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Immune Checkpoint Inhibitors in the Treatment of Melanoma: From Basic Science to Clinical Application.

Rausch MP, Hastings KT.

In: Ward WH, Farma JM, editors. Cutaneous Melanoma: Etiology and Therapy [Internet]. Brisbane (AU): Codon Publications; 2017 Dec 21. Chapter 9.


Survival of adult Steller sea lions in Alaska: senescence, annual variation and covariation with male reproductive success.

Hastings KK, Jemison LA, Pendleton GW.

R Soc Open Sci. 2018 Jan 17;5(1):170665. doi: 10.1098/rsos.170665. eCollection 2018 Jan.


A Multiple-Imputation "Forward Bridging" Approach to Address Changes in the Classification of Asian Race/Ethnicity on the US Death Certificate.

Thompson CA, Boothroyd DB, Hastings KG, Cullen MR, Palaniappan LP, Rehkopf DH.

Am J Epidemiol. 2018 Feb 1;187(2):347-357. doi: 10.1093/aje/kwx215.


Nativity Status and Cardiovascular Disease Mortality Among Hispanic Adults.

Rodriguez F, Hastings KG, Hu J, Lopez L, Cullen M, Harrington RA, Palaniappan LP.

J Am Heart Assoc. 2017 Dec 13;6(12). pii: e007207. doi: 10.1161/JAHA.117.007207.


Metabolic Syndrome and Associated Diseases: From the Bench to the Clinic.

Mendrick DL, Diehl AM, Topor LS, Dietert RR, Will Y, La Merrill MA, Bouret S, Varma V, Hastings KL, Schug TT, Emeigh Hart SG, Burleson FG.

Toxicol Sci. 2018 Mar 1;162(1):36-42. doi: 10.1093/toxsci/kfx233.


Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer.

Gettinger S, Choi J, Hastings K, Truini A, Datar I, Sowell R, Wurtz A, Dong W, Cai G, Melnick MA, Du VY, Schlessinger J, Goldberg SB, Chiang A, Sanmamed MF, Melero I, Agorreta J, Montuenga LM, Lifton R, Ferrone S, Kavathas P, Rimm DL, Kaech SM, Schalper K, Herbst RS, Politi K.

Cancer Discov. 2017 Dec;7(12):1420-1435. doi: 10.1158/2159-8290.CD-17-0593. Epub 2017 Oct 12.


Thyroid cancer mortality is higher in Filipinos in the United States: An analysis using national mortality records from 2003 through 2012.

Nguyen MT, Hu J, Hastings KG, Daza EJ, Cullen MR, Orloff LA, Palaniappan LP.

Cancer. 2017 Dec 15;123(24):4860-4867. doi: 10.1002/cncr.30958. Epub 2017 Sep 7.


Geographic Variations in Cardiovascular Disease Mortality Among Asian American Subgroups, 2003-2011.

Pu J, Hastings KG, Boothroyd D, Jose PO, Chung S, Shah JB, Cullen MR, Palaniappan LP, Rehkopf DH.

J Am Heart Assoc. 2017 Jul 12;6(7). pii: e005597. doi: 10.1161/JAHA.117.005597.


Natal and breeding philopatry of female Steller sea lions in southeastern Alaska.

Hastings KK, Jemison LA, Pendleton GW, Raum-Suryan KL, Pitcher KW.

PLoS One. 2017 Jun 7;12(6):e0176840. doi: 10.1371/journal.pone.0176840. eCollection 2017.


Nab2 maintains thymus cellularity with aging and stress.

Hastings KT, Elizalde D, Muppana L, Levine S, Kamel CM, Ingram WM, Kirkpatrick JT, Hu C, Rausch MP, Gallitano AL.

Mol Immunol. 2017 May;85:185-195. doi: 10.1016/j.molimm.2017.02.019. Epub 2017 Mar 8.


Social and clinically-relevant cardiovascular risk factors in Asian Americans adults: NHANES 2011-2014.

Echeverria SE, Mustafa M, Pentakota SR, Kim S, Hastings KG, Amadi C, Palaniappan L.

Prev Med. 2017 Jun;99:222-227. doi: 10.1016/j.ypmed.2017.02.016. Epub 2017 Feb 17.


Disaggregation of Cause-Specific Cardiovascular Disease Mortality Among Hispanic Subgroups.

Rodriguez F, Hastings KG, Boothroyd DB, Echeverria S, Lopez L, Cullen M, Harrington RA, Palaniappan LP.

JAMA Cardiol. 2017 Mar 1;2(3):240-247. doi: 10.1001/jamacardio.2016.4653.


Cross-national comparisons of increasing suicidal mortality rates for Koreans in the Republic of Korea and Korean Americans in the USA, 2003-2012.

Kung A, Hastings KG, Kapphahn KI, Wang EJ, Cullen MR, Ivey SL, Palaniappan LP, Chung S.

Epidemiol Psychiatr Sci. 2018 Feb;27(1):62-73. doi: 10.1017/S2045796016000792. Epub 2016 Nov 10.


Mortality outcomes for Chinese and Japanese immigrants in the USA and countries of origin (Hong Kong, Japan): a comparative analysis using national mortality records from 2003 to 2011.

Hastings KG, Eggleston K, Boothroyd D, Kapphahn KI, Cullen MR, Barry M, Palaniappan LP.

BMJ Open. 2016 Oct 28;6(10):e012201. doi: 10.1136/bmjopen-2016-012201.


The Burden of Cancer in Asian Americans: A Report of National Mortality Trends by Asian Ethnicity.

Thompson CA, Gomez SL, Hastings KG, Kapphahn K, Yu P, Shariff-Marco S, Bhatt AS, Wakelee HA, Patel MI, Cullen MR, Palaniappan LP.

Cancer Epidemiol Biomarkers Prev. 2016 Oct;25(10):1371-1382.


Evaluation of potential human health effects associated with the agricultural uses of 1,3-D: Spatial and temporal stochastic risk analysis.

Driver JH, Price PS, Van Wesenbeeck I, Ross JH, Gehen S, Holden LR, Landenberger B, Hastings K, Yan ZJ, Rasoulpour R.

Sci Total Environ. 2016 Nov 15;571:410-5. doi: 10.1016/j.scitotenv.2016.06.172. Epub 2016 Jul 25.


Gamma-interferon-inducible lysosomal thiol reductase is upregulated in human melanoma.

Nguyen J, Bernert R, In K, Kang P, Sebastiao N, Hu C, Hastings KT.

Melanoma Res. 2016 Apr;26(2):125-37. doi: 10.1097/CMR.0000000000000230.


Dyslipidemia in Special Ethnic Populations.

Pu J, Romanelli R, Zhao B, Azar KM, Hastings KG, Nimbal V, Fortmann SP, Palaniappan LP.

Endocrinol Metab Clin North Am. 2016 Mar;45(1):205-16. doi: 10.1016/j.ecl.2015.09.013. Review.


Management and Treatment of Attention-Deficit/Hyperactivity Disorder on College Campuses.

Amyx ML, Hastings KB, Reynolds EJ, Weakley JA, Dinkel S, Patzel B.

J Psychosoc Nurs Ment Health Serv. 2015 Nov;53(11):46-51. doi: 10.3928/02793695-20151021-03.


Diverse cellular and organismal functions of the lysosomal thiol reductase GILT.

Rausch MP, Hastings KT.

Mol Immunol. 2015 Dec;68(2 Pt A):124-8. doi: 10.1016/j.molimm.2015.06.008. Epub 2015 Jun 23. Review.


Inactivation of the ubiquitin-specific protease 19 deubiquitinating enzyme protects against muscle wasting.

Bédard N, Jammoul S, Moore T, Wykes L, Hallauer PL, Hastings KE, Stretch C, Baracos V, Chevalier S, Plourde M, Coyne E, Wing SS.

FASEB J. 2015 Sep;29(9):3889-98. doi: 10.1096/fj.15-270579. Epub 2015 Jun 5.


A pipeline for the systematic identification of non-redundant full-ORF cDNAs for polymorphic and evolutionary divergent genomes: Application to the ascidian Ciona intestinalis.

Gilchrist MJ, Sobral D, Khoueiry P, Daian F, Laporte B, Patrushev I, Matsumoto J, Dewar K, Hastings KE, Satou Y, Lemaire P, Rothbächer U.

Dev Biol. 2015 Aug 15;404(2):149-63. doi: 10.1016/j.ydbio.2015.05.014. Epub 2015 May 27.


Dyslipidemia in special ethnic populations.

Pu J, Romanelli R, Zhao B, Azar KM, Hastings KG, Nimbal V, Fortmann SP, Palaniappan LP.

Cardiol Clin. 2015 May;33(2):325-33. doi: 10.1016/j.ccl.2015.01.005. Review.


Leading Causes of Death among Asian American Subgroups (2003-2011).

Hastings KG, Jose PO, Kapphahn KI, Frank AT, Goldstein BA, Thompson CA, Eggleston K, Cullen MR, Palaniappan LP.

PLoS One. 2015 Apr 27;10(4):e0124341. doi: 10.1371/journal.pone.0124341. eCollection 2015.


An exhaustion-like phenotype constrains the activity of CD4+ T cells specific for a self and melanoma antigen.

Rausch MP, Hastings KT.

PLoS One. 2015 Apr 15;10(4):e0123332. doi: 10.1371/journal.pone.0123332. eCollection 2015.


FutureTox II: in vitro data and in silico models for predictive toxicology.

Knudsen TB, Keller DA, Sander M, Carney EW, Doerrer NG, Eaton DL, Fitzpatrick SC, Hastings KL, Mendrick DL, Tice RR, Watkins PB, Whelan M.

Toxicol Sci. 2015 Feb;143(2):256-67. doi: 10.1093/toxsci/kfu234.


Cardiovascular disease mortality in Asian Americans.

Jose PO, Frank AT, Kapphahn KI, Goldstein BA, Eggleston K, Hastings KG, Cullen MR, Palaniappan LP.

J Am Coll Cardiol. 2014 Dec 16;64(23):2486-94. doi: 10.1016/j.jacc.2014.08.048.


GILT: Shaping the MHC Class II-Restricted Peptidome and CD4(+) T Cell-Mediated Immunity.

Hastings KT.

Front Immunol. 2013 Dec 4;4:429. doi: 10.3389/fimmu.2013.00429. Review.


Low GILT Expression is Associated with Poor Patient Survival in Diffuse Large B-Cell Lymphoma.

Phipps-Yonas H, Cui H, Sebastiao N, Brunhoeber PS, Haddock E, Deymier MJ, Klapper W, Lybarger L, Roe DJ, Hastings KT.

Front Immunol. 2013 Dec 4;4:425. doi: 10.3389/fimmu.2013.00425. eCollection 2013.


Inter-population movements of steller sea lions in Alaska with implications for population separation.

Jemison LA, Pendleton GW, Fritz LW, Hastings KK, Maniscalco JM, Trites AW, Gelatt TS.

PLoS One. 2013 Aug 5;8(8):e70167. doi: 10.1371/journal.pone.0070167. Print 2013.


Hardships of end-of-life care with court-appointed guardians.

Hastings KB.

Am J Hosp Palliat Care. 2014 Feb;31(1):57-60. doi: 10.1177/1049909113481100. Epub 2013 Mar 15.


Workshop proceedings: challenges and opportunities in evaluating protein allergenicity across biotechnology industries.

Stagg NJ, Ghantous HN, Ladics GS, House RV, Gendel SM, Hastings KL.

Int J Toxicol. 2013 Jan-Feb;32(1):4-10. doi: 10.1177/1091581812471864. Epub 2013 Jan 16.


GILT expression in B cells diminishes cathepsin S steady-state protein expression and activity.

Phipps-Yonas H, Semik V, Hastings KT.

Eur J Immunol. 2013 Jan;43(1):65-74. doi: 10.1002/eji.201242379. Epub 2012 Nov 26.


Storm forecasting: additional lessons from the CD28 superagonist TGN1412 trial.

Horvath C, Andrews L, Baumann A, Black L, Blanset D, Cavagnaro J, Hastings KL, Hutto DL, MacLachlan TK, Milton M, Reynolds T, Roberts S, Rogge M, Sims J, Treacy G, Warner G, Green JD.

Nat Rev Immunol. 2012 Oct;12(10):740; author reply 740. doi: 10.1038/nri3192-c1. Epub 2012 Aug 31. No abstract available. Erratum in: Nat Rev Immunol. 2012 Oct;12(10):740.


GILT modulates CD4+ T-cell tolerance to the melanocyte differentiation antigen tyrosinase-related protein 1.

Rausch MP, Hastings KT.

J Invest Dermatol. 2012 Jan;132(1):154-62. doi: 10.1038/jid.2011.236. Epub 2011 Aug 11.


Disulfide reduction in the endocytic pathway: immunological functions of gamma-interferon-inducible lysosomal thiol reductase.

Hastings KT, Cresswell P.

Antioxid Redox Signal. 2011 Aug 1;15(3):657-68. doi: 10.1089/ars.2010.3684. Epub 2011 Apr 20. Review.


Cross-validated methods for promoter/transcription start site mapping in SL trans-spliced genes, established using the Ciona intestinalis troponin I gene.

Khare P, Mortimer SI, Cleto CL, Okamura K, Suzuki Y, Kusakabe T, Nakai K, Meedel TH, Hastings KE.

Nucleic Acids Res. 2011 Apr;39(7):2638-48. doi: 10.1093/nar/gkq1151. Epub 2010 Nov 24.


Casemix Funding Optimisation: Working Together to Make the Most of Every Episode.

Uzkuraitis C, Hastings K, Torney B.

Health Inf Manag. 2010 Oct;39(3):47-49. doi: 10.1177/183335831003900309.


GILT accelerates autoimmunity to the melanoma antigen tyrosinase-related protein 1.

Rausch MP, Irvine KR, Antony PA, Restifo NP, Cresswell P, Hastings KT.

J Immunol. 2010 Sep 1;185(5):2828-35. doi: 10.4049/jimmunol.1000945. Epub 2010 Jul 28.


Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.

Palpant NJ, Houang EM, Delport W, Hastings KE, Onufriev AV, Sham YY, Metzger JM.

Physiol Genomics. 2010 Jul 7;42(2):287-99. doi: 10.1152/physiolgenomics.00033.2010. Epub 2010 Apr 27.


High-throughput sequence analysis of Ciona intestinalis SL trans-spliced mRNAs: alternative expression modes and gene function correlates.

Matsumoto J, Dewar K, Wasserscheid J, Wiley GB, Macmil SL, Roe BA, Zeller RW, Satou Y, Hastings KE.

Genome Res. 2010 May;20(5):636-45. doi: 10.1101/gr.100271.109. Epub 2010 Mar 8.


SL RNA genes of the ascidian tunicates Ciona intestinalis and Ciona savignyi.

Yeats B, Matsumoto J, Mortimer SI, Shoguchi E, Satoh N, Hastings KE.

Zoolog Sci. 2010 Feb;27(2):171-80. doi: 10.2108/zsj.27.171.


Strong muscle-specific regulatory cassettes based on multiple copies of the human slow troponin I gene upstream enhancer.

Blain M, Zeng Y, Bendjelloul M, Hallauer PL, Kumar A, Hastings KE, Karpati G, Massie B, Gilbert R.

Hum Gene Ther. 2010 Jan;21(1):127-34. doi: 10.1089/hum.2008.208.


George karpati (1934-2009).

Hastings K.

Muscle Nerve. 2009 Aug;40(2):169-70. doi: 10.1002/mus.21437. No abstract available.


Summary of a workshop on nonclinical and clinical immunotoxicity assessment of immunomodulatory drugs.

Piccotti JR, Lebrec HN, Evans E, Herzyk DJ, Hastings KL, Burns-Naas LA, Gourley IS, Wierda D, Kawabata TT.

J Immunotoxicol. 2009 Mar;6(1):1-10. doi: 10.1080/15476910802656440.


Acknowledgement of contributions of Dr. Harihara Mehendale as editor-in-chief of International Journal of Toxicology.

Hastings KL, Hayes AW.

Int J Toxicol. 2008 Nov;27(6):399. doi: 10.1080/10915810802642806. No abstract available.


Prospects for developmental immunotoxicity guidance and an update on ICH S8.

Hastings KL.

J Immunotoxicol. 2005 Oct 1;2(4):217-20. doi: 10.1080/15476910500387173.


Development of the ICH guidelines for immunotoxicology evaluation of pharmaceuticals using a survey of industry practices.

Weaver JL, Tsutsui N, Hisada S, Vidal JM, Spanhaak S, Sawada J, Hastings KL, van der Laan JW, van Loveren H, Kawabata TT, Sims J, Durham SK, Fueki O, Matula TI, Kusunoki H, Ulrich P, Nakamura K.

J Immunotoxicol. 2005 Jul 1;2(3):171-80. doi: 10.1080/15476910500241339.


Evaluation of a lymph node proliferation assay for its ability to detect pharmaceuticals with potential to cause immune-mediated drug reactions.

Weaver JL, Chapdelaine JM, Descotes J, Germolec D, Holsapple M, House R, Lebrec H, Meade J, Pieters R, Hastings KL, Dean JH.

J Immunotoxicol. 2005 Jan 1;2(1):11-20. doi: 10.1080/15476910590930100.


Multidimensional immunomodulation.

House RV, Hastings KL.

J Immunotoxicol. 2004 Apr;1(2):123-9. doi: 10.1080/15476910490503646. No abstract available.


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