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Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

Vlachogiannis G, Hedayat S, Vatsiou A, Jamin Y, Fernández-Mateos J, Khan K, Lampis A, Eason K, Huntingford I, Burke R, Rata M, Koh DM, Tunariu N, Collins D, Hulkki-Wilson S, Ragulan C, Spiteri I, Moorcraft SY, Chau I, Rao S, Watkins D, Fotiadis N, Bali M, Darvish-Damavandi M, Lote H, Eltahir Z, Smyth EC, Begum R, Clarke PA, Hahne JC, Dowsett M, de Bono J, Workman P, Sadanandam A, Fassan M, Sansom OJ, Eccles S, Starling N, Braconi C, Sottoriva A, Robinson SP, Cunningham D, Valeri N.

Science. 2018 Feb 23;359(6378):920-926. doi: 10.1126/science.aao2774.


KRAS and BRAF mutations in circulating tumour DNA from locally advanced rectal cancer.

Sclafani F, Chau I, Cunningham D, Hahne JC, Vlachogiannis G, Eltahir Z, Lampis A, Braconi C, Kalaitzaki E, De Castro DG, Wotherspoon A, Capdevila J, Glimelius B, Tarazona N, Begum R, Lote H, Hulkki Wilson S, Mentrasti G, Brown G, Tait D, Oates J, Valeri N.

Sci Rep. 2018 Jan 23;8(1):1445. doi: 10.1038/s41598-018-19212-5.


First-line dose-dense chemotherapy with docetaxel, cisplatin, folinic acid and 5-fluorouracil (DCF) plus panitumumab in patients with locally advanced or metastatic cancer of the stomach or gastroesophageal junction: final results and biomarker analysis from an Italian oncology group for clinical research (GOIRC) phase II study.

Tomasello G, Valeri N, Ghidini M, Smyth EC, Liguigli W, Toppo L, Mattioli R, Curti A, Hahne JC, Negri FM, Panni S, Ratti M, Lazzarelli S, Gerevini F, Colombi C, Panni A, Rovatti M, Treccani L, Martinotti M, Passalacqua R.

Oncotarget. 2017 Dec 4;8(67):111795-111806. doi: 10.18632/oncotarget.22909. eCollection 2017 Dec 19.


MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma.

Lampis A, Carotenuto P, Vlachogiannis G, Cascione L, Hedayat S, Burke R, Clarke P, Bosma E, Simbolo M, Scarpa A, Yu S, Cole R, Smyth E, Mateos JF, Begum R, Hezelova B, Eltahir Z, Wotherspoon A, Fotiadis N, Bali MA, Nepal C, Khan K, Stubbs M, Hahne JC, Gasparini P, Guzzardo V, Croce CM, Eccles S, Fassan M, Cunningham D, Andersen JB, Workman P, Valeri N, Braconi C.

Gastroenterology. 2017 Nov 4. pii: S0016-5085(17)36331-X. doi: 10.1053/j.gastro.2017.10.043. [Epub ahead of print]


Real-time robustness evaluation of regression based myoelectric control against arm position change and donning/doffing.

Hwang HJ, Hahne JM, Müller KR.

PLoS One. 2017 Nov 2;12(11):e0186318. doi: 10.1371/journal.pone.0186318. eCollection 2017.


Characterisation of the immune-related transcriptome in resected biliary tract cancers.

Ghidini M, Cascione L, Carotenuto P, Lampis A, Trevisani F, Previdi MC, Hahne JC, Said-Huntingford I, Raj M, Zerbi A, Mescoli C, Cillo U, Rugge M, Roncalli M, Torzilli G, Rimassa L, Santoro A, Valeri N, Fassan M, Braconi C.

Eur J Cancer. 2017 Nov;86:158-165. doi: 10.1016/j.ejca.2017.09.005. Epub 2017 Oct 6.


Clinical development of mTor inhibitors for renal cancer.

Ghidini M, Petrelli F, Ghidini A, Tomasello G, Hahne JC, Passalacqua R, Barni S.

Expert Opin Investig Drugs. 2017 Nov;26(11):1229-1237. doi: 10.1080/13543784.2017.1384813. Epub 2017 Oct 3. Review.


Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study.

Khan K, Rata M, Cunningham D, Koh DM, Tunariu N, Hahne JC, Vlachogiannis G, Hedayat S, Marchetti S, Lampis A, Damavandi MD, Lote H, Rana I, Williams A, Eccles SA, Fontana E, Collins D, Eltahir Z, Rao S, Watkins D, Starling N, Thomas J, Kalaitzaki E, Fotiadis N, Begum R, Bali M, Rugge M, Temple E, Fassan M, Chau I, Braconi C, Valeri N.

Gut. 2017 Aug 8. pii: gutjnl-2017-314178. doi: 10.1136/gutjnl-2017-314178. [Epub ahead of print]


Context-dependent adaptation improves robustness of myoelectric control for upper-limb prostheses.

Patel GK, Hahne JM, Castellini C, Farina D, Dosen S.

J Neural Eng. 2017 Oct;14(5):056016. doi: 10.1088/1741-2552/aa7e82. Epub 2017 Jul 10.


User adaptation in Myoelectric Man-Machine Interfaces.

Hahne JM, Markovic M, Farina D.

Sci Rep. 2017 Jun 30;7(1):4437. doi: 10.1038/s41598-017-04255-x.


How are socio-demographic and psycho-social factors associated with the prevalence and chronicity of severe pain in 14 different body sites? A cross-sectional population-based survey.

Dorner TE, Stein KV, Hahne J, Wepner F, Friedrich M, Mittendorfer-Rutz E.

Wien Klin Wochenschr. 2018 Jan;130(1-2):14-22. doi: 10.1007/s00508-017-1223-x. Epub 2017 Jun 20.


Integration of Continuous-Time Dynamics in a Spiking Neural Network Simulator.

Hahne J, Dahmen D, Schuecker J, Frommer A, Bolten M, Helias M, Diesmann M.

Front Neuroinform. 2017 May 24;11:34. doi: 10.3389/fninf.2017.00034. eCollection 2017.


Neural Engineering for Rehabilitation.

Hwang HJ, Kim DW, Hahne JM, Son J.

Biomed Res Int. 2017;2017:9638098. doi: 10.1155/2017/9638098. Epub 2017 Apr 30. No abstract available.


Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.

Lote H, Spiteri I, Ermini L, Vatsiou A, Roy A, McDonald A, Maka N, Balsitis M, Bose N, Simbolo M, Mafficini A, Lampis A, Hahne JC, Trevisani F, Eltahir Z, Mentrasti G, Findlay C, Kalkman EAJ, Punta M, Werner B, Lise S, Aktipis A, Maley C, Greaves M, Braconi C, White J, Fassan M, Scarpa A, Sottoriva A, Valeri N.

Ann Oncol. 2017 Jun 1;28(6):1243-1249. doi: 10.1093/annonc/mdx074.


Clinical outcome and molecular characterization of brain metastases from esophageal and gastric cancer: a systematic review.

Ghidini M, Petrelli F, Hahne JC, De Giorgi A, Toppo L, Pizzo C, Ratti M, Barni S, Passalacqua R, Tomasello G.

Med Oncol. 2017 Apr;34(4):62. doi: 10.1007/s12032-017-0919-0. Epub 2017 Mar 18. Review.


MicroRNA 193b-3p as a predictive biomarker of chronic kidney disease in patients undergoing radical nephrectomy for renal cell carcinoma.

Trevisani F, Ghidini M, Larcher A, Lampis A, Lote H, Manunta P, Alibrandi MT, Zagato L, Citterio L, Dell'Antonio G, Carenzi C, Capasso G, Rugge M, Rigotti P, Bertini R, Cascione L, Briganti A, Salonia A, Benigni F, Braconi C, Fassan M, Hahne JC, Montorsi F, Valeri N.

Br J Cancer. 2016 Nov 22;115(11):1343-1350. doi: 10.1038/bjc.2016.329. Epub 2016 Nov 1.


Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers.

Carotenuto P, Fassan M, Pandolfo R, Lampis A, Vicentini C, Cascione L, Paulus-Hock V, Boulter L, Guest R, Quagliata L, Hahne JC, Ridgway R, Jamieson T, Athineos D, Veronese A, Visone R, Murgia C, Ferrari G, Guzzardo V, Evans TRJ, MacLeod M, Feng GJ, Dale T, Negrini M, Forbes SJ, Terracciano L, Scarpa A, Patel T, Valeri N, Workman P, Sansom O, Braconi C.

Gut. 2017 Jul;66(7):1268-1277. doi: 10.1136/gutjnl-2016-312278. Epub 2016 Sep 12.


Rotational gait patterns in children and adolescents following tension band plating of idiopathic genua valga.

Farr S, Kranzl A, Hahne J, Ganger R.

J Orthop Res. 2017 Aug;35(8):1617-1624. doi: 10.1002/jor.23434. Epub 2016 Sep 22.


New developments in the treatment of chemotherapy-induced neutropenia: focus on balugrastim.

Ghidini M, Hahne JC, Trevisani F, Panni S, Ratti M, Toppo L, Tomasello G.

Ther Clin Risk Manag. 2016 Jun 24;12:1009-15. doi: 10.2147/TCRM.S80732. eCollection 2016. Review.


Sequence variation in mature microRNA-608 and benefit from neo-adjuvant treatment in locally advanced rectal cancer patients.

Sclafani F, Chau I, Cunningham D, Lampis A, Hahne JC, Ghidini M, Lote H, Zito D, Tabernero J, Glimelius B, Cervantes A, Begum R, De Castro DG, Wilson SH, Peckitt C, Eltahir Z, Wotherspoon A, Tait D, Brown G, Oates J, Braconi C, Valeri N.

Carcinogenesis. 2016 Sep;37(9):852-7. doi: 10.1093/carcin/bgw073. Epub 2016 Jul 5.


Intraoperative Diagnosis of Periprosthetic Joint Infection Using a Novel Alpha-Defensin Lateral Flow Assay.

Kasparek MF, Kasparek M, Boettner F, Faschingbauer M, Hahne J, Dominkus M.

J Arthroplasty. 2016 Dec;31(12):2871-2874. doi: 10.1016/j.arth.2016.05.033. Epub 2016 May 27.


Effect of Pathologic Tumor Response and Nodal Status on Survival in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy Trial.

Smyth EC, Fassan M, Cunningham D, Allum WH, Okines AF, Lampis A, Hahne JC, Rugge M, Peckitt C, Nankivell M, Langley R, Ghidini M, Braconi C, Wotherspoon A, Grabsch HI, Valeri N.

J Clin Oncol. 2016 Aug 10;34(23):2721-7. doi: 10.1200/JCO.2015.65.7692. Epub 2016 Jun 13.


A Novel Percutaneous Electrode Implant for Improving Robustness in Advanced Myoelectric Control.

Hahne JM, Farina D, Jiang N, Liebetanz D.

Front Neurosci. 2016 Mar 31;10:114. doi: 10.3389/fnins.2016.00114. eCollection 2016.


Approaches to optimize focused extracorporeal shockwave therapy (ESWT) based on an observational study of 363 feet with recalcitrant plantar fasciitis.

Scheuer R, Friedrich M, Hahne J, Holzapfel J, Machacek P, Ogon M, Pallamar M.

Int J Surg. 2016 Mar;27:1-7. doi: 10.1016/j.ijsu.2016.01.042. Epub 2016 Jan 20.


Dehydroepiandrosterone Stimulation of Osteoblastogenesis in Human MSCs Requires IGF-I Signaling.

Liang X, Glowacki J, Hahne J, Xie L, LeBoff MS, Zhou S.

J Cell Biochem. 2016 Aug;117(8):1769-74. doi: 10.1002/jcb.25475. Epub 2016 Jan 15.


Correction to "Concurrent Adaptation of Human and Machine Improves Simultaneous and Proportional Myoelectric Control".

Hahne JM, Dahne S, Hwang HJ, Muller KR, Parra LC.

IEEE Trans Neural Syst Rehabil Eng. 2015 Nov;23(6):1128. doi: 10.1109/TNSRE.2015.2497038. No abstract available.


Improving the Robustness of Myoelectric Pattern Recognition for Upper Limb Prostheses by Covariate Shift Adaptation.

Vidovic MM, Hwang HJ, Amsuss S, Hahne JM, Farina D, Muller KR.

IEEE Trans Neural Syst Rehabil Eng. 2016 Sep;24(9):961-970. doi: 10.1109/TNSRE.2015.2492619. Epub 2015 Oct 26.


Arthroscopic tenodesis versus tenotomy of the long head of biceps tendon in simultaneous rotator cuff repair.

Meraner D, Sternberg C, Vega J, Hahne J, Kleine M, Leuzinger J.

Arch Orthop Trauma Surg. 2016 Jan;136(1):101-6. Epub 2015 Oct 24.


A unified framework for spiking and gap-junction interactions in distributed neuronal network simulations.

Hahne J, Helias M, Kunkel S, Igarashi J, Bolten M, Frommer A, Diesmann M.

Front Neuroinform. 2015 Sep 9;9:22. doi: 10.3389/fninf.2015.00022. eCollection 2015.


Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer: results of the EXPERT-C trial.

Sclafani F, Chau I, Cunningham D, Peckitt C, Lampis A, Hahne JC, Braconi C, Tabernero J, Glimelius B, Cervantes A, Begum R, Gonzalez De Castro D, Hulkki Wilson S, Eltahir Z, Wotherspoon A, Tait D, Brown G, Oates J, Valeri N.

Ann Oncol. 2015 Sep;26(9):1936-41. doi: 10.1093/annonc/mdv285. Epub 2015 Jul 10.


Three-way analysis of spectrospatial electromyography data: classification and interpretation.

Kauppi JP, Hahne J, Müller KR, Hyvärinen A.

PLoS One. 2015 Jun 3;10(6):e0127231. doi: 10.1371/journal.pone.0127231. eCollection 2015.


Concurrent Adaptation of Human and Machine Improves Simultaneous and Proportional Myoelectric Control.

Hahne JM, Dahne S, Hwang HJ, Muller KR, Parra LC.

IEEE Trans Neural Syst Rehabil Eng. 2015 Jul;23(4):618-27. doi: 10.1109/TNSRE.2015.2401134. Epub 2015 Feb 10. Erratum in: IEEE Trans Neural Syst Rehabil Eng. 2015 Nov;23(6):1128.


Covariate shift adaptation in EMG pattern recognition for prosthetic device control.

Vidovic MM, Paredes LP, Han-Jeong Hwang, Amsüss S, Pahl J, Hahne JM, Graimann B, Farina D, Müller KR.

Conf Proc IEEE Eng Med Biol Soc. 2014;2014:4370-3. doi: 10.1109/EMBC.2014.6944592.


Anti-tumour activity of phosphoinositide-3-kinase antagonist AEZS-126 in models of ovarian cancer.

Hahne JC, Kurz A, Meyer SR, Dietl J, Engel JB, Honig A.

Arch Gynecol Obstet. 2015 Jan;291(1):131-41. doi: 10.1007/s00404-014-3389-z. Epub 2014 Aug 13.


Channel selection for simultaneous and proportional myoelectric prosthesis control of multiple degrees-of-freedom.

Hwang HJ, Hahne JM, Müller KR.

J Neural Eng. 2014 Oct;11(5):056008. doi: 10.1088/1741-2560/11/5/056008. Epub 2014 Aug 1.


The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro.

Hahne JC, Meyer SR, Dietl J, Honig A.

Int J Oncol. 2014 Jul;45(1):373-82. doi: 10.3892/ijo.2014.2414. Epub 2014 May 5.


Linear and nonlinear regression techniques for simultaneous and proportional myoelectric control.

Hahne JM, Biessmann F, Jiang N, Rehbaum H, Farina D, Meinecke FC, Muller KR, Parra LC.

IEEE Trans Neural Syst Rehabil Eng. 2014 Mar;22(2):269-79. doi: 10.1109/TNSRE.2014.2305520.


Effects of vitamin D on patients with fibromyalgia syndrome: a randomized placebo-controlled trial.

Wepner F, Scheuer R, Schuetz-Wieser B, Machacek P, Pieler-Bruha E, Cross HS, Hahne J, Friedrich M.

Pain. 2014 Feb;155(2):261-8. doi: 10.1016/j.pain.2013.10.002.


Studies on the role of osteopontin-1 in endometrial cancer cell lines.

Hahne JC, Meyer SR, Kranke P, Dietl J, Guckenberger M, Polat B, Hönig A.

Strahlenther Onkol. 2013 Dec;189(12):1040-8. doi: 10.1007/s00066-013-0434-y. Epub 2013 Oct 16.


Mechanisms of tumor immune escape in triple-negative breast cancers (TNBC) with and without mutated BRCA 1.

Engel JB, Honig A, Kapp M, Hahne JC, Meyer SR, Dietl J, Segerer SE.

Arch Gynecol Obstet. 2014 Jan;289(1):141-7. doi: 10.1007/s00404-013-2922-9. Epub 2013 Jul 5.


e-Health Part 3. Overcoming health information challenges in Aboriginal Health Services.

Hahne J.

Aust Nurs J. 2012 Dec-2013 Jan;20(6):33. No abstract available.


Immune escape of AKT overexpressing ovarian cancer cells.

Hahne JC, Meyer SR, Gambaryan S, Walter U, Dietl J, Engel JB, Honig A.

Int J Oncol. 2013 May;42(5):1630-5. doi: 10.3892/ijo.2013.1846. Epub 2013 Mar 4.


Anti-tumour activity of phosphoinositide-3-kinase antagonist AEZS 126 in models of triple-negative breast cancer.

Hahne JC, Schmidt H, Meyer SR, Engel JB, Dietl J, Honig A.

J Cancer Res Clin Oncol. 2013 Jun;139(6):905-14. doi: 10.1007/s00432-013-1399-z. Epub 2013 Feb 26.


Downregulation of AKT reverses platinum resistance of human ovarian cancers in vitro.

Hahne JC, Honig A, Meyer SR, Gambaryan S, Walter U, Wischhusen J, Häussler SF, Segerer SE, Fujita N, Dietl J, Engel JB.

Oncol Rep. 2012 Dec;28(6):2023-8. doi: 10.3892/or.2012.2041. Epub 2012 Sep 18.


Peptidomimetic GnRH antagonist AEZS-115 inhibits the growth of ovarian and endometrial cancer cells.

Engel JB, Hahne JC, Häusler SF, Meyer S, Segerer SE, Diessner J, Dietl J, Honig A.

Anticancer Res. 2012 May;32(5):2063-8.


PI3K inhibitor D-116883 is effective in in vitro models of ovarian cancer.

Honig A, Hahne JC, Meyer S, Kranke P, Häusler S, Diessner J, Dietl J, Engel JB.

Anticancer Res. 2012 May;32(5):2035-41.


Clinical characteristics influence in vitro action of 1,25-dihydroxyvitamin D(3) in human marrow stromal cells.

Zhou S, Glowacki J, Kim SW, Hahne J, Geng S, Mueller SM, Shen L, Bleiberg I, LeBoff MS.

J Bone Miner Res. 2012 Sep;27(9):1992-2000. doi: 10.1002/jbmr.1655.


Spatial filtering for robust myoelectric control.

Hahne JM, Graimann B, Müller KR.

IEEE Trans Biomed Eng. 2012 May;59(5):1436-43. doi: 10.1109/TBME.2012.2188799. Epub 2012 Feb 23.


Effects of lobaplatin as a single agent and in combination with TRAIL on the growth of triple-negative p53-mutated breast cancers in vitro.

Engel JB, Martens T, Hahne JC, Häusler SF, Krockenberger M, Segerer S, Djakovic A, Meyer S, Dietl J, Wischhusen J, Honig A.

Anticancer Drugs. 2012 Apr;23(4):426-36. doi: 10.1097/CAD.0b013e32834fb8ce.


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