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Items: 1 to 50 of 422

1.

Correlating Oxygen Delivery During Cardiopulmonary Bypass With the Neurologic Injury Biomarker Ubiquitin C-Terminal Hydrolase L1 (UCH-L1).

Magruder JT, Fraser CD 3rd, Grimm JC, Crawford TC, Beaty CA, Suarez-Pierre A, Hayes RL, Johnston MV, Baumgartner WA.

J Cardiothorac Vasc Anesth. 2018 Jun 11. pii: S1053-0770(18)30354-9. doi: 10.1053/j.jvca.2018.05.021. [Epub ahead of print]

PMID:
29903683
2.

Predicting Binding Free Energies in a Large Combinatorial Chemical Space Using Multisite λ Dynamics.

Vilseck JZ, Armacost KA, Hayes RL, Goh GB, Brooks CL 3rd.

J Phys Chem Lett. 2018 Jun 6:3328-3332. doi: 10.1021/acs.jpclett.8b01284. [Epub ahead of print]

PMID:
29847134
3.

Preclinical Testing of Therapies for Traumatic Brain Injury.

DeWitt D, Hawkins BE, Dixon CE, Kochanek PM, Armstead WM, Bass C', Bramlett HM, Büki A, Dietrich WD, Ferguson AR, Hall ED, Hayes RL, Hinds Ii CSR, LaPlaca M, Long J, Meaney D, Mondello S, Noble-Haeusslein L, Poloyac SM, Prough DS, Robertson CS, Saatman KE, Shultz SR, Shear DA, Smith DH Dr, Valadka A, VandeVord PJ, Zhang L.

J Neurotrauma. 2018 May 14. doi: 10.1089/neu.2018.5778. [Epub ahead of print]

PMID:
29756522
4.

Operation Brain Trauma Therapy: 2016 Update.

Kochanek PM, Bramlett HM, Dixon CE, Dietrich WD, Mondello S, Wang KKW, Hayes RL, Lafrenaye A, Povlishock JT, Tortella FC, Poloyac SM, Empey P, Shear DA.

Mil Med. 2018 Mar 1;183(suppl_1):303-312. doi: 10.1093/milmed/usx184.

PMID:
29635589
5.

Metabolomics and Precision Medicine in Trauma: The State of the Field.

Jayaraman SP, Anand RJ, DeAntonio JH, Mangino M, Aboutanos MB, Kasirajan V, Ivatury RR, Valadka AB, Glushakova O, Hayes RL, Bachmann LM, Brophy GM, Contaifer D, Warncke UO, Brophy DF, Wijesinghe DS.

Shock. 2018 Jul;50(1):5-13. doi: 10.1097/SHK.0000000000001093.

PMID:
29280924
6.

Erratum to: Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.

Kobeissy FH, Liu MC, Yang Z, Zhang Z, Zheng W, Glushakova O, Mondello S, Anagli J, Hayes RL, Wang KKW.

Mol Neurobiol. 2018 Jan;55(1):898-900. doi: 10.1007/s12035-017-0764-3. No abstract available.

PMID:
28975597
7.

Temporal Profile of Microtubule-Associated Protein 2: A Novel Indicator of Diffuse Brain Injury Severity and Early Mortality after Brain Trauma.

Papa L, Robicsek SA, Brophy GM, Wang KKW, Hannay HJ, Heaton S, Schmalfuss I, Gabrielli A, Hayes RL, Robertson CS.

J Neurotrauma. 2018 Jan 1;35(1):32-40. doi: 10.1089/neu.2017.4994. Epub 2017 Nov 3.

PMID:
28895474
8.

CDOCKER and λ-dynamics for prospective prediction in D₃R Grand Challenge 2.

Ding X, Hayes RL, Vilseck JZ, Charles MK, Brooks CL 3rd.

J Comput Aided Mol Des. 2018 Jan;32(1):89-102. doi: 10.1007/s10822-017-0050-5. Epub 2017 Sep 7.

PMID:
28884249
9.

Prospective Assessment of Acute Blood Markers of Brain Injury in Sport-Related Concussion.

Meier TB, Nelson LD, Huber DL, Bazarian JJ, Hayes RL, McCrea MA.

J Neurotrauma. 2017 Nov 15;34(22):3134-3142. doi: 10.1089/neu.2017.5046. Epub 2017 Aug 4.

PMID:
28699381
10.

Role of Caspase-3-Mediated Apoptosis in Chronic Caspase-3-Cleaved Tau Accumulation and Blood-Brain Barrier Damage in the Corpus Callosum after Traumatic Brain Injury in Rats.

Glushakova OY, Glushakov AO, Borlongan CV, Valadka AB, Hayes RL, Glushakov AV.

J Neurotrauma. 2018 Jan 1;35(1):157-173. doi: 10.1089/neu.2017.4999. Epub 2017 Jul 21.

PMID:
28637381
11.

Gibbs Sampler-Based λ-Dynamics and Rao-Blackwell Estimator for Alchemical Free Energy Calculation.

Ding X, Vilseck JZ, Hayes RL, Brooks CL 3rd.

J Chem Theory Comput. 2017 Jun 13;13(6):2501-2510. doi: 10.1021/acs.jctc.7b00204. Epub 2017 May 26.

12.

Temporal Profile and Severity Correlation of a Panel of Rat Spinal Cord Injury Protein Biomarkers.

Yang Z, Bramlett HM, Moghieb A, Yu D, Wang P, Lin F, Bauer C, Selig TM, Jaalouk E, Weissman AS, Rathore DS, Romo P, Zhang Z, Hayes RL, Wang MY, Dietrich WD, Wang KKW.

Mol Neurobiol. 2018 Mar;55(3):2174-2184. doi: 10.1007/s12035-017-0424-7. Epub 2017 Mar 13.

PMID:
28290147
13.

A magnesium-induced triplex pre-organizes the SAM-II riboswitch.

Roy S, Lammert H, Hayes RL, Chen B, LeBlanc R, Dayie TK, Onuchic JN, Sanbonmatsu KY.

PLoS Comput Biol. 2017 Mar 1;13(3):e1005406. doi: 10.1371/journal.pcbi.1005406. eCollection 2017 Mar.

14.

Adaptive Landscape Flattening Accelerates Sampling of Alchemical Space in Multisite λ Dynamics.

Hayes RL, Armacost KA, Vilseck JZ, Brooks CL 3rd.

J Phys Chem B. 2017 Apr 20;121(15):3626-3635. doi: 10.1021/acs.jpcb.6b09656. Epub 2017 Feb 10.

15.

Neuroproteomics and Systems Biology Approach to Identify Temporal Biomarker Changes Post Experimental Traumatic Brain Injury in Rats.

Kobeissy FH, Guingab-Cagmat JD, Zhang Z, Moghieb A, Glushakova OY, Mondello S, Boutté AM, Anagli J, Rubenstein R, Bahmad H, Wagner AK, Hayes RL, Wang KK.

Front Neurol. 2016 Nov 22;7:198. eCollection 2016.

16.

Animal Models of Posttraumatic Seizures and Epilepsy.

Glushakov AV, Glushakova OY, Doré S, Carney PR, Hayes RL.

Methods Mol Biol. 2016;1462:481-519. doi: 10.1007/978-1-4939-3816-2_27.

PMID:
27604735
17.

Connecting the Sequence-Space of Bacterial Signaling Proteins to Phenotypes Using Coevolutionary Landscapes.

Cheng RR, Nordesjö O, Hayes RL, Levine H, Flores SC, Onuchic JN, Morcos F.

Mol Biol Evol. 2016 Dec;33(12):3054-3064. Epub 2016 Sep 7.

18.

Serum Concentrations of Ubiquitin C-Terminal Hydrolase-L1 and Glial Fibrillary Acidic Protein after Pediatric Traumatic Brain Injury.

Mondello S, Kobeissy F, Vestri A, Hayes RL, Kochanek PM, Berger RP.

Sci Rep. 2016 Jun 20;6:28203. doi: 10.1038/srep28203.

19.

Assessment of Serum UCH-L1 and GFAP in Acute Stroke Patients.

Ren C, Kobeissy F, Alawieh A, Li N, Li N, Zibara K, Zoltewicz S, Guingab-Cagmat J, Larner SF, Ding Y, Hayes RL, Ji X, Mondello S.

Sci Rep. 2016 Apr 14;6:24588. doi: 10.1038/srep24588.

20.

SMOG 2: A Versatile Software Package for Generating Structure-Based Models.

Noel JK, Levi M, Raghunathan M, Lammert H, Hayes RL, Onuchic JN, Whitford PC.

PLoS Comput Biol. 2016 Mar 10;12(3):e1004794. doi: 10.1371/journal.pcbi.1004794. eCollection 2016 Mar.

21.

Exploratory study of serum ubiquitin carboxyl-terminal esterase L1 and glial fibrillary acidic protein for outcome prognostication after pediatric cardiac arrest.

Fink EL, Berger RP, Clark RS, Watson RS, Angus DC, Panigrahy A, Richichi R, Callaway CW, Bell MJ, Mondello S, Hayes RL, Kochanek PM.

Resuscitation. 2016 Apr;101:65-70. doi: 10.1016/j.resuscitation.2016.01.024. Epub 2016 Feb 6.

22.

Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy.

Mondello S, Shear DA, Bramlett HM, Dixon CE, Schmid KE, Dietrich WD, Wang KK, Hayes RL, Glushakova O, Catania M, Richieri SP, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):595-605. doi: 10.1089/neu.2015.4132.

PMID:
26671651
23.

Levetiracetam Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Browning M, Shear DA, Bramlett HM, Dixon CE, Mondello S, Schmid KE, Poloyac SM, Dietrich WD, Hayes RL, Wang KK, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):581-94. doi: 10.1089/neu.2015.4131.

PMID:
26671550
24.

Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy.

Kochanek PM, Bramlett HM, Shear DA, Dixon CE, Mondello S, Dietrich WD, Hayes RL, Wang KK, Poloyac SM, Empey PE, Povlishock JT, Mountney A, Browning M, Deng-Bryant Y, Yan HQ, Jackson TC, Catania M, Glushakova O, Richieri SP, Tortella FC.

J Neurotrauma. 2016 Mar 15;33(6):606-14. doi: 10.1089/neu.2015.4133. Review.

PMID:
26671284
25.

Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Dixon CE, Bramlett HM, Dietrich WD, Shear DA, Yan HQ, Deng-Bryant Y, Mondello S, Wang KK, Hayes RL, Empey PE, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):553-66. doi: 10.1089/neu.2015.4122.

PMID:
26671075
26.

Nicotinamide Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Shear DA, Dixon CE, Bramlett HM, Mondello S, Dietrich WD, Deng-Bryant Y, Schmid KE, Wang KK, Hayes RL, Povlishock JT, Kochanek PM, Tortella FC.

J Neurotrauma. 2016 Mar 15;33(6):523-37. doi: 10.1089/neu.2015.4115.

PMID:
26670792
27.

Erythropoietin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Bramlett HM, Dietrich WD, Dixon CE, Shear DA, Schmid KE, Mondello S, Wang KK, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM.

J Neurotrauma. 2016 Mar 15;33(6):538-52. doi: 10.1089/neu.2015.4116.

PMID:
26670694
28.

Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy.

Mountney A, Bramlett HM, Dixon CE, Mondello S, Dietrich WD, Wang KK, Caudle K, Empey PE, Poloyac SM, Hayes RL, Povlishock JT, Tortella FC, Kochanek PM, Shear DA.

J Neurotrauma. 2016 Mar 15;33(6):567-80. doi: 10.1089/neu.2015.4130. Epub 2016 Jan 20.

PMID:
26541177
29.

Ability of Serum Glial Fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B To Differentiate Normal and Abnormal Head Computed Tomography Findings in Patients with Suspected Mild or Moderate Traumatic Brain Injury.

Welch RD, Ayaz SI, Lewis LM, Unden J, Chen JY, Mika VH, Saville B, Tyndall JA, Nash M, Buki A, Barzo P, Hack D, Tortella FC, Schmid K, Hayes RL, Vossough A, Sweriduk ST, Bazarian JJ.

J Neurotrauma. 2016 Jan 15;33(2):203-14. doi: 10.1089/neu.2015.4149. Epub 2015 Dec 18.

30.

Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy.

Kochanek PM, Bramlett HM, Dixon CE, Shear DA, Dietrich WD, Schmid KE, Mondello S, Wang KK, Hayes RL, Povlishock JT, Tortella FC.

J Neurotrauma. 2016 Mar 15;33(6):513-22. doi: 10.1089/neu.2015.4113. Epub 2015 Dec 10. Review.

PMID:
26439468
31.

CNS Trauma Biomarkers and Surrogate Endpoints Pipeline from Bench to Bedside: A Translational Perspective.

Mouhieddine TH, El Houjeiri L, Sabra M, Hayes RL, Mondello S.

In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 20.

32.

Potential Use of Calpain Inhibitors as Brain Injury Therapy.

Cagmat EB, Guingab-Cagmat JD, Vakulenko AV, Hayes RL, Anagli J.

In: Kobeissy FH, editor. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. Boca Raton (FL): CRC Press/Taylor & Francis; 2015. Chapter 40.

33.

Generalized Manning Condensation Model Captures the RNA Ion Atmosphere.

Hayes RL, Noel JK, Mandic A, Whitford PC, Sanbonmatsu KY, Mohanty U, Onuchic JN.

Phys Rev Lett. 2015 Jun 26;114(25):258105. Epub 2015 Jun 26.

34.

Expert consensus document: Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions.

Carman AJ, Ferguson R, Cantu R, Comstock RD, Dacks PA, DeKosky ST, Gandy S, Gilbert J, Gilliland C, Gioia G, Giza C, Greicius M, Hainline B, Hayes RL, Hendrix J, Jordan B, Kovach J, Lane RF, Mannix R, Murray T, Seifert T, Shineman DW, Warren E, Wilde E, Willard H, Fillit HM.

Nat Rev Neurol. 2015 Apr;11(4):230-44. doi: 10.1038/nrneurol.2015.30. Epub 2015 Mar 17. Review.

PMID:
25776822
35.

Acute Temporal Profiles of Serum Levels of UCH-L1 and GFAP and Relationships to Neuronal and Astroglial Pathology following Traumatic Brain Injury in Rats.

Huang XJ, Glushakova O, Mondello S, Van K, Hayes RL, Lyeth BG.

J Neurotrauma. 2015 Aug 15;32(16):1179-89. doi: 10.1089/neu.2015.3873. Epub 2015 May 14.

PMID:
25763798
36.

Lateral Ventricle Volume Asymmetry Predicts Midline Shift in Severe Traumatic Brain Injury.

Tóth A, Schmalfuss I, Heaton SC, Gabrielli A, Hannay HJ, Papa L, Brophy GM, Wang KK, Büki A, Schwarcz A, Hayes RL, Robertson CS, Robicsek SA.

J Neurotrauma. 2015 Sep 1;32(17):1307-11. doi: 10.1089/neu.2014.3696. Epub 2015 May 19.

37.

Biomarkers.

Mondello S, Hayes RL.

Handb Clin Neurol. 2015;127:245-65. doi: 10.1016/B978-0-444-52892-6.00016-7. Review.

PMID:
25702221
38.

UCH-L1 and GFAP Serum Levels in Neonates with Hypoxic-Ischemic Encephalopathy: A Single Center Pilot Study.

Douglas-Escobar MV, Heaton SC, Bennett J, Young LJ, Glushakova O, Xu X, Barbeau DY, Rossignol C, Miller C, Old Crow AM, Hayes RL, Weiss MD.

Front Neurol. 2014 Dec 19;5:273. doi: 10.3389/fneur.2014.00273. eCollection 2014.

39.

Minor and repetitive head injury.

Buki A, Kovacs N, Czeiter E, Schmid K, Berger RP, Kobeissy F, Italiano D, Hayes RL, Tortella FC, Mezosi E, Schwarcz A, Toth A, Nemes O, Mondello S.

Adv Tech Stand Neurosurg. 2015;42:147-92. doi: 10.1007/978-3-319-09066-5_8. Review.

PMID:
25411149
40.

Degradation of βII-Spectrin Protein by Calpain-2 and Caspase-3 Under Neurotoxic and Traumatic Brain Injury Conditions.

Kobeissy FH, Liu MC, Yang Z, Zhang Z, Zheng W, Glushakova O, Mondello S, Anagli J, Hayes RL, Wang KK.

Mol Neurobiol. 2015 Aug;52(1):696-709. doi: 10.1007/s12035-014-8898-z. Epub 2014 Oct 2. Erratum in: Mol Neurobiol. 2017 Sep 27;:.

41.

Intercellular stress reconstitution from traction force data.

Zimmermann J, Hayes RL, Basan M, Onuchic JN, Rappel WJ, Levine H.

Biophys J. 2014 Aug 5;107(3):548-554. doi: 10.1016/j.bpj.2014.06.036.

42.

Biomarkers improve clinical outcome predictors of mortality following non-penetrating severe traumatic brain injury.

Papa L, Robertson CS, Wang KK, Brophy GM, Hannay HJ, Heaton S, Schmalfuss I, Gabrielli A, Hayes RL, Robicsek SA.

Neurocrit Care. 2015 Feb;22(1):52-64. doi: 10.1007/s12028-014-0028-2.

PMID:
25052159
43.

GFAP out-performs S100β in detecting traumatic intracranial lesions on computed tomography in trauma patients with mild traumatic brain injury and those with extracranial lesions.

Papa L, Silvestri S, Brophy GM, Giordano P, Falk JL, Braga CF, Tan CN, Ameli NJ, Demery JA, Dixit NK, Mendes ME, Hayes RL, Wang KK, Robertson CS.

J Neurotrauma. 2014 Nov 15;31(22):1815-22. doi: 10.1089/neu.2013.3245. Epub 2014 Sep 12.

44.

Reduced model captures Mg(2+)-RNA interaction free energy of riboswitches.

Hayes RL, Noel JK, Whitford PC, Mohanty U, Sanbonmatsu KY, Onuchic JN.

Biophys J. 2014 Apr 1;106(7):1508-19. doi: 10.1016/j.bpj.2014.01.042.

45.

A neuroproteomic and systems biology analysis of rat brain post intracerebral hemorrhagic stroke.

Ren C, Guingab-Cagmat J, Kobeissy F, Zoltewicz S, Mondello S, Gao M, Hafeez A, Li N, Geng X, Larner SF, Anagli J, Hayes RL, Ji X, Ding Y.

Brain Res Bull. 2014 Mar;102:46-56. doi: 10.1016/j.brainresbull.2014.02.005. Epub 2014 Feb 26.

PMID:
24583080
46.
47.

Serum biomarkers predict acute symptom burden in children after concussion: a preliminary study.

Mannix R, Eisenberg M, Berry M, Meehan WP 3rd, Hayes RL.

J Neurotrauma. 2014 Jun 1;31(11):1072-5. doi: 10.1089/neu.2013.3265. Epub 2014 Apr 8.

PMID:
24494742
48.

Different expression of ubiquitin C-terminal hydrolase-L1 and αII-spectrin in ischemic and hemorrhagic stroke: Potential biomarkers in diagnosis.

Ren C, Zoltewicz S, Guingab-Cagmat J, Anagli J, Gao M, Hafeez A, Li N, Cao J, Geng X, Kobeissy F, Mondello S, Larner SF, Hayes RL, Ji X, Ding Y.

Brain Res. 2013 Dec 2;1540:84-91. doi: 10.1016/j.brainres.2013.09.051. Epub 2013 Oct 16.

PMID:
24140110
49.

Preoperative-induced mild hypothermia attenuates neuronal damage in a rat subdural hematoma model.

Yokobori S, Bullock R, Gajavelli S, Burks S, Mondello S, Mo J, Wang KK, Hayes RL, Bramlett H, Dietrich D.

Acta Neurochir Suppl. 2013;118:77-81. doi: 10.1007/978-3-7091-1434-6_13.

PMID:
23564108
50.

The challenge of mild traumatic brain injury: role of biochemical markers in diagnosis of brain damage.

Mondello S, Schmid K, Berger RP, Kobeissy F, Italiano D, Jeromin A, Hayes RL, Tortella FC, Buki A.

Med Res Rev. 2014 May;34(3):503-31. doi: 10.1002/med.21295. Epub 2013 Jun 28. Review.

PMID:
23813922

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