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Crystallisation in basaltic magmas revealed via in situ 4D synchrotron X-ray microtomography.

Polacci M, Arzilli F, La Spina G, Le Gall N, Cai B, Hartley ME, Di Genova D, Vo NT, Nonni S, Atwood RC, Llewellin EW, Lee PD, Burton MR.

Sci Rep. 2018 May 30;8(1):8377. doi: 10.1038/s41598-018-26644-6.


Sobetirome and its amide prodrug Sob-AM2 exert thyromimetic actions in Mct8-deficient brain.

Bárez-López S, Hartley MD, Grijota-Martínez C, Scanlan T, Guadaño-Ferraz A.

Thyroid. 2018 May 30. doi: 10.1089/thy.2018.0008. [Epub ahead of print]


Detection of novel astroviruses MLB1 and MLB2 in the sera of febrile Tanzanian children.

Cordey S, Hartley MA, Keitel K, Laubscher F, Brito F, Junier T, Kagoro F, Samaka J, Masimba J, Said Z, Temba H, Mlaganile T, Docquier M, Fellay J, Kaiser L, D'Acremont V.

Emerg Microbes Infect. 2018 Mar 14;7(1):27. doi: 10.1038/s41426-018-0025-1. No abstract available.


Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β.

Hartley MA, Eren RO, Rossi M, Prevel F, Castiglioni P, Isorce N, Desponds C, Lye LF, Beverley SM, Drexler SK, Fasel N.

Microb Cell. 2018 Jan 14;5(3):137-149. doi: 10.15698/mic2018.03.619.


Comparing and optimizing ultraviolet germicidal irradiation systems use for patient room terminal disinfection: an exploratory study using radiometry and commercial test cards.

Masse V, Hartley MJ, Edmond MB, Diekema DJ.

Antimicrob Resist Infect Control. 2018 Feb 22;7:29. doi: 10.1186/s13756-018-0317-1. eCollection 2018.


Morphometrics of complex cell shapes: lobe contribution elliptic Fourier analysis (LOCO-EFA).

Sánchez-Corrales YE, Hartley M, van Rooij J, Marée AFM, Grieneisen VA.

Development. 2018 Mar 20;145(6). pii: dev156778. doi: 10.1242/dev.156778.


A phase I study of intravenous artesunate in patients with advanced solid tumor malignancies.

Deeken JF, Wang H, Hartley M, Cheema AK, Smaglo B, Hwang JJ, He AR, Weiner LM, Marshall JL, Giaccone G, Liu S, Luecht J, Spiegel JY, Pishvaian MJ.

Cancer Chemother Pharmacol. 2018 Mar;81(3):587-596. doi: 10.1007/s00280-018-3533-8. Epub 2018 Feb 1.


Human papillomavirus type 18 E5 oncogene supports cell cycle progression and impairs epithelial differentiation by modulating growth factor receptor signalling during the virus life cycle.

Wasson CW, Morgan EL, Müller M, Ross RL, Hartley M, Roberts S, Macdonald A.

Oncotarget. 2017 Oct 6;8(61):103581-103600. doi: 10.18632/oncotarget.21658. eCollection 2017 Nov 28.


Pavement cells and the topology puzzle.

Carter R, Sánchez-Corrales YE, Hartley M, Grieneisen VA, Marée AFM.

Development. 2017 Dec 1;144(23):4386-4397. doi: 10.1242/dev.157073. Epub 2017 Oct 30.


Erratum: Strong constraints on aerosol-cloud interactions from volcanic eruptions.

Malavelle FF, Haywood JM, Jones A, Gettelman A, Clarisse L, Bauduin S, Allan RP, Karset IHH, Kristjánsson JE, Oreopoulos L, Cho N, Lee D, Bellouin N, Boucher O, Grosvenor DP, Carslaw KS, Dhomse S, Mann GW, Schmidt A, Coe H, Hartley ME, Dalvi M, Hill AA, Johnson BT, Johnson CE, Knight JR, O'Connor FM, Partridge DG, Stier P, Myhre G, Platnick S, Stephens GL, Takahashi H, Thordarson T.

Nature. 2017 Nov 9;551(7679):256. doi: 10.1038/nature24275. Epub 2017 Oct 4.


Regorafenib in advanced hepatocellular carcinoma (HCC): considerations for treatment.

Kim K, Jha R, Prins PA, Wang H, Chacha M, Hartley ML, He AR.

Cancer Chemother Pharmacol. 2017 Nov;80(5):945-954. doi: 10.1007/s00280-017-3431-5. Epub 2017 Sep 20.


Safety and effectiveness of antireflux surgery in obese patients.

Tandon A, Rao R, Hotouras A, Nunes QM, Hartley M, Gunasekera R, Howes N.

Ann R Coll Surg Engl. 2017 Sep;99(7):515-523. doi: 10.1308/rcsann.2017.0144. Review.


Distinct phases of Polycomb silencing to hold epigenetic memory of cold in Arabidopsis.

Yang H, Berry S, Olsson TSG, Hartley M, Howard M, Dean C.

Science. 2017 Sep 15;357(6356):1142-1145. doi: 10.1126/science.aan1121. Epub 2017 Aug 17.


Use of axenic media to determine antibiotic efficacy against coxiella burnetii.

Clay KA, Hartley MG, Russell P, Norville IH.

Int J Antimicrob Agents. 2018 May;51(5):806-808. doi: 10.1016/j.ijantimicag.2017.08.006. Epub 2017 Aug 9.


Strong constraints on aerosol-cloud interactions from volcanic eruptions.

Malavelle FF, Haywood JM, Jones A, Gettelman A, Clarisse L, Bauduin S, Allan RP, Karset IHH, Kristjánsson JE, Oreopoulos L, Cho N, Lee D, Bellouin N, Boucher O, Grosvenor DP, Carslaw KS, Dhomse S, Mann GW, Schmidt A, Coe H, Hartley ME, Dalvi M, Hill AA, Johnson BT, Johnson CE, Knight JR, O'Connor FM, Partridge DG, Stier P, Myhre G, Platnick S, Stephens GL, Takahashi H, Thordarson T.

Nature. 2017 Jun 22;546(7659):485-491. doi: 10.1038/nature22974. Erratum in: Nature. 2017 Oct 04;:.


Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats.

Estridge TB, Dey AB, Reidy C, Yu X, Zhang Y, Hartley M, Milligan PL, Jin N, Kowala MC, Leohr JK, Fretland AJ, Mabry TE, Luffer-Atlas D, Luo MJ.

J Pharmacol Exp Ther. 2017 Jul;362(1):108-118. doi: 10.1124/jpet.117.240242. Epub 2017 May 2.


Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis.

Rossi M, Castiglioni P, Hartley MA, Eren RO, Prével F, Desponds C, Utzschneider DT, Zehn D, Cusi MG, Kuhlmann FM, Beverley SM, Ronet C, Fasel N.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):4987-4992. doi: 10.1073/pnas.1621447114. Epub 2017 Apr 24.


Ester-to-amide rearrangement of ethanolamine-derived prodrugs of sobetirome with increased blood-brain barrier penetration.

Ferrara SJ, Meinig JM, Placzek AT, Banerji T, McTigue P, Hartley MD, Sanford-Crane HS, Banerji T, Bourdette D, Scanlan TS.

Bioorg Med Chem. 2017 May 15;25(10):2743-2753. doi: 10.1016/j.bmc.2017.03.047. Epub 2017 Mar 23.


Predicting Ebola infection: A malaria-sensitive triage score for Ebola virus disease.

Hartley MA, Young A, Tran AM, Okoni-Williams HH, Suma M, Mancuso B, Al-Dikhari A, Faouzi M.

PLoS Negl Trop Dis. 2017 Feb 23;11(2):e0005356. doi: 10.1371/journal.pntd.0005356. eCollection 2017 Feb.


A Thyroid Hormone-Based Strategy for Correcting the Biochemical Abnormality in X-Linked Adrenoleukodystrophy.

Hartley MD, Kirkemo LL, Banerji T, Scanlan TS.

Endocrinology. 2017 May 1;158(5):1328-1338. doi: 10.1210/en.2016-1842.


Predicting Ebola Severity: A Clinical Prioritization Score for Ebola Virus Disease.

Hartley MA, Young A, Tran AM, Okoni-Williams HH, Suma M, Mancuso B, Al-Dikhari A, Faouzi M.

PLoS Negl Trop Dis. 2017 Feb 2;11(2):e0005265. doi: 10.1371/journal.pntd.0005265. eCollection 2017 Feb.


Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid.

Castiglioni P, Hartley MA, Rossi M, Prevel F, Desponds C, Utzschneider DT, Eren RO, Zangger H, Brunner L, Collin N, Zehn D, Kuhlmann FM, Beverley SM, Fasel N, Ronet C.

PLoS Negl Trop Dis. 2017 Jan 18;11(1):e0005240. doi: 10.1371/journal.pntd.0005240. eCollection 2017 Jan.


A method for detecting single mRNA molecules in Arabidopsis thaliana.

Duncan S, Olsson TSG, Hartley M, Dean C, Rosa S.

Plant Methods. 2016 Aug 5;12:13. doi: 10.1186/s13007-016-0114-x. eCollection 2016.


jicbioimage: a tool for automated and reproducible bioimage analysis.

Olsson TS, Hartley M.

PeerJ. 2016 Nov 15;4:e2674. eCollection 2016.


Sobetirome prodrug esters with enhanced blood-brain barrier permeability.

Placzek AT, Ferrara SJ, Hartley MD, Sanford-Crane HS, Meinig JM, Scanlan TS.

Bioorg Med Chem. 2016 Nov 15;24(22):5842-5854. doi: 10.1016/j.bmc.2016.09.038. Epub 2016 Sep 16.


FoldAtlas: a repository for genome-wide RNA structure probing data.

Norris M, Kwok CK, Cheema J, Hartley M, Morris RJ, Aviran S, Ding Y.

Bioinformatics. 2017 Jan 15;33(2):306-308. doi: 10.1093/bioinformatics/btw611. Epub 2016 Sep 22.


Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A.

Hartley MA, Bourreau E, Rossi M, Castiglioni P, Eren RO, Prevel F, Couppié P, Hickerson SM, Launois P, Beverley SM, Ronet C, Fasel N.

PLoS Pathog. 2016 Sep 22;12(9):e1005852. doi: 10.1371/journal.ppat.1005852. eCollection 2016 Sep.


Topical Simvastatin as Host-Directed Therapy against Severity of Cutaneous Leishmaniasis in Mice.

Parihar SP, Hartley MA, Hurdayal R, Guler R, Brombacher F.

Sci Rep. 2016 Sep 16;6:33458. doi: 10.1038/srep33458.


Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence.

Eren RO, Reverte M, Rossi M, Hartley MA, Castiglioni P, Prevel F, Martin R, Desponds C, Lye LF, Drexler SK, Reith W, Beverley SM, Ronet C, Fasel N.

Cell Host Microbe. 2016 Sep 14;20(3):318-328. doi: 10.1016/j.chom.2016.08.001. Epub 2016 Sep 1.


Neoadjuvant Combined-Modality Therapy for Locally Advanced Rectal Cancer and Its Future Direction.

Salem ME, Hartley M, Unger K, Marshall JL.

Oncology (Williston Park). 2016 Jun;30(6):546-62. Review.


Methods of Disease Risk Analysis in Wildlife Translocations for Conservation Purposes.

Hartley M, Sainsbury A.

Ecohealth. 2017 Mar;14(Suppl 1):16-29. doi: 10.1007/s10393-016-1134-8. Epub 2016 Jun 10. No abstract available.


Distal Femoral Osteotomy for the Valgus Knee: Medial Closing Wedge Versus Lateral Opening Wedge: A Systematic Review.

Wylie JD, Jones DL, Hartley MK, Kapron AL, Krych AJ, Aoki SK, Maak TG.

Arthroscopy. 2016 Oct;32(10):2141-2147. doi: 10.1016/j.arthro.2016.04.010. Epub 2016 Jun 3. Review.


A paradigm shift from one-size-fits-all to tailor-made therapy for metastatic colorectal cancer.

Weinberg BA, Marshall JL, Hartley M, Salem ME.

Clin Adv Hematol Oncol. 2016 Feb;14(2):116-28. Review.


Exceptional Response to Systemic Therapy in Advanced Metastatic Gastric Cancer: A Case Report.

Colton B, Hartley M, Manning MA, Carroll JE, Xiu J, Smaglo BG, Mikhail S, Salem ME.

Cureus. 2016 Jan 12;8(1):e457. doi: 10.7759/cureus.457.


Raising the issue of DNAR orders in vascular surgery patients.

McIntosh R, Webb H, Hartley M, Brooks M.

BMJ Qual Improv Rep. 2016 Feb 8;5(1). pii: u206293.w3610. doi: 10.1136/bmjquality.u206293.w3610. eCollection 2016.


Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus.

Parmentier L, Cusini A, Müller N, Zangger H, Hartley MA, Desponds C, Castiglioni P, Dubach P, Ronet C, Beverley SM, Fasel N.

Am J Trop Med Hyg. 2016 Apr;94(4):840-3. doi: 10.4269/ajtmh.15-0803. Epub 2016 Feb 1.


Improving phlebotomy handover of untaken blood tests to junior doctors.

Brown E, Jarrett H, Churchhouse G, Hartley M, Cohen D, Kyprianou K, Murphy S, Walker B, Hill C.

BMJ Qual Improv Rep. 2015 Aug 27;4(1). pii: u206278.w3267. doi: 10.1136/bmjquality.u206278.w3267. eCollection 2015.


Statistical modelling of survival for babies with oesophageal atresia.

Hartley MJ, Smith NP, Jaffray B.

J Pediatr Surg. 2016 Jul;51(7):1110-4. doi: 10.1016/j.jpedsurg.2015.11.016. Epub 2015 Nov 28.


The Philani Mentor Mothers Intervention: Neighbourhood wide impact on child growth in Cape Town's peri-urban settlements.

Tomlinson M, Hartley M, le Roux I, Rotheram-Borus MJ.

Vulnerable Child Youth Stud. 2016;11(3):221-222. doi: 10.1080/17450128.2016.1220658. Epub 2016 Aug 30.


Failures and Reoperations After Matrix-Assisted Cartilage Repair of the Knee: A Systematic Review.

Wylie JD, Hartley MK, Kapron AL, Aoki SK, Maak TG.

Arthroscopy. 2016 Feb;32(2):386-92. doi: 10.1016/j.arthro.2015.07.025. Epub 2015 Sep 28. Review.


Incorporating prior knowledge improves detection of differences in bacterial growth rate.

Rickett LM, Pullen N, Hartley M, Zipfel C, Kamoun S, Baranyi J, Morris RJ.

BMC Syst Biol. 2015 Sep 21;9:60. doi: 10.1186/s12918-015-0204-9.



Hartley M, Roberts H.

J Zoo Wildl Med. 2015 Sep;46(3):540-6. doi: 10.1638/2015-0001.1.


Comparison of Relative Activation Energies Obtained by Density Functional Theory and the Random Phase Approximation for Several Claisen Rearrangements.

Hartley MK, Vine S, Walsh E, Avrantinis S, Daub GW, Cave RJ.

J Phys Chem B. 2016 Mar 3;120(8):1486-96. doi: 10.1021/acs.jpcb.5b06646. Epub 2015 Sep 1.


Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse.

Bourreau E, Ginouves M, Prévot G, Hartley MA, Gangneux JP, Robert-Gangneux F, Dufour J, Sainte-Marie D, Bertolotti A, Pratlong F, Martin R, Schütz F, Couppié P, Fasel N, Ronet C.

J Infect Dis. 2016 Jan 1;213(1):105-11. doi: 10.1093/infdis/jiv355. Epub 2015 Jun 29.


Local chromatin environment of a Polycomb target gene instructs its own epigenetic inheritance.

Berry S, Hartley M, Olsson TS, Dean C, Howard M.

Elife. 2015 May 8;4. doi: 10.7554/eLife.07205.


Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape.

Hancks DC, Hartley MK, Hagan C, Clark NL, Elde NC.

PLoS Genet. 2015 May 5;11(5):e1005203. doi: 10.1371/journal.pgen.1005203. eCollection 2015 May.


Pancreatic cancer, treatment options, and GI-4000.

Hartley ML, Bade NA, Prins PA, Ampie L, Marshall JL.

Hum Vaccin Immunother. 2015;11(4):931-7. doi: 10.1080/21645515.2015.1011017. Review.

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