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Items: 19


Immune monitoring technology primer: Single Cell Network Profiling (SCNP).

Hawtin RE, Cesano A.

J Immunother Cancer. 2015 Aug 18;3:34. doi: 10.1186/s40425-015-0075-z. eCollection 2015. No abstract available.


Quantitative measurement of alterations in DNA damage repair (DDR) pathways using single cell network profiling (SCNP).

Rosen DB, Leung LY, Louie B, Cordeiro JA, Conroy A, Shapira I, Fields SZ, Cesano A, Hawtin RE.

J Transl Med. 2014 Jun 25;12:184. doi: 10.1186/1479-5876-12-184.


High-dimensional analysis of the aging immune system: verification of age-associated differences in immune signaling responses in healthy donors.

Longo DM, Louie B, Ptacek J, Friedland G, Evensen E, Putta S, Atallah M, Spellmeyer D, Wang E, Pos Z, Marincola FM, Schaeffer A, Lukac S, Railkar R, Beals CR, Cesano A, Carayannopoulos LN, Hawtin RE.

J Transl Med. 2014 Jun 21;12:178. doi: 10.1186/1479-5876-12-178.


Functional pathway analysis using SCNP of FLT3 receptor pathway deregulation in AML provides prognostic information independent from mutational status.

Cesano A, Putta S, Rosen DB, Cohen AC, Gayko U, Mathi K, Woronicz J, Hawtin RE, Cripe L, Sun Z, Tallman MS, Paietta E.

PLoS One. 2013;8(2):e56714. doi: 10.1371/journal.pone.0056714. Epub 2013 Feb 19.


AKT signaling as a novel factor associated with in vitro resistance of human AML to gemtuzumab ozogamicin.

Rosen DB, Harrington KH, Cordeiro JA, Leung LY, Putta S, Lacayo N, Laszlo GS, Gudgeon CJ, Hogge DE, Hawtin RE, Cesano A, Walter RB.

PLoS One. 2013;8(1):e53518. doi: 10.1371/journal.pone.0053518. Epub 2013 Jan 8.


Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies.

Cesano A, Perbellini O, Evensen E, Chu CC, Cioffi F, Ptacek J, Damle RN, Chignola R, Cordeiro J, Yan XJ, Hawtin RE, Nichele I, Ware JR, Cavallini C, Lovato O, Zanotti R, Rai KR, Chiorazzi N, Pizzolo G, Scupoli MT.

Haematologica. 2013 Apr;98(4):626-34. doi: 10.3324/haematol.2012.071910. Epub 2012 Nov 9.


Racial differences in B cell receptor signaling pathway activation.

Longo DM, Louie B, Mathi K, Pos Z, Wang E, Hawtin RE, Marincola FM, Cesano A.

J Transl Med. 2012 Jun 6;10:113. doi: 10.1186/1479-5876-10-113.


Assessing signaling pathways associated with in vitro resistance to cytotoxic agents in AML.

Rosen DB, Cordeiro JA, Cohen A, Lacayo N, Hogge D, Hawtin RE, Cesano A.

Leuk Res. 2012 Jul;36(7):900-4. doi: 10.1016/j.leukres.2012.02.022. Epub 2012 Apr 21.


Single-cell network profiling of peripheral blood mononuclear cells from healthy donors reveals age- and race-associated differences in immune signaling pathway activation.

Longo DM, Louie B, Putta S, Evensen E, Ptacek J, Cordeiro J, Wang E, Pos Z, Hawtin RE, Marincola FM, Cesano A.

J Immunol. 2012 Feb 15;188(4):1717-25. doi: 10.4049/jimmunol.1102514. Epub 2012 Jan 13.


Inter-donor variation in cell subset specific immune signaling responses in healthy individuals.

Longo DM, Louie B, Wang E, Pos Z, Marincola FM, Hawtin RE, Cesano A.

Am J Clin Exp Immunol. 2012 Apr 24;1(1):1-11. Print 2012.


Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks.

Hawtin RE, Stockett DE, Wong OK, Lundin C, Helleday T, Fox JA.

Oncotarget. 2010 Nov;1(7):606-19.


Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line.

Chen R, Chubb S, Cheng T, Hawtin RE, Gandhi V, Plunkett W.

Cancer Res. 2010 Aug 15;70(16):6587-97. doi: 10.1158/0008-5472.CAN-09-3578. Epub 2010 Jul 27.


Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

Hawtin RE, Stockett DE, Byl JA, McDowell RS, Nguyen T, Arkin MR, Conroy A, Yang W, Osheroff N, Fox JA.

PLoS One. 2010 Apr 15;5(4):e10186. doi: 10.1371/journal.pone.0010186.


Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo.

Scatena CD, Kumer JL, Arbitrario JP, Howlett AR, Hawtin RE, Fox JA, Silverman JA.

Cancer Chemother Pharmacol. 2010 Oct;66(5):881-8. doi: 10.1007/s00280-009-1234-z. Epub 2010 Jan 8.


Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.

Chen R, Wierda WG, Chubb S, Hawtin RE, Fox JA, Keating MJ, Gandhi V, Plunkett W.

Blood. 2009 May 7;113(19):4637-45. doi: 10.1182/blood-2008-12-190256. Epub 2009 Feb 20.


SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.

Conroy A, Stockett DE, Walker D, Arkin MR, Hoch U, Fox JA, Hawtin RE.

Cancer Chemother Pharmacol. 2009 Sep;64(4):723-32. doi: 10.1007/s00280-008-0921-5. Epub 2009 Jan 24.


Liquefaction of Autographa californica nucleopolyhedrovirus-infected insects is dependent on the integrity of virus-encoded chitinase and cathepsin genes.

Hawtin RE, Zarkowska T, Arnold K, Thomas CJ, Gooday GW, King LA, Kuzio JA, Possee RD.

Virology. 1997 Nov 24;238(2):243-53.


Identification and preliminary characterization of a chitinase gene in the Autographa californica nuclear polyhedrosis virus genome.

Hawtin RE, Arnold K, Ayres MD, Zanotto PM, Howard SC, Gooday GW, Chappell LH, Kitts PA, King LA, Possee RD.

Virology. 1995 Oct 1;212(2):673-85.


Red-shifted excitation mutants of the green fluorescent protein.

Delagrave S, Hawtin RE, Silva CM, Yang MM, Youvan DC.

Biotechnology (N Y). 1995 Feb;13(2):151-4.


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