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Items: 1 to 50 of 477

1.

Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing.

Garcia-Hermoso D, Criscuolo A, Lee SC, Legrand M, Chaouat M, Denis B, Lafaurie M, Rouveau M, Soler C, Schaal JV, Mimoun M, Mebazaa A, Heitman J, Dromer F, Brisse S, Bretagne S, Alanio A.

MBio. 2018 Apr 24;9(2). pii: e00573-18. doi: 10.1128/mBio.00573-18.

PMID:
29691339
2.

The Skin Commensal Yeast Malassezia globosa Thwarts Bacterial Biofilms to Benefit the Host.

Ianiri G, Heitman J, Scheynius A.

J Invest Dermatol. 2018 May;138(5):1026-1029. doi: 10.1016/j.jid.2018.01.008.

PMID:
29681390
3.

Phylogenetic and Phylogenomic Definition of Rhizopus Species.

Gryganskyi AP, Golan J, Dolatabadi S, Mondo S, Robb S, Idnurm A, Muszewska A, Steczkiewicz K, Masonjones S, Liao HL, Gajdeczka MT, Anike F, Vuek A, Anishchenko IM, Voigt K, de Hoog GS, Smith ME, Heitman J, Vilgalys R, Stajich JE.

G3 (Bethesda). 2018 Apr 19. pii: g3.200235.2018. doi: 10.1534/g3.118.200235. [Epub ahead of print]

4.

A High Resolution Map of Meiotic Recombination in Cryptococcus deneoformans Demonstrates Decreased Recombination in Unisexual Reproduction.

Roth C, Sun S, Billmyre RB, Heitman J, Magwene PM.

Genetics. 2018 Apr 6. pii: genetics.300996.2018. doi: 10.1534/genetics.118.300996. [Epub ahead of print]

5.

Pearls collections: What we can learn about infectious disease and cancer.

Knoll LJ, Hogan DA, Leong JM, Heitman J, Condit RC.

PLoS Pathog. 2018 Mar 29;14(3):e1006915. doi: 10.1371/journal.ppat.1006915. eCollection 2018 Mar. No abstract available.

6.

RNAi is a critical determinant of centromere evolution in closely related fungi.

Yadav V, Sun S, Billmyre RB, Thimmappa BC, Shea T, Lintner R, Bakkeren G, Cuomo CA, Heitman J, Sanyal K.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3108-3113. doi: 10.1073/pnas.1713725115. Epub 2018 Mar 5.

7.

Whole-Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen Trichophyton rubrum.

Persinoti GF, Martinez DA, Li W, Döğen A, Billmyre RB, Averette A, Goldberg JM, Shea T, Young S, Zeng Q, Oliver BG, Barton R, Metin B, Hilmioğlu-Polat S, Ilkit M, Gräser Y, Martinez-Rossi NM, White TC, Heitman J, Cuomo CA.

Genetics. 2018 Apr;208(4):1657-1669. doi: 10.1534/genetics.117.300573. Epub 2018 Feb 21.

8.

Incapacitated Surrogates: A New and Increasing Dilemma in Hospital Care.

Smith KL, Fedel P, Heitman J.

J Clin Ethics. 2017 Winter;28(4):279-289.

PMID:
29257763
9.

Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans.

Jung WH, Son YE, Oh SH, Fu C, Kim HS, Kwak JH, Cardenas ME, Heitman J, Park HS.

G3 (Bethesda). 2018 Feb 2;8(2):643-652. doi: 10.1534/g3.117.300444.

10.

Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans.

Fu C, Donadio N, Cardenas ME, Heitman J.

Genetics. 2018 Feb;208(2):639-653. doi: 10.1534/genetics.117.300422. Epub 2017 Dec 12.

PMID:
29233811
11.

Erratum for Ianiri et al., "FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in Malassezia".

Ianiri G, Applen Clancey S, Lee SC, Heitman J.

MBio. 2017 Dec 5;8(6). pii: e02055-17. doi: 10.1128/mBio.02055-17. No abstract available.

12.

PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex.

Fu C, Heitman J.

PLoS Genet. 2017 Nov 27;13(11):e1007113. doi: 10.1371/journal.pgen.1007113. eCollection 2017 Nov.

13.

FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in Malassezia.

Ianiri G, Applen Clancey S, Lee SC, Heitman J.

MBio. 2017 Oct 24;8(5). pii: e01752-17. doi: 10.1128/mBio.01752-17. Erratum in: MBio. 2017 Dec 5;8(6):.

14.

Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii.

Billmyre RB, Clancey SA, Heitman J.

Elife. 2017 Sep 26;6. pii: e28802. doi: 10.7554/eLife.28802.

15.

Genetic and epigenetic engines of diversity in pathogenic microbes.

Billmyre RB, Heitman J.

PLoS Pathog. 2017 Sep 14;13(9):e1006468. doi: 10.1371/journal.ppat.1006468. eCollection 2017 Sep. Review. No abstract available.

16.

The effect of HIV infection and HCV viremia on inflammatory mediators and hepatic injury-The Women's Interagency HIV Study.

Keating SM, Dodge JL, Norris PJ, Heitman J, Gange SJ, French AL, Glesby MJ, Edlin BR, Latham PS, Villacres MC, Greenblatt RM, Peters MG; Women’s Interagency HIV Study.

PLoS One. 2017 Sep 13;12(9):e0181004. doi: 10.1371/journal.pone.0181004. eCollection 2017.

17.

Eukaryotic Sexual Reproduction Evoked "with a Little Help from My Friends".

Umen J, Goodenough U, Heitman J.

Cell. 2017 Sep 7;170(6):1059-1061. doi: 10.1016/j.cell.2017.08.038.

PMID:
28886378
18.

A multi-year study of tillage and amendment effects on compacted soils.

Mohammadshirazi F, McLaughlin RA, Heitman JL, Brown VK.

J Environ Manage. 2017 Dec 1;203(Pt 1):533-541. doi: 10.1016/j.jenvman.2017.07.031. Epub 2017 Aug 30.

19.

Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination.

Sun S, Yadav V, Billmyre RB, Cuomo CA, Nowrousian M, Wang L, Souciet JL, Boekhout T, Porcel B, Wincker P, Granek JA, Sanyal K, Heitman J.

PLoS Biol. 2017 Aug 11;15(8):e2002527. doi: 10.1371/journal.pbio.2002527. eCollection 2017 Aug.

20.

MTL genotypes, phenotypic switching, and susceptibility profiles of Candida parapsilosis species group compared to Lodderomyces elongisporus.

Döğen A, Metin B, Ilkit M, de Hoog GS, Heitman J.

PLoS One. 2017 Aug 3;12(8):e0182653. doi: 10.1371/journal.pone.0182653. eCollection 2017.

21.

Dynamics of parasitophorous vacuoles formed by the microsporidian pathogen Encephalitozoon cuniculi.

Lee SC, Heitman J.

Fungal Genet Biol. 2017 Oct;107:20-23. doi: 10.1016/j.fgb.2017.07.006. Epub 2017 Jul 25.

PMID:
28754285
22.

Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level.

Rhodes J, Desjardins CA, Sykes SM, Beale MA, Vanhove M, Sakthikumar S, Chen Y, Gujja S, Saif S, Chowdhary A, Lawson DJ, Ponzio V, Colombo AL, Meyer W, Engelthaler DM, Hagen F, Illnait-Zaragozi MT, Alanio A, Vreulink JM, Heitman J, Perfect JR, Litvintseva AP, Bicanic T, Harrison TS, Fisher MC, Cuomo CA.

Genetics. 2017 Sep;207(1):327-346. doi: 10.1534/genetics.117.203836. Epub 2017 Jul 5.

23.

Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans.

Desjardins CA, Giamberardino C, Sykes SM, Yu CH, Tenor JL, Chen Y, Yang T, Jones AM, Sun S, Haverkamp MR, Heitman J, Litvintseva AP, Perfect JR, Cuomo CA.

Genome Res. 2017 Jul;27(7):1207-1219. doi: 10.1101/gr.218727.116.

24.

Serum from dengue virus-infected patients with and without plasma leakage differentially affects endothelial cells barrier function in vitro.

Tramontini Gomes de Sousa Cardozo F, Baimukanova G, Lanteri MC, Keating SM, Moraes Ferreira F, Heitman J, Pannuti CS, Pati S, Romano CM, Cerdeira Sabino E.

PLoS One. 2017 Jun 6;12(6):e0178820. doi: 10.1371/journal.pone.0178820. eCollection 2017.

25.

Construction of a Recyclable Genetic Marker and Serial Gene Deletions in the Human Pathogenic Mucorales Mucor circinelloides.

Garcia A, Adedoyin G, Heitman J, Lee SC.

G3 (Bethesda). 2017 Jul 5;7(7):2047-2054. doi: 10.1534/g3.117.041095.

26.

Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans.

Chow EW, Clancey SA, Billmyre RB, Averette AF, Granek JA, Mieczkowski P, Cardenas ME, Heitman J.

PLoS Genet. 2017 Apr 4;13(4):e1006667. doi: 10.1371/journal.pgen.1006667. eCollection 2017 Apr.

27.

A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides.

Calo S, Nicolás FE, Lee SC, Vila A, Cervantes M, Torres-Martinez S, Ruiz-Vazquez RM, Cardenas ME, Heitman J.

PLoS Genet. 2017 Mar 24;13(3):e1006686. doi: 10.1371/journal.pgen.1006686. eCollection 2017 Mar.

28.

Plants promote mating and dispersal of the human pathogenic fungus Cryptococcus.

Springer DJ, Mohan R, Heitman J.

PLoS One. 2017 Feb 17;12(2):e0171695. doi: 10.1371/journal.pone.0171695. eCollection 2017.

29.

Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis.

Zhu Y, Engström PG, Tellgren-Roth C, Baudo CD, Kennell JC, Sun S, Billmyre RB, Schröder MS, Andersson A, Holm T, Sigurgeirsson B, Wu G, Sankaranarayanan SR, Siddharthan R, Sanyal K, Lundeberg J, Nystedt B, Boekhout T, Dawson TL Jr, Heitman J, Scheynius A, Lehtiö J.

Nucleic Acids Res. 2017 Mar 17;45(5):2629-2643. doi: 10.1093/nar/gkx006.

30.

Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication In Vitro and Modulate HIV Restriction Factor Expression.

Jacobs ES, Keating SM, Abdel-Mohsen M, Gibb SL, Heitman JW, Inglis HC, Martin JN, Zhang J, Kaidarova Z, Deng X, Wu S, Anastos K, Crystal H, Villacres MC, Young M, Greenblatt RM, Landay AL, Gange SJ, Deeks SG, Golub ET, Pillai SK, Norris PJ.

J Virol. 2017 Feb 28;91(6). pii: e02051-16. doi: 10.1128/JVI.02051-16. Print 2017 Mar 15.

31.

Gene Function Analysis in the Ubiquitous Human Commensal and Pathogen Malassezia Genus.

Ianiri G, Averette AF, Kingsbury JM, Heitman J, Idnurm A.

MBio. 2016 Nov 29;7(6). pii: e01853-16. doi: 10.1128/mBio.01853-16.

32.

Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans.

Yang DH, Jung KW, Bang S, Lee JW, Song MH, Floyd-Averette A, Festa RA, Ianiri G, Idnurm A, Thiele DJ, Heitman J, Bahn YS.

Genetics. 2017 Jan;205(1):201-219. doi: 10.1534/genetics.116.190595. Epub 2016 Nov 18.

33.

Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood.

Jackman RP, Muench MO, Inglis H, Heitman JW, Marschner S, Goodrich RP, Norris PJ.

Transfusion. 2017 Feb;57(2):337-348. doi: 10.1111/trf.13895. Epub 2016 Nov 18.

34.

New facets of antifungal therapy.

Chang YL, Yu SJ, Heitman J, Wellington M, Chen YL.

Virulence. 2017 Feb 17;8(2):222-236. doi: 10.1080/21505594.2016.1257457. Epub 2016 Nov 7. Review.

35.

Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates.

Keating SM, Heitman JW, Wu S, Deng X, Stacey AR, Zahn RC, de la Rosa M, Finstad SL, Lifson JD, Piatak M Jr, Gauduin MC, Kessler BM, Ternette N, Carville A, Johnson RP, Desrosiers RC, Letvin NL, Borrow P, Norris PJ, Schmitz JE.

J Virol. 2016 Oct 28;90(22):10339-10350. Print 2016 Nov 15.

36.

Sexual Reproduction in Dermatophytes.

Metin B, Heitman J.

Mycopathologia. 2017 Feb;182(1-2):45-55. doi: 10.1007/s11046-016-0072-x. Epub 2016 Sep 30.

37.

Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis.

Polvi EJ, Averette AF, Lee SC, Kim T, Bahn YS, Veri AO, Robbins N, Heitman J, Cowen LE.

PLoS Genet. 2016 Oct 3;12(10):e1006350. doi: 10.1371/journal.pgen.1006350. eCollection 2016 Oct.

38.

Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans.

Lee KT, So YS, Yang DH, Jung KW, Choi J, Lee DG, Kwon H, Jang J, Wang LL, Cha S, Meyers GL, Jeong E, Jin JH, Lee Y, Hong J, Bang S, Ji JH, Park G, Byun HJ, Park SW, Park YM, Adedoyin G, Kim T, Averette AF, Choi JS, Heitman J, Cheong E, Lee YH, Bahn YS.

Nat Commun. 2016 Sep 28;7:12766. doi: 10.1038/ncomms12766.

39.

Calcineurin Targets Involved in Stress Survival and Fungal Virulence.

Park HS, Chow EW, Fu C, Soderblom EJ, Moseley MA, Heitman J, Cardenas ME.

PLoS Pathog. 2016 Sep 9;12(9):e1005873. doi: 10.1371/journal.ppat.1005873. eCollection 2016 Sep.

40.

Dual action antifungal small molecule modulates multidrug efflux and TOR signaling.

Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, Sanglard D, Andes D, Nislow C, Coccetti P, Gingras AC, Heitman J, Gunatilaka AA, Cowen LE.

Nat Chem Biol. 2016 Oct;12(10):867-75. doi: 10.1038/nchembio.2165. Epub 2016 Aug 29.

41.

Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability.

Kingsbury JM, Shamaprasad N, Billmyre RB, Heitman J, Cardenas ME.

Hum Mol Genet. 2016 Aug 15;25(16):3524-3538. doi: 10.1093/hmg/ddw195. Epub 2016 Jul 17.

42.

Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.

Juvvadi PR, Lee SC, Heitman J, Steinbach WJ.

Virulence. 2017 Feb 17;8(2):186-197. doi: 10.1080/21505594.2016.1201250. Epub 2016 Jun 20. Review.

43.

Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.

Corrochano LM, Kuo A, Marcet-Houben M, Polaino S, Salamov A, Villalobos-Escobedo JM, Grimwood J, Álvarez MI, Avalos J, Bauer D, Benito EP, Benoit I, Burger G, Camino LP, Cánovas D, Cerdá-Olmedo E, Cheng JF, Domínguez A, Eliáš M, Eslava AP, Glaser F, Gutiérrez G, Heitman J, Henrissat B, Iturriaga EA, Lang BF, Lavín JL, Lee SC, Li W, Lindquist E, López-García S, Luque EM, Marcos AT, Martin J, McCluskey K, Medina HR, Miralles-Durán A, Miyazaki A, Muñoz-Torres E, Oguiza JA, Ohm RA, Olmedo M, Orejas M, Ortiz-Castellanos L, Pisabarro AG, Rodríguez-Romero J, Ruiz-Herrera J, Ruiz-Vázquez R, Sanz C, Schackwitz W, Shahriari M, Shelest E, Silva-Franco F, Soanes D, Syed K, Tagua VG, Talbot NJ, Thon MR, Tice H, de Vries RP, Wiebenga A, Yadav JS, Braun EL, Baker SE, Garre V, Schmutz J, Horwitz BA, Torres-Martínez S, Idnurm A, Herrera-Estrella A, Gabaldón T, Grigoriev IV.

Curr Biol. 2016 Jun 20;26(12):1577-1584. doi: 10.1016/j.cub.2016.04.038. Epub 2016 May 26.

44.

Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function.

Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA.

MBio. 2016 Apr 26;7(2):e00492-16. doi: 10.1128/mBio.00492-16.

45.

Reduced alloimmunization in mice following repeated transfusion with pathogen-reduced platelets.

Muench MO, Heitman JW, Inglis H, Fomin ME, Marschner S, Goodrich RP, Norris PJ, Jackman RP.

Transfusion. 2016 Jun;56(6):1419-29. doi: 10.1111/trf.13579. Epub 2016 Mar 29.

PMID:
27028210
46.

Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex.

Feretzaki M, Billmyre RB, Clancey SA, Wang X, Heitman J.

PLoS Genet. 2016 Mar 4;12(3):e1005868. doi: 10.1371/journal.pgen.1005868. eCollection 2016 Mar.

48.

From Two to One: Unipolar Sexual Reproduction.

Sun S, Heitman J.

Fungal Biol Rev. 2015 Dec 1;29(3-4):118-125. Epub 2015 Jul 10.

49.

An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens.

Robbins N, Spitzer M, Yu T, Cerone RP, Averette AK, Bahn YS, Heitman J, Sheppard DC, Tyers M, Wright GD.

Cell Rep. 2015 Nov 17;13(7):1481-1492. doi: 10.1016/j.celrep.2015.10.018. Epub 2015 Nov 5.

50.

On the Discovery of TOR As the Target of Rapamycin.

Heitman J.

PLoS Pathog. 2015 Nov 5;11(11):e1005245. doi: 10.1371/journal.ppat.1005245. eCollection 2015. Review. No abstract available.

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