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Items: 1 to 50 of 670

1.
2.

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food.

Cohen SM, Eisenbrand G, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Davidsen JM, Harman CL, Taylor SV.

Food Chem Toxicol. 2018 Jan 31;113:171-178. doi: 10.1016/j.fct.2018.01.021. [Epub ahead of print]

3.

A New Editorial Team for CRT.

Hecht SS.

Chem Res Toxicol. 2018 Jan 16;31(1):1. doi: 10.1021/acs.chemrestox.7b00318. Epub 2017 Dec 28. No abstract available.

PMID:
29283558
4.

Identification and analysis of a mercapturic acid conjugate of indole-3-methyl isothiocyanate in the urine of humans who consumed cruciferous vegetables.

Upadhyaya P, Zarth AT, Fujioka N, Fritz VA, Hecht SS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 1;1072:341-346. doi: 10.1016/j.jchromb.2017.12.001. Epub 2017 Dec 2.

PMID:
29223047
5.

Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS.

Carcinogenesis. 2018 Feb 9;39(2):232-241. doi: 10.1093/carcin/bgx135.

PMID:
29194532
6.
7.

Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.

Ma B, Zarth AT, Carlson ES, Villalta PW, Upadhyaya P, Stepanov I, Hecht SS.

Chem Res Toxicol. 2018 Jan 16;31(1):48-57. doi: 10.1021/acs.chemrestox.7b00281. Epub 2017 Nov 30.

8.

Ultrasensitive High-Resolution Mass Spectrometric Analysis of a DNA Adduct of the Carcinogen Benzo[a]pyrene in Human Lung.

Villalta PW, Hochalter JB, Hecht SS.

Anal Chem. 2017 Dec 5;89(23):12735-12742. doi: 10.1021/acs.analchem.7b02856. Epub 2017 Nov 17.

PMID:
29111668
9.

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s.

Carlson ES, Upadhyaya P, Hecht SS.

J Vis Exp. 2017 Sep 25;(127). doi: 10.3791/56312.

PMID:
28994777
10.

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice.

Puppala M, Narayanapillai SC, Leitzman P, Sun H, Upadhyaya P, O'Sullivan MG, Hecht SS, Xing C.

J Med Chem. 2017 Sep 28;60(18):7935-7940. doi: 10.1021/acs.jmedchem.7b00921. Epub 2017 Sep 13.

11.

Investigation of the presence in human urine of mercapturic acids derived from phenanthrene, a representative polycyclic aromatic hydrocarbon.

Cheng G, Zarth AT, Upadhyaya P, Villalta PW, Balbo S, Hecht SS.

Chem Biol Interact. 2017 Aug 25;274:80-88. doi: 10.1016/j.cbi.2017.07.005. Epub 2017 Jul 8.

PMID:
28693886
12.

High Level of Tobacco Carcinogen-Derived DNA Damage in Oral Cells Is an Independent Predictor of Oral/Head and Neck Cancer Risk in Smokers.

Khariwala SS, Ma B, Ruszczak C, Carmella SG, Lindgren B, Hatsukami DK, Hecht SS, Stepanov I.

Cancer Prev Res (Phila). 2017 Sep;10(9):507-513. doi: 10.1158/1940-6207.CAPR-17-0140. Epub 2017 Jul 5.

13.

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco Secondhand Smoke: Implications for regulating hookah tobacco products.

Kassem NOF, Kassem NO, Liles S, Zarth AT, Jackson SR, Daffa RM, Chatfield DA, Carmella SG, Hecht SS, Hovell MF.

Nicotine Tob Res. 2017 Jun 7. doi: 10.1093/ntr/ntx133. [Epub ahead of print]

PMID:
28591850
14.

Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study.

Park SL, Murphy SE, Wilkens LR, Stram DO, Hecht SS, Le Marchand L.

PLoS One. 2017 May 25;12(5):e0178435. doi: 10.1371/journal.pone.0178435. eCollection 2017.

15.

Biomarkers of exposure to new and emerging tobacco delivery products.

Schick SF, Blount BC, Jacob P Rd, Saliba NA, Bernert JT, El Hellani A, Jatlow P, Pappas RS, Wang L, Foulds J, Ghosh A, Hecht SS, Gomez JC, Martin JR, Mesaros C, Srivastava S, St Helen G, Tarran R, Lorkiewicz PK, Blair IA, Kimmel HL, Doerschuk CM, Benowitz NL, Bhatnagar A.

Am J Physiol Lung Cell Mol Physiol. 2017 Sep 1;313(3):L425-L452. doi: 10.1152/ajplung.00343.2016. Epub 2017 May 18. Review.

PMID:
28522563
16.
17.

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study.

Yuan JM, Nelson HH, Carmella SG, Wang R, Kuriger-Laber J, Jin A, Adams-Haduch J, Hecht SS, Koh WP, Murphy SE.

Carcinogenesis. 2017 Apr 1;38(4):411-418. doi: 10.1093/carcin/bgx012.

PMID:
28182203
18.

Analysis of N'-nitrosonornicotine enantiomers in human urine by chiral stationary phase liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry.

Yang J, Carmella SG, Hecht SS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Feb 15;1044-1045:127-131. doi: 10.1016/j.jchromb.2017.01.008. Epub 2017 Jan 9.

19.

The Core Competencies for General Orthopaedic Surgeons.

Kellam JF, Archibald D, Barber JW, Christian EP, D'Ascoli RJ, Haynes RJ, Hecht SS, Hurwitz SR, Kellam JF, McLaren AC, Peabody TD, Southworth SR, Strauss RW, Wadey VM.

J Bone Joint Surg Am. 2017 Jan 18;99(2):175-181. doi: 10.2106/JBJS.16.00761.

PMID:
28099309
20.

Oral Cell DNA Adducts as Potential Biomarkers for Lung Cancer Susceptibility in Cigarette Smokers.

Hecht SS.

Chem Res Toxicol. 2017 Jan 17;30(1):367-375. doi: 10.1021/acs.chemrestox.6b00372. Epub 2016 Dec 1. Review.

21.

A Special Issue of CRT: Celebrating Volume 30.

Hecht SS.

Chem Res Toxicol. 2017 Jan 17;30(1):1. doi: 10.1021/acs.chemrestox.6b00440. No abstract available.

PMID:
28092940
22.

Tobacco, e-cigarettes, and child health.

Peterson LA, Hecht SS.

Curr Opin Pediatr. 2017 Apr;29(2):225-230. doi: 10.1097/MOP.0000000000000456. Review.

PMID:
28059903
23.

Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines.

Carlson ES, Upadhyaya P, Hecht SS.

Chem Res Toxicol. 2016 Dec 19;29(12):2194-2205. Epub 2016 Dec 6.

24.

Safety evaluation of substituted thiophenes used as flavoring ingredients.

Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IM, Smith RL, Bastaki M, Harman CL, McGowen MM, Valerio LG, Taylor SV.

Food Chem Toxicol. 2017 Jan;99:40-59. doi: 10.1016/j.fct.2016.10.023. Epub 2016 Nov 9. Review.

25.

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial.

Hatsukami DK, Luo X, Dick L, Kangkum M, Allen SS, Murphy SE, Hecht SS, Shields PG, al'Absi M.

Addiction. 2017 Jan;112(1):156-167. doi: 10.1111/add.13603. Epub 2016 Nov 2.

26.

FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results.

Cohen SM, Fukushima S, Gooderham NJ, Guengerich FP, Hecht SS, Rietjens IMCM, Smith RL, Bastaki M, Harman CL, McGowen MM, Taylor SV.

Food Chem Toxicol. 2016 Dec;98(Pt B):201-209. doi: 10.1016/j.fct.2016.10.020. Epub 2016 Oct 20. Review.

27.

Harnessing the Power of Cruciferous Vegetables: Developing a Biomarker for Brassica Vegetable Consumption Using Urinary 3,3'-Diindolylmethane.

Fujioka N, Ransom BW, Carmella SG, Upadhyaya P, Lindgren BR, Roper-Batker A, Hatsukami DK, Fritz VA, Rohwer C, Hecht SS.

Cancer Prev Res (Phila). 2016 Oct;9(10):788-793. Epub 2016 Aug 18.

28.

Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

Patel YM, Park SL, Carmella SG, Paiano V, Olvera N, Stram DO, Haiman CA, Le Marchand L, Hecht SS.

PLoS One. 2016 Jun 8;11(6):e0156203. doi: 10.1371/journal.pone.0156203. eCollection 2016.

29.

A Randomized Controlled Trial of Progressively Reduced Nicotine Content Cigarettes on Smoking Behaviors, Biomarkers of Exposure, and Subjective Ratings.

Mercincavage M, Souprountchouk V, Tang KZ, Dumont RL, Wileyto EP, Carmella SG, Hecht SS, Strasser AA.

Cancer Epidemiol Biomarkers Prev. 2016 Jul;25(7):1125-33. doi: 10.1158/1055-9965.EPI-15-1088. Epub 2016 Apr 27.

30.

Tobacco-specific N-nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study.

Yershova K, Yuan JM, Wang R, Valentin L, Watson C, Gao YT, Hecht SS, Stepanov I.

Int J Cancer. 2016 Sep 15;139(6):1261-9. doi: 10.1002/ijc.30178. Epub 2016 Jun 17.

31.

2-Phenethyl Isothiocyanate, Glutathione S-transferase M1 and T1 Polymorphisms, and Detoxification of Volatile Organic Carcinogens and Toxicants in Tobacco Smoke.

Yuan JM, Murphy SE, Stepanov I, Wang R, Carmella SG, Nelson HH, Hatsukami D, Hecht SS.

Cancer Prev Res (Phila). 2016 Jul;9(7):598-606. doi: 10.1158/1940-6207.CAPR-16-0032. Epub 2016 Apr 20.

32.

Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort.

Haiman CA, Patel YM, Stram DO, Carmella SG, Chen M, Wilkens LR, Le Marchand L, Hecht SS.

PLoS One. 2016 Mar 9;11(3):e0150641. doi: 10.1371/journal.pone.0150641. eCollection 2016.

33.

Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers.

Yuan JM, Stepanov I, Murphy SE, Wang R, Allen S, Jensen J, Strayer L, Adams-Haduch J, Upadhyaya P, Le C, Kurzer MS, Nelson HH, Yu MC, Hatsukami D, Hecht SS.

Cancer Prev Res (Phila). 2016 May;9(5):396-405. doi: 10.1158/1940-6207.CAPR-15-0380. Epub 2016 Mar 7.

34.

Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg.

Fujioka N, Fritz V, Upadhyaya P, Kassie F, Hecht SS.

Mol Nutr Food Res. 2016 Jun;60(6):1228-38. doi: 10.1002/mnfr.201500889. Epub 2016 May 23. Review.

PMID:
26840393
35.

DNA Adduct Formation from Metabolic 5'-Hydroxylation of the Tobacco-Specific Carcinogen N'-Nitrosonornicotine in Human Enzyme Systems and in Rats.

Zarth AT, Upadhyaya P, Yang J, Hecht SS.

Chem Res Toxicol. 2016 Mar 21;29(3):380-9. doi: 10.1021/acs.chemrestox.5b00520. Epub 2016 Feb 9.

36.

Transcriptome profiling in oral cavity and esophagus tissues from (S)-N'-nitrosonornicotine-treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis.

Khammanivong A, Anandharaj A, Qian X, Song JM, Upadhyaya P, Balbo S, Bandyopadhyay D, Dickerson EB, Hecht SS, Kassie F.

Mol Carcinog. 2016 Dec;55(12):2168-2182. doi: 10.1002/mc.22459. Epub 2016 Jan 19.

37.

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification.

Narayanapillai SC, von Weymarn LB, Carmella SG, Leitzman P, Paladino J, Upadhyaya P, Hecht SS, Murphy SE, Xing C.

Drug Metab Dispos. 2016 Mar;44(3):422-7. doi: 10.1124/dmd.115.068387. Epub 2016 Jan 7.

38.

Exposure and Metabolic Activation Biomarkers of Carcinogenic Tobacco-Specific Nitrosamines.

Hecht SS, Stepanov I, Carmella SG.

Acc Chem Res. 2016 Jan 19;49(1):106-14. doi: 10.1021/acs.accounts.5b00472. Epub 2015 Dec 17.

39.

Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study.

Yuan JM, Nelson HH, Butler LM, Carmella SG, Wang R, Kuriger-Laber JK, Adams-Haduch J, Hecht SS, Gao YT, Murphy SE.

Int J Cancer. 2016 May 1;138(9):2161-71. doi: 10.1002/ijc.29963. Epub 2016 Jan 21.

40.

Analysis of O(6)-[4-(3-Pyridyl)-4-oxobut-1-yl]-2'-deoxyguanosine and Other DNA Adducts in Rats Treated with Enantiomeric or Racemic N'-Nitrosonornicotine.

Yang J, Villalta PW, Upadhyaya P, Hecht SS.

Chem Res Toxicol. 2016 Jan 19;29(1):87-95. doi: 10.1021/acs.chemrestox.5b00425. Epub 2015 Dec 18.

41.

Dietary Consumption of Black Raspberries or Their Anthocyanin Constituents Alters Innate Immune Cell Trafficking in Esophageal Cancer.

Peiffer DS, Wang LS, Zimmerman NP, Ransom BW, Carmella SG, Kuo CT, Chen JH, Oshima K, Huang YW, Hecht SS, Stoner GD.

Cancer Immunol Res. 2016 Jan;4(1):72-82. doi: 10.1158/2326-6066.CIR-15-0091. Epub 2015 Nov 24.

42.

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis.

Smith MT, Guyton KZ, Gibbons CF, Fritz JM, Portier CJ, Rusyn I, DeMarini DM, Caldwell JC, Kavlock RJ, Lambert PF, Hecht SS, Bucher JR, Stewart BW, Baan RA, Cogliano VJ, Straif K.

Environ Health Perspect. 2016 Jun;124(6):713-21. doi: 10.1289/ehp.1509912. Epub 2015 Nov 24.

43.

Combined analysis of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the urine of cigarette smokers and e-cigarette users.

Kotandeniya D, Carmella SG, Pillsbury ME, Hecht SS.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Dec 15;1007:121-6. doi: 10.1016/j.jchromb.2015.10.012. Epub 2015 Oct 31.

44.

Associations Between Genetic Ancestries and Nicotine Metabolism Biomarkers in the Multiethnic Cohort Study.

Wang H, Park SL, Stram DO, Haiman CA, Wilkens LR, Hecht SS, Kolonel LN, Murphy SE, Le Marchand L.

Am J Epidemiol. 2015 Dec 1;182(11):945-51. doi: 10.1093/aje/kwv138. Epub 2015 Nov 14.

45.

Benzene oxide is a substrate for glutathione S-transferases.

Zarth AT, Murphy SE, Hecht SS.

Chem Biol Interact. 2015 Dec 5;242:390-5. doi: 10.1016/j.cbi.2015.11.005. Epub 2015 Nov 7.

46.

Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS(3) Adductomic Approach.

Stornetta A, Villalta PW, Hecht SS, Sturla SJ, Balbo S.

Anal Chem. 2015 Dec 1;87(23):11706-13. doi: 10.1021/acs.analchem.5b02759. Epub 2015 Nov 10.

47.

Randomized Trial of Reduced-Nicotine Standards for Cigarettes.

Donny EC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG, al'Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, McClernon FJ, Montoya ID, Murphy SE, Robinson JD, Stitzer ML, Strasser AA, Tindle H, Hatsukami DK.

N Engl J Med. 2015 Oct;373(14):1340-9. doi: 10.1056/NEJMsa1502403.

48.

Comprehensive High-Resolution Mass Spectrometric Analysis of DNA Phosphate Adducts Formed by the Tobacco-Specific Lung Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone.

Ma B, Villalta PW, Zarth AT, Kotandeniya D, Upadhyaya P, Stepanov I, Hecht SS.

Chem Res Toxicol. 2015 Nov 16;28(11):2151-9. doi: 10.1021/acs.chemrestox.5b00318. Epub 2015 Oct 12.

49.

Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer.

Park SL, Carmella SG, Chen M, Patel Y, Stram DO, Haiman CA, Le Marchand L, Hecht SS.

PLoS One. 2015 Jun 8;10(6):e0124841. doi: 10.1371/journal.pone.0124841. eCollection 2015.

50.

Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching.

Hatsukami DK, Severson H, Anderson A, Vogel RI, Jensen J, Broadbent B, Murphy SE, Carmella S, Hecht SS.

Tob Control. 2016 May;25(3):267-74. doi: 10.1136/tobaccocontrol-2014-052080. Epub 2015 May 19.

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