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Items: 37


A fast and reliable DSC-based method to determine the monomolecular loading capacity of drugs with good glass-forming ability in mesoporous silica.

Hempel NJ, Brede K, Olesen NE, Genina N, Knopp MM, Löbmann K.

Int J Pharm. 2018 Apr 18. pii: S0378-5173(18)30252-7. doi: 10.1016/j.ijpharm.2018.04.035. [Epub ahead of print]


Inhibin is a novel paracrine factor for tumor angiogenesis and metastasis.

Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K.

Cancer Res. 2018 Mar 13. pii: canres.2316.2017. doi: 10.1158/0008-5472.CAN-17-2316. [Epub ahead of print]


Insights into the Dichotomous Regulation of SOD2 in Cancer.

Kim YS, Gupta Vallur P, Phaëton R, Mythreye K, Hempel N.

Antioxidants (Basel). 2017 Nov 3;6(4). pii: E86. doi: 10.3390/antiox6040086. Review.


Clonal evolution in paired endometrial intraepithelial neoplasia/atypical hyperplasia and endometrioid adenocarcinoma.

Russo M, Broach J, Sheldon K, Houser KR, Liu DJ, Kesterson J, Phaeton R, Hossler C, Hempel N, Baker M, Newell JM, Zaino R, Warrick JI.

Hum Pathol. 2017 Sep;67:69-77. doi: 10.1016/j.humpath.2017.07.003. Epub 2017 Jul 14.


Cationic dendritic starch as a vehicle for photodynamic therapy and siRNA co-delivery.

Engelberth SA, Hempel N, Bergkvist M.

J Photochem Photobiol B. 2017 Mar;168:185-192. doi: 10.1016/j.jphotobiol.2017.02.013. Epub 2017 Feb 20.


Mitochondria control store-operated Ca2+ entry through Na+ and redox signals.

Ben-Kasus Nissim T, Zhang X, Elazar A, Roy S, Stolwijk JA, Zhou Y, Motiani RK, Gueguinou M, Hempel N, Hershfinkel M, Gill DL, Trebak M, Sekler I.

EMBO J. 2017 Mar 15;36(6):797-815. doi: 10.15252/embj.201592481. Epub 2017 Feb 20.


Crosstalk between calcium and reactive oxygen species signaling in cancer.

Hempel N, Trebak M.

Cell Calcium. 2017 May;63:70-96. doi: 10.1016/j.ceca.2017.01.007. Epub 2017 Jan 18. Review.


Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion.

Kumar S, Pan CC, Shah N, Wheeler SE, Hoyt KR, Hempel N, Mythreye K, Lee NY.

Mol Cell. 2016 May 19;62(4):520-31. doi: 10.1016/j.molcel.2016.04.010. Epub 2016 May 12.


Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma.

Hemachandra LP, Shin DH, Dier U, Iuliano JN, Engelberth SA, Uusitalo LM, Murphy SK, Hempel N.

Cancer Res. 2015 Nov 15;75(22):4973-84. doi: 10.1158/0008-5472.CAN-14-3799. Epub 2015 Sep 10.


Regulation of MMP-1 expression in response to hypoxia is dependent on the intracellular redox status of metastatic bladder cancer cells.

Shin DH, Dier U, Melendez JA, Hempel N.

Biochim Biophys Acta. 2015 Dec;1852(12):2593-602. doi: 10.1016/j.bbadis.2015.09.001. Epub 2015 Sep 5.


Chemically Modified Dendritic Starch: A Novel Nanomaterial for siRNA Delivery.

Engelberth SA, Hempel N, Bergkvist M.

Bioconjug Chem. 2015 Aug 19;26(8):1766-74. doi: 10.1021/acs.bioconjchem.5b00313. Epub 2015 Aug 11.


Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis.

Zhang J, Gao Q, Zhou Y, Dier U, Hempel N, Hochwald SN.

Oncogene. 2016 Apr 14;35(15):1926-42. doi: 10.1038/onc.2015.256. Epub 2015 Jun 29.


Metastatic bladder cancer cells distinctively sense and respond to physical cues of collagen fibril-mimetic nanotopography.

Iuliano JN, Kutscha PD, Biderman NJ, Subbaram S, Groves TR, Tenenbaum SA, Hempel N.

Exp Biol Med (Maywood). 2015 May;240(5):601-10. doi: 10.1177/1535370214560973. Epub 2014 Dec 2.


Development of nanoscale approaches for ovarian cancer therapeutics and diagnostics.

Engelberth SA, Hempel N, Bergkvist M.

Crit Rev Oncog. 2014;19(3-4):281-315. Review.


Bioenergetic analysis of ovarian cancer cell lines: profiling of histological subtypes and identification of a mitochondria-defective cell line.

Dier U, Shin DH, Hemachandra LP, Uusitalo LM, Hempel N.

PLoS One. 2014 May 23;9(5):e98479. doi: 10.1371/journal.pone.0098479. eCollection 2014.


Intracellular redox status controls membrane localization of pro- and anti-migratory signaling molecules.

Hempel N, Melendez JA.

Redox Biol. 2014 Jan 20;2:245-50. doi: 10.1016/j.redox.2014.01.005. eCollection 2014.


Redox-control of the alarmin, Interleukin-1α.

McCarthy DA, Ranganathan A, Subbaram S, Flaherty NL, Patel N, Trebak M, Hempel N, Melendez JA.

Redox Biol. 2013 Apr 17;1:218-25. doi: 10.1016/j.redox.2013.03.001. eCollection 2013.


Acquisition of the metastatic phenotype is accompanied by H2O2-dependent activation of the p130Cas signaling complex.

Hempel N, Bartling TR, Mian B, Melendez JA.

Mol Cancer Res. 2013 Mar;11(3):303-12. doi: 10.1158/1541-7786.MCR-12-0478. Epub 2013 Jan 23.


Recent advances in intracellular and in vivo ROS sensing: focus on nanoparticle and nanotube applications.

Uusitalo LM, Hempel N.

Int J Mol Sci. 2012;13(9):10660-79. doi: 10.3390/ijms130910660. Epub 2012 Aug 24. Review.


Manganese superoxide dismutase (Sod2) and redox-control of signaling events that drive metastasis.

Hempel N, Carrico PM, Melendez JA.

Anticancer Agents Med Chem. 2011 Feb;11(2):191-201. Review.


Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma.

Cooper SJ, Zou H, Legrand SN, Marlow LA, von Roemeling CA, Radisky DC, Wu KJ, Hempel N, Margulis V, Tun HW, Blobe GC, Wood CG, Copland JA.

Oncogene. 2010 May 20;29(20):2905-15. doi: 10.1038/onc.2010.64. Epub 2010 Mar 8.


The type III TGF-beta receptor suppresses breast cancer progression through GIPC-mediated inhibition of TGF-beta signaling.

Lee JD, Hempel N, Lee NY, Blobe GC.

Carcinogenesis. 2010 Feb;31(2):175-83. doi: 10.1093/carcin/bgp271. Epub 2009 Dec 2.


Altered redox status accompanies progression to metastatic human bladder cancer.

Hempel N, Ye H, Abessi B, Mian B, Melendez JA.

Free Radic Biol Med. 2009 Jan 1;46(1):42-50. doi: 10.1016/j.freeradbiomed.2008.09.020. Epub 2008 Oct 1.


Expression of the type III TGF-beta receptor is negatively regulated by TGF-beta.

Hempel N, How T, Cooper SJ, Green TR, Dong M, Copland JA, Wood CG, Blobe GC.

Carcinogenesis. 2008 May;29(5):905-12. doi: 10.1093/carcin/bgn049. Epub 2008 Feb 24.


Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells.

Connor KM, Hempel N, Nelson KK, Dabiri G, Gamarra A, Belarmino J, Van De Water L, Mian BM, Melendez JA.

Cancer Res. 2007 Nov 1;67(21):10260-7.


Loss of betaglycan expression in ovarian cancer: role in motility and invasion.

Hempel N, How T, Dong M, Murphy SK, Fields TA, Blobe GC.

Cancer Res. 2007 Jun 1;67(11):5231-8. Epub 2007 May 23.


The type III transforming growth factor-beta receptor as a novel tumor suppressor gene in prostate cancer.

Turley RS, Finger EC, Hempel N, How T, Fields TA, Blobe GC.

Cancer Res. 2007 Feb 1;67(3):1090-8.


The type III TGF-beta receptor suppresses breast cancer progression.

Dong M, How T, Kirkbride KC, Gordon KJ, Lee JD, Hempel N, Kelly P, Moeller BJ, Marks JR, Blobe GC.

J Clin Invest. 2007 Jan;117(1):206-17. Epub 2006 Dec 7.


Human cytosolic sulfotransferase SULT1A1.

Hempel N, Gamage N, Martin JL, McManus ME.

Int J Biochem Cell Biol. 2007;39(4):685-9. Epub 2006 Oct 7. Review.


Human SULT1A genes: cloning and activity assays of the SULT1A promoters.

Hempel N, Negishi M, McManus ME.

Methods Enzymol. 2005;400:147-65.


Human sulfotransferases and their role in chemical metabolism.

Gamage N, Barnett A, Hempel N, Duggleby RG, Windmill KF, Martin JL, McManus ME.

Toxicol Sci. 2006 Mar;90(1):5-22. Epub 2005 Dec 1. Review.


Negative regulation of TRPC3 channels by protein kinase C-mediated phosphorylation of serine 712.

Trebak M, Hempel N, Wedel BJ, Smyth JT, Bird GS, Putney JW Jr.

Mol Pharmacol. 2005 Feb;67(2):558-63. Epub 2004 Nov 8.


The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein.

Hempel N, Wang H, LeCluyse EL, McManus ME, Negishi M.

Mol Pharmacol. 2004 Dec;66(6):1690-701. Epub 2004 Sep 21.


Site-directed mutagenesis of the substrate-binding cleft of human estrogen sulfotransferase.

Hempel N, Barnett AC, Bolton-Grob RM, Liyou NE, McManus ME.

Biochem Biophys Res Commun. 2000 Sep 16;276(1):224-30.


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