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Submandibular gland sparing when irradiating neck level IB in the treatment of oral squamous cell carcinoma.

Jackson WC, Hawkins PG, Arnould GS, Yao J, Mayo C, Mierzwa M.

Med Dosim. 2018 May 16. pii: S0958-3947(18)30067-0. doi: 10.1016/j.meddos.2018.04.003. [Epub ahead of print]


Randomized phase I trial HIV-CORE 003: Depletion of serum amyloid P component and immunogenicity of DNA vaccination against HIV-1.

Borthwick NJ, Lane T, Moyo N, Crook A, Shim JM, Baines I, Wee EG, Hawkins PN, Gillmore JD, Hanke T, Pepys MB.

PLoS One. 2018 May 17;13(5):e0197299. doi: 10.1371/journal.pone.0197299. eCollection 2018.


Author Correction: Femtosecond Laser Mass Spectrometry and High Harmonic Spectroscopy of Xylene Isomers.

Alharbi A, Boguslavskiy AE, Austin D, Thiré N, Wood D, Hawkins P, McGrath F, Johnson AS, Lopez-Quintas I, Schmidt B, Légaré F, Marangos JP, Le AT, Bhardwaj R.

Sci Rep. 2018 May 9;8(1):7536. doi: 10.1038/s41598-018-25623-1.


Lightwave valleytronics in a monolayer of tungsten diselenide.

Langer F, Schmid CP, Schlauderer S, Gmitra M, Fabian J, Nagler P, Schüller C, Korn T, Hawkins PG, Steiner JT, Huttner U, Koch SW, Kira M, Huber R.

Nature. 2018 May;557(7703):76-80. doi: 10.1038/s41586-018-0013-6. Epub 2018 May 2.


Global distribution of invasive serotype 35D Streptococcus pneumoniae post-PCV13 introduction.

Lo SW, Gladstone RA, van Tonder AJ, Hawkins PA, Kwambana-Adams B, Cornick JE, Madhi SA, Nzenze SA, du Plessis M, Kandasamy R, Carter PE, Köseoglu Eser Ö, Ho PL, Elmdaghri N, Shakoor S, Clarke SC, Antonio M, Everett DB, von Gottberg A, Klugman KP, McGee L, Breiman RF, Bentley SD; Global Pneumococcal Sequencing Consortium.

J Clin Microbiol. 2018 May 2. pii: JCM.00228-18. doi: 10.1128/JCM.00228-18. [Epub ahead of print]


Cardiac amyloidosis.

Martinez-Naharro A, Hawkins PN, Fontana M.

Clin Med (Lond). 2018 Apr 1;18(Suppl 2):s30-s35. doi: 10.7861/clinmedicine.18-2-s30.


Cardiac Structural and Functional Consequences of Amyloid Deposition by Cardiac Magnetic Resonance and Echocardiography and Their Prognostic Roles.

Knight DS, Zumbo G, Barcella W, Steeden JA, Muthurangu V, Martinez-Naharro A, Treibel TA, Abdel-Gadir A, Bulluck H, Kotecha T, Francis R, Rezk T, Quarta CC, Whelan CJ, Lachmann HJ, Wechalekar AD, Gillmore JD, Moon JC, Hawkins PN, Fontana M.

JACC Cardiovasc Imaging. 2018 Apr 13. pii: S1936-878X(18)30213-4. doi: 10.1016/j.jcmg.2018.02.016. [Epub ahead of print]


Extracardiac 18F-florbetapir imaging in patients with systemic amyloidosis: more than hearts and minds.

Wagner T, Page J, Burniston M, Skillen A, Ross JC, Manwani R, McCool D, Hawkins PN, Wechalekar AD.

Eur J Nucl Med Mol Imaging. 2018 Jul;45(7):1129-1138. doi: 10.1007/s00259-018-3995-2. Epub 2018 Apr 12.


Dynamics of Colonization of Streptococcus pneumoniae Strains in Healthy Peruvian Children.

Nelson KN, Grijalva CG, Chochua S, Hawkins PA, Gil AI, Lanata CF, Griffin MR, Edwards KM, Klugman KP, Vidal JE.

Open Forum Infect Dis. 2018 Feb 17;5(3):ofy039. doi: 10.1093/ofid/ofy039. eCollection 2018 Mar.


Native T1 and Extracellular Volume in Transthyretin Amyloidosis.

Martinez-Naharro A, Kotecha T, Norrington K, Boldrini M, Rezk T, Quarta C, Treibel TA, Whelan CJ, Knight DS, Kellman P, Ruberg FL, Gillmore JD, Moon JC, Hawkins PN, Fontana M.

JACC Cardiovasc Imaging. 2018 Mar 12. pii: S1936-878X(18)30198-0. doi: 10.1016/j.jcmg.2018.02.006. [Epub ahead of print]


Cerebral blood flow predicts differential neurotransmitter activity.

Dukart J, Holiga Š, Chatham C, Hawkins P, Forsyth A, McMillan R, Myers J, Lingford-Hughes AR, Nutt DJ, Merlo-Pich E, Risterucci C, Boak L, Umbricht D, Schobel S, Liu T, Mehta MA, Zelaya FO, Williams SC, Brown G, Paulus M, Honey GD, Muthukumaraswamy S, Hipp J, Bertolino A, Sambataro F.

Sci Rep. 2018 Mar 6;8(1):4074. doi: 10.1038/s41598-018-22444-0.


Femtosecond Laser Mass Spectrometry and High Harmonic Spectroscopy of Xylene Isomers.

Alharbi A, Boguslavskiy AE, Austin D, Thiré N, Wood D, Hawkins P, McGrath F, Johnson AS, Lopez-Quintas I, Schmidt B, Légaré F, Marangos JP, Le AT, Bhardwaj R.

Sci Rep. 2018 Feb 28;8(1):3789. doi: 10.1038/s41598-018-22055-9. Erratum in: Sci Rep. 2018 May 9;8(1):7536.


Adaptive Boost Target Definition in High-Risk Head and Neck Cancer Based on Multi-imaging Risk Biomarkers.

Teng F, Aryal M, Lee J, Lee C, Shen X, Hawkins PG, Mierzwa M, Eisbruch A, Cao Y.

Int J Radiat Oncol Biol Phys. 2017 Dec 21. pii: S0360-3016(17)34492-9. doi: 10.1016/j.ijrobp.2017.12.269. [Epub ahead of print]


Total Synthesis of Ecumicin.

Hawkins PME, Giltrap AM, Nagalingam G, Britton WJ, Payne RJ.

Org Lett. 2018 Feb 16;20(4):1019-1022. doi: 10.1021/acs.orglett.7b03967. Epub 2018 Feb 7.


Diagnosis, pathogenesis and outcome in leucocyte chemotactic factor 2 (ALECT2) amyloidosis.

Rezk T, Gilbertson JA, Rowczenio D, Bass P, Lachmann HJ, Wechalekar AD, Fontana M, Mahmood S, Sachchithanantham S, Whelan CJ, Wong J, Rendell N, Taylor GW, Hawkins PN, Gillmore JD.

Nephrol Dial Transplant. 2018 Feb 1;33(2):241-247. doi: 10.1093/ndt/gfw375.


Prevalence of Cardiac Amyloidosis in Patients Referred for Transcatheter Aortic Valve Replacement.

Scully PR, Treibel TA, Fontana M, Lloyd G, Mullen M, Pugliese F, Hartman N, Hawkins PN, Menezes LJ, Moon JC.

J Am Coll Cardiol. 2018 Jan 30;71(4):463-464. doi: 10.1016/j.jacc.2017.11.037. No abstract available.


Rapid hematologic responses improve outcomes in patients with very advanced (stage IIIb) cardiac immunoglobulin light chain amyloidosis.

Manwani R, Foard D, Mahmood S, Sachchithanantham S, Lane T, Quarta C, Youngstein T, Rezk T, Lachmann HJ, Gillmore JD, Fontana M, Whelan C, Hawkins PN, Wechalekar A.

Haematologica. 2018 Apr;103(4):e165-e168. doi: 10.3324/haematol.2017.178095. Epub 2018 Jan 5. No abstract available.


Repeat doses of antibody to serum amyloid P component clear amyloid deposits in patients with systemic amyloidosis.

Richards DB, Cookson LM, Barton SV, Liefaard L, Lane T, Hutt DF, Ritter JM, Fontana M, Moon JC, Gillmore JD, Wechalekar A, Hawkins PN, Pepys MB.

Sci Transl Med. 2018 Jan 3;10(422). pii: eaan3128. doi: 10.1126/scitranslmed.aan3128.


Molecular genetic investigation, clinical features, and response to treatment in 21 patients with Schnitzler syndrome.

Rowczenio DM, Pathak S, Arostegui JI, Mensa-Vilaro A, Omoyinmi E, Brogan P, Lipsker D, Scambler T, Owen R, Trojer H, Baginska A, Gillmore JD, Wechalekar AD, Lane T, Williams R, Youngstein T, Hawkins PN, Savic S, Lachmann HJ.

Blood. 2018 Mar 1;131(9):974-981. doi: 10.1182/blood-2017-10-810366. Epub 2017 Dec 28.


In-depth PtdIns(3,4,5)P3 signalosome analysis identifies DAPP1 as a negative regulator of GPVI-driven platelet function.

Durrant TN, Hutchinson JL, Heesom KJ, Anderson KE, Stephens LR, Hawkins PT, Marshall AJ, Moore SF, Hers I.

Blood Adv. 2017 Jun 13;1(14):918-932. doi: 10.1182/bloodadvances.2017005173.


Prognostic Value of c-MET Expression in Patients With Pancreatic Cancer Receiving Adjuvant and Neoadjuvant Chemoradiation Therapy.

Cuneo KC, Morgan MA, Griffith KA, Hawkins PG, Greenson JK, Ben-Josef E, Lawrence TS, Zalupski MM.

Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):490-497. doi: 10.1016/j.ijrobp.2017.10.030. Epub 2017 Oct 28.


Prediction of Radiation Esophagitis in Non-Small Cell Lung Cancer Using Clinical Factors, Dosimetric Parameters, and Pretreatment Cytokine Levels.

Hawkins PG, Boonstra PS, Hobson ST, Hayman JA, Ten Haken RK, Matuszak MM, Stanton P, Kalemkerian GP, Lawrence TS, Schipper MJ, Kong FS, Jolly S.

Transl Oncol. 2018 Feb;11(1):102-108. doi: 10.1016/j.tranon.2017.11.005. Epub 2017 Dec 18.


Ligand-Based Methods in GPCR Computer-Aided Drug Design.

Hawkins PCD, Stahl G.

Methods Mol Biol. 2018;1705:365-374. doi: 10.1007/978-1-4939-7465-8_18.


To Group or Not to Group? Good Practice for Housing Male Laboratory Mice.

Kappel S, Hawkins P, Mendl MT.

Animals (Basel). 2017 Nov 24;7(12). pii: E88. doi: 10.3390/ani7120088. Review.


Organ-Sparing in Radiotherapy for Head-and-Neck Cancer: Improving Quality of Life.

Hawkins PG, Kadam AS, Jackson WC, Eisbruch A.

Semin Radiat Oncol. 2018 Jan;28(1):46-52. doi: 10.1016/j.semradonc.2017.08.002. Review.


Late-Onset Cryopyrin-Associated Periodic Syndromes Caused by Somatic NLRP3 Mosaicism-UK Single Center Experience.

Rowczenio DM, Gomes SM, Aróstegui JI, Mensa-Vilaro A, Omoyinmi E, Trojer H, Baginska A, Baroja-Mazo A, Pelegrin P, Savic S, Lane T, Williams R, Brogan P, Lachmann HJ, Hawkins PN.

Front Immunol. 2017 Oct 31;8:1410. doi: 10.3389/fimmu.2017.01410. eCollection 2017.


Prospective comparison of novel dark blood late gadolinium enhancement with conventional bright blood imaging for the detection of scar.

Francis R, Kellman P, Kotecha T, Baggiano A, Norrington K, Martinez-Naharro A, Nordin S, Knight DS, Rakhit RD, Lockie T, Hawkins PN, Moon JC, Hausenloy DJ, Xue H, Hansen MS, Fontana M.

J Cardiovasc Magn Reson. 2017 Nov 21;19(1):91. doi: 10.1186/s12968-017-0407-x.


Extracellular volume with bolus-only technique in amyloidosis patients: Diagnostic accuracy, correlation with other clinical cardiac measures, and ability to track changes in amyloid load over time.

Zumbo G, Barton SV, Thompson D, Sun M, Abdel-Gadir A, Treibel TA, Knight D, Martinez-Naharro A, Thirusha L, Gillmore JD, Moon JC, Hawkins PN, Fontana M.

J Magn Reson Imaging. 2017 Nov 21. doi: 10.1002/jmri.25907. [Epub ahead of print]


Renal Amyloidosis Associated With 5 Novel Variants in the Fibrinogen A Alpha Chain Protein.

Rowczenio D, Stensland M, de Souza GA, Strøm EH, Gilbertson JA, Taylor G, Rendell N, Minogue S, Efebera YA, Lachmann HJ, Wechalekar AD, Hawkins PN, Heimdal KR, Selvig K, Lægreid IK, Demoulin N, Aydin S, Gillmore JD, Wien TN.

Kidney Int Rep. 2016 Nov 19;2(3):461-469. doi: 10.1016/j.ekir.2016.11.005. eCollection 2017 May.


An apparatus for quantitative high-harmonic generation spectroscopy in molecular vapours.

McGrath F, Johnson AS, Austin DR, Hawkins P, Wood D, Miseikis L, Simpson ER, Castillejo M, Torres R, Parker S, Siegel T, Marangos JP.

Rev Sci Instrum. 2017 Oct;88(10):103108. doi: 10.1063/1.4986037.


Role of 99m Tc-DPD scintigraphy in imaging extra-cardiac light chain (AL) amyloidosis.

Sachchithanantham S, Hutt DF, Quigley AM, Hawkins P, Wechalekar AD.

Br J Haematol. 2017 Oct 30. doi: 10.1111/bjh.14988. [Epub ahead of print] No abstract available.


An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers.

Hawkins PCT, Wood TC, Vernon AC, Bertolino A, Sambataro F, Dukart J, Merlo-Pich E, Risterucci C, Silber-Baumann H, Walsh E, Mazibuko N, Zelaya FO, Mehta MA.

Hum Brain Mapp. 2018 Jan;39(1):319-331. doi: 10.1002/hbm.23844. Epub 2017 Oct 23.


PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K.

Malek M, Kielkowska A, Chessa T, Anderson KE, Barneda D, Pir P, Nakanishi H, Eguchi S, Koizumi A, Sasaki J, Juvin V, Kiselev VY, Niewczas I, Gray A, Valayer A, Spensberger D, Imbert M, Felisbino S, Habuchi T, Beinke S, Cosulich S, Le Novère N, Sasaki T, Clark J, Hawkins PT, Stephens LR.

Mol Cell. 2017 Nov 2;68(3):566-580.e10. doi: 10.1016/j.molcel.2017.09.024. Epub 2017 Oct 19.


SGK1 Is a Critical Component of an AKT-Independent Pathway Essential for PI3K-Mediated Tumor Development and Maintenance.

Orlacchio A, Ranieri M, Brave M, Arciuch VA, Forde T, De Martino D, Anderson KE, Hawkins P, Di Cristofano A.

Cancer Res. 2017 Dec 15;77(24):6914-6926. doi: 10.1158/0008-5472.CAN-17-2105. Epub 2017 Oct 20.


Serum MicroRNA Signature Predicts Response to High-Dose Radiation Therapy in Locally Advanced Non-Small Cell Lung Cancer.

Sun Y, Hawkins PG, Bi N, Dess RT, Tewari M, Hearn JWD, Hayman JA, Kalemkerian GP, Lawrence TS, Ten Haken RK, Matuszak MM, Kong FM, Jolly S, Schipper MJ.

Int J Radiat Oncol Biol Phys. 2018 Jan 1;100(1):107-114. doi: 10.1016/j.ijrobp.2017.08.039. Epub 2017 Sep 4.


A new staging system for cardiac transthyretin amyloidosis.

Gillmore JD, Damy T, Fontana M, Hutchinson M, Lachmann HJ, Martinez-Naharro A, Quarta CC, Rezk T, Whelan CJ, Gonzalez-Lopez E, Lane T, Gilbertson JA, Rowczenio D, Petrie A, Hawkins PN.

Eur Heart J. 2017 Oct 18. doi: 10.1093/eurheartj/ehx589. [Epub ahead of print]


Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue.

Canetti D, Rendell NB, Di Vagno L, Gilbertson JA, Rowczenio D, Rezk T, Gillmore JD, Hawkins PN, Verona G, Mangione PP, Giorgetti S, Mauri P, Motta S, De Palma A, Bellotti V, Taylor GW.

Amyloid. 2017 Dec;24(4):233-241. doi: 10.1080/13506129.2017.1385452. Epub 2017 Oct 10.


Immunoparesis defined by heavy+light chain suppression is a novel marker of long-term outcomes in cardiac AL amyloidosis.

Sachchithanantham S, Berlanga O, Alvi A, Mahmood SA, Lachmann HJ, Gillmore JD, Hawkins PN, Harding S, Wechalekar AD.

Br J Haematol. 2017 Nov;179(4):575-585. doi: 10.1111/bjh.14908. Epub 2017 Oct 8.


Pitfalls in conducting prospective trials in stage III cardiac amyloidosis - experience from the REVEAL study.

Phillips EH, Nash S, Adedayo T, Whelan CJ, Fontana M, Mahmood S, Lachmann HJ, Gillmore JD, Smith P, Clifton-Hadley L, Hawkins PN, Wechalekar AD.

Amyloid. 2017 Dec;24(4):242-244. doi: 10.1080/13506129.2017.1385453. Epub 2017 Oct 6. No abstract available.


International multi-centre study of pregnancy outcomes with interleukin-1 inhibitors.

Youngstein T, Hoffmann P, Gül A, Lane T, Williams R, Rowczenio DM, Ozdogan H, Ugurlu S, Ryan J, Harty L, Riminton S, Headley AP, Roesler J, Blank N, Kuemmerle-Deschner JB, Simon A, Woolf AS, Hawkins PN, Lachmann HJ.

Rheumatology (Oxford). 2017 Dec 1;56(12):2102-2108. doi: 10.1093/rheumatology/kex305.


Radiation-induced lung toxicity in non-small-cell lung cancer: Understanding the interactions of clinical factors and cytokines with the dose-toxicity relationship.

Hawkins PG, Boonstra PS, Hobson ST, Hearn JWD, Hayman JA, Ten Haken RK, Matuszak MM, Stanton P, Kalemkerian GP, Ramnath N, Lawrence TS, Schipper MJ, Spring Kong FM, Jolly S.

Radiother Oncol. 2017 Oct;125(1):66-72. doi: 10.1016/j.radonc.2017.09.005. Epub 2017 Sep 23.


Sparing all salivary glands with IMRT for head and neck cancer: Longitudinal study of patient-reported xerostomia and head-and-neck quality of life.

Hawkins PG, Lee JY, Mao Y, Li P, Green M, Worden FP, Swiecicki PL, Mierzwa ML, Spector ME, Schipper MJ, Eisbruch A.

Radiother Oncol. 2018 Jan;126(1):68-74. doi: 10.1016/j.radonc.2017.08.002. Epub 2017 Aug 16.


Antimicrobial resistance determinants and susceptibility profiles of pneumococcal isolates recovered in Trinidad and Tobago.

Hawkins PA, Akpaka PE, Nurse-Lucas M, Gladstone R, Bentley SD, Breiman RF, McGee L, Swanston WH.

J Glob Antimicrob Resist. 2017 Dec;11:148-151. doi: 10.1016/j.jgar.2017.08.004. Epub 2017 Aug 14.


Validation of β-lactam minimum inhibitory concentration predictions for pneumococcal isolates with newly encountered penicillin binding protein (PBP) sequences.

Li Y, Metcalf BJ, Chochua S, Li Z, Gertz RE Jr, Walker H, Hawkins PA, Tran T, McGee L, Beall BW; Active Bacterial Core surveillance team.

BMC Genomics. 2017 Aug 15;18(1):621. doi: 10.1186/s12864-017-4017-7.


Key features of invasive pneumococcal isolates recovered in Lima, Peru determined through whole genome sequencing.

Hawkins P, Mercado E, Chochua S, Castillo ME, Reyes I, Chaparro E, Gladstone R, Bentley SD, Breiman RF, Metcalf BJ, Beall B, Ochoa TJ, McGee L.

Int J Med Microbiol. 2017 Oct;307(7):415-421. doi: 10.1016/j.ijmm.2017.07.008. Epub 2017 Jul 22.


Clinical impact of a targeted next-generation sequencing gene panel for autoinflammation and vasculitis.

Omoyinmi E, Standing A, Keylock A, Price-Kuehne F, Melo Gomes S, Rowczenio D, Nanthapisal S, Cullup T, Nyanhete R, Ashton E, Murphy C, Clarke M, Ahlfors H, Jenkins L, Gilmour K, Eleftheriou D, Lachmann HJ, Hawkins PN, Klein N, Brogan PA.

PLoS One. 2017 Jul 27;12(7):e0181874. doi: 10.1371/journal.pone.0181874. eCollection 2017.


Safety and efficacy of empirical interleukin-1 inhibition using anakinra in AA amyloidosis of uncertain aetiology.

Lane T, Wechalekar AD, Gillmore JD, Hawkins PN, Lachmann HJ.

Amyloid. 2017 Sep;24(3):189-193. doi: 10.1080/13506129.2017.1352503. Epub 2017 Jul 26.


Prolonged renal survival in light chain amyloidosis: speed and magnitude of light chain reduction is the crucial factor.

Rezk T, Lachmann HJ, Fontana M, Sachchithanantham S, Mahmood S, Petrie A, Whelan CJ, Pinney JH, Foard D, Lane T, Youngstein T, Wechalekar AD, Bass P, Hawkins PN, Gillmore JD.

Kidney Int. 2017 Dec;92(6):1476-1483. doi: 10.1016/j.kint.2017.05.004. Epub 2017 Jul 18.


Magnetic Resonance in Transthyretin Cardiac Amyloidosis.

Martinez-Naharro A, Treibel TA, Abdel-Gadir A, Bulluck H, Zumbo G, Knight DS, Kotecha T, Francis R, Hutt DF, Rezk T, Rosmini S, Quarta CC, Whelan CJ, Kellman P, Gillmore JD, Moon JC, Hawkins PN, Fontana M.

J Am Coll Cardiol. 2017 Jul 25;70(4):466-477. doi: 10.1016/j.jacc.2017.05.053.


Changing epidemiology of AA amyloidosis: clinical observations over 25 years at a single national referral centre.

Lane T, Pinney JH, Gilbertson JA, Hutt DF, Rowczenio DM, Mahmood S, Sachchithanantham S, Fontana M, Youngstein T, Quarta CC, Wechalekar AD, Gillmore JD, Hawkins PN, Lachmann HJ.

Amyloid. 2017 Sep;24(3):162-166. doi: 10.1080/13506129.2017.1342235. Epub 2017 Jul 7.


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