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Items: 28

1.

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.

Howard DM, Adams MJ, Shirali M, Clarke TK, Marioni RE, Davies G, Coleman JRI, Alloza C, Shen X, Barbu MC, Wigmore EM, Gibson J; 23andMe Research Team, Hagenaars SP, Lewis CM, Ward J, Smith DJ, Sullivan PF, Haley CS, Breen G, Deary IJ, McIntosh AM.

Nat Commun. 2018 Apr 16;9(1):1470. doi: 10.1038/s41467-018-03819-3.

PMID:
29662059
2.

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Feitosa MF, Kilpeläinen TO, Richard MA, Noordam R, Aslibekyan S, Aschard H, Bartz TM, Dorajoo R, Liu Y, Manning AK, Rankinen T, Smith AV, Tajuddin SM, Tayo BO, Warren HR, Zhao W, Zhou Y, Matoba N, Sofer T, Alver M, Amini M, Boissel M, Chai JF, Chen X, Divers J, Gandin I, Gao C, Giulianini F, Goel A, Harris SE, Hartwig FP, Horimoto ARVR, Hsu FC, Jackson AU, Kähönen M, Kasturiratne A, Kühnel B, Leander K, Lee WJ, Lin KH, 'an Luan J, McKenzie CA, Meian H, Nelson CP, Rauramaa R, Schupf N, Scott RA, Sheu WHH, Stančáková A, Takeuchi F, van der Most PJ, Varga TV, Wang H, Wang Y, Ware EB, Weiss S, Wen W, Yanek LR, Zhang W, Zhao JH, Afaq S, Alfred T, Amin N, Arking D, Aung T, Barr RG, Bielak LF, Boerwinkle E, Bottinger EP, Braund PS, Brody JA, Broeckel U, Cabrera CP, Cade B, Caizheng Y, Campbell A, Canouil M, Chakravarti A; CHARGE Neurology Working Group, Chauhan G, Christensen K, Cocca M; COGENT-Kidney Consortium, Collins FS, Connell JM, de Mutsert R, de Silva HJ, Debette S, Dörr M, Duan Q, Eaton CB, Ehret G, Evangelou E, Faul JD, Fisher VA, Forouhi NG, Franco OH, Friedlander Y, Gao H; GIANT Consortium, Gigante B, Graff M, Gu CC, Gu D, Gupta P, Hagenaars SP, Harris TB, He J, Heikkinen S, Heng CK, Hirata M, Hofman A, Howard BV, Hunt S, Irvin MR, Jia Y, Joehanes R, Justice AE, Katsuya T, Kaufman J, Kerrison ND, Khor CC, Koh WP, Koistinen HA, Komulainen P, Kooperberg C, Krieger JE, Kubo M, Kuusisto J, Langefeld CD, Langenberg C, Launer LJ, Lehne B, Lewis CE, Li Y; Lifelines Cohort Study, Lim SH, Lin S, Liu CT, Liu J, Liu J, Liu K, Liu Y, Loh M, Lohman KK, Long J, Louie T, Mägi R, Mahajan A, Meitinger T, Metspalu A, Milani L, Momozawa Y, Morris AP, Mosley TH Jr., Munson P, Murray AD, Nalls MA, Nasri U, Norris JM, North K, Ogunniyi A, Padmanabhan S, Palmas WR, Palmer ND, Pankow JS, Pedersen NL, Peters A, Peyser PA, Polasek O, Raitakari OT, Renström F, Rice TK, Ridker PM, Robino A, Robinson JG, Rose LM, Rudan I, Sabanayagam C, Salako BL, Sandow K, Schmidt CO, Schreiner PJ, Scott WR, Seshadri S, Sever P, Sitlani CM, Smith JA, Snieder H, Starr JM, Strauch K, Tang H, Taylor KD, Teo YY, Tham YC, Uitterlinden AG, Waldenberger M, Wang L, Wang YX, Wei WB, Williams C, Wilson G, Wojczynski MK, Yao J, Yuan JM, Zonderman AB, Becker DM, Boehnke M, Bowden DW, Chambers JC, Chen YI, de Faire U, Deary IJ, Esko T, Farrall M, Forrester T, Franks PW, Freedman BI, Froguel P, Gasparini P, Gieger C, Horta BL, Hung YJ, Jonas JB, Kato N, Kooner JS, Laakso M, Lehtimäki T, Liang KW, Magnusson PKE, Newman AB, Oldehinkel AJ, Pereira AC, Redline S, Rettig R, Samani NJ, Scott J, Shu XO, van der Harst P, Wagenknecht LE, Wareham NJ, Watkins H, Weir DR, Wickremasinghe AR, Wu T, Zheng W, Kamatani Y, Laurie CC, Bouchard C, Cooper RS, Evans MK, Gudnason V, Kardia SLR, Kritchevsky SB, Levy D, O'Connell JR, Psaty BM, van Dam RM, Sims M, Arnett DK, Mook-Kanamori DO, Kelly TN, Fox ER, Hayward C, Fornage M, Rotimi CN, Province MA, van Duijn CM, Tai ES, Wong TY, Loos RJF, Reiner AP, Rotter JI, Zhu X, Bierut LJ, Gauderman WJ, Caulfield MJ, Elliott P, Rice K, Munroe PB, Morrison AC, Cupples LA, Rao DC, Chasman DI.

Am J Hum Genet. 2018 Mar 1;102(3):375-400. doi: 10.1016/j.ajhg.2018.01.015. Epub 2018 Feb 15.

PMID:
29455858
3.

A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.

Hill WD, Marioni RE, Maghzian O, Ritchie SJ, Hagenaars SP, McIntosh AM, Gale CR, Davies G, Deary IJ.

Mol Psychiatry. 2018 Jan 11. doi: 10.1038/s41380-017-0001-5. [Epub ahead of print]

PMID:
29326435
4.

Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank.

Hall LS, Adams MJ, Arnau-Soler A, Clarke TK, Howard DM, Zeng Y, Davies G, Hagenaars SP, Maria Fernandez-Pujals A, Gibson J, Wigmore EM, Boutin TS, Hayward C, Scotland G; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Porteous DJ, Deary IJ, Thomson PA, Haley CS, McIntosh AM.

Transl Psychiatry. 2018 Jan 10;8(1):9. doi: 10.1038/s41398-017-0034-1.

5.

Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.

Luciano M, Hagenaars SP, Davies G, Hill WD, Clarke TK, Shirali M, Harris SE, Marioni RE, Liewald DC, Fawns-Ritchie C, Adams MJ, Howard DM, Lewis CM, Gale CR, McIntosh AM, Deary IJ.

Nat Genet. 2018 Jan;50(1):6-11. doi: 10.1038/s41588-017-0013-8. Epub 2017 Dec 18.

PMID:
29255261
6.

Haplotype-based association analysis of general cognitive ability in Generation Scotland, the English Longitudinal Study of Ageing, and UK Biobank.

Howard DM, Adams MJ, Clarke TK, Wigmore EM, Zeng Y, Hagenaars SP, Lyall DM, Thomson PA, Evans KL, Porteous DJ, Nagy R, Hayward C, Haley CS, Smith BH, Murray AD, Batty GD, Deary IJ, McIntosh AM.

Wellcome Open Res. 2017 Aug 10;2:61. doi: 10.12688/wellcomeopenres.12171.1. eCollection 2017.

7.

Genetic contributions to Trail Making Test performance in UK Biobank.

Hagenaars SP, Cox SR, Hill WD, Davies G, Liewald DCM; CHARGE consortium Cognitive Working Group, Harris SE, McIntosh AM, Gale CR, Deary IJ.

Mol Psychiatry. 2017 Sep 19. doi: 10.1038/mp.2017.189. [Epub ahead of print]

PMID:
28924184
8.

Single Nucleotide Polymorphisms Associated with Reading Ability Show Connection to Socio-Economic Outcomes.

Luciano M, Hagenaars SP, Cox SR, Hill WD, Davies G, Harris SE, Deary IJ, Evans DM, Martin NG, Wright MJ, Bates TC.

Behav Genet. 2017 Sep;47(5):469-479. doi: 10.1007/s10519-017-9859-x. Epub 2017 Jul 15.

9.

Cognitive ability and physical health: a Mendelian randomization study.

Hagenaars SP, Gale CR, Deary IJ, Harris SE.

Sci Rep. 2017 Jun 1;7(1):2651. doi: 10.1038/s41598-017-02837-3.

10.

Genetic contributions to self-reported tiredness.

Deary V, Hagenaars SP, Harris SE, Hill WD, Davies G, Liewald DCM; International Consortium for Blood Pressure GWAS; CHARGE consortium Aging and Longevity Group; CHARGE consortium Inflammation Group, McIntosh AM, Gale CR, Deary IJ.

Mol Psychiatry. 2018 Mar;23(3):789-790. doi: 10.1038/mp.2017.70. Epub 2017 Mar 21.

11.

Genetic Stratification to Identify Risk Groups for Alzheimer's Disease.

Marioni RE, Campbell A, Hagenaars SP, Nagy R, Amador C, Hayward C, Porteous DJ, Visscher PM, Deary IJ.

J Alzheimers Dis. 2017;57(1):275-283. doi: 10.3233/JAD-161070.

12.

Genetic prediction of male pattern baldness.

Hagenaars SP, Hill WD, Harris SE, Ritchie SJ, Davies G, Liewald DC, Gale CR, Porteous DJ, Deary IJ, Marioni RE.

PLoS Genet. 2017 Feb 14;13(2):e1006594. doi: 10.1371/journal.pgen.1006594. eCollection 2017 Feb.

13.

Genetic contributions to self-reported tiredness.

Deary V, Hagenaars SP, Harris SE, Hill WD, Davies G, Liewald DCM; International Consortium for Blood Pressure GWAS; CHARGE Consortium Aging and Longevity Group; CHARGE Consortium Inflammation Group, McIntosh AM, Gale CR, Deary IJ.

Mol Psychiatry. 2018 Mar;23(3):609-620. doi: 10.1038/mp.2017.5. Epub 2017 Feb 14. Erratum in: Mol Psychiatry. 2018 Mar;23 (3):789-790.

14.

Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank.

Reus LM, Shen X, Gibson J, Wigmore E, Ligthart L, Adams MJ, Davies G, Cox SR, Hagenaars SP, Bastin ME, Deary IJ, Whalley HC, McIntosh AM.

Sci Rep. 2017 Feb 10;7:42140. doi: 10.1038/srep42140.

15.

Ageing and brain white matter structure in 3,513 UK Biobank participants.

Cox SR, Ritchie SJ, Tucker-Drob EM, Liewald DC, Hagenaars SP, Davies G, Wardlaw JM, Gale CR, Bastin ME, Deary IJ.

Nat Commun. 2016 Dec 15;7:13629. doi: 10.1038/ncomms13629.

16.

Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions.

Hill WD, Davies G, Harris SE, Hagenaars SP; neuroCHARGE Cognitive Working group, Liewald DC, Penke L, Gale CR, Deary IJ.

Transl Psychiatry. 2016 Dec 13;6(12):e980. doi: 10.1038/tp.2016.246.

17.

Molecular genetic contributions to self-rated health.

Harris SE, Hagenaars SP, Davies G, David Hill W, Liewald DCM, Ritchie SJ, Marioni RE; METASTROKE Consortium, International Consortium for Blood Pressure Genome-Wide Association Studies; International Consortium for Blood Pressure Genome-Wide Association Studies; CHARGE Consortium Aging and Longevity Group; CHARGE Consortium Cognitive Group, Sudlow CLM, Wardlaw JM, McIntosh AM, Gale CR, Deary IJ.

Int J Epidemiol. 2017 Jun 1;46(3):994-1009. doi: 10.1093/ije/dyw219.

18.

Molecular Genetic Contributions to Social Deprivation and Household Income in UK Biobank.

Hill WD, Hagenaars SP, Marioni RE, Harris SE, Liewald DCM, Davies G, Okbay A, McIntosh AM, Gale CR, Deary IJ.

Curr Biol. 2016 Nov 21;26(22):3083-3089. doi: 10.1016/j.cub.2016.09.035. Epub 2016 Nov 3.

19.

Dissection of major depressive disorder using polygenic risk scores for schizophrenia in two independent cohorts.

Whalley HC, Adams MJ, Hall LS, Clarke TK, Fernandez-Pujals AM, Gibson J, Wigmore E, Hafferty J, Hagenaars SP, Davies G, Campbell A, Hayward C, Lawrie SM, Porteous DJ, Deary IJ, McIntosh AM.

Transl Psychiatry. 2016 Nov 1;6(11):e938. doi: 10.1038/tp.2016.207.

20.

Genetic variants linked to education predict longevity.

Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, Adams MJ, Hill WD, Davies G; Social Science Genetic Association Consortium, Nagy R, Amador C, Läll K, Metspalu A, Liewald DC, Campbell A, Wilson JF, Hayward C, Esko T, Porteous DJ, Gale CR, Deary IJ.

Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13366-13371. Epub 2016 Oct 31.

21.

Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.

Smith DJ, Escott-Price V, Davies G, Bailey ME, Colodro-Conde L, Ward J, Vedernikov A, Marioni R, Cullen B, Lyall D, Hagenaars SP, Liewald DC, Luciano M, Gale CR, Ritchie SJ, Hayward C, Nicholl B, Bulik-Sullivan B, Adams M, Couvy-Duchesne B, Graham N, Mackay D, Evans J, Smith BH, Porteous DJ, Medland SE, Martin NG, Holmans P, McIntosh AM, Pell JP, Deary IJ, O'Donovan MC.

Mol Psychiatry. 2016 Nov;21(11):1644. doi: 10.1038/mp.2016.177. Epub 2016 Sep 13. No abstract available.

22.

Shared genetic aetiology between cognitive functions and physical and mental health in UK Biobank (N=112 151) and 24 GWAS consortia.

Hagenaars SP, Harris SE, Davies G, Hill WD, Liewald DC, Ritchie SJ, Marioni RE, Fawns-Ritchie C, Cullen B, Malik R; METASTROKE Consortium, International Consortium for Blood Pressure GWAS; SpiroMeta Consortium; CHARGE Consortium Pulmonary Group, CHARGE Consortium Aging and Longevity Group, Worrall BB, Sudlow CL, Wardlaw JM, Gallacher J, Pell J, McIntosh AM, Smith DJ, Gale CR, Deary IJ.

Mol Psychiatry. 2016 Nov;21(11):1624-1632. doi: 10.1038/mp.2015.225. Epub 2016 Jan 26.

23.

Personality Polygenes, Positive Affect, and Life Satisfaction.

Weiss A, Baselmans BM, Hofer E, Yang J, Okbay A, Lind PA, Miller MB, Nolte IM, Zhao W, Hagenaars SP, Hottenga JJ, Matteson LK, Snieder H, Faul JD, Hartman CA, Boyle PA, Tiemeier H, Mosing MA, Pattie A, Davies G, Liewald DC, Schmidt R, De Jager PL, Heath AC, Jokela M, Starr JM, Oldehinkel AJ, Johannesson M, Cesarini D, Hofman A, Harris SE, Smith JA, Keltikangas-Järvinen L, Pulkki-Råback L, Schmidt H, Smith J, Iacono WG, McGue M, Bennett DA, Pedersen NL, Magnusson PK, Deary IJ, Martin NG, Boomsma DI, Bartels M, Luciano M.

Twin Res Hum Genet. 2016 Oct;19(5):407-17. doi: 10.1017/thg.2016.65. Epub 2016 Aug 22.

24.

Genetic and Environmental Risk for Chronic Pain and the Contribution of Risk Variants for Major Depressive Disorder: A Family-Based Mixed-Model Analysis.

McIntosh AM, Hall LS, Zeng Y, Adams MJ, Gibson J, Wigmore E, Hagenaars SP, Davies G, Fernandez-Pujals AM, Campbell AI, Clarke TK, Hayward C, Haley CS, Porteous DJ, Deary IJ, Smith DJ, Nicholl BI, Hinds DA, Jones AV, Scollen S, Meng W, Smith BH, Hocking LJ.

PLoS Med. 2016 Aug 16;13(8):e1002090. doi: 10.1371/journal.pmed.1002090. eCollection 2016 Aug.

25.

Pleiotropy between neuroticism and physical and mental health: findings from 108 038 men and women in UK Biobank.

Gale CR, Hagenaars SP, Davies G, Hill WD, Liewald DC, Cullen B, Penninx BW; International Consortium for Blood Pressure GWAS, CHARGE Consortium Aging and Longevity Group, Boomsma DI, Pell J, McIntosh AM, Smith DJ, Deary IJ, Harris SE.

Transl Psychiatry. 2016 Apr 26;6:e791. doi: 10.1038/tp.2016.56.

26.

Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.

Smith DJ, Escott-Price V, Davies G, Bailey ME, Colodro-Conde L, Ward J, Vedernikov A, Marioni R, Cullen B, Lyall D, Hagenaars SP, Liewald DC, Luciano M, Gale CR, Ritchie SJ, Hayward C, Nicholl B, Bulik-Sullivan B, Adams M, Couvy-Duchesne B, Graham N, Mackay D, Evans J, Smith BH, Porteous DJ, Medland SE, Martin NG, Holmans P, McIntosh AM, Pell JP, Deary IJ, O'Donovan MC.

Mol Psychiatry. 2016 Jun;21(6):749-57. doi: 10.1038/mp.2016.49. Epub 2016 Apr 12.

27.

Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151).

Davies G, Marioni RE, Liewald DC, Hill WD, Hagenaars SP, Harris SE, Ritchie SJ, Luciano M, Fawns-Ritchie C, Lyall D, Cullen B, Cox SR, Hayward C, Porteous DJ, Evans J, McIntosh AM, Gallacher J, Craddock N, Pell JP, Smith DJ, Gale CR, Deary IJ.

Mol Psychiatry. 2016 Jun;21(6):758-67. doi: 10.1038/mp.2016.45. Epub 2016 Apr 5.

28.

Polygenic risk for coronary artery disease is associated with cognitive ability in older adults.

Hagenaars SP, Harris SE, Clarke TK, Hall L, Luciano M, Fernandez-Pujals AM, Davies G, Hayward C; Generation Scotland, Starr JM, Porteous DJ, McIntosh AM, Deary IJ.

Int J Epidemiol. 2016 Jan 28. pii: dyv354. [Epub ahead of print]

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