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Items: 1 to 50 of 232

1.

Corrigendum: Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.

Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robbez-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J, Kermorgant S.

Nat Commun. 2016 Jul 22;7:12392. doi: 10.1038/ncomms12392. No abstract available.

2.

Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes.

Barrow-McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche BA, Noval AJ, Mai A, Guzmán C, Robert-Masson L, Iturrioz X, Hulit J, Brennan CH, Hart IR, Parker PJ, Ivaska J, Kermorgant S.

Nat Commun. 2016 Jun 23;7:11942. doi: 10.1038/ncomms11942.

3.

Therapeutic targeting of integrin αvβ6 in breast cancer.

Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR, Haider S, Brouilette K, Saha A, Vallath S, Bowen R, Chelala C, Eccles D, Tapper WJ, Thompson AM, Quinlan P, Jordan L, Gillett C, Brentnall A, Violette S, Weinreb PH, Kendrew J, Barry ST, Hart IR, Jones JL, Marshall JF.

J Natl Cancer Inst. 2014 Jun 28;106(8). pii: dju169. doi: 10.1093/jnci/dju169. Print 2014 Aug.

4.

RhoC interacts with integrin α5β1 and enhances its trafficking in migrating pancreatic carcinoma cells.

Li NF, Gemenetzidis E, Marshall FJ, Davies D, Yu Y, Frese K, Froeling FE, Woolf AK, Feakins RM, Naito Y, Iacobuzio-Donahue C, Tuveson DA, Hart IR, Kocher HM.

PLoS One. 2013 Dec 3;8(12):e81575. doi: 10.1371/journal.pone.0081575. eCollection 2013.

5.

Functional analysis of a breast cancer-associated FGFR2 single nucleotide polymorphism using zinc finger mediated genome editing.

Robbez-Masson LJ, Bödör C, Jones JL, Hurst HC, Fitzgibbon J, Hart IR, Grose RP.

PLoS One. 2013 Nov 12;8(11):e78839. doi: 10.1371/journal.pone.0078839. eCollection 2013.

6.

Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence.

Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA, Dickinson S, Edwards DR, Pennington CJ, Sestak I, Cuzick J, Marshall JF, Hart IR, Jones JL.

Clin Cancer Res. 2014 Jan 15;20(2):344-57. doi: 10.1158/1078-0432.CCR-13-1504. Epub 2013 Oct 22.

7.

FAK-heterozygous mice display enhanced tumour angiogenesis.

Kostourou V, Lechertier T, Reynolds LE, Lees DM, Baker M, Jones DT, Tavora B, Ramjaun AR, Birdsey GM, Robinson SD, Parsons M, Randi AM, Hart IR, Hodivala-Dilke K.

Nat Commun. 2013;4:2020. doi: 10.1038/ncomms3020.

8.

Combined fiber modifications both to target α(v)β(6) and detarget the coxsackievirus-adenovirus receptor improve virus toxicity profiles in vivo but fail to improve antitumoral efficacy relative to adenovirus serotype 5.

Coughlan L, Vallath S, Gros A, Giménez-Alejandre M, Van Rooijen N, Thomas GJ, Baker AH, Cascalló M, Alemany R, Hart IR.

Hum Gene Ther. 2012 Sep;23(9):960-79. doi: 10.1089/hum.2011.218. Epub 2012 Aug 27.

PMID:
22708837
9.

β3-integrin is required for differentiation in OC-2 cells derived from mammalian embryonic inner ear.

Brunetta I, Casalotti SO, Hart IR, Forge A, Reynolds LE.

BMC Cell Biol. 2012 Mar 17;13:5. doi: 10.1186/1471-2121-13-5.

10.

Non-junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris.

Tsang SM, Brown L, Lin K, Liu L, Piper K, O'Toole EA, Grose R, Hart IR, Garrod DR, Fortune F, Wan H.

J Pathol. 2012 May;227(1):81-93. doi: 10.1002/path.3982. Epub 2012 Feb 17.

PMID:
22294297
11.

Proteome of formalin-fixed paraffin-embedded pancreatic ductal adenocarcinoma and lymph node metastases.

Naidoo K, Jones R, Dmitrovic B, Wijesuriya N, Kocher H, Hart IR, Crnogorac-Jurcevic T.

J Pathol. 2012 Apr;226(5):756-63. doi: 10.1002/path.3959. Epub 2012 Jan 17. Erratum in: J Pathol. 2012 Aug;227(4):e8.

PMID:
22081483
12.

Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression.

Froeling FE, Feig C, Chelala C, Dobson R, Mein CE, Tuveson DA, Clevers H, Hart IR, Kocher HM.

Gastroenterology. 2011 Oct;141(4):1486-97, 1497.e1-14. doi: 10.1053/j.gastro.2011.06.047. Epub 2011 Jun 24.

PMID:
21704588
13.

A direct role for Met endocytosis in tumorigenesis.

Joffre C, Barrow R, Ménard L, Calleja V, Hart IR, Kermorgant S.

Nat Cell Biol. 2011 Jun 5;13(7):827-37. doi: 10.1038/ncb2257.

PMID:
21642981
14.

Editorial: Special section on "site-specific metastasis".

Allgayer H, Hart IR.

Int J Cancer. 2011 Jun 1;128(11):2509-10. doi: 10.1002/ijc.26050. No abstract available.

15.

Clinical and functional significance of α9β1 integrin expression in breast cancer: a novel cell-surface marker of the basal phenotype that promotes tumour cell invasion.

Allen MD, Vaziri R, Green M, Chelala C, Brentnall AR, Dreger S, Vallath S, Nitch-Smith H, Hayward J, Carpenter R, Holliday DL, Walker RA, Hart IR, Jones JL.

J Pathol. 2011 Apr;223(5):646-58. doi: 10.1002/path.2833. Epub 2011 Feb 21.

PMID:
21341269
16.

Stromal features are predictive of disease mortality in oral cancer patients.

Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N, Violette SM, Weinreb PH, Chester KA, Chana JS, Marshall JF, Hart IR, Hackshaw AK, Piper K, Thomas GJ.

J Pathol. 2011 Mar;223(4):470-81. doi: 10.1002/path.2830. Epub 2011 Jan 5.

PMID:
21294121
17.

Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.

Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF, Fortune F, Tilakaratne WM, Hart IR, Thomas GJ.

J Pathol. 2011 Feb;223(3):366-77. doi: 10.1002/path.2786. Epub 2010 Oct 25.

PMID:
21171082
18.

Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src.

Tsang SM, Liu L, Teh MT, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F, Wan H.

PLoS One. 2010 Dec 3;5(12):e14211. doi: 10.1371/journal.pone.0014211.

19.

Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion.

Morgan MR, Jazayeri M, Ramsay AG, Thomas GJ, Boulanger MJ, Hart IR, Marshall JF.

Oncogene. 2011 Mar 24;30(12):1422-35. doi: 10.1038/onc.2010.535. Epub 2010 Dec 6.

PMID:
21132011
20.

Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.

da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kostourou V, Germain MA, Reynolds AR, Jones DT, Watson AR, Jones JL, Harris A, Hart IR, Iruela-Arispe ML, Dipersio CM, Kreidberg JA, Hodivala-Dilke KM.

Am J Pathol. 2010 Sep;177(3):1534-48. doi: 10.2353/ajpath.2010.100043. Epub 2010 Jul 16.

21.

High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alphavbeta6.

Saha A, Ellison D, Thomas GJ, Vallath S, Mather SJ, Hart IR, Marshall JF.

J Pathol. 2010 Sep;222(1):52-63. doi: 10.1002/path.2745.

PMID:
20629113
22.

Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome.

Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, Turnell AS, Kermorgant S, Imhof BA, Adams R, Fisher EM, Tybulewicz VL, Hart IR, Hodivala-Dilke KM.

Nature. 2010 Jun 10;465(7299):813-7. doi: 10.1038/nature09106. Erratum in: Nature. 2010 Jul 15;466(7304):398.

23.

New evidence for tumour embolism as a mode of metastasis.

Hart IR.

J Pathol. 2009 Nov;219(3):275-6. doi: 10.1002/path.2616.

PMID:
19768739
24.

Loss-of-function FERMT1 mutations in kindler syndrome implicate a role for fermitin family homolog-1 in integrin activation.

Lai-Cheong JE, Parsons M, Tanaka A, Ussar S, South AP, Gomathy S, Mee JB, Barbaroux JB, Techanukul T, Almaani N, Clements SE, Hart IR, McGrath JA.

Am J Pathol. 2009 Oct;175(4):1431-41. doi: 10.2353/ajpath.2009.081154. Epub 2009 Sep 17.

25.

Organotypic culture model of pancreatic cancer demonstrates that stromal cells modulate E-cadherin, beta-catenin, and Ezrin expression in tumor cells.

Froeling FE, Mirza TA, Feakins RM, Seedhar A, Elia G, Hart IR, Kocher HM.

Am J Pathol. 2009 Aug;175(2):636-48. doi: 10.2353/ajpath.2009.090131. Epub 2009 Jul 16.

26.

In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery.

Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, Marshall JF, Hart IR, Thomas GJ.

J Virol. 2009 Jul;83(13):6416-28. doi: 10.1128/JVI.00445-09. Epub 2009 Apr 15.

27.

Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors.

Reynolds AR, Hart IR, Watson AR, Welti JC, Silva RG, Robinson SD, Da Violante G, Gourlaouen M, Salih M, Jones MC, Jones DT, Saunders G, Kostourou V, Perron-Sierra F, Norman JC, Tucker GC, Hodivala-Dilke KM.

Nat Med. 2009 Apr;15(4):392-400. doi: 10.1038/nm.1941. Epub 2009 Mar 22.

PMID:
19305413
28.

Ezrin interacts with cortactin to form podosomal rosettes in pancreatic cancer cells.

Kocher HM, Sandle J, Mirza TA, Li NF, Hart IR.

Gut. 2009 Feb;58(2):271-84. doi: 10.1136/gut.2008.159871. Epub 2008 Oct 13.

PMID:
18852256
29.

Colocalization of kindlin-1, kindlin-2, and migfilin at keratinocyte focal adhesion and relevance to the pathophysiology of Kindler syndrome.

Lai-Cheong JE, Ussar S, Arita K, Hart IR, McGrath JA.

J Invest Dermatol. 2008 Sep;128(9):2156-65. doi: 10.1038/jid.2008.58. Epub 2008 Jun 5.

30.

Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues.

Lees DM, Hart IR, Marshall JF.

J Mol Biol. 2008 Jun 13;379(4):645-55. doi: 10.1016/j.jmb.2008.04.020. Epub 2008 Apr 12.

PMID:
18472110
31.

alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation.

Marsh D, Dickinson S, Neill GW, Marshall JF, Hart IR, Thomas GJ.

Cancer Res. 2008 May 1;68(9):3295-303. doi: 10.1158/0008-5472.CAN-08-0174.

32.

alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice.

Reynolds LE, Conti FJ, Silva R, Robinson SD, Iyer V, Rudling R, Cross B, Nye E, Hart IR, Dipersio CM, Hodivala-Dilke KM.

J Clin Invest. 2008 Mar;118(3):965-74. doi: 10.1172/JCI33538.

33.

Early onset of breast cancer in a group of British black women.

Bowen RL, Duffy SW, Ryan DA, Hart IR, Jones JL.

Br J Cancer. 2008 Jan 29;98(2):277-81. doi: 10.1038/sj.bjc.6604174. Epub 2008 Jan 8.

34.

Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness.

Dicara D, Burman A, Clark S, Berryman S, Howard MJ, Hart IR, Marshall JF, Jackson T.

J Virol. 2008 Feb;82(3):1537-46. Epub 2007 Nov 28.

35.

Integrin trafficking and its role in cancer metastasis.

Ramsay AG, Marshall JF, Hart IR.

Cancer Metastasis Rev. 2007 Dec;26(3-4):567-78. Review.

PMID:
17786537
36.

HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6.

Ramsay AG, Keppler MD, Jazayeri M, Thomas GJ, Parsons M, Violette S, Weinreb P, Hart IR, Marshall JF.

Cancer Res. 2007 Jun 1;67(11):5275-84.

37.

Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression.

Pourreyron C, Cox G, Mao X, Volz A, Baksh N, Wong T, Fassihi H, Arita K, O'Toole EA, Ocampo-Candiani J, Chen M, Hart IR, Bruckner-Tuderman L, Salas-Alanis JC, McGrath JA, Leigh IM, South AP.

J Invest Dermatol. 2007 Oct;127(10):2438-44. Epub 2007 May 10.

38.

Increased keratinocyte proliferation initiated through downregulation of desmoplakin by RNA interference.

Wan H, South AP, Hart IR.

Exp Cell Res. 2007 Jul 1;313(11):2336-44. Epub 2007 Jan 30.

PMID:
17475244
39.

The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development.

Grose R, Fantl V, Werner S, Chioni AM, Jarosz M, Rudling R, Cross B, Hart IR, Dickson C.

EMBO J. 2007 Mar 7;26(5):1268-78. Epub 2007 Feb 15.

40.

Ability to acquire drug resistance arises early during the tumorigenesis process.

Yagüe E, Arance A, Kubitza L, O'Hare M, Jat P, Ogilvie CM, Hart IR, Higgins CF, Raguz S.

Cancer Res. 2007 Feb 1;67(3):1130-7.

41.

Stem/progenitor cell-like properties of desmoglein 3dim cells in primary and immortalized keratinocyte lines.

Wan H, Yuan M, Simpson C, Allen K, Gavins FN, Ikram MS, Basu S, Baksh N, O'Toole EA, Hart IR.

Stem Cells. 2007 May;25(5):1286-97. Epub 2007 Jan 25.

42.

Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands.

DiCara D, Rapisarda C, Sutcliffe JL, Violette SM, Weinreb PH, Hart IR, Howard MJ, Marshall JF.

J Biol Chem. 2007 Mar 30;282(13):9657-65. Epub 2007 Jan 23.

43.

Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.

Nystrom ML, McCulloch D, Weinreb PH, Violette SM, Speight PM, Marshall JF, Hart IR, Thomas GJ.

Cancer Res. 2006 Nov 15;66(22):10833-42.

44.

A new role for the anti-apoptotic gene A20 in angiogenesis.

Chng HW, Camplejohn RS, Stone MG, Hart IR, Nicholson LJ.

Exp Cell Res. 2006 Sep 10;312(15):2897-907. Epub 2006 Jun 6.

PMID:
16824518
45.

Development of a quantitative method to analyse tumour cell invasion in organotypic culture.

Nyström ML, Thomas GJ, Stone M, Mackenzie IC, Hart IR, Marshall JF.

J Pathol. 2005 Mar;205(4):468-75.

PMID:
15685705
46.

Role of integrins in tumor invasion and metastasis.

Hart IR.

Exp Dermatol. 2004 Oct;13(10):663. No abstract available.

PMID:
15447732
47.

The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9.

Morgan MR, Thomas GJ, Russell A, Hart IR, Marshall JF.

J Biol Chem. 2004 Jun 18;279(25):26533-9. Epub 2004 Apr 2.

48.

Reduction of TSG101 protein has a negative impact on tumor cell growth.

Zhu G, Gilchrist R, Borley N, Chng HW, Morgan M, Marshall JF, Camplejohn RS, Muir GH, Hart IR.

Int J Cancer. 2004 Apr 20;109(4):541-7.

49.
50.

Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes.

Wan H, Stone MG, Simpson C, Reynolds LE, Marshall JF, Hart IR, Hodivala-Dilke KM, Eady RA.

J Cell Sci. 2003 Oct 15;116(Pt 20):4239-48. Epub 2003 Sep 2.

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