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Items: 1 to 50 of 493

1.

Haptic-based perception-empathy biofeedback system for balance rehabilitation in patients with chronic stroke: Concepts and initial feasibility study.

Yasuda K, Saichi K, Kaibuki N, Harashima H, Iwata H.

Gait Posture. 2018 May;62:484-489. doi: 10.1016/j.gaitpost.2018.04.013. Epub 2018 Apr 14.

PMID:
29677663
2.

A hepatic pDNA delivery system based on an intracellular environment sensitive vitamin E-scaffold lipid-like material with the aid of an anti-inflammatory drug.

Togashi R, Tanaka H, Nakamura S, Yokota H, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H.

J Control Release. 2018 Apr 17;279:262-270. doi: 10.1016/j.jconrel.2018.04.022. [Epub ahead of print]

PMID:
29673647
3.

Reducing the Cytotoxicity of Lipid Nanoparticles Associated with a Fusogenic Cationic Lipid in a Natural Killer Cell Line by Introducing a Polycation-Based siRNA Core.

Nakamura T, Yamada K, Fujiwara Y, Sato Y, Harashima H.

Mol Pharm. 2018 Apr 30. doi: 10.1021/acs.molpharmaceut.7b01166. [Epub ahead of print]

PMID:
29668291
4.

In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration.

Tanaka H, Nakatani T, Furihata T, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H.

Mol Pharm. 2018 May 7;15(5):2060-2067. doi: 10.1021/acs.molpharmaceut.7b01084. Epub 2018 Apr 11.

PMID:
29638135
5.

Advances in microfluidics for lipid nanoparticles and extracellular vesicles and applications in drug delivery systems.

Maeki M, Kimura N, Sato Y, Harashima H, Tokeshi M.

Adv Drug Deliv Rev. 2018 Mar 19. pii: S0169-409X(18)30047-4. doi: 10.1016/j.addr.2018.03.008. [Epub ahead of print]

PMID:
29567396
6.

Synergism between a cell penetrating peptide and a pH-sensitive cationic lipid in efficient gene delivery based on double-coated nanoparticles.

Khalil IA, Kimura S, Sato Y, Harashima H.

J Control Release. 2018 Apr 10;275:107-116. doi: 10.1016/j.jconrel.2018.02.016. Epub 2018 Feb 13.

PMID:
29452131
7.

Mitochondrial transgene expression via an artificial mitochondrial DNA vector in cells from a patient with a mitochondrial disease.

Ishikawa T, Somiya K, Munechika R, Harashima H, Yamada Y.

J Control Release. 2018 Mar 28;274:109-117. doi: 10.1016/j.jconrel.2018.02.005. Epub 2018 Feb 3.

PMID:
29408532
8.

An efficient PEGylated gene delivery system with improved targeting: Synergism between octaarginine and a fusogenic peptide.

Khalil IA, Harashima H.

Int J Pharm. 2018 Mar 1;538(1-2):179-187. doi: 10.1016/j.ijpharm.2018.01.007. Epub 2018 Jan 16.

PMID:
29341911
9.

Barth Syndrome: Different Approaches to Diagnosis.

Imai-Okazaki A, Kishita Y, Kohda M, Yatsuka Y, Hirata T, Mizuno Y, Harashima H, Hirono K, Ichida F, Noguchi A, Yoshida M, Tokorodani C, Nishiuchi R, Takeda A, Nakaya A, Sakata Y, Murayama K, Ohtake A, Okazaki Y.

J Pediatr. 2018 Feb;193:256-260. doi: 10.1016/j.jpeds.2017.09.075. Epub 2017 Dec 15.

PMID:
29249525
10.

Packaging of the Coenzyme Q10 into a Liposome for Mitochondrial Delivery and the Intracellular Observation in Patient Derived Mitochondrial Disease Cells.

Yamada Y, Burger L, Kawamura E, Harashima H.

Biol Pharm Bull. 2017;40(12):2183-2190. doi: 10.1248/bpb.b17-00609.

11.

Understanding the formation mechanism of lipid nanoparticles in microfluidic devices with chaotic micromixers.

Maeki M, Fujishima Y, Sato Y, Yasui T, Kaji N, Ishida A, Tani H, Baba Y, Harashima H, Tokeshi M.

PLoS One. 2017 Nov 28;12(11):e0187962. doi: 10.1371/journal.pone.0187962. eCollection 2017.

12.

Optical control of mitochondrial reductive reactions in living cells using an electron donor-acceptor linked molecule.

Takano Y, Munechika R, Biju V, Harashima H, Imahori H, Yamada Y.

Nanoscale. 2017 Dec 7;9(47):18690-18698. doi: 10.1039/c7nr06310e.

PMID:
29165486
13.

Cardiac progenitor cells activated by mitochondrial delivery of resveratrol enhance the survival of a doxorubicin-induced cardiomyopathy mouse model via the mitochondrial activation of a damaged myocardium.

Abe J, Yamada Y, Takeda A, Harashima H.

J Control Release. 2018 Jan 10;269:177-188. doi: 10.1016/j.jconrel.2017.11.024. Epub 2017 Nov 14.

PMID:
29146241
14.

Failure of active targeting by a cholesterol-anchored ligand and improvement by altering the lipid composition to prevent ligand desorption.

Yamamoto S, Sakurai Y, Harashima H.

Int J Pharm. 2018 Jan 30;536(1):42-49. doi: 10.1016/j.ijpharm.2017.11.010. Epub 2017 Nov 7.

PMID:
29126905
15.

Integration of nano drug-delivery system with cancer immunotherapy.

Nakamura T, Harashima H.

Ther Deliv. 2017 Nov;8(11):987-1000. doi: 10.4155/tde-2017-0071.

PMID:
29061103
16.

Preparation of envelope-type lipid nanoparticles containing gold nanorods for photothermal cancer therapy.

Paraiso WKD, Tanaka H, Sato Y, Shirane D, Suzuki N, Ogra Y, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H.

Colloids Surf B Biointerfaces. 2017 Dec 1;160:715-723. doi: 10.1016/j.colsurfb.2017.10.027. Epub 2017 Oct 9.

PMID:
29035819
17.

In Vivo Transgene Expression in the Pancreas by the Intraductal Injection of Naked Plasmid DNA.

Yamada Y, Tabata M, Abe J, Nomura M, Harashima H.

J Pharm Sci. 2018 Feb;107(2):647-653. doi: 10.1016/j.xphs.2017.09.021. Epub 2017 Oct 6.

PMID:
28989012
18.

Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus.

Sato Y, Matsui H, Yamamoto N, Sato R, Munakata T, Kohara M, Harashima H.

J Control Release. 2017 Nov 28;266:216-225. doi: 10.1016/j.jconrel.2017.09.044. Epub 2017 Oct 3.

PMID:
28986168
19.

Nano-sized drug carriers: Extravasation, intratumoral distribution, and their modeling.

Nichols JW, Sakurai Y, Harashima H, Bae YH.

J Control Release. 2017 Dec 10;267:31-46. doi: 10.1016/j.jconrel.2017.08.003. Epub 2017 Aug 12.

PMID:
28807683
20.

Efficient siRNA Delivery by Lipid Nanoparticles Modified with a Nonstandard Macrocyclic Peptide for EpCAM-Targeting.

Sakurai Y, Mizumura W, Murata M, Hada T, Yamamoto S, Ito K, Iwasaki K, Katoh T, Goto Y, Takagi A, Kohara M, Suga H, Harashima H.

Mol Pharm. 2017 Oct 2;14(10):3290-3298. doi: 10.1021/acs.molpharmaceut.7b00362. Epub 2017 Aug 25.

PMID:
28789523
21.

pH-labile PEGylation of siRNA-loaded lipid nanoparticle improves active targeting and gene silencing activity in hepatocytes.

Hashiba K, Sato Y, Harashima H.

J Control Release. 2017 Sep 28;262:239-246. doi: 10.1016/j.jconrel.2017.07.046. Epub 2017 Aug 1.

PMID:
28774839
22.

Size-Dependency of the Surface Ligand Density of Liposomes Prepared by Post-insertion.

Lee SH, Sato Y, Hyodo M, Harashima H.

Biol Pharm Bull. 2017;40(7):1002-1009. doi: 10.1248/bpb.b16-00990.

23.

Identification and Evaluation of the Minimum Unit of a KALA Peptide Required for Gene Delivery and Immune Activation.

Miura N, Tange K, Nakai Y, Yoshioka H, Harashima H, Akita H.

J Pharm Sci. 2017 Oct;106(10):3113-3119. doi: 10.1016/j.xphs.2017.05.014. Epub 2017 May 20.

PMID:
28535977
24.

Validation of the use of an artificial mitochondrial reporter DNA vector containing a Cytomegalovirus promoter for mitochondrial transgene expression.

Yamada Y, Ishikawa T, Harashima H.

Biomaterials. 2017 Aug;136:56-66. doi: 10.1016/j.biomaterials.2017.05.016. Epub 2017 May 10.

PMID:
28521201
25.

PEGylation of the GALA Peptide Enhances the Lung-Targeting Activity of Nanocarriers That Contain Encapsulated siRNA.

Santiwarangkool S, Akita H, Nakatani T, Kusumoto K, Kimura H, Suzuki M, Nishimura M, Sato Y, Harashima H.

J Pharm Sci. 2017 Sep;106(9):2420-2427. doi: 10.1016/j.xphs.2017.04.075. Epub 2017 May 5.

PMID:
28483420
26.

Mitochondrial Delivery of Doxorubicin Using MITO-Porter Kills Drug-Resistant Renal Cancer Cells via Mitochondrial Toxicity.

Yamada Y, Munechika R, Kawamura E, Sakurai Y, Sato Y, Harashima H.

J Pharm Sci. 2017 Sep;106(9):2428-2437. doi: 10.1016/j.xphs.2017.04.058. Epub 2017 May 3.

PMID:
28478130
27.

RETINOBLASTOMA RELATED1 mediates germline entry in Arabidopsis.

Zhao X, Bramsiepe J, Van Durme M, Komaki S, Prusicki MA, Maruyama D, Forner J, Medzihradszky A, Wijnker E, Harashima H, Lu Y, Schmidt A, Guthörl D, Logroño RS, Guan Y, Pochon G, Grossniklaus U, Laux T, Higashiyama T, Lohmann JU, Nowack MK, Schnittger A.

Science. 2017 Apr 28;356(6336). pii: eaaf6532. doi: 10.1126/science.aaf6532.

PMID:
28450583
28.

The effect of a haptic biofeedback system on postural control in patients with stroke: An experimental pilot study.

Yasuda K, Kaibuki N, Harashima H, Iwata H.

Somatosens Mot Res. 2017 Jun;34(2):65-71. doi: 10.1080/08990220.2017.1292236. Epub 2017 Apr 3.

PMID:
28372470
29.

The retinoblastoma homolog RBR1 mediates localization of the repair protein RAD51 to DNA lesions in Arabidopsis.

Biedermann S, Harashima H, Chen P, Heese M, Bouyer D, Sofroni K, Schnittger A.

EMBO J. 2017 May 2;36(9):1279-1297. doi: 10.15252/embj.201694571. Epub 2017 Mar 20.

30.

Modifying Antigen-Encapsulating Liposomes with KALA Facilitates MHC Class I Antigen Presentation and Enhances Anti-tumor Effects.

Miura N, Akita H, Tateshita N, Nakamura T, Harashima H.

Mol Ther. 2017 Apr 5;25(4):1003-1013. doi: 10.1016/j.ymthe.2017.01.020. Epub 2017 Feb 22.

31.

Modality of tumor endothelial VEGFR2 silencing-mediated improvement in intratumoral distribution of lipid nanoparticles.

Yamamoto S, Kato A, Sakurai Y, Hada T, Harashima H.

J Control Release. 2017 Apr 10;251:1-10. doi: 10.1016/j.jconrel.2017.02.010. Epub 2017 Feb 10.

PMID:
28192155
32.

Scalable preparation of poly(ethylene glycol)-grafted siRNA-loaded lipid nanoparticles using a commercially available fluidic device and tangential flow filtration.

Sakurai Y, Hada T, Harashima H.

J Biomater Sci Polym Ed. 2017 Jul - Aug;28(10-12):1086-1096. doi: 10.1080/09205063.2017.1291297. Epub 2017 Feb 10.

PMID:
28157422
33.

Modifying Cationic Liposomes with Cholesteryl-PEG Prevents Their Aggregation in Human Urine and Enhances Cellular Uptake by Bladder Cancer Cells.

Nakamura T, Noma Y, Sakurai Y, Harashima H.

Biol Pharm Bull. 2017;40(2):234-237. doi: 10.1248/bpb.b16-00770.

34.

Drug Delivery Research for the Future: Expanding the Nano Horizons and Beyond.

Mitragotri S, Lammers T, Bae YH, Schwendeman S, De Smedt S, Leroux JC, Peer D, Kwon IC, Harashima H, Kikuchi A, Oh YK, Torchilin V, Hennink W, Hanes J, Park K.

J Control Release. 2017 Jan 28;246:183-184. doi: 10.1016/j.jconrel.2017.01.011. No abstract available.

PMID:
28110715
35.

WIND1 Promotes Shoot Regeneration through Transcriptional Activation of ENHANCER OF SHOOT REGENERATION1 in Arabidopsis.

Iwase A, Harashima H, Ikeuchi M, Rymen B, Ohnuma M, Komaki S, Morohashi K, Kurata T, Nakata M, Ohme-Takagi M, Grotewold E, Sugimoto K.

Plant Cell. 2017 Jan;29(1):54-69. doi: 10.1105/tpc.16.00623. Epub 2016 Dec 23.

36.

Temperature and pH sensitivity of a stabilized self-nanoemulsion formed using an ionizable lipid-like material via an oil-to-surfactant transition.

Tanaka H, Oasa S, Kinjo M, Tange K, Nakai Y, Harashima H, Akita H.

Colloids Surf B Biointerfaces. 2017 Mar 1;151:95-101. doi: 10.1016/j.colsurfb.2016.11.020. Epub 2016 Nov 18.

PMID:
27987460
37.
38.

Small-sized, stable lipid nanoparticle for the efficient delivery of siRNA to human immune cell lines.

Nakamura T, Kuroi M, Fujiwara Y, Warashina S, Sato Y, Harashima H.

Sci Rep. 2016 Nov 28;6:37849. doi: 10.1038/srep37849.

39.

MITO-Porter for Mitochondrial Delivery and Mitochondrial Functional Analysis.

Yamada Y, Harashima H.

Handb Exp Pharmacol. 2017;240:457-472. doi: 10.1007/164_2016_4. Review.

PMID:
27830347
40.

Innovative Technologies in Nanomedicines: From Passive Targeting to Active Targeting/From Controlled Pharmacokinetics to Controlled Intracellular Pharmacokinetics.

Sato Y, Sakurai Y, Kajimoto K, Nakamura T, Yamada Y, Akita H, Harashima H.

Macromol Biosci. 2017 Jan;17(1). doi: 10.1002/mabi.201600179. Epub 2016 Oct 31.

PMID:
27797146
41.

Enhanced transgene expression by plasmid-specific recruitment of histone acetyltransferase.

Nishihara M, Kanda GN, Suzuki T, Yamakado S, Harashima H, Kamiya H.

J Biosci Bioeng. 2017 Mar;123(3):277-280. doi: 10.1016/j.jbiosc.2016.09.008. Epub 2016 Oct 13.

PMID:
27746157
42.

Liver-Specific Silencing of Lipin1 Reduces Fat Mass as Well as Hepatic Triglyceride Biosynthesis in Mice.

Kajimoto K, Suemitsu E, Sato Y, Sakurai Y, Harashima H.

Biol Pharm Bull. 2016;39(10):1653-1661.

43.

Modulation of plant growth in vivo and identification of kinase substrates using an analog-sensitive variant of CYCLIN-DEPENDENT KINASE A;1.

Harashima H, Dissmeyer N, Hammann P, Nomura Y, Kramer K, Nakagami H, Schnittger A.

BMC Plant Biol. 2016 Sep 26;16(1):209.

44.

Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation.

de Lucas M, Pu L, Turco G, Gaudinier A, Morao AK, Harashima H, Kim D, Ron M, Sugimoto K, Roudier F, Brady SM.

Plant Cell. 2016 Oct;28(10):2616-2631. Epub 2016 Sep 20.

45.

Remodeling of the Extracellular Matrix by Endothelial Cell-Targeting siRNA Improves the EPR-Based Delivery of 100 nm Particles.

Sakurai Y, Hada T, Yamamoto S, Kato A, Mizumura W, Harashima H.

Mol Ther. 2016 Dec;24(12):2090-2099. doi: 10.1038/mt.2016.178. Epub 2016 Sep 16.

46.

Identification of a Nucleoporin358-Specific RNA Aptamer for Use as a Nucleus-Targeting Liposomal Delivery System.

Shrivastava G, Hyodo M, Yoshimura SH, Akita H, Harashima H.

Nucleic Acid Ther. 2016 Oct;26(5):286-298. Epub 2016 Aug 22.

PMID:
27548508
47.

The plant-specific CDKB1-CYCB1 complex mediates homologous recombination repair in Arabidopsis.

Weimer AK, Biedermann S, Harashima H, Roodbarkelari F, Takahashi N, Foreman J, Guan Y, Pochon G, Heese M, Van Damme D, Sugimoto K, Koncz C, Doerner P, Umeda M, Schnittger A.

EMBO J. 2016 Oct 4;35(19):2068-2086. Epub 2016 Aug 5.

48.

Development of a multifunctional envelope-type nano device and its application to nanomedicine.

Sato Y, Nakamura T, Yamada Y, Harashima H.

J Control Release. 2016 Dec 28;244(Pt B):194-204. doi: 10.1016/j.jconrel.2016.06.042. Epub 2016 Jun 29. Review.

PMID:
27374187
49.

Elimination of the biphasic pharmacodynamics of 15d-PGJ2 by controlling its release from a nanoemulsion.

Abbasi S, Kajimoto K, Harashima H.

Int J Nanomedicine. 2016 Jun 8;11:2685-94. doi: 10.2147/IJN.S106297. eCollection 2016.

50.

Insertion and Deletion Mismatches Distant from the Target Position Improve Gene Correction with a Tailed Duplex.

Kamiya H, Nishigaki N, Ikeda A, Yukawa S, Morita Y, Nakatsu Y, Tsuzuki T, Harashima H.

Nucleosides Nucleotides Nucleic Acids. 2016 Jul 2;35(7):379-88. doi: 10.1080/15257770.2016.1163384. Epub 2016 Jun 2.

PMID:
27253876

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