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Items: 1 to 50 of 310

1.

Preparation of Cellular Extracts from Xenopus Eggs and Embryos.

Good MC, Heald R.

Cold Spring Harb Protoc. 2018 Feb 7. doi: 10.1101/pdb.prot097055. [Epub ahead of print]

PMID:
29437998
2.

Delaying surgery after neoadjuvant chemoradiotherapy in rectal cancer has no influence in surgical approach or short-term clinical outcomes.

Figueiredo N, Panteleimonitis S, Popeskou S, Cunha JF, Qureshi T, Beets GL, Heald RJ, Parvaiz A.

Eur J Surg Oncol. 2018 Feb 1. pii: S0748-7983(18)30125-2. doi: 10.1016/j.ejso.2018.01.088. [Epub ahead of print]

PMID:
29398323
3.

Paternal chromosome loss and metabolic crisis contribute to hybrid inviability in Xenopus.

Gibeaux R, Acker R, Kitaoka M, Georgiou G, van Kruijsbergen I, Ford B, Marcotte EM, Nomura DK, Kwon T, Veenstra GJC, Heald R.

Nature. 2018 Jan 18;553(7688):337-341. doi: 10.1038/nature25188. Epub 2018 Jan 10.

PMID:
29320479
4.

The Perfect Total Mesorectal Excision Obviates the Need for Anything Else in the Management of Most Rectal Cancers.

Heald RJ, Santiago I, Pares O, Carvalho C, Figueiredo N.

Clin Colon Rectal Surg. 2017 Nov;30(5):324-332. doi: 10.1055/s-0037-1606109. Epub 2017 Nov 27. Review.

PMID:
29184467
5.

Regulatory remodeling in the allo-tetraploid frog Xenopus laevis.

Elurbe DM, Paranjpe SS, Georgiou G, van Kruijsbergen I, Bogdanovic O, Gibeaux R, Heald R, Lister R, Huynen MA, van Heeringen SJ, Veenstra GJC.

Genome Biol. 2017 Oct 24;18(1):198. doi: 10.1186/s13059-017-1335-7.

6.

Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles.

Safina BS, Elliott RL, Forrest AK, Heald RA, Murray JM, Nonomiya J, Pang J, Salphati L, Seward EM, Staben ST, Ultsch M, Wei B, Yang W, Sutherlin DP.

ACS Med Chem Lett. 2017 Aug 25;8(9):936-940. doi: 10.1021/acsmedchemlett.7b00170. eCollection 2017 Sep 14.

PMID:
28947940
7.

A DNA Crosslinker Collects Mitotic Chromosomes.

Sun M, Heald R.

Dev Cell. 2017 Sep 11;42(5):440-442. doi: 10.1016/j.devcel.2017.08.010.

PMID:
28898675
8.

Tailored-made robotic abdominoperineal resection, using the da Vinci Xi, for a regrowth of rectal tumour after complete clinical response - a video vignette.

Panteleimonitis S, Ahmed J, Popeskou SG, Figueiredo N, Qureshi T, Heald RJ, Parvaiz A.

Colorectal Dis. 2017 Jul;19(7):696-697. doi: 10.1111/codi.13725. No abstract available.

PMID:
28503846
9.

Physician Courtesy and Patient Satisfaction in a Pediatric Plastic and Oral Surgery Department.

Daniels KM, Yorlets RR, Flath-Sporn SJ, Labow BI, Heald RR, Taghinia AH.

J Healthc Manag. 2017 May/Jun;62(3):211-219. doi: 10.1097/JHM-D-16-00002.

PMID:
28471859
10.

Assessing the Cost of Prophylactic Antibiotic Use After Cleft Lip and Lip Adhesion Procedures.

Daniels KM, Lappi MD, Sporn SF, Caillouette CN, Heald R, Meara JG.

J Healthc Manag. 2016 Jul/Aug;61(4):282-289.

PMID:
28199275
11.

Local Excision Techniques for Rectal Cancer After Neoadjuvant Chemoradiotherapy: What Are We Doing?

Smith FM, Ahad A, Perez RO, Marks J, Bujko K, Heald RJ.

Dis Colon Rectum. 2017 Feb;60(2):228-239. doi: 10.1097/DCR.0000000000000749. Review.

PMID:
28059920
12.

Total Mesorectal Irradiation: The "Next Step" in the Multidisciplinary Management of Rectal Adenocarcinoma?

Pares O, Santiago I, Greco C, Heald R.

Dis Colon Rectum. 2016 Dec;59(12):1222-1226. No abstract available.

PMID:
27824708
13.

Physician Assistants Improve Efficiency and Decrease Costs in Outpatient Oral and Maxillofacial Surgery.

Resnick CM, Daniels KM, Flath-Sporn SJ, Doyle M, Heald R, Padwa BL.

J Oral Maxillofac Surg. 2016 Nov;74(11):2128-2135. doi: 10.1016/j.joms.2016.06.195. Epub 2016 Jul 22.

PMID:
27528102
14.

The mesorectum and mesocolon - Making sense of words.

Dattani M, Santiago I, Mahadevan V, Heald RJ.

Int J Surg. 2016 Dec;36(Pt A):390-391. doi: 10.1016/j.ijsu.2016.09.097. Epub 2016 Oct 15. No abstract available.

PMID:
27756645
15.

Genome evolution in the allotetraploid frog Xenopus laevis.

Session AM, Uno Y, Kwon T, Chapman JA, Toyoda A, Takahashi S, Fukui A, Hikosaka A, Suzuki A, Kondo M, van Heeringen SJ, Quigley I, Heinz S, Ogino H, Ochi H, Hellsten U, Lyons JB, Simakov O, Putnam N, Stites J, Kuroki Y, Tanaka T, Michiue T, Watanabe M, Bogdanovic O, Lister R, Georgiou G, Paranjpe SS, van Kruijsbergen I, Shu S, Carlson J, Kinoshita T, Ohta Y, Mawaribuchi S, Jenkins J, Grimwood J, Schmutz J, Mitros T, Mozaffari SV, Suzuki Y, Haramoto Y, Yamamoto TS, Takagi C, Heald R, Miller K, Haudenschild C, Kitzman J, Nakayama T, Izutsu Y, Robert J, Fortriede J, Burns K, Lotay V, Karimi K, Yasuoka Y, Dichmann DS, Flajnik MF, Houston DW, Shendure J, DuPasquier L, Vize PD, Zorn AM, Ito M, Marcotte EM, Wallingford JB, Ito Y, Asashima M, Ueno N, Matsuda Y, Veenstra GJ, Fujiyama A, Harland RM, Taira M, Rokhsar DS.

Nature. 2016 Oct 20;538(7625):336-343. doi: 10.1038/nature19840.

16.

Transcription brings the complex(ity) to the centromere.

Grenfell AW, Strzelecka M, Heald R.

Cell Cycle. 2017 Feb;16(3):235-236. doi: 10.1080/15384101.2016.1242962. Epub 2016 Oct 13. No abstract available.

17.

Adjuvant chemotherapy may improve disease-free survival in patients with rectal cancer positive for MRI-detected extramural venous invasion following chemoradiation.

Chand M, Rasheed S, Heald R, Swift I, West N, Rao S, Tekkis P, Brown G.

Colorectal Dis. 2017 Jun;19(6):537-543. doi: 10.1111/codi.13535.

PMID:
27673438
18.

A collaborative review of the current concepts and challenges of anastomotic leaks in colorectal surgery.

Vallance A, Wexner S, Berho M, Cahill R, Coleman M, Haboubi N, Heald RJ, Kennedy RH, Moran B, Mortensen N, Motson RW, Novell R, O'Connell PR, Ris F, Rockall T, Senapati A, Windsor A, Jayne DG.

Colorectal Dis. 2017 Jan;19(1):O1-O12. doi: 10.1111/codi.13534.

PMID:
27671222
19.

Correction: Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus.

Grenfell AW, Heald R, Strzelecka M.

J Cell Biol. 2016 Sep 12;214(6):783. doi: 10.1083/jcb.20160402908222016c. Epub 2016 Sep 5. No abstract available.

20.

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.

Chan BK, Hanan EJ, Bowman KK, Bryan MC, Burdick D, Chan E, Chen Y, Clausen S, Dela Vega T, Dotson J, Eigenbrot C, Elliott RL, Heald RA, Jackson PS, Knight JD, La H, Lainchbury MD, Malek S, Purkey HE, Schaefer G, Schmidt S, Seward EM, Sideris S, Shao L, Wang S, Yeap SK, Yen I, Yu C, Heffron TP.

J Med Chem. 2016 Oct 13;59(19):9080-9093. Epub 2016 Sep 12.

PMID:
27564586
21.

Mitotic noncoding RNA processing promotes kinetochore and spindle assembly in Xenopus.

Grenfell AW, Heald R, Strzelecka M.

J Cell Biol. 2016 Jul 18;214(2):133-41. doi: 10.1083/jcb.201604029. Epub 2016 Jul 11. Erratum in: J Cell Biol. 2016 Sep 12;214(6):783.

22.

Microtubules: 50 years on from the discovery of tubulin.

Borisy G, Heald R, Howard J, Janke C, Musacchio A, Nogales E.

Nat Rev Mol Cell Biol. 2016 Apr 22;17(5):322-8. doi: 10.1038/nrm.2016.45. Review.

23.

An ontogenetic approach to gynecologic malignancies.

Santiago IA, Gomes AP, Heald RJ.

Insights Imaging. 2016 Jun;7(3):329-39. doi: 10.1007/s13244-016-0480-y. Epub 2016 Apr 15. Review.

24.

A versatile multivariate image analysis pipeline reveals features of Xenopus extract spindles.

Grenfell AW, Strzelecka M, Crowder ME, Helmke KJ, Schlaitz AL, Heald R.

J Cell Biol. 2016 Apr 11;213(1):127-36. doi: 10.1083/jcb.201509079. Epub 2016 Apr 4.

25.

Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Heald R, Bowman KK, Bryan MC, Burdick D, Chan B, Chan E, Chen Y, Clausen S, Dominguez-Fernandez B, Eigenbrot C, Elliott R, Hanan EJ, Jackson P, Knight J, La H, Lainchbury M, Malek S, Mann S, Merchant M, Mortara K, Purkey H, Schaefer G, Schmidt S, Seward E, Sideris S, Shao L, Wang S, Yeap K, Yen I, Yu C, Heffron TP.

J Med Chem. 2016 Mar 24;59(6):2848. doi: 10.1021/acs.jmedchem.6b00301. Epub 2016 Mar 11. No abstract available.

PMID:
26967667
26.

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

Bryan MC, Burdick DJ, Chan BK, Chen Y, Clausen S, Dotson J, Eigenbrot C, Elliott R, Hanan EJ, Heald R, Jackson P, La H, Lainchbury M, Malek S, Mann SE, Purkey HE, Schaefer G, Schmidt S, Seward E, Sideris S, Wang S, Yen I, Yu C, Heffron TP.

ACS Med Chem Lett. 2015 Dec 17;7(1):100-4. doi: 10.1021/acsmedchemlett.5b00428. eCollection 2016 Jan 14.

27.

The Rational Design of Selective Benzoxazepin Inhibitors of the α-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).

Heffron TP, Heald RA, Ndubaku C, Wei B, Augistin M, Do S, Edgar K, Eigenbrot C, Friedman L, Gancia E, Jackson PS, Jones G, Kolesnikov A, Lee LB, Lesnick JD, Lewis C, McLean N, Mörtl M, Nonomiya J, Pang J, Price S, Prior WW, Salphati L, Sideris S, Staben ST, Steinbacher S, Tsui V, Wallin J, Sampath D, Olivero AG.

J Med Chem. 2016 Feb 11;59(3):985-1002. doi: 10.1021/acs.jmedchem.5b01483. Epub 2016 Jan 20.

PMID:
26741947
28.

Thirty years of search and capture: The complex simplicity of mitotic spindle assembly.

Heald R, Khodjakov A.

J Cell Biol. 2015 Dec 21;211(6):1103-11. doi: 10.1083/jcb.201510015. Epub 2015 Dec 14. Review.

29.

Robotic total mesorectal excision - precision surgery with even more precise tools.

Chand M, Heald RJ, Parvaiz A.

J R Soc Med. 2016 Feb;109(2):78-9. doi: 10.1177/0141076815617695. Epub 2015 Nov 25. No abstract available.

PMID:
26609124
30.

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Heald R, Bowman KK, Bryan MC, Burdick D, Chan B, Chan E, Chen Y, Clausen S, Dominguez-Fernandez B, Eigenbrot C, Elliott R, Hanan EJ, Jackson P, Knight J, La H, Lainchbury M, Malek S, Mann S, Merchant M, Mortara K, Purkey H, Schaefer G, Schmidt S, Seward E, Sideris S, Shao L, Wang S, Yeap K, Yen I, Yu C, Heffron TP.

J Med Chem. 2015 Nov 25;58(22):8877-95. doi: 10.1021/acs.jmedchem.5b01412. Epub 2015 Nov 12. Erratum in: J Med Chem. 2016 Mar 24;59(6):2848.

PMID:
26455919
31.

Biological Scaling Problems and Solutions in Amphibians.

Levy DL, Heald R.

Cold Spring Harb Perspect Biol. 2015 Aug 10;8(1):a019166. doi: 10.1101/cshperspect.a019166. Review.

32.

Enzymatically Generated CRISPR Libraries for Genome Labeling and Screening.

Lane AB, Strzelecka M, Ettinger A, Grenfell AW, Wittmann T, Heald R.

Dev Cell. 2015 Aug 10;34(3):373-8. doi: 10.1016/j.devcel.2015.06.003. Epub 2015 Jul 23.

33.

Transanal Total Mesorectal Excision for Rectal Cancer: Outcomes after 140 Patients.

Lacy AM, Tasende MM, Delgado S, Fernandez-Hevia M, Jimenez M, De Lacy B, Castells A, Bravo R, Wexner SD, Heald RJ.

J Am Coll Surg. 2015 Aug;221(2):415-23. doi: 10.1016/j.jamcollsurg.2015.03.046. Epub 2015 Mar 30.

PMID:
26206640
34.

A comparative analysis of spindle morphometrics across metazoans.

Crowder ME, Strzelecka M, Wilbur JD, Good MC, von Dassow G, Heald R.

Curr Biol. 2015 Jun 1;25(11):1542-50. doi: 10.1016/j.cub.2015.04.036. Epub 2015 May 21.

35.

Glutamylation of Nap1 modulates histone H1 dynamics and chromosome condensation in Xenopus.

Miller KE, Heald R.

J Cell Biol. 2015 Apr 27;209(2):211-20. doi: 10.1083/jcb.201412097. Epub 2015 Apr 20.

36.

Structured training in robotic colorectal surgery.

Tou S, Bergamaschi R, Heald RJ, Parvaiz A.

Colorectal Dis. 2015 Mar;17(3):185. doi: 10.1111/codi.12898. No abstract available.

PMID:
25678329
37.

RUVs drive chromosome decondensation after mitosis.

Strzelecka M, Heald R.

Dev Cell. 2014 Nov 10;31(3):259-60. doi: 10.1016/j.devcel.2014.10.018. Epub 2014 Nov 10.

38.

Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation.

Hanan EJ, Eigenbrot C, Bryan MC, Burdick DJ, Chan BK, Chen Y, Dotson J, Heald RA, Jackson PS, La H, Lainchbury MD, Malek S, Purkey HE, Schaefer G, Schmidt S, Seward EM, Sideris S, Tam C, Wang S, Yeap SK, Yen I, Yin J, Yu C, Zilberleyb I, Heffron TP.

J Med Chem. 2014 Dec 11;57(23):10176-91. doi: 10.1021/jm501578n. Epub 2014 Nov 20.

39.

Adjuvant therapy decisions based on magnetic resonance imaging of extramural venous invasion and other prognostic factors in colorectal cancer.

Chand M, Swift RI, Chau I, Heald RJ, Tekkis PP, Brown G.

Ann R Coll Surg Engl. 2014 Oct;96(7):543-6. doi: 10.1308/003588414X13814021678835.

40.

The prognostic significance of postchemoradiotherapy high-resolution MRI and histopathology detected extramural venous invasion in rectal cancer.

Chand M, Evans J, Swift RI, Tekkis PP, West NP, Stamp G, Heald RJ, Brown G.

Ann Surg. 2015 Mar;261(3):473-9. doi: 10.1097/SLA.0000000000000848.

PMID:
25243543
41.

Total mesorectal excision optimized by pelvic MRI.

Chand M, Brown G, Tekkis P, Heald RJ.

Colorectal Dis. 2014 Nov;16(11):847-53. doi: 10.1111/codi.12773. Review. No abstract available.

PMID:
25204633
42.

Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.

Robarge KD, Lee W, Eigenbrot C, Ultsch M, Wiesmann C, Heald R, Price S, Hewitt J, Jackson P, Savy P, Burton B, Choo EF, Pang J, Boggs J, Yang A, Yang X, Baumgardner M.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4714-4723. doi: 10.1016/j.bmcl.2014.08.008. Epub 2014 Aug 15.

PMID:
25193232
43.

TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts.

Helmke KJ, Heald R.

J Cell Biol. 2014 Aug 4;206(3):385-93. doi: 10.1083/jcb.201401014. Epub 2014 Jul 28.

44.

Durhane Wong-Rieger: championing patients.

Heald R.

Lancet Diabetes Endocrinol. 2014 Sep;2(9):689. doi: 10.1016/S2213-8587(14)70133-0. Epub 2014 Jul 8. No abstract available.

PMID:
25022974
46.

Morphology and function of membrane-bound organelles.

Heald R, Cohen-Fix O.

Curr Opin Cell Biol. 2014 Feb;26:79-86. doi: 10.1016/j.ceb.2013.10.006. Epub 2013 Nov 16. Review.

47.

The cost of third molar management.

Inverso G, Heald R, Padwa BL.

J Oral Maxillofac Surg. 2014 Jun;72(6):1038-9. doi: 10.1016/j.joms.2013.12.009. Epub 2013 Dec 17. No abstract available.

PMID:
24480764
48.

The rationale behind complete mesocolic excision (CME) and a central vascular ligation for colon cancer in open and laparoscopic surgery : proceedings of a consensus conference.

Søndenaa K, Quirke P, Hohenberger W, Sugihara K, Kobayashi H, Kessler H, Brown G, Tudyka V, D'Hoore A, Kennedy RH, West NP, Kim SH, Heald R, Storli KE, Nesbakken A, Moran B.

Int J Colorectal Dis. 2014 Apr;29(4):419-28. doi: 10.1007/s00384-013-1818-2. Epub 2014 Jan 31.

PMID:
24477788
49.

Increasing value in plagiocephaly care: a time-driven activity-based costing pilot study.

Inverso G, Lappi MD, Flath-Sporn SJ, Heald R, Kim DC, Meara JG.

Ann Plast Surg. 2015 Jun;74(6):672-6. doi: 10.1097/SAP.0000000000000002.

PMID:
24317242
50.

Lymph node status does not predict local recurrence in the total mesorectal excision era.

Chand M, Moran BJ, Jones RG, Heald RJ, Brown G.

Dis Colon Rectum. 2014 Jan;57(1):127-9. doi: 10.1097/DCR.0000000000000001. No abstract available.

PMID:
24316956

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