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Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates.

Li F, Xu R, Low BE, Lin CL, Garcia-Barros M, Schrandt J, Mileva I, Snider A, Luo CK, Jiang XC, Li MS, Hannun YA, Obeid LM, Wiles MV, Mao C.

FASEB J. 2018 Jan 22:fj201700445RR. doi: 10.1096/fj.201700445RR. [Epub ahead of print]


Correction: Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.

Wang K, Xu R, Schrandt J, Shah P, Gong YZ, Preston C, Wang L, Yi JK, Lin CL, Sun W, Spyropoulos DD, Rhee S, Li M, Zhou J, Ge S, Zhang G, Snider AJ, Hannun YA, Obeid LM, Mao C.

PLoS Genet. 2018 Jan 23;14(1):e1007190. doi: 10.1371/journal.pgen.1007190. eCollection 2018 Jan.


An intrinsic lipid-binding interface controls sphingosine kinase 1 function.

Pulkoski-Gross MJ, Jenkins ML, Truman JP, Salama MF, Clarke CJ, Burke JE, Hannun YA, Obeid LM.

J Lipid Res. 2018 Jan 11. pii: jlr.M081307. doi: 10.1194/jlr.M081307. [Epub ahead of print]


A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway.

Carroll BL, Bonica J, Shamseddine AA, Hannun YA, Obeid LM.

FEBS Open Bio. 2017 Dec 8;8(1):27-40. doi: 10.1002/2211-5463.12344. eCollection 2018 Jan.


Loss of acid ceramidase in myeloid cells suppresses intestinal neutrophil recruitment.

Espaillat MP, Snider AJ, Qiu Z, Channer B, Coant N, Schuchman EH, Kew RR, Sheridan BS, Hannun YA, Obeid LM.

FASEB J. 2018 Jan 8:fj201700585R. doi: 10.1096/fj.201700585R. [Epub ahead of print]


Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2.

Xu R, Garcia-Barros M, Wen S, Li F, Lin CL, Hannun YA, Obeid LM, Mao C.

Cell Death Differ. 2017 Dec 11. doi: 10.1038/s41418-017-0018-y. [Epub ahead of print]


Sphingosine 1-phosphate activation of ERM contributes to vascular calcification.

Morris TG, Borland SJ, Clarke CJ, Wilson C, Hannun YA, Ohanian V, Canfield AE, Ohanian J.

J Lipid Res. 2018 Jan;59(1):69-78. doi: 10.1194/jlr.M079731. Epub 2017 Nov 22.


Sphingolipids and their metabolism in physiology and disease.

Hannun YA, Obeid LM.

Nat Rev Mol Cell Biol. 2018 Mar;19(3):175-191. doi: 10.1038/nrm.2017.107. Epub 2017 Nov 22. Review.


Decreased ceramide underlies mitochondrial dysfunction in Charcot-Marie-Tooth 2F.

Schwartz NU, Linzer RW, Truman JP, Gurevich M, Hannun YA, Senkal CE, Obeid LM.

FASEB J. 2018 Jan 3:fj201701067R. doi: 10.1096/fj.201701067R. [Epub ahead of print]


Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae.

Ren J, Snider J, Airola MV, Zhong A, Rana NA, Obeid LM, Hannun YA.

J Lipid Res. 2018 Jan;59(1):162-170. doi: 10.1194/jlr.D078535. Epub 2017 Nov 1.


Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells.

Lin CL, Xu R, Yi JK, Li F, Chen J, Jones EC, Slutsky JB, Huang L, Rigas B, Cao J, Zhong X, Snider AJ, Obeid LM, Hannun YA, Mao C.

Stem Cell Reports. 2017 Nov 14;9(5):1488-1500. doi: 10.1016/j.stemcr.2017.09.015. Epub 2017 Oct 19.


Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis.

Furuya H, Tamashiro PM, Shimizu Y, Iino K, Peres R, Chen R, Sun Y, Hannun YA, Obeid LM, Kawamori T.

Carcinogenesis. 2017 Dec 7;38(12):1218-1227. doi: 10.1093/carcin/bgx104.


The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1.

Vilaça R, Barros I, Matmati N, Silva E, Martins T, Teixeira V, Hannun YA, Costa V.

Biochim Biophys Acta. 2018 Jan;1864(1):79-88. doi: 10.1016/j.bbadis.2017.10.010. Epub 2017 Oct 6.


Contributions of the Intrinsic Mutation Process to Cancer Mutation and Risk Burdens.

Zhu W, Wu S, Hannun YA.

EBioMedicine. 2017 Oct;24:5-6. doi: 10.1016/j.ebiom.2017.09.026. Epub 2017 Sep 21. No abstract available.


Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation.

Liu M, Clarke CJ, Salama MF, Choi YJ, Obeid LM, Hannun YA.

PLoS One. 2017 Sep 19;12(9):e0184818. doi: 10.1371/journal.pone.0184818. eCollection 2017.


Wu et al. reply.

Wu S, Zhu W, Hannun YA.

Nature. 2017 Aug 9;548(7666):E15. doi: 10.1038/nature23303. No abstract available.


P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment.

Wada M, Canals D, Adada M, Coant N, Salama MF, Helke KL, Arthur JS, Shroyer KR, Kitatani K, Obeid LM, Hannun YA.

Oncogene. 2017 Nov 23;36(47):6649-6657. doi: 10.1038/onc.2017.274. Epub 2017 Aug 7.


Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation.

Airola MV, Shanbhogue P, Shamseddine AA, Guja KE, Senkal CE, Maini R, Bartke N, Wu BX, Obeid LM, Garcia-Diaz M, Hannun YA.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5549-E5558. doi: 10.1073/pnas.1705134114. Epub 2017 Jun 26.


Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase.

Bai A, Mao C, Jenkins RW, Szulc ZM, Bielawska A, Hannun YA.

PLoS One. 2017 Jun 14;12(6):e0177805. doi: 10.1371/journal.pone.0177805. eCollection 2017.


Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ.

J Lipid Res. 2017 Jul;58(7):1439-1452. doi: 10.1194/jlr.M076745. Epub 2017 May 10.


Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.

Pulkoski-Gross MJ, Uys JD, Orr-Gandy KA, Coant N, Bialkowska AB, Szulc ZM, Bai A, Bielawska A, Townsend DM, Hannun YA, Obeid LM, Snider AJ.

Prostaglandins Other Lipid Mediat. 2017 May;130:47-56. doi: 10.1016/j.prostaglandins.2017.03.006. Epub 2017 Apr 2.


Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets.

Senkal CE, Salama MF, Snider AJ, Allopenna JJ, Rana NA, Koller A, Hannun YA, Obeid LM.

Cell Metab. 2017 Mar 7;25(3):686-697. doi: 10.1016/j.cmet.2017.02.010.


Ceramidases, roles in sphingolipid metabolism and in health and disease.

Coant N, Sakamoto W, Mao C, Hannun YA.

Adv Biol Regul. 2017 Jan;63:122-131. doi: 10.1016/j.jbior.2016.10.002. Epub 2016 Oct 11. Review.


Signal-Oriented Pathway Analyses Reveal a Signaling Complex as a Synthetic Lethal Target for p53 Mutations.

Lu S, Cai C, Yan G, Zhou Z, Wan Y, Chen V, Chen L, Cooper GF, Obeid LM, Hannun YA, Lee AV, Lu X.

Cancer Res. 2016 Dec 1;76(23):6785-6794. Epub 2016 Oct 10.


Role of neutral ceramidase in colon cancer.

García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA.

FASEB J. 2016 Dec;30(12):4159-4171. Epub 2016 Sep 8.


Murine Model for Colitis-Associated Cancer of the Colon.

Snider AJ, Bialkowska AB, Ghaleb AM, Yang VW, Obeid LM, Hannun YA.

Methods Mol Biol. 2016;1438:245-54. doi: 10.1007/978-1-4939-3661-8_14. Review.


ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation.

Clarke CJ, Shamseddine AA, Jacob JJ, Khalife G, Burns TA, Hannun YA.

J Lipid Res. 2016 May;57(5):868-81. doi: 10.1194/jlr.M067447. Epub 2016 Mar 24.


Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function.

Yi JK, Xu R, Jeong E, Mileva I, Truman JP, Lin CL, Wang K, Snider J, Wen S, Obeid LM, Hannun YA, Mao C.

Oncotarget. 2016 Apr 19;7(16):21124-44. doi: 10.18632/oncotarget.8195.


Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.

Xu R, Wang K, Mileva I, Hannun YA, Obeid LM, Mao C.

Oncotarget. 2016 Apr 5;7(14):18440-57. doi: 10.18632/oncotarget.7825.


Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.

Wang K, Xu R, Snider AJ, Schrandt J, Li Y, Bialkowska AB, Li M, Zhou J, Hannun YA, Obeid LM, Yang VW, Mao C.

Cell Death Dis. 2016 Mar 3;7:e2124. doi: 10.1038/cddis.2016.36.


CHK1 regulates NF-κB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles.

Carroll BL, Pulkoski-Gross MJ, Hannun YA, Obeid LM.

Oncotarget. 2016 Apr 5;7(14):18159-70. doi: 10.18632/oncotarget.7566.


New role for ceramide in the pheromone response.

Matmati N, Kitagaki H, Hannun YA.

Cell Cycle. 2016;15(5):617-8. doi: 10.1080/15384101.2016.1143271. No abstract available.


Analysis of the Involvement of Different Ceramide Variants in the Response to Hydroxyurea Stress in Baker's Yeast.

Chen PW, Fonseca LL, Hannun YA, Voit EO.

PLoS One. 2016 Jan 19;11(1):e0146839. doi: 10.1371/journal.pone.0146839. eCollection 2016.


Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.

Sundaram K, Mather AR, Marimuthu S, Shah PP, Snider AJ, Obeid LM, Hannun YA, Beverly LJ, Siskind LJ.

Biochem J. 2016 Mar 15;473(6):743-55. doi: 10.1042/BJ20150586. Epub 2016 Jan 8.


Substantial contribution of extrinsic risk factors to cancer development.

Wu S, Powers S, Zhu W, Hannun YA.

Nature. 2016 Jan 7;529(7584):43-7. doi: 10.1038/nature16166. Epub 2015 Dec 16.


P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.

Shamseddine AA, Clarke CJ, Carroll B, Airola MV, Mohammed S, Rella A, Obeid LM, Hannun YA.

Cell Death Dis. 2015 Oct 29;6:e1947. doi: 10.1038/cddis.2015.268.


Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.

Wang K, Xu R, Schrandt J, Shah P, Gong YZ, Preston C, Wang L, Yi JK, Lin CL, Sun W, Spyropoulos DD, Rhee S, Li M, Zhou J, Ge S, Zhang G, Snider AJ, Hannun YA, Obeid LM, Mao C.

PLoS Genet. 2015 Oct 16;11(10):e1005591. doi: 10.1371/journal.pgen.1005591. eCollection 2015 Oct. Erratum in: PLoS Genet. 2018 Jan 23;14 (1):e1007190.


Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration.

Zhao L, Spassieva S, Gable K, Gupta SD, Shi LY, Wang J, Bielawski J, Hicks WL, Krebs MP, Naggert J, Hannun YA, Dunn TM, Nishina PM.

Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):12962-7. doi: 10.1073/pnas.1516733112. Epub 2015 Oct 5.


Ceramide limits phosphatidylinositol-3-kinase C2β-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid.

Kitatani K, Usui T, Sriraman SK, Toyoshima M, Ishibashi M, Shigeta S, Nagase S, Sakamoto M, Ogiso H, Okazaki T, Hannun YA, Torchilin VP, Yaegashi N.

Oncogene. 2016 May;35(21):2801-12. doi: 10.1038/onc.2015.330. Epub 2015 Sep 14.


Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.

Hernández-Corbacho MJ, Canals D, Adada MM, Liu M, Senkal CE, Yi JK, Mao C, Luberto C, Hannun YA, Obeid LM.

J Biol Chem. 2015 Oct 16;290(42):25356-73. doi: 10.1074/jbc.M115.658658. Epub 2015 Aug 28.


Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease.

Kitatani K, Wada M, Perry D, Usui T, Sun Y, Obeid LM, Yaegashi N, Grabowski GA, Hannun YA.

PLoS One. 2015 Aug 27;10(8):e0136633. doi: 10.1371/journal.pone.0136633. eCollection 2015.


Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols.

Casasampere M, Camacho L, Cingolani F, Casas J, Egido-Gabás M, Abad JL, Bedia C, Xu R, Wang K, Canals D, Hannun YA, Mao C, Fabrias G.

J Lipid Res. 2015 Oct;56(10):2019-28. doi: 10.1194/jlr.D061564. Epub 2015 Aug 18. Erratum in: J Lipid Res. 2016 Aug;57(8):1598.


Dynamics of the Heat Stress Response of Ceramides with Different Fatty-Acyl Chain Lengths in Baker's Yeast.

Chen PW, Fonseca LL, Hannun YA, Voit EO.

PLoS Comput Biol. 2015 Aug 4;11(8):e1004373. doi: 10.1371/journal.pcbi.1004373. eCollection 2015 Aug.


Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.

Adada MM, Canals D, Jeong N, Kelkar AD, Hernandez-Corbacho M, Pulkoski-Gross MJ, Donaldson JC, Hannun YA, Obeid LM.

FASEB J. 2015 Nov;29(11):4654-69. doi: 10.1096/fj.15-274340. Epub 2015 Jul 24.


Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.

Airola MV, Allen WJ, Pulkoski-Gross MJ, Obeid LM, Rizzo RC, Hannun YA.

Structure. 2015 Aug 4;23(8):1482-91. doi: 10.1016/j.str.2015.06.013. Epub 2015 Jul 16.


Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration.

Wu BX, Fan J, Boyer NP, Jenkins RW, Koutalos Y, Hannun YA, Crosson CE.

PLoS One. 2015 Jul 13;10(7):e0133032. doi: 10.1371/journal.pone.0133032. eCollection 2015.


IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.

Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA.

PLoS One. 2015 Jun 5;10(6):e0129314. doi: 10.1371/journal.pone.0129314. eCollection 2015.


A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.

Salama MF, Carroll B, Adada M, Pulkoski-Gross M, Hannun YA, Obeid LM.

FASEB J. 2015 Jul;29(7):2803-13. doi: 10.1096/fj.15-270413. Epub 2015 Mar 24.


GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS.

Lu Z, Li Y, Jin J, Zhang X, Hannun YA, Huang Y.

Atherosclerosis. 2015 May;240(1):163-73. doi: 10.1016/j.atherosclerosis.2015.03.013. Epub 2015 Mar 14.

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