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TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells.

Mariathasan S, Turley SJ, Nickles D, Castiglioni A, Yuen K, Wang Y, Kadel Iii EE, Koeppen H, Astarita JL, Cubas R, Jhunjhunwala S, Banchereau R, Yang Y, Guan Y, Chalouni C, Ziai J, Şenbabaoğlu Y, Santoro S, Sheinson D, Hung J, Giltnane JM, Pierce AA, Mesh K, Lianoglou S, Riegler J, Carano RAD, Eriksson P, Höglund M, Somarriba L, Halligan DL, van der Heijden MS, Loriot Y, Rosenberg JE, Fong L, Mellman I, Chen DS, Green M, Derleth C, Fine GD, Hegde PS, Bourgon R, Powles T.

Nature. 2018 Feb 22;554(7693):544-548. doi: 10.1038/nature25501. Epub 2018 Feb 14.


Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with Carboplatin, Paclitaxel, and Bevacizumab for First-Line Nonsquamous Non-Small Cell Lung Cancer.

von Pawel J, Spigel DR, Ervin T, Losonczy G, Barlesi F, Juhász E, Anderson M, McCall B, Wakshull E, Hegde P, Ye W, Chen D, Chang I, Rhee I, Reck M.

Oncologist. 2018 Feb 7. pii: theoncologist.2017-0690. doi: 10.1634/theoncologist.2017-0690. [Epub ahead of print]


Natural Immunomodulators.

Ortuño-Sahagún D, Zänker K, Rawat AKS, Kaveri SV, Hegde P.

J Immunol Res. 2017;2017:7529408. doi: 10.1155/2017/7529408. Epub 2017 Dec 14. No abstract available.


A mitogenic lectin from Rhizoctonia bataticola arrests growth, inhibits metastasis, and induces apoptosis in human colon epithelial cancer cells.

Hegde P, Rajakumar SB, Swamy BM, Inamdar SR.

J Cell Biochem. 2018 Jan 31. doi: 10.1002/jcb.26740. [Epub ahead of print]


Combined Endosonography Reduces Time to Diagnose Pulmonary Coccidioidomycosis.

Shah RA, Vempilly JJ, Noor Ul Husnain SM, Hegde P.

J Bronchology Interv Pulmonol. 2018 Jan 16. doi: 10.1097/LBR.0000000000000454. [Epub ahead of print]


Development of a PD-L1 Complementary Diagnostic Immunohistochemistry Assay (SP142) for Atezolizumab.

Vennapusa B, Baker B, Kowanetz M, Boone J, Menzl I, Bruey JM, Fine G, Mariathasan S, McCaffery I, Mocci S, Rost S, Smith D, Dennis E, Tang SY, Damadzadeh B, Walker E, Hegde PS, Williams JA, Koeppen H, Boyd Z.

Appl Immunohistochem Mol Morphol. 2018 Jan 16. doi: 10.1097/PAI.0000000000000594. [Epub ahead of print]


Tumor Infiltration Depth as a Prognostic Parameter for Nodal Metastasis in Oral Squamous Cell Carcinoma.

Hegde P, Roy S, Shetty T, Prasad BR, Shetty U.

Int J Appl Basic Med Res. 2017 Oct-Dec;7(4):252-257. doi: 10.4103/ijabmr.IJABMR_66_17. Review.


Atezolizumab versus chemotherapy in patients with platinum-treated locally advanced or metastatic urothelial carcinoma (IMvigor211): a multicentre, open-label, phase 3 randomised controlled trial.

Powles T, Durán I, van der Heijden MS, Loriot Y, Vogelzang NJ, De Giorgi U, Oudard S, Retz MM, Castellano D, Bamias A, Fléchon A, Gravis G, Hussain S, Takano T, Leng N, Kadel EE 3rd, Banchereau R, Hegde PS, Mariathasan S, Cui N, Shen X, Derleth CL, Green MC, Ravaud A.

Lancet. 2018 Feb 24;391(10122):748-757. doi: 10.1016/S0140-6736(17)33297-X. Epub 2017 Dec 18.


Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics.

Hegde PS, Wallin JJ, Mancao C.

Semin Cancer Biol. 2017 Dec 8. pii: S1044-579X(17)30204-3. doi: 10.1016/j.semcancer.2017.12.002. [Epub ahead of print] Review.


Noise Removal in Dermoscopic Images Using a Novel Software.

Hegde PR, Shenoy MM, Shekar BH.

Indian Dermatol Online J. 2017 Nov-Dec;8(6):513-514. doi: 10.4103/idoj.IDOJ_417_16. No abstract available.


Molecular and Histopathological Characterization of the Tumor Immune Microenvironment in Advanced Stage of Malignant Pleural Mesothelioma.

Patil NS, Righi L, Koeppen H, Zou W, Izzo S, Grosso F, Libener R, Loiacono M, Monica V, Buttigliero C, Novello S, Hegde PS, Papotti M, Kowanetz M, Scagliotti GV.

J Thorac Oncol. 2018 Jan;13(1):124-133. doi: 10.1016/j.jtho.2017.09.1968. Epub 2017 Oct 24.


Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with FOLFOX and Bevacizumab for First-Line Metastatic Colorectal Cancer.

García-Carbonero R, van Cutsem E, Rivera F, Jassem J, Gore I Jr, Tebbutt N, Braiteh F, Argiles G, Wainberg ZA, Funke R, Anderson M, McCall B, Stroh M, Wakshull E, Hegde P, Ye W, Chen D, Chang I, Rhee I, Hurwitz H.

Oncologist. 2017 Oct;22(10):1281. doi: 10.1634/theoncologist.2016-0133erratum. No abstract available.


Aspergillus fumigatus Cell Wall α-(1,3)-Glucan Stimulates Regulatory T-Cell Polarization by Inducing PD-L1 Expression on Human Dendritic Cells.

Stephen-Victor E, Karnam A, Fontaine T, Beauvais A, Das M, Hegde P, Prakhar P, Holla S, Balaji KN, Kaveri SV, Latgé JP, Aimanianda V, Bayry J.

J Infect Dis. 2017 Dec 5;216(10):1281-1294. doi: 10.1093/infdis/jix469.


Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease.

Vasquez V, Mitra J, Hegde PM, Pandey A, Sengupta S, Mitra S, Rao KS, Hegde ML.

J Alzheimers Dis. 2017;60(s1):S133-S150. doi: 10.3233/JAD-170342.


High mannose N-glycan binding lectin from Remusatia vivipara (RVL) limits cell growth, motility and invasiveness of human breast cancer cells.

Sindhura BR, Hegde P, Chachadi VB, Inamdar SR, Swamy BM.

Biomed Pharmacother. 2017 Sep;93:654-665. doi: 10.1016/j.biopha.2017.06.081. Epub 2017 Jul 4.


Obstetric interventions and maternal morbidity among women who experience severe postpartum hemorrhage during cesarean delivery.

Seligman K, Ramachandran B, Hegde P, Riley ET, El-Sayed YY, Nelson LM, Butwick AJ.

Int J Obstet Anesth. 2017 May;31:27-36. doi: 10.1016/j.ijoa.2017.03.009. Epub 2017 Mar 22.


Chemical Constituents of Carbonaceous and Nitrogen Aerosols over Thumba Region, Trivandrum, India.

Hegde P, Kawamura K.

Arch Environ Contam Toxicol. 2017 Oct;73(3):456-473. doi: 10.1007/s00244-017-0426-5. Epub 2017 Jul 1.


Discovery of putative breast cancer antigens using an integrative platform of genomics-driven immunoproteomics.

Qendro V, Lundgren DH, Palczewski S, Hegde P, Stevenson C, Perpetua L, Latifi A, Merriman J, Bugos G, Han DK.

Proteomics. 2017 Aug;17(15-16). doi: 10.1002/pmic.201600318.


Extinction of Contextual Fear with Timed Exposure to Enriched Environment: A Differential Effect.

Hegde P, O'Mara S, Laxmi TR.

Ann Neurosci. 2017 May;24(2):90-104. doi: 10.1159/000475898. Epub 2017 May 12.


Gene Expression Profiling in BRAF-Mutated Melanoma Reveals Patient Subgroups with Poor Outcomes to Vemurafenib That May Be Overcome by Cobimetinib Plus Vemurafenib.

Wongchenko MJ, McArthur GA, Dréno B, Larkin J, Ascierto PA, Sosman J, Andries L, Kockx M, Hurst SD, Caro I, Rooney I, Hegde PS, Molinero L, Yue H, Chang I, Amler L, Yan Y, Ribas A.

Clin Cancer Res. 2017 Sep 1;23(17):5238-5245. doi: 10.1158/1078-0432.CCR-17-0172. Epub 2017 May 23.


Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis.

Wang H, Peng B, Pandita RK, Engler DA, Matsunami RK, Xu X, Hegde PM, Butler BE, Pandita TK, Mitra S, Xu B, Hegde ML.

Oncotarget. 2017 Jul 25;8(30):48671-48687. doi: 10.18632/oncotarget.16225.


Iron addiction: a novel therapeutic target in ovarian cancer.

Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV.

Oncogene. 2017 Jul 20;36(29):4089-4099. doi: 10.1038/onc.2017.11. Epub 2017 Mar 20.


Risk Factors for Severe Postpartum Hemorrhage After Cesarean Delivery: Case-Control Studies.

Butwick AJ, Ramachandran B, Hegde P, Riley ET, El-Sayed YY, Nelson LM.

Anesth Analg. 2017 Aug;125(2):523-532. doi: 10.1213/ANE.0000000000001962.


Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with FOLFOX and Bevacizumab for First-Line Metastatic Colorectal Cancer.

García-Carbonero R, van Cutsem E, Rivera F, Jassem J, Gore I Jr, Tebbutt N, Braiteh F, Argiles G, Wainberg ZA, Funke R, Anderson M, McCall B, Stroh M, Wakshull E, Hegde P, Ye W, Chen D, Chang I, Rhee I, Hurwitz H.

Oncologist. 2017 Apr;22(4):375-e30. doi: 10.1634/theoncologist.2016-0133. Epub 2017 Mar 8. Erratum in: Oncologist. 2017 Oct;22(10 ):1281.


DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.

Lemler DJ, Lynch ML, Tesfay L, Deng Z, Paul BT, Wang X, Hegde P, Manz DH, Torti SV, Torti FM.

Breast Cancer Res. 2017 Mar 7;19(1):25. doi: 10.1186/s13058-017-0814-9.


Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex.

Dutta A, Eckelmann B, Adhikari S, Ahmed KM, Sengupta S, Pandey A, Hegde PM, Tsai MS, Tainer JA, Weinfeld M, Hegde ML, Mitra S.

Nucleic Acids Res. 2017 Mar 17;45(5):2585-2599. doi: 10.1093/nar/gkw1262.


Atezolizumab as first-line treatment in cisplatin-ineligible patients with locally advanced and metastatic urothelial carcinoma: a single-arm, multicentre, phase 2 trial.

Balar AV, Galsky MD, Rosenberg JE, Powles T, Petrylak DP, Bellmunt J, Loriot Y, Necchi A, Hoffman-Censits J, Perez-Gracia JL, Dawson NA, van der Heijden MS, Dreicer R, Srinivas S, Retz MM, Joseph RW, Drakaki A, Vaishampayan UN, Sridhar SS, Quinn DI, Durán I, Shaffer DR, Eigl BJ, Grivas PD, Yu EY, Li S, Kadel EE 3rd, Boyd Z, Bourgon R, Hegde PS, Mariathasan S, Thåström A, Abidoye OO, Fine GD, Bajorin DF; IMvigor210 Study Group.

Lancet. 2017 Jan 7;389(10064):67-76. doi: 10.1016/S0140-6736(16)32455-2. Epub 2016 Dec 8.


AMPKα Is Suppressed in Bladder Cancer through Macrophage-Mediated Mechanisms.

Kopsiaftis S, Hegde P, Taylor JA 3rd, Claffey KP.

Transl Oncol. 2016 Dec;9(6):606-616. doi: 10.1016/j.tranon.2016.07.007.


Endobronchial and Endoscopic Ultrasound-Guided Transvascular Biopsy of Mediastinal, Hilar, and Lung Lesions.

Kazakov J, Hegde P, Tahiri M, Thiffault V, Ferraro P, Liberman M.

Ann Thorac Surg. 2017 Mar;103(3):951-955. doi: 10.1016/j.athoracsur.2016.08.111. Epub 2016 Nov 16.


Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A.

Yang C, Sengupta S, Hegde PM, Mitra J, Jiang S, Holey B, Sarker AH, Tsai MS, Hegde ML, Mitra S.

Nucleic Acids Res. 2017 Jan 25;45(2):739-748. doi: 10.1093/nar/gkw1024. Epub 2016 Oct 27.


Clinical profile of young diabetics attending a tertiary care hospital in South India.

Hegde P.

J Assoc Physicians India. 2016 Jan;64(1):40. No abstract available.


TDP-43/FUS in motor neuron disease: Complexity and challenges.

Guerrero EN, Wang H, Mitra J, Hegde PM, Stowell SE, Liachko NF, Kraemer BC, Garruto RM, Rao KS, Hegde ML.

Prog Neurobiol. 2016 Oct - Nov;145-146:78-97. doi: 10.1016/j.pneurobio.2016.09.004. Epub 2016 Sep 28. Review.


Knowledge of blood loss at delivery among postpartum patients.

Farber MK, Miller CM, Ramachandran B, Hegde P, Akbar K, Goodnough LT, Butwick AJ.

PeerJ. 2016 Aug 31;4:e2361. doi: 10.7717/peerj.2361. eCollection 2016.


Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma.

Wallin JJ, Bendell JC, Funke R, Sznol M, Korski K, Jones S, Hernandez G, Mier J, He X, Hodi FS, Denker M, Leveque V, Cañamero M, Babitski G, Koeppen H, Ziai J, Sharma N, Gaire F, Chen DS, Waterkamp D, Hegde PS, McDermott DF.

Nat Commun. 2016 Aug 30;7:12624. doi: 10.1038/ncomms12624.


Mediastinal Staging: Endosonographic Ultrasound Lymph Node Biopsy or Mediastinoscopy.

Hegde PV, Liberman M.

Thorac Surg Clin. 2016 Aug;26(3):243-9. doi: 10.1016/j.thorsurg.2016.04.005. Review.


Simulations to Predict Clinical Trial Outcome of Bevacizumab Plus Chemotherapy vs. Chemotherapy Alone in Patients With First-Line Gastric Cancer and Elevated Plasma VEGF-A.

Han K, Claret L, Piao Y, Hegde P, Joshi A, Powell JR, Jin J, Bruno R.

CPT Pharmacometrics Syst Pharmacol. 2016 Jul;5(7):352-8. doi: 10.1002/psp4.12064. Epub 2016 Jul 12.


Pulmonary Artery Sealing With an Ultrasonic Energy Device in Video-Assisted Thoracoscopic Surgery Lobectomy: An Animal Survival Study.

Goudie E, Khereba M, Tahiri M, Hegde P, Thiffault V, Hadjeres R, Berdugo J, Ferraro P, Liberman M.

Ann Thorac Surg. 2016 Oct;102(4):1088-94. doi: 10.1016/j.athoracsur.2016.04.050. Epub 2016 Jun 24.


Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions.

Hegde ML, Dutta A, Yang C, Mantha AK, Hegde PM, Pandey A, Sengupta S, Yu Y, Calsou P, Chen D, Lees-Miller SP, Mitra S.

Oncotarget. 2016 Aug 23;7(34):54430-54444. doi: 10.18632/oncotarget.9914.


Evaluation of the efficacy of platelet-rich plasma and platelet-rich fibrin in alveolar defects after removal of impacted bilateral mandibular third molars.

Doiphode AM, Hegde P, Mahindra U, Santhosh Kumar SM, Tenglikar PD, Tripathi V.

J Int Soc Prev Community Dent. 2016 Apr;6(Suppl 1):S47-52. doi: 10.4103/2231-0762.181167.


Hypercalcemia in a Young Man.

Canfarotta M, Hegde P, Parham K.

JAMA Otolaryngol Head Neck Surg. 2016 Nov 1;142(11):1125-1126. doi: 10.1001/jamaoto.2016.0072. No abstract available.


The Where, the When, and the How of Immune Monitoring for Cancer Immunotherapies in the Era of Checkpoint Inhibition.

Hegde PS, Karanikas V, Evers S.

Clin Cancer Res. 2016 Apr 15;22(8):1865-74. doi: 10.1158/1078-0432.CCR-15-1507. Review.


Influence of non-thermal TiCl4/Ar+O2 plasma-assisted TiOx based coatings on the surface of polypropylene (PP) films for the tailoring of surface properties and cytocompatibility.

Pandiyaraj KN, Kumar AA, Ramkumar MC, Sachdev A, Gopinath P, Cools P, De Geyter N, Morent R, Deshmukh RR, Hegde P, Han C, Nadagouda MN.

Mater Sci Eng C Mater Biol Appl. 2016 May;62:908-18. doi: 10.1016/j.msec.2016.02.042. Epub 2016 Feb 17.


Assessment of Functional Differences in Malignant and Benign Breast Lesions and Improvement of Diagnostic Accuracy by Using US-guided Diffuse Optical Tomography in Conjunction with Conventional US.

Zhu Q, Ricci A Jr, Hegde P, Kane M, Cronin E, Merkulov A, Xu Y, Tavakoli B, Tannenbaum S.

Radiology. 2016 Aug;280(2):387-97. doi: 10.1148/radiol.2016151097. Epub 2016 Mar 2.


Long term exposure to combination paradigm of environmental enrichment, physical exercise and diet reverses the spatial memory deficits and restores hippocampal neurogenesis in ventral subicular lesioned rats.

Kapgal V, Prem N, Hegde P, Laxmi TR, Kutty BM.

Neurobiol Learn Mem. 2016 Apr;130:61-70. doi: 10.1016/j.nlm.2016.01.013. Epub 2016 Feb 2.


Mesenteric Lymphangioma Presenting as Ileal Volvulus.

Elukoti HN, Alcasoas S, Vernekar J, Hegde P, Pereira S.

J Clin Diagn Res. 2015 Dec;9(12):TJ05-6. doi: 10.7860/JCDR/2015/16631.6994. Epub 2015 Dec 1. No abstract available.


Heme oxygenase-1 is dispensable for the anti-inflammatory activity of intravenous immunoglobulin.

Galeotti C, Hegde P, Das M, Stephen-Victor E, Canale F, Muñoz M, Sharma VK, Dimitrov JD, Kaveri SV, Bayry J.

Sci Rep. 2016 Jan 22;6:19592. doi: 10.1038/srep19592.


Novel technologies and emerging biomarkers for personalized cancer immunotherapy.

Yuan J, Hegde PS, Clynes R, Foukas PG, Harari A, Kleen TO, Kvistborg P, Maccalli C, Maecker HT, Page DB, Robins H, Song W, Stack EC, Wang E, Whiteside TL, Zhao Y, Zwierzina H, Butterfield LH, Fox BA.

J Immunother Cancer. 2016 Jan 19;4:3. doi: 10.1186/s40425-016-0107-3. eCollection 2016. Review.


Transepidermal Water Loss in Neonates: Baseline Values Using a Closed-Chamber System.

Mathanda TR, M Bhat R, Hegde P, Anand S.

Pediatr Dermatol. 2016 Jan-Feb;33(1):33-7. doi: 10.1111/pde.12704. Epub 2015 Oct 8.


Atezolizumab, an Anti-Programmed Death-Ligand 1 Antibody, in Metastatic Renal Cell Carcinoma: Long-Term Safety, Clinical Activity, and Immune Correlates From a Phase Ia Study.

McDermott DF, Sosman JA, Sznol M, Massard C, Gordon MS, Hamid O, Powderly JD, Infante JR, Fassò M, Wang YV, Zou W, Hegde PS, Fine GD, Powles T.

J Clin Oncol. 2016 Mar 10;34(8):833-42. doi: 10.1200/JCO.2015.63.7421. Epub 2016 Jan 11.


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