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Items: 1 to 50 of 98

1.

SIL1, the endoplasmic-reticulum-localized BiP co-chaperone, plays a crucial role in maintaining skeletal muscle proteostasis and physiology.

Ichhaporia VP, Kim J, Kavdia K, Vogel P, Horner L, Frase S, Hendershot LM.

Dis Model Mech. 2018 May 10;11(5). pii: dmm033043. doi: 10.1242/dmm.033043.

2.

Members of the Hsp70 Family Recognize Distinct Types of Sequences to Execute ER Quality Control.

Behnke J, Mann MJ, Scruggs FL, Feige MJ, Hendershot LM.

Mol Cell. 2016 Sep 1;63(5):739-52. doi: 10.1016/j.molcel.2016.07.012. Epub 2016 Aug 18.

3.

The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.

Joo JH, Wang B, Frankel E, Ge L, Xu L, Iyengar R, Li-Harms X, Wright C, Shaw TI, Lindsten T, Green DR, Peng J, Hendershot LM, Kilic F, Sze JY, Audhya A, Kundu M.

Mol Cell. 2016 Jun 16;62(6):982. doi: 10.1016/j.molcel.2016.05.030. Epub 2016 Jun 16. No abstract available.

4.

The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis.

Joo JH, Wang B, Frankel E, Ge L, Xu L, Iyengar R, Li-Harms X, Wright C, Shaw TI, Lindsten T, Green DR, Peng J, Hendershot LM, Kilic F, Sze JY, Audhya A, Kundu M.

Mol Cell. 2016 May 19;62(4):491-506. doi: 10.1016/j.molcel.2016.04.020. Erratum in: Mol Cell. 2016 Jun 16;62(6):982.

5.

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker.

Preissler S, Chambers JE, Crespillo-Casado A, Avezov E, Miranda E, Perez J, Hendershot LM, Harding HP, Ron D.

Elife. 2015 Oct 16;4:e08961. doi: 10.7554/eLife.08961.

6.

Dimerization-dependent folding underlies assembly control of the clonotypic αβT cell receptor chains.

Feige MJ, Behnke J, Mittag T, Hendershot LM.

J Biol Chem. 2015 Oct 30;290(44):26821-31. doi: 10.1074/jbc.M115.689471. Epub 2015 Sep 23.

7.

BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions.

Behnke J, Feige MJ, Hendershot LM.

J Mol Biol. 2015 Apr 10;427(7):1589-608. doi: 10.1016/j.jmb.2015.02.011. Epub 2015 Feb 16. Review.

8.

Sil1, a nucleotide exchange factor for BiP, is not required for antibody assembly or secretion.

Ichhaporia VP, Sanford T, Howes J, Marion TN, Hendershot LM.

Mol Biol Cell. 2015 Feb 1;26(3):420-9. doi: 10.1091/mbc.E14-09-1392. Epub 2014 Dec 3.

9.

Dissection of structural and functional requirements that underlie the interaction of ERdj3 protein with substrates in the endoplasmic reticulum.

Otero JH, Lizák B, Feige MJ, Hendershot LM.

J Biol Chem. 2014 Oct 3;289(40):27504-12. doi: 10.1074/jbc.M114.587147. Epub 2014 Aug 20.

10.

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins.

Feige MJ, Gräwert MA, Marcinowski M, Hennig J, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J.

Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8155-60. doi: 10.1073/pnas.1321502111. Epub 2014 May 15.

11.

Herp coordinates compartmentalization and recruitment of HRD1 and misfolded proteins for ERAD.

Leitman J, Shenkman M, Gofman Y, Shtern NO, Ben-Tal N, Hendershot LM, Lederkremer GZ.

Mol Biol Cell. 2014 Apr;25(7):1050-60. doi: 10.1091/mbc.E13-06-0350. Epub 2014 Jan 29.

12.
13.

The large Hsp70 Grp170 binds to unfolded protein substrates in vivo with a regulation distinct from conventional Hsp70s.

Behnke J, Hendershot LM.

J Biol Chem. 2014 Jan 31;289(5):2899-907. doi: 10.1074/jbc.M113.507491. Epub 2013 Dec 10.

14.

Quality control of integral membrane proteins by assembly-dependent membrane integration.

Feige MJ, Hendershot LM.

Mol Cell. 2013 Aug 8;51(3):297-309. doi: 10.1016/j.molcel.2013.07.013.

15.

Examination of a second node of translational control in the unfolded protein response.

Preston AM, Hendershot LM.

J Cell Sci. 2013 Sep 15;126(Pt 18):4253-61. doi: 10.1242/jcs.130336. Epub 2013 Jul 10.

16.

Acidification activates ERp44--a molecular litmus test for protein assembly.

Hendershot LM, Feige MJ, Buchner J.

Mol Cell. 2013 Jun 27;50(6):779-81. doi: 10.1016/j.molcel.2013.06.008.

17.

A shared endoplasmic reticulum-associated degradation pathway involving the EDEM1 protein for glycosylated and nonglycosylated proteins.

Shenkman M, Groisman B, Ron E, Avezov E, Hendershot LM, Lederkremer GZ.

J Biol Chem. 2013 Jan 25;288(4):2167-78. doi: 10.1074/jbc.M112.438275. Epub 2012 Dec 11.

18.

UPR-induced resistance to etoposide is downstream of PERK and independent of changes in topoisomerase IIα levels.

Mann MJ, Pereira ER, Liao N, Hendershot LM.

PLoS One. 2012;7(10):e47931. doi: 10.1371/journal.pone.0047931. Epub 2012 Oct 29.

19.

ERdj4 protein is a soluble endoplasmic reticulum (ER) DnaJ family protein that interacts with ER-associated degradation machinery.

Lai CW, Otero JH, Hendershot LM, Snapp E.

J Biol Chem. 2012 Mar 9;287(11):7969-78. doi: 10.1074/jbc.M111.311290. Epub 2012 Jan 20.

20.

C-terminal mutations destabilize SIL1/BAP and can cause Marinesco-Sjögren syndrome.

Howes J, Shimizu Y, Feige MJ, Hendershot LM.

J Biol Chem. 2012 Mar 9;287(11):8552-60. doi: 10.1074/jbc.M111.333286. Epub 2012 Jan 4.

21.

Intra-Golgi formation of IgM-glycosaminoglycan complexes promotes Ig deposition.

Khan SN, Cox JV, Nishimoto SK, Chen C, Fritzler MJ, Hendershot LM, Weigert M, Radic M.

J Immunol. 2011 Sep 15;187(6):3198-207. doi: 10.4049/jimmunol.1101336. Epub 2011 Aug 12.

22.

Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids.

Shimizu Y, Okuda-Shimizu Y, Hendershot LM.

Mol Cell. 2010 Dec 22;40(6):917-26. doi: 10.1016/j.molcel.2010.11.033.

23.

FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA.

Santiago T, Kulemzin SV, Reshetnikova ES, Chikaev NA, Volkova OY, Mechetina LV, Zhao M, Davis RS, Taranin AV, Najakshin AM, Hendershot LM, Burrows PD.

Int Immunol. 2011 Jan;23(1):43-53. doi: 10.1093/intimm/dxq456. Epub 2010 Dec 13.

24.

Disulfide bonds in ER protein folding and homeostasis.

Feige MJ, Hendershot LM.

Curr Opin Cell Biol. 2011 Apr;23(2):167-75. doi: 10.1016/j.ceb.2010.10.012. Epub 2010 Dec 7. Review.

25.

Transcriptional and post-transcriptional regulation of proangiogenic factors by the unfolded protein response.

Pereira ER, Liao N, Neale GA, Hendershot LM.

PLoS One. 2010 Sep 2;5(9). pii: e12521. doi: 10.1371/journal.pone.0012521.

26.

J domain co-chaperone specificity defines the role of BiP during protein translocation.

Vembar SS, Jonikas MC, Hendershot LM, Weissman JS, Brodsky JL.

J Biol Chem. 2010 Jul 16;285(29):22484-94. doi: 10.1074/jbc.M110.102186. Epub 2010 Apr 29.

27.

CHOP-independent apoptosis and pathway-selective induction of the UPR in developing plasma cells.

Masciarelli S, Fra AM, Pengo N, Bertolotti M, Cenci S, Fagioli C, Ron D, Hendershot LM, Sitia R.

Mol Immunol. 2010 Mar;47(6):1356-65. doi: 10.1016/j.molimm.2009.12.003. Epub 2009 Dec 30.

28.

Life and death of a BiP substrate.

Otero JH, Lizák B, Hendershot LM.

Semin Cell Dev Biol. 2010 Jul;21(5):472-8. doi: 10.1016/j.semcdb.2009.12.008. Epub 2009 Dec 21. Review.

29.

How antibodies fold.

Feige MJ, Hendershot LM, Buchner J.

Trends Biochem Sci. 2010 Apr;35(4):189-98. doi: 10.1016/j.tibs.2009.11.005. Epub 2009 Dec 21. Review.

30.

Plasma cell differentiation initiates a limited ER stress response by specifically suppressing the PERK-dependent branch of the unfolded protein response.

Ma Y, Shimizu Y, Mann MJ, Jin Y, Hendershot LM.

Cell Stress Chaperones. 2010 May;15(3):281-93. doi: 10.1007/s12192-009-0142-9. Epub 2009 Nov 8.

31.

pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin.

Shimizu Y, Meunier L, Hendershot LM.

Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17013-8. doi: 10.1073/pnas.0811591106. Epub 2009 Sep 17.

32.

The mammalian Hsp40 ERdj3 requires its Hsp70 interaction and substrate-binding properties to complement various yeast Hsp40-dependent functions.

Vembar SS, Jin Y, Brodsky JL, Hendershot LM.

J Biol Chem. 2009 Nov 20;284(47):32462-71. doi: 10.1074/jbc.M109.000729. Epub 2009 Sep 11.

33.

An unfolded CH1 domain controls the assembly and secretion of IgG antibodies.

Feige MJ, Groscurth S, Marcinowski M, Shimizu Y, Kessler H, Hendershot LM, Buchner J.

Mol Cell. 2009 Jun 12;34(5):569-79. doi: 10.1016/j.molcel.2009.04.028.

34.

Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species.

Shimizu Y, Hendershot LM.

Antioxid Redox Signal. 2009 Sep;11(9):2317-31. doi: 10.1089/ARS.2009.2501. Review.

35.

ERdj3, a luminal ER DnaJ homologue, binds directly to unfolded proteins in the mammalian ER: identification of critical residues.

Jin Y, Zhuang M, Hendershot LM.

Biochemistry. 2009 Jan 13;48(1):41-9. doi: 10.1021/bi8015923.

36.

Regulated association of misfolded endoplasmic reticulum lumenal proteins with P58/DNAJc3.

Petrova K, Oyadomari S, Hendershot LM, Ron D.

EMBO J. 2008 Nov 5;27(21):2862-72. doi: 10.1038/emboj.2008.199. Epub 2008 Oct 16.

37.

Regulated release of ERdj3 from unfolded proteins by BiP.

Jin Y, Awad W, Petrova K, Hendershot LM.

EMBO J. 2008 Nov 5;27(21):2873-82. doi: 10.1038/emboj.2008.207. Epub 2008 Oct 16.

38.

BiP mutants that are unable to interact with endoplasmic reticulum DnaJ proteins provide insights into interdomain interactions in BiP.

Awad W, Estrada I, Shen Y, Hendershot LM.

Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1164-9. doi: 10.1073/pnas.0702132105. Epub 2008 Jan 18.

39.

Characterization of an ERAD pathway for nonglycosylated BiP substrates, which require Herp.

Okuda-Shimizu Y, Hendershot LM.

Mol Cell. 2007 Nov 30;28(4):544-54.

40.
41.

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.

Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL, Cardozo AK.

Diabetes. 2007 Apr;56(4):1069-77.

42.

The cellular world according to Hsp90.

Richter K, Hendershot LM, Freeman BC.

Nat Struct Mol Biol. 2007 Feb;14(2):90-4.

PMID:
17277798
43.

Organization of the functions and components of the endoplasmic reticulum.

Shimizu Y, Hendershot LM.

Adv Exp Med Biol. 2007;594:37-46. Review.

PMID:
17205673
44.

ER stress and cancer.

Lee AS, Hendershot LM.

Cancer Biol Ther. 2006 Jul;5(7):721-2. Epub 2006 Jul 1. Review. No abstract available.

PMID:
16880733
45.

UPR activation alters chemosensitivity of tumor cells.

Mann MJ, Hendershot LM.

Cancer Biol Ther. 2006 Jul;5(7):736-40. Epub 2006 Jul 1. Review.

PMID:
16861918
46.

Mutations in SIL1 cause Marinesco-Sjögren syndrome, a cerebellar ataxia with cataract and myopathy.

Senderek J, Krieger M, Stendel C, Bergmann C, Moser M, Breitbach-Faller N, Rudnik-Schöneborn S, Blaschek A, Wolf NI, Harting I, North K, Smith J, Muntoni F, Brockington M, Quijano-Roy S, Renault F, Herrmann R, Hendershot LM, Schröder JM, Lochmüller H, Topaloglu H, Voit T, Weis J, Ebinger F, Zerres K.

Nat Genet. 2005 Dec;37(12):1312-4. Epub 2005 Nov 13.

PMID:
16282977
47.

ERj1p has a basic role in protein biogenesis at the endoplasmic reticulum.

Dudek J, Greiner M, Müller A, Hendershot LM, Kopsch K, Nastainczyk W, Zimmermann R.

Nat Struct Mol Biol. 2005 Nov;12(11):1008-14.

PMID:
16244664
49.

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum.

Alder NN, Shen Y, Brodsky JL, Hendershot LM, Johnson AE.

J Cell Biol. 2005 Jan 31;168(3):389-99. Erratum in: J Cell Biol. 2005 Apr 11;169(1):203.

50.

Building an antibody factory: a job for the unfolded protein response.

Brewer JW, Hendershot LM.

Nat Immunol. 2005 Jan;6(1):23-9. Review. Erratum in: Nat Immunol. 2005 Feb;6(2):219.

PMID:
15611778

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