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Treatment choices and neuropsychological symptoms of a large cohort of early MS.

von Bismarck O, Dankowski T, Ambrosius B, Hessler N, Antony G, Ziegler A, Hoshi MM, Aly L, Luessi F, Groppa S, Klotz L, Meuth SG, Tackenberg B, Stoppe M, Then Bergh F, Tumani H, Kümpfel T, Stangel M, Heesen C, Wildemann B, Paul F, Bayas A, Warnke C, Weber F, Linker RA, Ziemann U, Zettl UK, Zipp F, Wiendl H, Hemmer B, Gold R, Salmen A.

Neurol Neuroimmunol Neuroinflamm. 2018 Mar 1;5(3):e446. doi: 10.1212/NXI.0000000000000446. eCollection 2018 May.


Sexual dysfunctions in MS in relation to neuropsychiatric aspects and its psychological treatment: A scoping review.

Pöttgen J, Rose A, van de Vis W, Engelbrecht J, Pirard M, Lau S, Heesen C, Köpke S; RiMS Special Interest Group Psychology and Neuropsychology.

PLoS One. 2018 Feb 27;13(2):e0193381. doi: 10.1371/journal.pone.0193381. eCollection 2018.


Does cladribine have an impact on brain atrophy in people with relapsing remitting multiple sclerosis?

Schiffmann I, Scheiderbauer J, Riemann-Lorenz K, Heesen C.

Mult Scler. 2018 Jan 1:1352458517749895. doi: 10.1177/1352458517749895. [Epub ahead of print] No abstract available.


A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial).

Stürner KH, Stellmann JP, Dörr J, Paul F, Friede T, Schammler S, Reinhardt S, Gellissen S, Weissflog G, Faizy TD, Werz O, Fleischer S, Vaas LAI, Herrmann F, Pless O, Martin R, Heesen C.

J Neurol Neurosurg Psychiatry. 2018 Apr;89(4):330-338. doi: 10.1136/jnnp-2017-317101. Epub 2017 Dec 16.


Perceptions on the value of bodily functions in multiple sclerosis.

Heesen C, Haase R, Melzig S, Poettgen J, Berghoff M, Paul F, Zettl U, Marziniak M, Angstwurm K, Kern R, Ziemssen T, Stellmann JP.

Acta Neurol Scand. 2018 Mar;137(3):356-362. doi: 10.1111/ane.12881. Epub 2017 Dec 3.


The use of multiparametric quantitative magnetic resonance imaging for evaluating visually assigned lesion groups in patients with multiple sclerosis.

Thaler C, Faizy TD, Sedlacik J, Bester M, Stellmann JP, Heesen C, Fiehler J, Siemonsen S.

J Neurol. 2018 Jan;265(1):127-133. doi: 10.1007/s00415-017-8683-9. Epub 2017 Nov 20.


What should a person with relapsing-remitting multiple sclerosis know? - Focus group and survey data of a risk knowledge questionnaire (RIKNO 2.0).

Heesen C, Pöttgen J, Rahn AC, Liethmann K, Kasper J, Vahter L, Drulovic J, Van Nunen A, Wilkie D, Beckmann Y, Paul F, Köpke S, Giordano A, Solari A; AutoMS-group.

Mult Scler Relat Disord. 2017 Nov;18:186-195. doi: 10.1016/j.msard.2017.09.020. Epub 2017 Sep 21.


Acute and long-term effects of fingolimod on heart rhythm and heart rate variability in patients with multiple sclerosis.

Akbulak RÖ, Rosenkranz SC, Schaeffer BN, Pinnschmidt HO, Willems S, Heesen C, Hoffmann BA.

Mult Scler Relat Disord. 2018 Jan;19:44-49. doi: 10.1016/j.msard.2017.10.020. Epub 2017 Nov 2.


Aberrant peak lactate response in MS.

Schlüter K, Maier J, Patra S, Gold SM, Heesen C, Schulz KH.

NeuroRehabilitation. 2017;41(4):811-822. doi: 10.3233/NRE-172182.


Low clinical conversion rate in clinically isolated syndrome patients - diagnostic benefit of McDonald 2010 criteria?

Rosenkranz SC, Kaulen B, Neuhaus A, Siemonsen S, Köpke S, Daumer M, Stellmann JP, Heesen C.

Eur J Neurol. 2018 Feb;25(2):247-e9. doi: 10.1111/ene.13476. Epub 2017 Dec 2.


Nurse-led immunotreatment DEcision Coaching In people with Multiple Sclerosis (DECIMS) - Feasibility testing, pilot randomised controlled trial and mixed methods process evaluation.

Rahn AC, Köpke S, Backhus I, Kasper J, Anger K, Untiedt B, Alegiani A, Kleiter I, Mühlhauser I, Heesen C.

Int J Nurs Stud. 2017 Aug 26. pii: S0020-7489(17)30189-X. doi: 10.1016/j.ijnurstu.2017.08.011. [Epub ahead of print]


Exercise in patients with multiple sclerosis.

Motl RW, Sandroff BM, Kwakkel G, Dalgas U, Feinstein A, Heesen C, Feys P, Thompson AJ.

Lancet Neurol. 2017 Oct;16(10):848-856. doi: 10.1016/S1474-4422(17)30281-8. Epub 2017 Sep 12. Review.


Effect of informed consent on patient characteristics in a stroke thrombolysis trial.

Thomalla G, Boutitie F, Fiebach JB, Simonsen CZ, Nighoghossian N, Pedraza S, Lemmens R, Roy P, Muir KW, Heesen C, Ebinger M, Ford I, Cheng B, Cho TH, Puig J, Thijs V, Endres M, Fiehler J, Gerloff C.

Neurology. 2017 Sep 26;89(13):1400-1407. doi: 10.1212/WNL.0000000000004414. Epub 2017 Aug 25.


Managing the transition (ManTra): a resource for persons with secondary progressive multiple sclerosis and their health professionals: protocol for a mixed-methods study in Italy.

Giovannetti AM, Giordano A, Pietrolongo E, Confalonieri P, De Luca G, Tortorella C, Trojano M, Messmer Uccelli M, Torri Clerici V, Gitto L, Köpke S, Borreani C, Heesen C, Solari A; ManTra project.

BMJ Open. 2017 Aug 23;7(8):e017254. doi: 10.1136/bmjopen-2017-017254.


Reduced rich-club connectivity is related to disability in primary progressive MS.

Stellmann JP, Hodecker S, Cheng B, Wanke N, Young KL, Hilgetag C, Gerloff C, Heesen C, Thomalla G, Siemonsen S.

Neurol Neuroimmunol Neuroinflamm. 2017 Jul 27;4(5):e375. doi: 10.1212/NXI.0000000000000375. eCollection 2017 Sep.


T1w dark blood imaging improves detection of contrast enhancing lesions in multiple sclerosis.

Thaler C, Schneider T, Sedlacik J, Kutzner D, Stellmann JP, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2017 Aug 10;12(8):e0183099. doi: 10.1371/journal.pone.0183099. eCollection 2017.


Numeracy of multiple sclerosis patients: A comparison of patients from the PERCEPT study to a German probabilistic sample.

Gaissmaier W, Giese H, Galesic M, Garcia-Retamero R, Kasper J, Kleiter I, Meuth SG, Köpke S, Heesen C.

Patient Educ Couns. 2018 Jan;101(1):74-78. doi: 10.1016/j.pec.2017.07.018. Epub 2017 Jul 17.


Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis?

Kjølhede T, Siemonsen S, Wenzel D, Stellmann JP, Ringgaard S, Pedersen BG, Stenager E, Petersen T, Vissing K, Heesen C, Dalgas U.

Mult Scler. 2017 Jul 1:1352458517722645. doi: 10.1177/1352458517722645. [Epub ahead of print]


No relevant impact of ambient temperature on disability measurements in a large cohort of patients with multiple sclerosis.

Stellmann JP, Young KL, Vettorazzi E, Pöttgen J, Heesen C.

Eur J Neurol. 2017 Jun;24(6):851-857. doi: 10.1111/ene.13301.


Training doctors briefly and in situ to involve their patients in making medical decisions-Preliminary testing of a newly developed module.

Kasper J, Liethmann K, Heesen C, Reissmann DR, Geiger F.

Health Expect. 2017 Dec;20(6):1254-1263. doi: 10.1111/hex.12565. Epub 2017 May 18.


Benefit-risk perception of natalizumab therapy in neurologists and a large cohort of multiple sclerosis patients.

Heesen C, Kleiter I, Meuth SG, Krämer J, Kasper J, Köpke S, Gaissmaier W.

J Neurol Sci. 2017 May 15;376:181-190. doi: 10.1016/j.jns.2017.03.001. Epub 2017 Mar 7.


Is the risk of progressive multifocal leukoencephalopathy the real reason for natalizumab discontinuation in patients with multiple sclerosis?

Krämer J, Tenberge JG, Kleiter I, Gaissmaier W, Ruck T, Heesen C, Meuth SG.

PLoS One. 2017 Apr 13;12(4):e0174858. doi: 10.1371/journal.pone.0174858. eCollection 2017.


Patient education for people with multiple sclerosis-associated fatigue: A systematic review.

Wendebourg MJ, Heesen C, Finlayson M, Meyer B, Pöttgen J, Köpke S.

PLoS One. 2017 Mar 7;12(3):e0173025. doi: 10.1371/journal.pone.0173025. eCollection 2017. Review.


Pattern of gray matter volumes related to retinal thickness and its association with cognitive function in relapsing-remitting MS.

Stellmann JP, Cetin H, Young KL, Hodecker S, Pöttgen J, Bittersohl D, Hassenstein A, Oberwahrenbrock T, Heesen C, Siemonsen S.

Brain Behav. 2016 Dec 20;7(2):e00614. doi: 10.1002/brb3.614. eCollection 2017 Feb.


Reliability of cortical lesion detection on double inversion recovery MRI applying the MAGNIMS-Criteria in multiple sclerosis patients within a 16-months period.

Faizy TD, Thaler C, Ceyrowski T, Broocks G, Treffler N, Sedlacik J, Stürner K, Stellmann JP, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2017 Feb 24;12(2):e0172923. doi: 10.1371/journal.pone.0172923. eCollection 2017.


Maraviroc as possible treatment for PML-IRIS in natalizumab-treated patients with MS.

Hodecker SC, Stürner KH, Becker V, Elias-Hamp B, Holst B, Friese MA, Heesen C.

Neurol Neuroimmunol Neuroinflamm. 2017 Feb 8;4(2):e325. doi: 10.1212/NXI.0000000000000325. eCollection 2017 Mar. No abstract available.


Ruxolitinib treatment in a patient with neuromyelitis optica: A case report.

Hodecker SC, Stellmann JP, Rosenkranz SC, Young K, Holst B, Friese MA, Heesen C.

Neurol Neuroimmunol Neuroinflamm. 2017 Feb 3;4(2):e328. doi: 10.1212/NXI.0000000000000328. eCollection 2017 Mar. No abstract available.


T1 Recovery Is Predominantly Found in Black Holes and Is Associated with Clinical Improvement in Patients with Multiple Sclerosis.

Thaler C, Faizy TD, Sedlacik J, Holst B, Stürner K, Heesen C, Stellmann JP, Fiehler J, Siemonsen S.

AJNR Am J Neuroradiol. 2017 Feb;38(2):264-269. doi: 10.3174/ajnr.A5004. Epub 2016 Nov 10.


A new graphical format to communicate treatment effects to patients-A web-based randomized controlled trial.

Kasper J, van de Roemer A, Pöttgen J, Rahn A, Backhus I, Bay Y, Köpke S, Heesen C.

Health Expect. 2017 Aug;20(4):797-804. doi: 10.1111/hex.12522. Epub 2016 Dec 16.


Dietary Interventions in Multiple Sclerosis: Development and Pilot-Testing of an Evidence Based Patient Education Program.

Riemann-Lorenz K, Eilers M, von Geldern G, Schulz KH, Köpke S, Heesen C.

PLoS One. 2016 Oct 20;11(10):e0165246. doi: 10.1371/journal.pone.0165246. eCollection 2016.


Effects of exercise on Irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis.

Briken S, Rosenkranz SC, Keminer O, Patra S, Ketels G, Heesen C, Hellweg R, Pless O, Schulz KH, Gold SM.

J Neuroimmunol. 2016 Oct 15;299:53-58. doi: 10.1016/j.jneuroim.2016.08.007. Epub 2016 Aug 5.


Disease Activity and Conversion into Multiple Sclerosis after Optic Neuritis Is Treated with Erythropoietin.

Sühs KW, Papanagiotou P, Hein K, Pul R, Scholz K, Heesen C, Diem R.

Int J Mol Sci. 2016 Sep 30;17(10). pii: E1666.


Short-term MRI measurements as predictors of EDSS progression in relapsing-remitting multiple sclerosis: grey matter atrophy but not lesions are predictive in a real-life setting.

von Gumberz J, Mahmoudi M, Young K, Schippling S, Martin R, Heesen C, Siemonsen S, Stellmann JP.

PeerJ. 2016 Sep 20;4:e2442. doi: 10.7717/peerj.2442. eCollection 2016.


Comprehension of confidence intervals - development and piloting of patient information materials for people with multiple sclerosis: qualitative study and pilot randomised controlled trial.

Rahn AC, Backhus I, Fuest F, Riemann-Lorenz K, Köpke S, van de Roemer A, Mühlhauser I, Heesen C.

BMC Med Inform Decis Mak. 2016 Sep 20;16(1):122. doi: 10.1186/s12911-016-0362-8.


Fampridine and real-life walking in multiple sclerosis: Low predictive value of clinical test for habitual short-term changes.

Stellmann JP, Jlussi M, Neuhaus A, Lederer C, Daumer M, Heesen C.

J Neurol Sci. 2016 Sep 15;368:318-25. doi: 10.1016/j.jns.2016.07.051. Epub 2016 Jul 25.


Subjective and objective knowledge and decisional role preferences in cerebrovascular patients compared to controls.

Riechel C, Alegiani AC, Köpke S, Kasper J, Rosenkranz M, Thomalla G, Heesen C.

Patient Prefer Adherence. 2016 Aug 2;10:1453-60. doi: 10.2147/PPA.S98342. eCollection 2016.


Development and Feasibility of an Evidence-Based Patient Education Program for Managing Fatigue in Multiple Sclerosis: The "Fatigue Management in MS" Program (FatiMa).

Wendebourg MJ, Feddersen LK, Lau S, Köpke S, Moss-Morris R, Heesen C, Pöttgen J.

Int J MS Care. 2016 May-Jun;18(3):129-37. doi: 10.7224/1537-2073.2014-105.


Patient education programme on immunotherapy in multiple sclerosis (PEPIMS): a controlled rater-blinded study.

Köpke S, Kasper J, Flachenecker P, Meißner H, Brandt A, Hauptmann B, Bender G, Backhus I, Rahn AC, Pöttgen J, Vettorazzi E, Heesen C.

Clin Rehabil. 2017 Feb;31(2):250-261. doi: 10.1177/0269215516639734. Epub 2016 Jul 10.


Heterogeneity of Multiple Sclerosis Lesions in Multislice Myelin Water Imaging.

Faizy TD, Thaler C, Kumar D, Sedlacik J, Broocks G, Grosser M, Stellmann JP, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2016 Mar 18;11(3):e0151496. doi: 10.1371/journal.pone.0151496. eCollection 2016.


Treatment of optic neuritis with erythropoietin (TONE): a randomised, double-blind, placebo-controlled trial-study protocol.

Diem R, Molnar F, Beisse F, Gross N, Drüschler K, Heinrich SP, Joachimsen L, Rauer S, Pielen A, Sühs KW, Linker RA, Huchzermeyer C, Albrecht P, Hassenstein A, Aktas O, Guthoff T, Tonagel F, Kernstock C, Hartmann K, Kümpfel T, Hein K, van Oterendorp C, Grotejohann B, Ihorst G, Maurer J, Müller M, Volkmann M, Wildemann B, Platten M, Wick W, Heesen C, Schiefer U, Wolf S, Lagrèze WA.

BMJ Open. 2016 Mar 1;6(3):e010956. doi: 10.1136/bmjopen-2015-010956.


Improved Lesion Detection by Using Axial T2-Weighted MRI with Full Spinal Cord Coverage in Multiple Sclerosis.

Galler S, Stellmann JP, Young KL, Kutzner D, Heesen C, Fiehler J, Siemonsen S.

AJNR Am J Neuroradiol. 2016 May;37(5):963-9. doi: 10.3174/ajnr.A4638. Epub 2016 Jan 7.


T1- Thresholds in Black Holes Increase Clinical-Radiological Correlation in Multiple Sclerosis Patients.

Thaler C, Faizy T, Sedlacik J, Holst B, Stellmann JP, Young KL, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2015 Dec 11;10(12):e0144693. doi: 10.1371/journal.pone.0144693. eCollection 2015.


Correction: Increased Perfusion in Normal Appearing White Matter in High Inflammatory Multiple Sclerosis Patients.

Bester M, Forkert ND, Stellmann JP, Stürner K, Aly L, Drabik A, Young KL, Heesen C, Fiehler J, Siemonsen S.

PLoS One. 2015 Nov 4;10(11):e0142464. doi: 10.1371/journal.pone.0142464. eCollection 2015. No abstract available.


Noise robust spatially regularized myelin water fraction mapping with the intrinsic B1-error correction based on the linearized version of the extended phase graph model.

Kumar D, Siemonsen S, Heesen C, Fiehler J, Sedlacik J.

J Magn Reson Imaging. 2016 Apr;43(4):800-17. doi: 10.1002/jmri.25078. Epub 2015 Oct 19.


Diagnostic accuracy for major depression in multiple sclerosis using self-report questionnaires.

Fischer A, Fischer M, Nicholls RA, Lau S, Poettgen J, Patas K, Heesen C, Gold SM.

Brain Behav. 2015 Sep;5(9):e00365. doi: 10.1002/brb3.365. Epub 2015 Jul 14.


Risk Knowledge in Relapsing Multiple Sclerosis (RIKNO 1.0)--Development of an Outcome Instrument for Educational Interventions.

Heesen C, Kasper J, Fischer K, Köpke S, Rahn A, Backhus I, Poettgen J, Vahter L, Drulovic J, Van Nunen A, Beckmann Y, Liethmann K, Giordano A, Fulcher G, Solari A; AutoMS-group.

PLoS One. 2015 Oct 2;10(10):e0138364. doi: 10.1371/journal.pone.0138364. eCollection 2015.


Central role of Th2/Tc2 lymphocytes in pattern II multiple sclerosis lesions.

Planas R, Metz I, Ortiz Y, Vilarrasa N, Jelčić I, Salinas-Riester G, Heesen C, Brück W, Martin R, Sospedra M.

Ann Clin Transl Neurol. 2015 Sep;2(9):875-93. doi: 10.1002/acn3.218. Epub 2015 Jun 8.


An online programme to reduce depression in patients with multiple sclerosis: a randomised controlled trial.

Fischer A, Schröder J, Vettorazzi E, Wolf OT, Pöttgen J, Lau S, Heesen C, Moritz S, Gold SM.

Lancet Psychiatry. 2015 Mar;2(3):217-23. doi: 10.1016/S2215-0366(14)00049-2. Epub 2015 Feb 25.


Changes of Motivational Variables in Patients with Multiple Sclerosis in an Exercise Intervention: Associations between Physical Performance and Motivational Determinants.

Geertz W, Dechow AS, Patra S, Heesen C, Gold SM, Schulz KH.

Behav Neurol. 2015;2015:248193. doi: 10.1155/2015/248193. Epub 2015 Jul 12.


Introducing a new method to assess vision: Computer-adaptive contrast-sensitivity testing predicts visual functioning better than charts in multiple sclerosis patients.

Stellmann JP, Young KL, Pöttgen J, Dorr M, Heesen C.

Mult Scler J Exp Transl Clin. 2015 Jul 21;1:2055217315596184. doi: 10.1177/2055217315596184. eCollection 2015 Jan-Dec.

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