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Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells.

Maturi V, Enroth S, Heldin CH, Moustakas A.

J Cell Physiol. 2018 May 10. doi: 10.1002/jcp.26634. [Epub ahead of print]


Genome-wide binding of transcription factor Snail1 in triple-negative breast cancer cells.

Maturi V, Morén A, Enroth S, Heldin CH, Moustakas A.

Mol Oncol. 2018 May 4. doi: 10.1002/1878-0261.12317. [Epub ahead of print]


PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.

Papadopoulos N, Lennartsson J, Heldin CH.

J Cell Biol. 2018 May 7;217(5):1701-1717. doi: 10.1083/jcb.201706118. Epub 2018 Mar 15.


The protein kinase SIK downregulates the polarity protein Par3.

Vanlandewijck M, Dadras MS, Lomnytska M, Mahzabin T, Lee Miller M, Busch C, Brunak S, Heldin CH, Moustakas A.

Oncotarget. 2017 Dec 31;9(5):5716-5735. doi: 10.18632/oncotarget.23788. eCollection 2018 Jan 19.


Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells.

Caja L, Tzavlaki K, Dadras MS, Tan EJ, Hatem G, Maturi NP, Morén A, Wik L, Watanabe Y, Savary K, Kamali-Moghaddan M, Uhrbom L, Heldin CH, Moustakas A.

Oncogene. 2018 May;37(19):2515-2531. doi: 10.1038/s41388-018-0136-0. Epub 2018 Feb 16.


TUFT1 interacts with RABGAP1 and regulates mTORC1 signaling.

Kawasaki N, Isogaya K, Dan S, Yamori T, Takano H, Yao R, Morishita Y, Taguchi L, Morikawa M, Heldin CH, Noda T, Ehata S, Miyazono K, Koinuma D.

Cell Discov. 2018 Jan 9;4:1. doi: 10.1038/s41421-017-0001-2. eCollection 2018.


The TGFβ superfamily in Lisbon: navigating through development and disease.

Christian JL, Heldin CH.

Development. 2017 Dec 15;144(24):4476-4480. doi: 10.1242/dev.159756.


Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.

Bellomo C, Caja L, Fabregat I, Mikulits W, Kardassis D, Heldin CH, Moustakas A.

Cell Death Differ. 2018 May;25(5):885-903. doi: 10.1038/s41418-017-0021-3. Epub 2017 Dec 11.


Pro-invasive properties of Snail1 are regulated by sumoylation in response to TGFβ stimulation in cancer.

Gudey SK, Sundar R, Heldin CH, Bergh A, Landström M.

Oncotarget. 2017 Aug 9;8(58):97703-97726. doi: 10.18632/oncotarget.20097. eCollection 2017 Nov 17.


JUNB governs a feed-forward network of TGFβ signaling that aggravates breast cancer invasion.

Sundqvist A, Morikawa M, Ren J, Vasilaki E, Kawasaki N, Kobayashi M, Koinuma D, Aburatani H, Miyazono K, Heldin CH, van Dam H, Ten Dijke P.

Nucleic Acids Res. 2018 Feb 16;46(3):1180-1195. doi: 10.1093/nar/gkx1190.


Intracellular trafficking of transforming growth factor β receptors.

Yakymovych I, Yakymovych M, Heldin CH.

Acta Biochim Biophys Sin (Shanghai). 2018 Jan 1;50(1):3-11. doi: 10.1093/abbs/gmx119.


Involvement of platelet-derived growth factor ligands and receptors in tumorigenesis.

Heldin CH, Lennartsson J, Westermark B.

J Intern Med. 2018 Jan;283(1):16-44. doi: 10.1111/joim.12690. Epub 2017 Oct 17. Review.


TGF-β promotes PI3K-AKT signaling and prostate cancer cell migration through the TRAF6-mediated ubiquitylation of p85α.

Hamidi A, Song J, Thakur N, Itoh S, Marcusson A, Bergh A, Heldin CH, Landström M.

Sci Signal. 2017 Jul 4;10(486). pii: eaal4186. doi: 10.1126/scisignal.aal4186.


The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function.

Mehić M, de Sa VK, Hebestreit S, Heldin CH, Heldin P.

Oncogenesis. 2017 Jun 12;6(6):e348. doi: 10.1038/oncsis.2017.45.


The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.

Okita Y, Kimura M, Xie R, Chen C, Shen LT, Kojima Y, Suzuki H, Muratani M, Saitoh M, Semba K, Heldin CH, Kato M.

Sci Signal. 2017 Apr 11;10(474). pii: eaak9397. doi: 10.1126/scisignal.aak9397.


Imatinib increases oxygen delivery in extracellular matrix-rich but not in matrix-poor experimental carcinoma.

Burmakin M, van Wieringen T, Olsson PO, Stuhr L, Åhgren A, Heldin CH, Reed RK, Rubin K, Hellberg C.

J Transl Med. 2017 Feb 23;15(1):47. doi: 10.1186/s12967-017-1142-7.


Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program.

Vasilaki E, Morikawa M, Koinuma D, Mizutani A, Hirano Y, Ehata S, Sundqvist A, Kawasaki N, Cedervall J, Olsson AK, Aburatani H, Moustakas A, Miyazono K, Heldin CH.

Sci Signal. 2016 Aug 23;9(442):ra84. doi: 10.1126/scisignal.aag3232.


Signaling Receptors for TGF-β Family Members.

Heldin CH, Moustakas A.

Cold Spring Harb Perspect Biol. 2016 Aug 1;8(8). pii: a022053. doi: 10.1101/cshperspect.a022053. Review.


Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.

Carthy JM, Stöter M, Bellomo C, Vanlandewijck M, Heldin A, Morén A, Kardassis D, Gahman TC, Shiau AK, Bickle M, Zerial M, Heldin CH, Moustakas A.

Sci Rep. 2016 Jul 19;6:29868. doi: 10.1038/srep29868.


Mechanisms of TGFβ-Induced Epithelial-Mesenchymal Transition.

Moustakas A, Heldin CH.

J Clin Med. 2016 Jun 29;5(7). pii: E63. doi: 10.3390/jcm5070063. Review.


Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling.

Tsioumpekou M, Papadopoulos N, Burovic F, Heldin CH, Lennartsson J.

Cell Signal. 2016 Sep;28(9):1422-31. doi: 10.1016/j.cellsig.2016.06.013. Epub 2016 Jun 21.


Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.

Watanabe Y, Papoutsoglou P, Maturi V, Tsubakihara Y, Hottiger MO, Heldin CH, Moustakas A.

J Biol Chem. 2016 Jun 10;291(24):12706-23. doi: 10.1074/jbc.M116.729699. Epub 2016 Apr 21.


The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling.

Rorsman C, Tsioumpekou M, Heldin CH, Lennartsson J.

J Biol Chem. 2016 May 27;291(22):11608-18. doi: 10.1074/jbc.M115.705814. Epub 2016 Apr 5.


Signals and Receptors.

Heldin CH, Lu B, Evans R, Gutkind JS.

Cold Spring Harb Perspect Biol. 2016 Apr 1;8(4):a005900. doi: 10.1101/cshperspect.a005900. Review.


BMP Sustains Embryonic Stem Cell Self-Renewal through Distinct Functions of Different Krüppel-like Factors.

Morikawa M, Koinuma D, Mizutani A, Kawasaki N, Holmborn K, Sundqvist A, Tsutsumi S, Watabe T, Aburatani H, Heldin CH, Miyazono K.

Stem Cell Reports. 2016 Jan 12;6(1):64-73. doi: 10.1016/j.stemcr.2015.12.004.


The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.

Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, Morén A, Watanabe Y, Voytyuk I, Botling J, Söderberg O, Micke P, Pyrowolakis G, Heldin CH, Moustakas A.

Oncotarget. 2016 Jan 12;7(2):1120-43. doi: 10.18632/oncotarget.6683.


Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification.

Vanlandewijck M, Lebouvier T, Andaloussi Mäe M, Nahar K, Hornemann S, Kenkel D, Cunha SI, Lennartsson J, Boss A, Heldin CH, Keller A, Betsholtz C.

PLoS One. 2015 Nov 23;10(11):e0143407. doi: 10.1371/journal.pone.0143407. eCollection 2015.


APPL proteins promote TGFβ-induced nuclear transport of the TGFβ type I receptor intracellular domain.

Song J, Mu Y, Li C, Bergh A, Miaczynska M, Heldin CH, Landström M.

Oncotarget. 2016 Jan 5;7(1):279-92. doi: 10.18632/oncotarget.6346.


Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-β Signaling.

Carthy JM, Engström U, Heldin CH, Moustakas A.

J Cell Biochem. 2016 Apr;117(4):938-45. doi: 10.1002/jcb.25378. Epub 2015 Sep 22.


Histidine-domain-containing protein tyrosine phosphatase regulates platelet-derived growth factor receptor intracellular sorting and degradation.

Ma H, Wardega P, Mazaud D, Klosowska-Wardega A, Jurek A, Engström U, Lennartsson J, Heldin CH.

Cell Signal. 2015 Nov;27(11):2209-19. doi: 10.1016/j.cellsig.2015.07.020. Epub 2015 Jul 30.


CIN85 modulates TGFβ signaling by promoting the presentation of TGFβ receptors on the cell surface.

Yakymovych I, Yakymovych M, Zang G, Mu Y, Bergh A, Landström M, Heldin CH.

J Cell Biol. 2015 Jul 20;210(2):319-32. doi: 10.1083/jcb.201411025. Epub 2015 Jul 13.


Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.

Carthy JM, Sundqvist A, Heldin A, van Dam H, Kletsas D, Heldin CH, Moustakas A.

J Cell Physiol. 2015 Dec;230(12):3084-92. doi: 10.1002/jcp.25049.


TRAF6 promotes TGFβ-induced invasion and cell-cycle regulation via Lys63-linked polyubiquitination of Lys178 in TGFβ type I receptor.

Sundar R, Gudey SK, Heldin CH, Landström M.

Cell Cycle. 2015;14(4):554-65. doi: 10.4161/15384101.2014.990302.


The high mobility group A2 protein epigenetically silences the Cdh1 gene during epithelial-to-mesenchymal transition.

Tan EJ, Kahata K, Idås O, Thuault S, Heldin CH, Moustakas A.

Nucleic Acids Res. 2015 Jan;43(1):162-78. doi: 10.1093/nar/gku1293. Epub 2014 Dec 9.


TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1.

Thakur N, Gudey SK, Marcusson A, Fu JY, Bergh A, Heldin CH, Landström M.

Cell Cycle. 2014;13(15):2400-14. doi: 10.4161/cc.29339.


Tony Pawson (1952-2013).

Heldin CH.

Growth Factors. 2014 Dec;32(6):174-5. doi: 10.3109/08977194.2014.983500. Epub 2014 Nov 17. No abstract available.


NR4A1 promotes PDGF-BB-induced cell colony formation in soft agar.

Eger G, Papadopoulos N, Lennartsson J, Heldin CH.

PLoS One. 2014 Sep 30;9(9):e109047. doi: 10.1371/journal.pone.0109047. eCollection 2014.


Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling.

Dahl M, Maturi V, Lönn P, Papoutsoglou P, Zieba A, Vanlandewijck M, van der Heide LP, Watanabe Y, Söderberg O, Hottiger MO, Heldin CH, Moustakas A.

PLoS One. 2014 Aug 18;9(8):e103651. doi: 10.1371/journal.pone.0103651. eCollection 2014.


Platelet-derived growth factor β-receptor, transforming growth factor β type I receptor, and CD44 protein modulate each other's signaling and stability.

Porsch H, Mehić M, Olofsson B, Heldin P, Heldin CH.

J Biol Chem. 2014 Jul 11;289(28):19747-57. doi: 10.1074/jbc.M114.547273. Epub 2014 May 23.


Nucleosome regulatory dynamics in response to TGFβ.

Enroth S, Andersson R, Bysani M, Wallerman O, Termén S, Tuch BB, De La Vega FM, Heldin CH, Moustakas A, Komorowski J, Wadelius C.

Nucleic Acids Res. 2014 Jun;42(11):6921-34. doi: 10.1093/nar/gku326. Epub 2014 Apr 25.


TRAF6 stimulates the tumor-promoting effects of TGFβ type I receptor through polyubiquitination and activation of presenilin 1.

Gudey SK, Sundar R, Mu Y, Wallenius A, Zang G, Bergh A, Heldin CH, Landström M.

Sci Signal. 2014 Jan 7;7(307):ra2. doi: 10.1126/scisignal.2004207.


Targeting the PDGF signaling pathway in tumor treatment.

Heldin CH.

Cell Commun Signal. 2013 Dec 20;11:97. doi: 10.1186/1478-811X-11-97. Review.


Coordination of TGF-β signaling by ubiquitylation.

Moustakas A, Heldin CH.

Mol Cell. 2013 Sep 12;51(5):555-6. doi: 10.1016/j.molcel.2013.08.034.


Structural and functional properties of platelet-derived growth factor and stem cell factor receptors.

Heldin CH, Lennartsson J.

Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a009100. doi: 10.1101/cshperspect.a009100. Review.


Targeting the PDGF signaling pathway in the treatment of non-malignant diseases.

Heldin CH.

J Neuroimmune Pharmacol. 2014 Mar;9(2):69-79. doi: 10.1007/s11481-013-9484-2. Epub 2013 Jun 25.


The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced signal transducer and activator of transcription 3 (STAT3) protein phosphorylation, colony formation in soft agar, and tumor growth in vivo.

Lennartsson J, Ma H, Wardega P, Pelka K, Engström U, Hellberg C, Heldin CH.

J Biol Chem. 2013 May 31;288(22):15736-44. doi: 10.1074/jbc.M113.476424. Epub 2013 Apr 15.


Snail depletes the tumorigenic potential of glioblastoma.

Savary K, Caglayan D, Caja L, Tzavlaki K, Bin Nayeem S, Bergström T, Jiang Y, Uhrbom L, Forsberg-Nilsson K, Westermark B, Heldin CH, Ferletta M, Moustakas A.

Oncogene. 2013 Nov 21;32(47):5409-20. doi: 10.1038/onc.2013.67. Epub 2013 Mar 25.


Dynamin inhibitors impair endocytosis and mitogenic signaling of PDGF.

Sadowski Ł, Jastrzębski K, Kalaidzidis Y, Heldin CH, Hellberg C, Miaczynska M.

Traffic. 2013 Jun;14(6):725-36. doi: 10.1111/tra.12061. Epub 2013 Mar 12.


Efficient TGFβ-induced epithelial-mesenchymal transition depends on hyaluronan synthase HAS2.

Porsch H, Bernert B, Mehić M, Theocharis AD, Heldin CH, Heldin P.

Oncogene. 2013 Sep 12;32(37):4355-65. doi: 10.1038/onc.2012.475. Epub 2012 Oct 29.

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