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Items: 1 to 50 of 200

1.

CO-independent modification of K+ channels by tricarbonyldichlororuthenium(II) dimer (CORM-2).

Gessner G, Sahoo N, Swain SM, Hirth G, Schönherr R, Mede R, Westerhausen M, Brewitz HH, Heimer P, Imhof D, Hoshi T, Heinemann SH.

Eur J Pharmacol. 2017 Nov 15;815:33-41. doi: 10.1016/j.ejphar.2017.10.006. Epub 2017 Oct 5.

PMID:
28987271
2.

Impact of higher-order heme degradation products on hepatic function and hemodynamics.

Seidel RA, Claudel T, Schleser FA, Ojha NK, Westerhausen M, Nietzsche S, Sponholz C, Cuperus F, Coldewey SM, Heinemann SH, Pohnert G, Trauner M, Bauer M.

J Hepatol. 2017 Aug;67(2):272-281. doi: 10.1016/j.jhep.2017.03.037. Epub 2017 Apr 12.

3.

Non-photonic sensing of membrane-delimited reactive species with a Na+ channel protein containing selenocysteine.

Ojha NK, Leipold E, Schönherr R, Hoshi T, Heinemann SH.

Sci Rep. 2017 Apr 5;7:46003. doi: 10.1038/srep46003.

4.

Synthesis and solution stability of water-soluble κ2N,κO-bis(3,5-dimethylpyrazolyl)ethanol manganese(i) tricarbonyl bromide (CORM-ONN1).

Mede R, Traber J, Klein M, Görls H, Gessner G, Hoffmann P, Schmitt M, Popp J, Heinemann SH, Neugebauer U, Westerhausen M.

Dalton Trans. 2017 Jan 31;46(5):1684-1693. doi: 10.1039/c6dt03551e.

PMID:
28102423
5.

Subtype-specific block of voltage-gated K+ channels by μ-conopeptides.

Leipold E, Ullrich F, Thiele M, Tietze AA, Terlau H, Imhof D, Heinemann SH.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1135-1140. doi: 10.1016/j.bbrc.2016.11.170. Epub 2016 Dec 2.

PMID:
27916464
6.

Bioactivity of topologically confined gramicidin A dimers.

Jadhav KB, Stein C, Makarewicz O, Pradel G, Lichtenecker RJ, Sack H, Heinemann SH, Arndt HD.

Bioorg Med Chem. 2017 Jan 1;25(1):261-268. doi: 10.1016/j.bmc.2016.10.033. Epub 2016 Nov 9.

PMID:
27865644
7.

Atomic determinants of BK channel activation by polyunsaturated fatty acids.

Tian Y, Aursnes M, Hansen TV, Tungen JE, Galpin JD, Leisle L, Ahern CA, Xu R, Heinemann SH, Hoshi T.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13905-13910. Epub 2016 Nov 14.

8.

Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel.

Marques-Carvalho MJ, Oppermann J, Muñoz E, Fernandes AS, Gabant G, Cadene M, Heinemann SH, Schönherr R, Morais-Cabral JH.

Structure. 2016 Oct 4;24(10):1742-1754. doi: 10.1016/j.str.2016.07.020. Epub 2016 Sep 8.

9.

Molecular interaction of δ-conopeptide EVIA with voltage-gated Na(+) channels.

Tietze D, Leipold E, Heimer P, Böhm M, Winschel W, Imhof D, Heinemann SH, Tietze AA.

Biochim Biophys Acta. 2016 Sep;1860(9):2053-63. doi: 10.1016/j.bbagen.2016.06.013. Epub 2016 Jun 15. No abstract available.

PMID:
27316322
10.

Modulation of BK Channels by Small Endogenous Molecules and Pharmaceutical Channel Openers.

Hoshi T, Heinemann SH.

Int Rev Neurobiol. 2016;128:193-237. doi: 10.1016/bs.irn.2016.03.020. Epub 2016 May 4. Review.

PMID:
27238265
11.

Stereospecific capillary electrophoresis assays using pentapeptide substrates for the study of Aspergillus nidulans methionine sulfoxide reductase A and mutant enzymes.

Zhu Q, El-Mergawy RG, Zhou Y, Chen C, Heinemann SH, Schönherr R, Robaa D, Sippl W, Scriba GK.

Electrophoresis. 2016 Jul;37(14):2083-90. doi: 10.1002/elps.201600181. Epub 2016 Jun 8.

PMID:
27145186
12.

Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations.

Han B, He K, Cai C, Tang Y, Yang L, Heinemann SH, Hoshi T, Hou S.

Sci Rep. 2016 Mar 23;6:23417. doi: 10.1038/srep23417.

13.

CORM-EDE1: A Highly Water-Soluble and Nontoxic Manganese-Based photoCORM with a Biogenic Ligand Sphere.

Mede R, Klein M, Claus RA, Krieck S, Quickert S, Görls H, Neugebauer U, Schmitt M, Gessner G, Heinemann SH, Popp J, Bauer M, Westerhausen M.

Inorg Chem. 2016 Jan 4;55(1):104-13. doi: 10.1021/acs.inorgchem.5b01904. Epub 2015 Dec 16.

PMID:
26672620
14.

Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant.

Leipold E, Hanson-Kahn A, Frick M, Gong P, Bernstein JA, Voigt M, Katona I, Oliver Goral R, Altmüller J, Nürnberg P, Weis J, Hübner CA, Heinemann SH, Kurth I.

Nat Commun. 2015 Dec 8;6:10049. doi: 10.1038/ncomms10049.

15.

Ca(2+)/calmodulin regulates Kvβ1.1-mediated inactivation of voltage-gated K(+) channels.

Swain SM, Sahoo N, Dennhardt S, Schönherr R, Heinemann SH.

Sci Rep. 2015 Oct 21;5:15509. doi: 10.1038/srep15509.

16.

Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglion neurons.

Schink M, Leipold E, Schirmeyer J, Schönherr R, Hoshi T, Heinemann SH.

Pflugers Arch. 2016 Jan;468(1):99-110. doi: 10.1007/s00424-015-1735-z. Epub 2015 Sep 17.

17.

Structure Elucidation and Activity of Kolossin A, the D-/L-Pentadecapeptide Product of a Giant Nonribosomal Peptide Synthetase.

Bode HB, Brachmann AO, Jadhav KB, Seyfarth L, Dauth C, Fuchs SW, Kaiser M, Waterfield NR, Sack H, Heinemann SH, Arndt HD.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10352-5. doi: 10.1002/anie.201502835. Epub 2015 Jun 26.

PMID:
26118790
18.

Heterologous expression of NaV1.9 chimeras in various cell systems.

Goral RO, Leipold E, Nematian-Ardestani E, Heinemann SH.

Pflugers Arch. 2015 Dec;467(12):2423-35. doi: 10.1007/s00424-015-1709-1. Epub 2015 Apr 29.

PMID:
25916202
19.

Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels.

Tian Y, Ullrich F, Xu R, Heinemann SH, Hou S, Hoshi T.

J Gen Physiol. 2015 Apr;145(4):331-43. doi: 10.1085/jgp.201511363.

20.

An approach to NMR assignment of intrinsically disordered proteins.

Goradia N, Wiedemann C, Herbst C, Görlach M, Heinemann SH, Ohlenschläger O, Ramachandran R.

Chemphyschem. 2015 Mar 16;16(4):739-46. doi: 10.1002/cphc.201402872. Epub 2015 Jan 30.

PMID:
25639453
21.

Carbon monoxide release properties and molecular structures of phenylthiolatomanganese(I) carbonyl complexes of the type [(OC)4Mn(μ-S-aryl)]2.

Mede R, Lorett-Velásquez VP, Klein M, Görls H, Schmitt M, Gessner G, Heinemann SH, Popp J, Westerhausen M.

Dalton Trans. 2015 Feb 21;44(7):3020-33. doi: 10.1039/c4dt03567d.

PMID:
25569035
22.

Application of room-temperature aprotic and protic ionic liquids for oxidative folding of cysteine-rich peptides.

Heimer P, Tietze AA, Böhm M, Giernoth R, Kuchenbuch A, Stark A, Leipold E, Heinemann SH, Kandt C, Imhof D.

Chembiochem. 2014 Dec 15;15(18):2754-65. doi: 10.1002/cbic.201402356. Epub 2014 Nov 5.

PMID:
25376613
23.

Capillary electrophoresis separation of peptide diastereomers that contain methionine sulfoxide by dual cyclodextrin-crown ether systems.

Zhu Q, Heinemann SH, Schönherr R, Scriba GK.

J Sep Sci. 2014 Dec;37(23):3548-54. doi: 10.1002/jssc.201400825. Epub 2014 Oct 20.

PMID:
25216019
24.

Experimental design-guided development of a stereospecific capillary electrophoresis assay for methionine sulfoxide reductase enzymes using a diastereomeric pentapeptide substrate.

Zhu Q, Huo X, Heinemann SH, Schönherr R, El-Mergawy R, Scriba GK.

J Chromatogr A. 2014 Sep 12;1359:224-9. doi: 10.1016/j.chroma.2014.07.009. Epub 2014 Jul 12.

PMID:
25064531
25.

Critical role of large-conductance calcium- and voltage-activated potassium channels in leptin-induced neuroprotection of N-methyl-d-aspartate-exposed cortical neurons.

Mancini M, Soldovieri MV, Gessner G, Wissuwa B, Barrese V, Boscia F, Secondo A, Miceli F, Franco C, Ambrosino P, Canzoniero LM, Bauer M, Hoshi T, Heinemann SH, Taglialatela M.

Pharmacol Res. 2014 Sep;87:80-6. doi: 10.1016/j.phrs.2014.06.010. Epub 2014 Jun 26.

26.

Exon 11 skipping of SCN10A coding for voltage-gated sodium channels in dorsal root ganglia.

Schirmeyer J, Szafranski K, Leipold E, Mawrin C, Platzer M, Heinemann SH.

Channels (Austin). 2014;8(3):210-5.

27.

Carbon monoxide--physiology, detection and controlled release.

Heinemann SH, Hoshi T, Westerhausen M, Schiller A.

Chem Commun (Camb). 2014 Apr 11;50(28):3644-60. doi: 10.1039/c3cc49196j. Review.

28.

Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species.

Ojha NK, Nematian-Ardestani E, Neugebauer S, Borowski B, El-Hussein A, Hoshi T, Leipold E, Heinemann SH.

Biochim Biophys Acta. 2014 May;1838(5):1412-9. doi: 10.1016/j.bbamem.2014.01.031. Epub 2014 Feb 7.

29.

Stereospecific electrophoretically mediated microanalysis assay for methionine sulfoxide reductase enzymes.

Zhu Q, El-Mergawy RG, Heinemann SH, Schönherr R, Jáč P, Scriba GK.

Anal Bioanal Chem. 2014 Feb;406(6):1723-9. doi: 10.1007/s00216-013-7596-4. Epub 2014 Jan 15.

PMID:
24424966
30.

Fixed charges in the gel matrix of sensor chips and dissociation in diffusion gradients influence the detection of fast protein-protein interactions.

Glaser RW, Schönherr R, Heinemann SH.

Biosystems. 2014 Feb;116:27-35. doi: 10.1016/j.biosystems.2013.09.009. Epub 2013 Dec 14.

PMID:
24342363
31.

A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid.

Hoshi T, Xu R, Hou S, Heinemann SH, Tian Y.

J Gen Physiol. 2013 Nov;142(5):507-22. doi: 10.1085/jgp.201311061. Epub 2013 Oct 14.

32.

Heme impairs the ball-and-chain inactivation of potassium channels.

Sahoo N, Goradia N, Ohlenschläger O, Schönherr R, Friedrich M, Plass W, Kappl R, Hoshi T, Heinemann SH.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):E4036-44. doi: 10.1073/pnas.1313247110. Epub 2013 Sep 30.

33.

Oxidative modulation of voltage-gated potassium channels.

Sahoo N, Hoshi T, Heinemann SH.

Antioxid Redox Signal. 2014 Aug 20;21(6):933-52. doi: 10.1089/ars.2013.5614. Epub 2013 Oct 26. Review.

34.

A de novo gain-of-function mutation in SCN11A causes loss of pain perception.

Leipold E, Liebmann L, Korenke GC, Heinrich T, Giesselmann S, Baets J, Ebbinghaus M, Goral RO, Stödberg T, Hennings JC, Bergmann M, Altmüller J, Thiele H, Wetzel A, Nürnberg P, Timmerman V, De Jonghe P, Blum R, Schaible HG, Weis J, Heinemann SH, Hübner CA, Kurth I.

Nat Genet. 2013 Nov;45(11):1399-404. doi: 10.1038/ng.2767. Epub 2013 Sep 15.

PMID:
24036948
35.

Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure.

Hoshi T, Wissuwa B, Tian Y, Tajima N, Xu R, Bauer M, Heinemann SH, Hou S.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2260. No abstract available.

36.

Stereospecific micellar electrokinetic chromatography assay of methionine sulfoxide reductase activity employing a multiple layer coated capillary.

Zhu Q, El-Mergawy RG, Heinemann SH, Schönherr R, Jáč P, Scriba GK.

Electrophoresis. 2013 Sep;34(18):2712-7. doi: 10.1002/elps.201300147. Epub 2013 Aug 9.

PMID:
23775584
37.

Analysis of Fe(III) heme binding to cysteine-containing heme-regulatory motifs in proteins.

Kühl T, Wißbrock A, Goradia N, Sahoo N, Galler K, Neugebauer U, Popp J, Heinemann SH, Ohlenschläger O, Imhof D.

ACS Chem Biol. 2013 Aug 16;8(8):1785-93. doi: 10.1021/cb400317x. Epub 2013 Jun 17.

PMID:
23730736
38.

Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA.

Hoshi T, Tian Y, Xu R, Heinemann SH, Hou S.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4822-7. doi: 10.1073/pnas.1222003110. Epub 2013 Mar 4.

39.

Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels.

Hoshi T, Wissuwa B, Tian Y, Tajima N, Xu R, Bauer M, Heinemann SH, Hou S.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4816-21. doi: 10.1073/pnas.1221997110. Epub 2013 Mar 4.

40.

Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis.

Sponholz C, Huse K, Kramer M, Giamarellos-Bourboulis EJ, Claus RA, Kern A, Engel C, Kuhnt E, Kiehntopf M, Routsi C, Mylona V, Tsangaris I, Heinemann SH, Reinhart K, Platzer M, Bauer M.

Shock. 2012 Nov;38(5):459-65. doi: 10.1097/SHK.0b013e31826ae951. Erratum in: Shock. 2013 Jan;39(1):115.

PMID:
23042203
41.

Kcnh1 voltage-gated potassium channels are essential for early zebrafish development.

Stengel R, Rivera-Milla E, Sahoo N, Ebert C, Bollig F, Heinemann SH, Schönherr R, Englert C.

J Biol Chem. 2012 Oct 12;287(42):35565-75. doi: 10.1074/jbc.M112.363978. Epub 2012 Aug 27.

42.

Visualizing individual sodium channels on the move.

Heinemann SH.

Chem Biol. 2012 Jul 27;19(7):790-1. doi: 10.1016/j.chembiol.2012.07.002.

43.

Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC.

Markgraf R, Leipold E, Schirmeyer J, Paolini-Bertrand M, Hartley O, Heinemann SH.

Br J Pharmacol. 2012 Oct;167(3):576-86. doi: 10.1111/j.1476-5381.2012.02004.x.

44.

Scorpion β-toxin interference with NaV channel voltage sensor gives rise to excitatory and depressant modes.

Leipold E, Borges A, Heinemann SH.

J Gen Physiol. 2012 Apr;139(4):305-19. doi: 10.1085/jgp.201110720.

45.

Structurally diverse μ-conotoxin PIIIA isomers block sodium channel NaV 1.4.

Tietze AA, Tietze D, Ohlenschläger O, Leipold E, Ullrich F, Kühl T, Mischo A, Buntkowsky G, Görlach M, Heinemann SH, Imhof D.

Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4058-61. doi: 10.1002/anie.201107011. Epub 2012 Mar 12. Review. No abstract available.

PMID:
22407516
46.

Molecular mechanism of pharmacological activation of BK channels.

Gessner G, Cui YM, Otani Y, Ohwada T, Soom M, Hoshi T, Heinemann SH.

Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3552-7. doi: 10.1073/pnas.1114321109. Epub 2012 Feb 13.

47.

Cysteines control the N- and C-linker-dependent gating of KCNH1 potassium channels.

Sahoo N, Schönherr R, Hoshi T, Heinemann SH.

Biochim Biophys Acta. 2012 May;1818(5):1187-95. doi: 10.1016/j.bbamem.2012.01.021. Epub 2012 Jan 28.

48.

Carbon monoxide and outcome of stroke--a dream CORM true?.

Bauer M, Witte OW, Heinemann SH.

Crit Care Med. 2012 Feb;40(2):687-8. doi: 10.1097/CCM.0b013e318232d31a. No abstract available.

PMID:
22249054
49.

A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors.

Favreau P, Benoit E, Hocking HG, Carlier L, D' hoedt D, Leipold E, Markgraf R, Schlumberger S, Córdova MA, Gaertner H, Paolini-Bertrand M, Hartley O, Tytgat J, Heinemann SH, Bertrand D, Boelens R, Stöcklin R, Molgó J.

Br J Pharmacol. 2012 Jul;166(5):1654-68. doi: 10.1111/j.1476-5381.2012.01837.x.

50.

Determination of hemin-binding characteristics of proteins by a combinatorial peptide library approach.

Kühl T, Sahoo N, Nikolajski M, Schlott B, Heinemann SH, Imhof D.

Chembiochem. 2011 Dec 16;12(18):2846-55. doi: 10.1002/cbic.201100556. Epub 2011 Nov 2.

PMID:
22045633

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