Henklein P, Meyer-Almes FJ, Moroni A, Difrancesco ML, Henkes LM, Kreim M, Kast SM, Schubert U, Thiel G.

PLoS One. 2010 Jun 15;5(6):e11112. doi: 10.1371/journal.pone.0011112.


A photo-cross-linking strategy to map sites of protein-protein interactions.

Chen Y, Wu Y, Henklein P, Li X, Hofmann KP, Nakanishi K, Ernst OP.

Chemistry. 2010 Jul 5;16(25):7389-94. doi: 10.1002/chem.201000441. No abstract available.


An unlocking/relocking barrier in conformational fluctuations of villin headpiece subdomain.

Reiner A, Henklein P, Kiefhaber T.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4955-60. doi: 10.1073/pnas.0910001107. Epub 2010 Mar 1.


Solution structure of the equine infectious anemia virus p9 protein: a rationalization of its different ALIX binding requirements compared to the analogous HIV-p6 protein.

Sharma A, Bruns K, Röder R, Henklein P, Votteler J, Wray V, Schubert U.

BMC Struct Biol. 2009 Dec 17;9:74. doi: 10.1186/1472-6807-9-74.


Generation of in silico predicted coxsackievirus B3-derived MHC class I epitopes by proteasomes.

Voigt A, Jäkel S, Textoris-Taube K, Keller C, Drung I, Szalay G, Klingel K, Henklein P, Stangl K, Kloetzel PM, Kuckelkorn U.

Amino Acids. 2010 Jun;39(1):243-55. doi: 10.1007/s00726-009-0434-5. Epub 2009 Dec 9.


On the use of N-dicyclopropylmethyl aspartyl-glycine synthone for backbone amide protection.

Röder R, Henklein P, Weisshoff H, Mügge C, Pätzel M, Schubert U, Carpino LA, Henklein P.

J Pept Sci. 2010 Jan;16(1):65-70. doi: 10.1002/psc.1196.


Helix formation in arrestin accompanies recognition of photoactivated rhodopsin.

Feuerstein SE, Pulvermüller A, Hartmann R, Granzin J, Stoldt M, Henklein P, Ernst OP, Heck M, Willbold D, Koenig BW.

Biochemistry. 2009 Nov 17;48(45):10733-42. doi: 10.1021/bi900544p.


Dicyclopropylmethyl peptide backbone protectant.

Carpino LA, Nasr K, Abdel-Maksoud AA, El-Faham A, Ionescu D, Henklein P, Wenschuh H, Beyermann M, Krause E, Bienert M.

Org Lett. 2009 Aug 20;11(16):3718-21. doi: 10.1021/ol901310q.


Inhibiting the inhibitors: retro-inverso Smac peptides.

Hossbach J, Michalsky E, Henklein P, Jaeger M, Daniel PT, Preissner R.

Peptides. 2009 Dec;30(12):2374-9. doi: 10.1016/j.peptides.2009.08.001. Epub 2009 Aug 12.


Modulating the activity of the channel-forming segment of Vpr protein from HIV-1.

Chen CP, Kremer C, Henklein P, Schubert U, Fink RH, Fischer WB.

Eur Biophys J. 2010 Jun;39(7):1089-95. doi: 10.1007/s00249-009-0518-x. Epub 2009 Jul 24.


Exogenous HIV-1 Vpr disrupts IFN-alpha response by plasmacytoid dendritic cells (pDCs) and subsequent pDC/NK interplay.

Hong HS, Bhatnagar N, Ballmaier M, Schubert U, Henklein P, Volgmann T, Heiken H, Schmidt RE, Meyer-Olson D.

Immunol Lett. 2009 Aug 15;125(2):100-4. doi: 10.1016/j.imlet.2009.06.008. Epub 2009 Jun 25.


Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion.

Kaufmann R, Oettel C, Horn A, Halbhuber KJ, Eitner A, Krieg R, Katenkamp K, Henklein P, Westermann M, Böhmer FD, Ramachandran R, Saifeddine M, Hollenberg MD, Settmacher U.

Carcinogenesis. 2009 Sep;30(9):1487-96. doi: 10.1093/carcin/bgp153. Epub 2009 Jun 22.


Phosphorylation of the influenza A virus protein PB1-F2 by PKC is crucial for apoptosis promoting functions in monocytes.

Mitzner D, Dudek SE, Studtrucker N, Anhlan D, Mazur I, Wissing J, Jänsch L, Wixler L, Bruns K, Sharma A, Wray V, Henklein P, Ludwig S, Schubert U.

Cell Microbiol. 2009 Oct;11(10):1502-16. doi: 10.1111/j.1462-5822.2009.01343.x. Epub 2009 Jun 11.


The Dcpm protecting group is a useful alternative to the Hmb residue.

Henklein P, Röder R, Weisshoff H, Henklein P, Carpino LA.

Adv Exp Med Biol. 2009;611:247-8. No abstract available.


Screening and characterization of surface-tethered cationic peptides for antimicrobial activity.

Hilpert K, Elliott M, Jenssen H, Kindrachuk J, Fjell CD, Körner J, Winkler DF, Weaver LL, Henklein P, Ulrich AS, Chiang SH, Farmer SW, Pante N, Volkmer R, Hancock RE.

Chem Biol. 2009 Jan 30;16(1):58-69. doi: 10.1016/j.chembiol.2008.11.006.

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