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Why prescribe exercise as therapy in type 2 diabetes? We have a pill for that!

Ried-Larsen M, MacDonald CS, Johansen MY, Hansen KB, Christensen R, Almdal TP, Pedersen BK, Karstoft K.

Diabetes Metab Res Rev. 2018 Feb 28. doi: 10.1002/dmrr.2999. [Epub ahead of print] Review.


Properties of triheteromeric NMDA receptors containing two distinct GluN1 isoforms.

Yi F, Zachariassen LG, Dorsett KN, Hansen KB.

Mol Pharmacol. 2018 Feb 26. pii: mol.117.111427. doi: 10.1124/mol.117.111427. [Epub ahead of print]


Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes.

Mandøe MJ, Hansen KB, Windeløv JA, Knop FK, Rehfeld JF, Rosenkilde MM, Holst JJ, Hansen HS.

Nutr Diabetes. 2018 Jan 12;8(1):2. doi: 10.1038/s41387-017-0011-z.


Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist.

Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L.

J Med Chem. 2017 Dec 14;60(23):9885-9904. doi: 10.1021/acs.jmedchem.7b01624. Epub 2017 Dec 5.


Selective Cell-Surface Expression of Triheteromeric NMDA Receptors.

Yi F, Traynelis SF, Hansen KB.

Methods Mol Biol. 2017;1677:145-162. doi: 10.1007/978-1-4939-7321-7_7.


NMDA Receptors in the Central Nervous System.

Hansen KB, Yi F, Perszyk RE, Menniti FS, Traynelis SF.

Methods Mol Biol. 2017;1677:1-80. doi: 10.1007/978-1-4939-7321-7_1.


Effect of an Intensive Lifestyle Intervention on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial.

Johansen MY, MacDonald CS, Hansen KB, Karstoft K, Christensen R, Pedersen M, Hansen LS, Zacho M, Wedell-Neergaard AS, Nielsen ST, Iepsen UW, Langberg H, Vaag AA, Pedersen BK, Ried-Larsen M.

JAMA. 2017 Aug 15;318(7):637-646. doi: 10.1001/jama.2017.10169.


Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.

Lind GE, Mou TC, Tamborini L, Pomper MG, De Micheli C, Conti P, Pinto A, Hansen KB.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6942-E6951. doi: 10.1073/pnas.1707752114. Epub 2017 Jul 31.


Identification of AICP as a GluN2C-Selective N-Methyl-d-Aspartate Receptor Superagonist at the GluN1 Glycine Site.

Jessen M, Frederiksen K, Yi F, Clausen RP, Hansen KB, Bräuner-Osborne H, Kilburn P, Damholt A.

Mol Pharmacol. 2017 Aug;92(2):151-161. doi: 10.1124/mol.117.108944. Epub 2017 Jun 6.


Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites.

Maolanon AR, Risgaard R, Wang SY, Snoep Y, Papangelis A, Yi F, Holley D, Barslund AF, Svenstrup N, Hansen KB, Clausen RP.

ACS Chem Neurosci. 2017 Aug 16;8(8):1681-1687. doi: 10.1021/acschemneuro.7b00117. Epub 2017 May 30.


Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties.

Sun W, Hansen KB, Jahr CE.

Neuron. 2017 Apr 5;94(1):58-64.e3. doi: 10.1016/j.neuron.2017.03.018.


Treatment profiles in a Danish psychiatric university hospital department.

Okkels N, Mogensen RB, Crean LC, Vestergaard CH, Skadhede S, Rasmussen C, Shanmuganathan JWD, Hansen KB, Munk-Jørgensen P.

Nord J Psychiatry. 2017 May;71(4):289-295. doi: 10.1080/08039488.2017.1279212. Epub 2017 Jan 23.


Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain.

Tamborini L, Chen Y, Foss CA, Pinto A, Horti AG, Traynelis SF, De Micheli C, Mease RC, Hansen KB, Conti P, Pomper MG.

J Med Chem. 2016 Dec 22;59(24):11110-11119. Epub 2016 Dec 6.


Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors.

Yi F, Mou TC, Dorsett KN, Volkmann RA, Menniti FS, Sprang SR, Hansen KB.

Neuron. 2016 Sep 21;91(6):1316-1329. doi: 10.1016/j.neuron.2016.08.014. Epub 2016 Sep 8.


Pharmacology of triheteromeric N-Methyl-D-Aspartate Receptors.

Cheriyan J, Balsara RD, Hansen KB, Castellino FJ.

Neurosci Lett. 2016 Mar 23;617:240-6. doi: 10.1016/j.neulet.2016.02.032. Epub 2016 Feb 23.


Extracellular HCO3- is sensed by mouse cerebral arteries: Regulation of tone by receptor protein tyrosine phosphatase γ.

Boedtkjer E, Hansen KB, Boedtkjer DM, Aalkjaer C, Boron WF.

J Cereb Blood Flow Metab. 2016 May;36(5):965-80. doi: 10.1177/0271678X15610787. Epub 2015 Oct 19.


Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.

Kristensen AS, Hansen KB, Naur P, Olsen L, Kurtkaya NL, Dravid SM, Kvist T, Yi F, Pøhlsgaard J, Clausen RP, Gajhede M, Kastrup JS, Traynelis SF.

Mol Pharmacol. 2016 Feb;89(2):253-62. doi: 10.1124/mol.115.100909. Epub 2015 Dec 10.


Head-to-head comparison of intensive lifestyle intervention (U-TURN) versus conventional multifactorial care in patients with type 2 diabetes: protocol and rationale for an assessor-blinded, parallel group and randomised trial.

Ried-Larsen M, Christensen R, Hansen KB, Johansen MY, Pedersen M, Zacho M, Hansen LS, Kofoed K, Thomsen K, Jensen MS, Nielsen RO, MacDonald C, Langberg H, Vaag AA, Pedersen BK, Karstoft K.

BMJ Open. 2015 Dec 9;5(12):e009764. doi: 10.1136/bmjopen-2015-009764.


Flocked nasal swab versus nasopharyngeal aspirate in adult emergency room patients: similar multiplex PCR respiratory pathogen results and patient discomfort.

Hansen KB, Westin J, Andersson LM, Lindh M, Widell A, Nilsson AC.

Infect Dis (Lond). 2016;48(3):246-50. doi: 10.3109/23744235.2015.1096956. Epub 2015 Oct 15.


A reduced-dimensional model for near-wall transport in cardiovascular flows.

Hansen KB, Shadden SC.

Biomech Model Mechanobiol. 2016 Jun;15(3):713-22. doi: 10.1007/s10237-015-0719-4. Epub 2015 Aug 23.


The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans.

Mandøe MJ, Hansen KB, Hartmann B, Rehfeld JF, Holst JJ, Hansen HS.

Am J Clin Nutr. 2015 Sep;102(3):548-55. doi: 10.3945/ajcn.115.106799. Epub 2015 Jul 15.


Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators".

Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC.

J Med Chem. 2015 Mar 26;58(6):2862. doi: 10.1021/acs.jmedchem.5b00199. Epub 2015 Mar 4. No abstract available.


Mechanical platelet activation potential in abdominal aortic aneurysms.

Hansen KB, Arzani A, Shadden SC.

J Biomech Eng. 2015 Apr;137(4):041005. doi: 10.1115/1.4029580. Epub 2015 Feb 5.


[Twisted arteriae et venae iliaca externa after total hip arthroplasty].

Hansen KB, Klitfod L.

Ugeskr Laeger. 2014 Dec 15;176(25A). pii: V08120478. Danish.


[Peritoneal tuberculosis in a 20-year-old Danish woman without known exposure to tuberculosis].

Hansen KB, Wejse C.

Ugeskr Laeger. 2014 Nov 24;176(48). pii: V06140316. Danish.


[Sparse evidence of antipsychotic drugs for the treatment of delirium].

Andersen CU, Høimark L, Dabrowski K, Hansen KB, Sædder E.

Ugeskr Laeger. 2014 Apr 14;176(16). pii: V11130658. Review. Danish.


[Sparse evidence of antipsychotic drugs for the treatment of delirium].

Andersen CU, Høimark L, Dabrowski K, Hansen KB, Sædder E.

Ugeskr Laeger. 2014 Sep 29;176(40). pii: V11130658. Review. Danish.


Glutamate receptors: mechanistic twists and turns.

Hansen KB, Traynelis SF.

Nat Chem Biol. 2014 Sep;10(9):698-9. doi: 10.1038/nchembio.1614. No abstract available.


Chronic Ulceration and Sinus Formation due to Foreign Body: An Often-Forgotten Problem.

Hansen KB, Gottrup F.

Int J Low Extrem Wounds. 2015 Dec;14(4):393-5. doi: 10.1177/1534734614550687. Epub 2014 Sep 25.


Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator.

Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF.

Mol Pharmacol. 2014 Nov;86(5):548-60. doi: 10.1124/mol.114.094516. Epub 2014 Sep 9.


Binding of ArgTX-636 in the NMDA receptor ion channel.

Poulsen MH, Andersen J, Christensen R, Hansen KB, Traynelis SF, Strømgaard K, Kristensen AS.

J Mol Biol. 2015 Jan 16;427(1):176-89. doi: 10.1016/j.jmb.2014.05.017. Epub 2014 May 24.


Children treated for severe acute malnutrition experience a rapid increase in physical activity a few days after admission.

Faurholt-Jepsen D, Hansen KB, van Hees VT, Christensen LB, Girma T, Friis H, Brage S.

J Pediatr. 2014 Jun;164(6):1421-4. doi: 10.1016/j.jpeds.2014.02.014. Epub 2014 Mar 20.


Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors.

Hansen KB, Ogden KK, Yuan H, Traynelis SF.

Neuron. 2014 Mar 5;81(5):1084-1096. doi: 10.1016/j.neuron.2014.01.035.


Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators.

Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC.

J Med Chem. 2014 Mar 27;57(6):2334-56. doi: 10.1021/jm401695d. Epub 2014 Feb 25. Erratum in: J Med Chem. 2015 Mar 26;58(6):2862.


Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy.

Yuan H, Hansen KB, Zhang J, Pierson TM, Markello TC, Fajardo KV, Holloman CM, Golas G, Adams DR, Boerkoel CF, Gahl WA, Traynelis SF.

Nat Commun. 2014;5:3251. doi: 10.1038/ncomms4251.


Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site.

Kvist T, Steffensen TB, Greenwood JR, Mehrzad Tabrizi F, Hansen KB, Gajhede M, Pickering DS, Traynelis SF, Kastrup JS, Bräuner-Osborne H.

J Biol Chem. 2013 Nov 15;288(46):33124-35. doi: 10.1074/jbc.M113.480210. Epub 2013 Sep 26.


Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors.

Kvist T, Greenwood JR, Hansen KB, Traynelis SF, Bräuner-Osborne H.

Neuropharmacology. 2013 Dec;75:324-36. doi: 10.1016/j.neuropharm.2013.08.003. Epub 2013 Aug 22.


Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors.

Hansen KB, Tajima N, Risgaard R, Perszyk RE, Jørgensen L, Vance KM, Ogden KK, Clausen RP, Furukawa H, Traynelis SF.

Mol Pharmacol. 2013 Jul;84(1):114-27. doi: 10.1124/mol.113.085803. Epub 2013 Apr 26.


Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists.

Risgaard R, Nielsen SD, Hansen KB, Jensen CM, Nielsen B, Traynelis SF, Clausen RP.

J Med Chem. 2013 May 23;56(10):4071-81. doi: 10.1021/jm400346a. Epub 2013 May 9.


Modal gating of GluN1/GluN2D NMDA receptors.

Vance KM, Hansen KB, Traynelis SF.

Neuropharmacology. 2013 Aug;71:184-90. doi: 10.1016/j.neuropharm.2013.03.018. Epub 2013 Apr 8.


GluN1 splice variant control of GluN1/GluN2D NMDA receptors.

Vance KM, Hansen KB, Traynelis SF.

J Physiol. 2012 Aug 15;590(16):3857-75. doi: 10.1113/jphysiol.2012.234062. Epub 2012 May 28.


Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

Hansen KB, Ogden KK, Traynelis SF.

J Neurosci. 2012 May 2;32(18):6197-208. doi: 10.1523/JNEUROSCI.5757-11.2012.


Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects.

Hansen KB, Vilsbøll T, Bagger JI, Holst JJ, Knop FK.

J Clin Endocrinol Metab. 2012 Apr;97(4):1363-70. doi: 10.1210/jc.2011-2594. Epub 2012 Feb 8.


Electroretinography in healthy subjects in relation to systemic glucocorticoid intake.

Kappelgaard P, Hansen KB, Vilsbøll T, Knop FK, Larsen M.

Doc Ophthalmol. 2012 Feb;124(1):49-57. doi: 10.1007/s10633-011-9303-0. Epub 2011 Dec 24.


Molecular pharmacology of human NMDA receptors.

Hedegaard M, Hansen KB, Andersen KT, Bräuner-Osborne H, Traynelis SF.

Neurochem Int. 2012 Sep;61(4):601-9. doi: 10.1016/j.neuint.2011.11.016. Epub 2011 Dec 17.


Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators.

Acker TM, Yuan H, Hansen KB, Vance KM, Ogden KK, Jensen HS, Burger PB, Mullasseril P, Snyder JP, Liotta DC, Traynelis SF.

Mol Pharmacol. 2011 Nov;80(5):782-95. doi: 10.1124/mol.111.073239. Epub 2011 Aug 1.


How glutamate receptor subunits mix and match: details uncovered.

Hansen KB, Traynelis SF.

Neuron. 2011 Jul 28;71(2):198-200. doi: 10.1016/j.neuron.2011.07.008.


2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans.

Hansen KB, Rosenkilde MM, Knop FK, Wellner N, Diep TA, Rehfeld JF, Andersen UB, Holst JJ, Hansen HS.

J Clin Endocrinol Metab. 2011 Sep;96(9):E1409-17. doi: 10.1210/jc.2011-0647. Epub 2011 Jul 21.


Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors.

Hansen KB, Traynelis SF.

J Neurosci. 2011 Mar 9;31(10):3650-61. doi: 10.1523/JNEUROSCI.5565-10.2011.


Gastric emptying of orally administered glucose solutions and incretin hormone responses are unaffected by laparoscopic adjustable gastric banding.

Usinger L, Hansen KB, Kristiansen VB, Larsen S, Holst JJ, Knop FK.

Obes Surg. 2011 May;21(5):625-32. doi: 10.1007/s11695-011-0362-9.


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