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Items: 47

1.

Calcium leucovorin and 5-fluorouridine cytotoxicity.

Berger SH, Hakala MT.

J S C Med Assoc. 1990 May;86(5):284-9. Erratum in: J S C Med Assoc 1990 Sep;86(9):517.

PMID:
2242115
2.
3.

Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil.

Yin MB, Zakrzewski SF, Hakala MT.

Mol Pharmacol. 1983 Jan;23(1):190-7. No abstract available.

PMID:
6688119
4.
5.

Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil.

Evans RM, Laskin JD, Hakala MT.

Cancer Res. 1981 Sep;41(9 Pt 1):3288-95. No abstract available.

6.

Biochemical pharmacology of lipophilic diaminopyrimidine antifolates in mouse and human cells in vitro.

Greco WR, Hakala MT.

Mol Pharmacol. 1980 Nov;18(3):521-8. No abstract available.

PMID:
6970329
7.

Assessment of growth-limiting events caused by 5-fluorouracil in mouse cells and in human cells.

Evans RM, Laskin JD, Hakala MT.

Cancer Res. 1980 Nov;40(11):4113-22. No abstract available.

8.

Cellular pharmacokinetics of lipophilic diaminopyrimidine antifolates.

Greco WR, Hakala MT.

J Pharmacol Exp Ther. 1980 Jan;212(1):39-46. No abstract available.

PMID:
7351624
9.

Evaluation of methods for estimating the dissociation constant of tight binding enzyme inhibitors.

Greco WR, Hakala MT.

J Biol Chem. 1979 Dec 10;254(23):12104-9. No abstract available.

10.

Basis for natural variation in sensitivity to 5-fluorouracil in mouse and human cells in culture.

Laskin JD, Evans RM, Slocum HK, Burke D, Hakala MT.

Cancer Res. 1979 Feb;39(2 Pt 1):383-90. No abstract available.

11.

On the inhibitory activity of 4-vinyl analogues of pyridoxal: enzyme and cell culture studies.

Korytnyk W, Hakala MT, Potti PG, Angelino N, Chang SC.

Biochemistry. 1976 Dec 14;15(25):5458-66.

PMID:
187217
12.
13.

Multifactorial cellular determinants of the action of antimetabolites.

Rustum YM, Grindey GB, Hakala MT, Mihich E.

Adv Enzyme Regul. 1976;14:281-95. No abstract available.

PMID:
184698
14.

N6-(delta2-isopentenyl)adenosine, an inhibitor of cellular transport of uridine and cytidine.

Hakala MT, Slocum HK, Gryko GJ.

J Cell Physiol. 1975 Oct;86(2 Pt 1):281-91.

PMID:
1194366
15.

Inhibition of the biosynthesis of 5'-phosphoribosyl-N-formylglycinamide in sarcoma 180 cells by homofolate.

Divekar AY, Hakala MT.

Mol Pharmacol. 1975 May;11(3):319-25. No abstract available.

PMID:
1079920
16.
17.

N6-(delta2-isopentenyl)adenosine 5'-monophosphate: formation and effect on purine metabolism in cellular and enzymatic systems.

Divekar AY, Slocum HK, Hakala MT.

Mol Pharmacol. 1974 May;10(3):529-43. No abstract available.

PMID:
4368972
18.

Antitumor activity of N6-phenyladenosine, and inhibitor of adenosine utilization, in combination with related purine analogs.

Grindey GB, Divekar AY, Hakala MT.

Cancer Res. 1973 Oct;33(10):2459-63. No abstract available.

19.

6-Ureido derivatives of 9-( -D-ribofuranosyl)purine as inhibitors of adenosine kinase.

Divekar AY, Hakala MT, Chheda GB, Hong CI.

Biochem Pharmacol. 1973 Feb 15;22(4):545-8. No abstract available.

PMID:
4691882
20.

Changes in sarcoma 180 cells associated with drug-induced resistance to adenosine analogs.

Divekar AY, Fleysher MH, Slocum HK, Kenny LN, Hakala MT.

Cancer Res. 1972 Nov;32(11):2530-7. No abstract available.

21.

5-(1-Adamantyl) pyrimidines as inhibitors of folate metabolism.

Ho YK, Hakala MT, Zakrzewski SF.

Cancer Res. 1972 May;32(5):1023-8. No abstract available.

22.

Adenosine kinase of sarcoma 180 cells N 6 -substituted adenosines as substrates and inhibitors.

Divekar AY, Hakala MT.

Mol Pharmacol. 1971 Nov;7(6):663-73. No abstract available.

PMID:
5169930
23.
24.

Homofolate and tetrahydrohomofolate, inhibitors of purine synthesis.

Hakala MT.

Cancer Res. 1971 Jun;31(6):813-6. No abstract available.

25.
26.

Synthesis and biological activity of some 5-(1-adamantyl)pyrimidines. 1.

Jonak JP, Zakrzewski SF, Mead LH, Hakala MT.

J Med Chem. 1970 Nov;13(6):1170-2. No abstract available.

PMID:
5529583
27.

Synthesis and biological activity of some new N6-substituted purine nucleosides.

Fleysher MH, Bloch A, Hakala MT, Nichol CA.

J Med Chem. 1969 Nov;12(6):1056-61. No abstract available.

PMID:
4900616
28.

Tetrahydrofolate-dependent enzymes in sarcoma 180 cells sensitive and resistant to amethopterin.

Aunio R, Hakala MT.

Biochem Pharmacol. 1968 Aug;17(8):1744-7. No abstract available.

PMID:
5672831
29.

Synthesis and biological activity of some N6-alkyladenosines.

Fleysher MH, Hakala MT, Bloch A, Hall RH.

J Med Chem. 1968 Jul;11(4):717-20. No abstract available.

PMID:
4970357
30.

The essential SH-groups in folate reductase.

Hakala MT.

Mol Pharmacol. 1968 Mar;4(2):162-7. No abstract available.

PMID:
4384619
31.

Comparison of folate reductases of sarcoma 180 cells, sensitive and resistant to amethopterin.

Raunio RP, Hakala MT.

Mol Pharmacol. 1967 May;3(3):279-83. No abstract available.

PMID:
6068342
32.

Specific protection of folate reductase against chemical and proteolytic inactivation.

Hakala MT, Suolinna EM.

Mol Pharmacol. 1966 Sep;2(5):465-80. No abstract available.

PMID:
6008166
33.

On the role of drug penetration in amethopterin resistance of Sarcoma-180 cells in vitro.

Hakala MT.

Biochim Biophys Acta. 1965 May 25;102(1):198-209. No abstract available.

PMID:
5890840
34.

On the nature of permeability of sarcoma-180 cells to amethopterin in vitro.

Hakala MT.

Biochim Biophys Acta. 1965 May 25;102(1):210-25. No abstract available.

PMID:
5294407
35.

PREVENTION OF THE GROWTH-INHIBITORY EFFECT OF 6-MERCAPTOPURINE BY 4-AMINOIMIDAZOLE-5-CARBOXAMIDE.

HAKALA MT, NICHOL CA.

Biochim Biophys Acta. 1964 Apr 27;80:665-8. No abstract available.

PMID:
14156738
36.

Change in pyrimidine deoxyribonucleoside metabolism in cell culture caused by Mycoplasma (PPLO) contamination.

HAKALA MT, HOLLAND JF, HOROSZEWICZ JS.

Biochem Biophys Res Commun. 1963 Jun 20;11:466-71. No abstract available.

PMID:
13952012
37.

Effect of 5-bromodeoxyuridine incorporation on survival of cultured mammalian cells.

HAKALA MT.

Biochim Biophys Acta. 1962 Nov 26;61:815-23. No abstract available.

PMID:
13952011
38.

Chromosomal constitution and amethopterin resistance in cultured mouse cells.

HAKALA MT, ISHIHARA T.

Cancer Res. 1962 Sep;22:987-92. No abstract available.

39.

Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells.

HAKALA MT, ZAKRZEWSKI SF, NICHOL CA.

J Biol Chem. 1961 Mar;236:952-8. No abstract available.

40.

Studies on the mode of action of 6-mercaptopurine and its ribonucleoside on mammalian cells in culture.

HAKALA MT, NICHOL CA.

J Biol Chem. 1959 Dec;234:3224-8. No abstract available.

41.

Mode of action of 5-bromodeoxyuridine on mammalian cells in culture.

HAKALA MT.

J Biol Chem. 1959 Dec;234:3072-6. No abstract available.

42.

The ability of purine and thymine derivatives and of glycine to support the growth of mammalian cells in culture.

HAKALA MT, TAYLOR E.

J Biol Chem. 1959 Jan;234(1):126-8. No abstract available.

43.

Prevention of toxicity of amethopterin for sarcoma-180 cells in tissue culture.

HAKALA MT.

Science. 1957 Aug 9;126(3267):255. No abstract available.

PMID:
13454808
44.

A polyglutamate form of citrovorum factor synthesized by Bacillus subtilis.

HAKALA MT, WELCH AD.

J Bacteriol. 1957 Jan;73(1):35-41. No abstract available.

45.

Lactic dehydrogenase. II. Variation of kinetic and equilibrium constants with temperature.

HAKALA MT, GLAID AJ, SCHWERT GW.

J Biol Chem. 1956 Jul;221(1):191-209. No abstract available.

46.

The dependence of difference spectra of DPN and of related substances upon hydrogen ion concentration.

HAKALA MT, SCHWERT GW.

Biochim Biophys Acta. 1955 Apr;16(4):489-93. No abstract available.

PMID:
14389265
47.

Lactic dehydrogenase. I. Kinetics.

SCHWERT GW, HAKALA MT.

Arch Biochem Biophys. 1952 Jul;38:55-65. No abstract available.

PMID:
12997079

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