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Items: 1 to 50 of 109

1.

Retraction Notice to: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling.

Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI.

Cell Host Microbe. 2018 Apr 11;23(4):571. doi: 10.1016/j.chom.2018.03.005. No abstract available.

2.

Binding of ISRIB reveals a regulatory site in the nucleotide exchange factor eIF2B.

Zyryanova AF, Weis F, Faille A, Alard AA, Crespillo-Casado A, Sekine Y, Harding HP, Allen F, Parts L, Fromont C, Fischer PM, Warren AJ, Ron D.

Science. 2018 Mar 30;359(6383):1533-1536. doi: 10.1126/science.aar5129.

PMID:
29599245
3.

A J-Protein Co-chaperone Recruits BiP to Monomerize IRE1 and Repress the Unfolded Protein Response.

Amin-Wetzel N, Saunders RA, Kamphuis MJ, Rato C, Preissler S, Harding HP, Ron D.

Cell. 2017 Dec 14;171(7):1625-1637.e13. doi: 10.1016/j.cell.2017.10.040. Epub 2017 Nov 30.

4.

Defective ATG16L1-mediated removal of IRE1α drives Crohn's disease-like ileitis.

Tschurtschenthaler M, Adolph TE, Ashcroft JW, Niederreiter L, Bharti R, Saveljeva S, Bhattacharyya J, Flak MB, Shih DQ, Fuhler GM, Parkes M, Kohno K, Iwawaki T, Janneke van der Woude C, Harding HP, Smith AM, Peppelenbosch MP, Targan SR, Ron D, Rosenstiel P, Blumberg RS, Kaser A.

J Exp Med. 2017 Feb;214(2):401-422. doi: 10.1084/jem.20160791. Epub 2017 Jan 12.

5.

Paradoxical Sensitivity to an Integrated Stress Response Blocking Mutation in Vanishing White Matter Cells.

Sekine Y, Zyryanova A, Crespillo-Casado A, Amin-Wetzel N, Harding HP, Ron D.

PLoS One. 2016 Nov 3;11(11):e0166278. doi: 10.1371/journal.pone.0166278. eCollection 2016.

6.

Dual role of the integrated stress response in medulloblastoma tumorigenesis.

Stone S, Ho Y, Li X, Jamison S, Harding HP, Ron D, Lin W.

Oncotarget. 2016 Sep 27;7(39):64124-64135. doi: 10.18632/oncotarget.11873.

7.

PERK Activation Promotes Medulloblastoma Tumorigenesis by Attenuating Premalignant Granule Cell Precursor Apoptosis.

Ho Y, Li X, Jamison S, Harding HP, McKinnon PJ, Ron D, Lin W.

Am J Pathol. 2016 Jul;186(7):1939-1951. doi: 10.1016/j.ajpath.2016.03.004. Epub 2016 May 12.

8.

Skeletal muscle-specific eukaryotic translation initiation factor 2α phosphorylation controls amino acid metabolism and fibroblast growth factor 21-mediated non-cell-autonomous energy metabolism.

Miyake M, Nomura A, Ogura A, Takehana K, Kitahara Y, Takahara K, Tsugawa K, Miyamoto C, Miura N, Sato R, Kurahashi K, Harding HP, Oyadomari M, Ron D, Oyadomari S.

FASEB J. 2016 Feb;30(2):798-812. doi: 10.1096/fj.15-275990. Epub 2015 Oct 20.

9.

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker.

Preissler S, Chambers JE, Crespillo-Casado A, Avezov E, Miranda E, Perez J, Hendershot LM, Harding HP, Ron D.

Elife. 2015 Oct 16;4:e08961. doi: 10.7554/eLife.08961.

10.

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly.

Abdulkarim B, Nicolino M, Igoillo-Esteve M, Daures M, Romero S, Philippi A, Senée V, Lopes M, Cunha DA, Harding HP, Derbois C, Bendelac N, Hattersley AT, Eizirik DL, Ron D, Cnop M, Julier C.

Diabetes. 2015 Nov;64(11):3951-62. doi: 10.2337/db15-0477. Epub 2015 Jul 9.

11.

Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.

Sekine Y, Zyryanova A, Crespillo-Casado A, Fischer PM, Harding HP, Ron D.

Science. 2015 May 29;348(6238):1027-30. doi: 10.1126/science.aaa6986. Epub 2015 Apr 9.

12.

G-actin provides substrate-specificity to eukaryotic initiation factor 2α holophosphatases.

Chen R, Rato C, Yan Y, Crespillo-Casado A, Clarke HJ, Harding HP, Marciniak SJ, Read RJ, Ron D.

Elife. 2015 Mar 16;4. doi: 10.7554/eLife.04871.

13.

A method to quantify FRET stoichiometry with phasor plot analysis and acceptor lifetime ingrowth.

Chen W, Avezov E, Schlachter SC, Gielen F, Laine RF, Harding HP, Hollfelder F, Ron D, Kaminski CF.

Biophys J. 2015 Mar 10;108(5):999-1002. doi: 10.1016/j.bpj.2015.01.012.

14.

Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity.

Halliday M, Radford H, Sekine Y, Moreno J, Verity N, le Quesne J, Ortori CA, Barrett DA, Fromont C, Fischer PM, Harding HP, Ron D, Mallucci GR.

Cell Death Dis. 2015 Mar 5;6:e1672. doi: 10.1038/cddis.2015.49.

15.

Retarded PDI diffusion and a reductive shift in poise of the calcium depleted endoplasmic reticulum.

Avezov E, Konno T, Zyryanova A, Chen W, Laine R, Crespillo-Casado A, Melo EP, Ushioda R, Nagata K, Kaminski CF, Harding HP, Ron D.

BMC Biol. 2015 Jan 10;13:2. doi: 10.1186/s12915-014-0112-2.

16.

Impaired eukaryotic translation initiation factor 2B activity specifically in oligodendrocytes reproduces the pathology of vanishing white matter disease in mice.

Lin Y, Pang X, Huang G, Jamison S, Fang J, Harding HP, Ron D, Lin W.

J Neurosci. 2014 Sep 3;34(36):12182-91. doi: 10.1523/JNEUROSCI.1373-14.2014.

17.

Intact protein folding in the glutathione-depleted endoplasmic reticulum implicates alternative protein thiol reductants.

Tsunoda S, Avezov E, Zyryanova A, Konno T, Mendes-Silva L, Pinho Melo E, Harding HP, Ron D.

Elife. 2014 Jul 29;3:e03421. doi: 10.7554/eLife.03421.

18.

Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2.

Nangalia J, Massie CE, Baxter EJ, Nice FL, Gundem G, Wedge DC, Avezov E, Li J, Kollmann K, Kent DG, Aziz A, Godfrey AL, Hinton J, Martincorena I, Van Loo P, Jones AV, Guglielmelli P, Tarpey P, Harding HP, Fitzpatrick JD, Goudie CT, Ortmann CA, Loughran SJ, Raine K, Jones DR, Butler AP, Teague JW, O'Meara S, McLaren S, Bianchi M, Silber Y, Dimitropoulou D, Bloxham D, Mudie L, Maddison M, Robinson B, Keohane C, Maclean C, Hill K, Orchard K, Tauro S, Du MQ, Greaves M, Bowen D, Huntly BJP, Harrison CN, Cross NCP, Ron D, Vannucchi AM, Papaemmanuil E, Campbell PJ, Green AR.

N Engl J Med. 2013 Dec 19;369(25):2391-2405. doi: 10.1056/NEJMoa1312542. Epub 2013 Dec 10.

19.

PERK activation preserves the viability and function of remyelinating oligodendrocytes in immune-mediated demyelinating diseases.

Lin Y, Huang G, Jamison S, Li J, Harding HP, Ron D, Lin W.

Am J Pathol. 2014 Feb;184(2):507-19. doi: 10.1016/j.ajpath.2013.10.009. Epub 2013 Nov 19.

20.

Targeting the unfolded protein response in disease.

Hetz C, Chevet E, Harding HP.

Nat Rev Drug Discov. 2013 Sep;12(9):703-19. doi: 10.1038/nrd3976. Review.

PMID:
23989796
21.

Selective inhibition of the unfolded protein response: targeting catalytic sites for Schiff base modification.

Tomasio SM, Harding HP, Ron D, Cross BC, Bond PJ.

Mol Biosyst. 2013 Oct;9(10):2408-16. doi: 10.1039/c3mb70234k. Review.

PMID:
23884086
22.

The unfolded protein response element IRE1α senses bacterial proteins invading the ER to activate RIG-I and innate immune signaling.

Cho JA, Lee AH, Platzer B, Cross BCS, Gardner BM, De Luca H, Luong P, Harding HP, Glimcher LH, Walter P, Fiebiger E, Ron D, Kagan JC, Lencer WI.

Cell Host Microbe. 2013 May 15;13(5):558-569. doi: 10.1016/j.chom.2013.03.011. Retraction in: Cell Host Microbe. 2018 Apr 11;23 (4):571.

23.

Lifetime imaging of a fluorescent protein sensor reveals surprising stability of ER thiol redox.

Avezov E, Cross BC, Kaminski Schierle GS, Winters M, Harding HP, Melo EP, Kaminski CF, Ron D.

J Cell Biol. 2013 Apr 15;201(2):337-49. doi: 10.1083/jcb.201211155.

24.

Oligodendrocyte-specific activation of PERK signaling protects mice against experimental autoimmune encephalomyelitis.

Lin W, Lin Y, Li J, Fenstermaker AG, Way SW, Clayton B, Jamison S, Harding HP, Ron D, Popko B.

J Neurosci. 2013 Apr 3;33(14):5980-91. doi: 10.1523/JNEUROSCI.1636-12.2013.

25.

Role for the obesity-related FTO gene in the cellular sensing of amino acids.

Gulati P, Cheung MK, Antrobus R, Church CD, Harding HP, Tung YC, Rimmington D, Ma M, Ron D, Lehner PJ, Ashcroft FM, Cox RD, Coll AP, O'Rahilly S, Yeo GS.

Proc Natl Acad Sci U S A. 2013 Feb 12;110(7):2557-62. doi: 10.1073/pnas.1222796110. Epub 2013 Jan 28.

26.

Protein-folding homeostasis in the endoplasmic reticulum and nutritional regulation.

Ron D, Harding HP.

Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12). pii: a013177. doi: 10.1101/cshperspect.a013177. Review.

27.

Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

Harding HP, Zyryanova AF, Ron D.

J Biol Chem. 2012 Dec 28;287(53):44338-44. doi: 10.1074/jbc.M112.428987. Epub 2012 Nov 12.

28.

Nine-year risk of depression diagnosis increases with increasing self-reported concussions in retired professional football players.

Kerr ZY, Marshall SW, Harding HP Jr, Guskiewicz KM.

Am J Sports Med. 2012 Oct;40(10):2206-12. Epub 2012 Aug 24.

PMID:
22922518
29.

Establishing a flow process to coumarin-8-carbaldehydes as important synthetic scaffolds.

Zak J, Ron D, Riva E, Harding HP, Cross BC, Baxendale IR.

Chemistry. 2012 Aug 6;18(32):9901-10. doi: 10.1002/chem.201201039. Epub 2012 Jul 10.

PMID:
22782929
30.

Death protein 5 and p53-upregulated modulator of apoptosis mediate the endoplasmic reticulum stress-mitochondrial dialog triggering lipotoxic rodent and human β-cell apoptosis.

Cunha DA, Igoillo-Esteve M, Gurzov EN, Germano CM, Naamane N, Marhfour I, Fukaya M, Vanderwinden JM, Gysemans C, Mathieu C, Marselli L, Marchetti P, Harding HP, Ron D, Eizirik DL, Cnop M.

Diabetes. 2012 Nov;61(11):2763-75. doi: 10.2337/db12-0123. Epub 2012 Jul 6.

31.

Kinetic analysis of FTO (fat mass and obesity-associated) reveals that it is unlikely to function as a sensor for 2-oxoglutarate.

Ma M, Harding HP, O'Rahilly S, Ron D, Yeo GS.

Biochem J. 2012 Jun 1;444(2):183-7. doi: 10.1042/BJ20120065.

PMID:
22435707
32.

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule.

Cross BC, Bond PJ, Sadowski PG, Jha BK, Zak J, Goodman JM, Silverman RH, Neubert TA, Baxendale IR, Ron D, Harding HP.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):E869-78. doi: 10.1073/pnas.1115623109. Epub 2012 Feb 6.

33.

Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides.

Gao N, Shang J, Huynh D, Manthati VL, Arias C, Harding HP, Kaufman RJ, Mohr I, Ron D, Falck JR, Lehrman MA.

Mol Biol Cell. 2011 Sep;22(17):2994-3009. doi: 10.1091/mbc.E11-04-0286. Epub 2011 Jul 7.

34.

A deregulated integrated stress response promotes interferon-γ-induced medulloblastoma.

Lin W, Lin Y, Li J, Harding HP, Ron D, Jamison S.

J Neurosci Res. 2011 Oct;89(10):1586-95. doi: 10.1002/jnr.22693. Epub 2011 Jun 17.

PMID:
21688289
35.

Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis.

Tsaytler P, Harding HP, Ron D, Bertolotti A.

Science. 2011 Apr 1;332(6025):91-4. doi: 10.1126/science.1201396. Epub 2011 Mar 3.

36.

Arginine deficiency causes runting in the suckling period by selectively activating the stress kinase GCN2.

Marion V, Sankaranarayanan S, de Theije C, van Dijk P, Lindsey P, Lamers MC, Harding HP, Ron D, Lamers WH, Köhler SE.

J Biol Chem. 2011 Mar 18;286(11):8866-74. doi: 10.1074/jbc.M110.216119. Epub 2011 Jan 14.

37.

A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity.

Blais JD, Chin KT, Zito E, Zhang Y, Heldman N, Harding HP, Fass D, Thorpe C, Ron D.

J Biol Chem. 2010 Jul 2;285(27):20993-1003. doi: 10.1074/jbc.M110.126599. Epub 2010 May 4.

38.

Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1.

Wiseman RL, Zhang Y, Lee KP, Harding HP, Haynes CM, Price J, Sicheri F, Ron D.

Mol Cell. 2010 Apr 23;38(2):291-304. doi: 10.1016/j.molcel.2010.04.001.

39.

ERO1-beta, a pancreas-specific disulfide oxidase, promotes insulin biogenesis and glucose homeostasis.

Zito E, Chin KT, Blais J, Harding HP, Ron D.

J Cell Biol. 2010 Mar 22;188(6):821-32. doi: 10.1083/jcb.200911086. Erratum in: J Cell Biol. 2010 May 17;189(4):769.

40.

Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development.

Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1832-7. doi: 10.1073/pnas.0809632106. Epub 2009 Jan 30.

41.

Enhanced integrated stress response promotes myelinating oligodendrocyte survival in response to interferon-gamma.

Lin W, Kunkler PE, Harding HP, Ron D, Kraig RP, Popko B.

Am J Pathol. 2008 Nov;173(5):1508-17. doi: 10.2353/ajpath.2008.080449. Epub 2008 Sep 25.

42.

Toward the discovery of new antifungal agents: the design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p.

Lackey JG, Ron D, Damha MJ, Harding HP.

Nucleic Acids Symp Ser (Oxf). 2008;(52):475-6. doi: 10.1093/nass/nrn241.

PMID:
18776460
43.

Novel function of PERK as a mediator of force-induced apoptosis.

Mak BC, Wang Q, Laschinger C, Lee W, Ron D, Harding HP, Kaufman RJ, Scheuner D, Austin RC, McCulloch CA.

J Biol Chem. 2008 Aug 22;283(34):23462-72. doi: 10.1074/jbc.M803194200. Epub 2008 Jun 11.

44.

Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice.

Oyadomari S, Harding HP, Zhang Y, Oyadomari M, Ron D.

Cell Metab. 2008 Jun;7(6):520-32. doi: 10.1016/j.cmet.2008.04.011.

45.

An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation.

Harding HP, Lackey JG, Hsu HC, Zhang Y, Deng J, Xu RM, Damha MJ, Ron D.

RNA. 2008 Feb;14(2):225-32. Epub 2007 Dec 19.

46.

Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation.

Su Q, Wang S, Gao HQ, Kazemi S, Harding HP, Ron D, Koromilas AE.

J Biol Chem. 2008 Jan 4;283(1):469-75. Epub 2007 Nov 12.

47.

Recurrent concussion and risk of depression in retired professional football players.

Guskiewicz KM, Marshall SW, Bailes J, McCrea M, Harding HP Jr, Matthews A, Mihalik JR, Cantu RC.

Med Sci Sports Exerc. 2007 Jun;39(6):903-9.

PMID:
17545878
48.

Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux.

Shang J, Gao N, Kaufman RJ, Ron D, Harding HP, Lehrman MA.

J Cell Biol. 2007 Feb 26;176(5):605-16.

49.

The integrated stress response prevents demyelination by protecting oligodendrocytes against immune-mediated damage.

Lin W, Bailey SL, Ho H, Harding HP, Ron D, Miller SD, Popko B.

J Clin Invest. 2007 Feb;117(2):448-56.

50.

Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress.

Blais JD, Addison CL, Edge R, Falls T, Zhao H, Wary K, Koumenis C, Harding HP, Ron D, Holcik M, Bell JC.

Mol Cell Biol. 2006 Dec;26(24):9517-32. Epub 2006 Oct 9.

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