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GENIPAC: A Genomic Information Portal for Head and Neck Cancer Cell Systems.

Lee BKB, Gan CP, Chang JK, Tan JL, Fadlullah MZ, Abdul Rahman ZA, Prime SS, Gutkind JS, Liew CS, Khang TF, Tan AC, Cheong SC.

J Dent Res. 2018 Mar 1:22034518759038. doi: 10.1177/0022034518759038. [Epub ahead of print]


The homozygous CX3CR1-M280 mutation impairs human monocyte survival.

Collar AL, Swamydas M, O'Hayre M, Sajib MS, Hoffman KW, Singh SP, Mourad A, Johnson MD, Ferre EM, Farber JM, Lim JK, Mikelis CM, Gutkind JS, Lionakis MS.

JCI Insight. 2018 Feb 8;3(3). pii: 95417. doi: 10.1172/jci.insight.95417. [Epub ahead of print]


Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance.

Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, Collins MT, Gutkind JS.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E428-E437. doi: 10.1073/pnas.1713710115. Epub 2017 Dec 27.


The NOTCH4-HEY1 Pathway Induces Epithelial-Mesenchymal Transition in Head and Neck Squamous Cell Carcinoma.

Fukusumi T, Guo TW, Sakai A, Ando M, Ren S, Haft S, Liu C, Amornphimoltham P, Gutkind JS, Califano JA.

Clin Cancer Res. 2018 Feb 1;24(3):619-633. doi: 10.1158/1078-0432.CCR-17-1366. Epub 2017 Nov 16.


The Next Frontier: Head and Neck Cancer Immunoprevention.

Gutkind JS, Bui JD.

Cancer Prev Res (Phila). 2017 Dec;10(12):681-683. doi: 10.1158/1940-6207.CAPR-17-0331. Epub 2017 Nov 14.


Genetic variants affecting equivalent protein family positions reflect human diversity.

Raimondi F, Betts MJ, Lu Q, Inoue A, Gutkind JS, Russell RB.

Sci Rep. 2017 Oct 6;7(1):12771. doi: 10.1038/s41598-017-12971-7.


A Novel Functional Splice Variant of AKT3 Defined by Analysis of Alternative Splice Expression in HPV-Positive Oropharyngeal Cancers.

Guo T, Sakai A, Afsari B, Considine M, Danilova L, Favorov AV, Yegnasubramanian S, Kelley DZ, Flam E, Ha PK, Khan Z, Wheelan SJ, Gutkind JS, Fertig EJ, Gaykalova DA, Califano J.

Cancer Res. 2017 Oct 1;77(19):5248-5258. doi: 10.1158/0008-5472.CAN-16-3106. Epub 2017 Jul 21.


Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK.

O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS.

Sci Signal. 2017 Jun 20;10(484). pii: eaal3395. doi: 10.1126/scisignal.aal3395.


E1a is an exogenous in vivo tumour suppressor.

Cimas FJ, Callejas-Valera JL, García-Olmo DC, Hernández-Losa J, Melgar-Rojas P, Ruiz-Hidalgo MJ, Pascual-Serra R, Ortega-Muelas M, Roche O, Marcos P, Garcia-Gil E, Fernandez-Aroca DM, Ramón Y Cajal S, Gutkind JS, Sanchez-Prieto R.

Cancer Lett. 2017 Jul 28;399:74-81. doi: 10.1016/j.canlet.2017.04.010. Epub 2017 Apr 15.


Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.

Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind JS.

PLoS One. 2017 Mar 16;12(3):e0173692. doi: 10.1371/journal.pone.0173692. eCollection 2017.


Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer.

Carter H, Marty R, Hofree M, Gross AM, Jensen J, Fisch KM, Wu X, DeBoever C, Van Nostrand EL, Song Y, Wheeler E, Kreisberg JF, Lippman SM, Yeo GW, Gutkind JS, Ideker T.

Cancer Discov. 2017 Apr;7(4):410-423. doi: 10.1158/2159-8290.CD-16-1045. Epub 2017 Feb 10.


Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC.

Gaykalova DA, Zizkova V, Guo T, Tiscareno I, Wei Y, Vatapalli R, Hennessey PT, Ahn J, Danilova L, Khan Z, Bishop JA, Gutkind JS, Koch WM, Westra WH, Fertig EJ, Ochs MF, Califano JA.

Oncotarget. 2017 Feb 28;8(9):15349-15363. doi: 10.18632/oncotarget.14856.


LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma.

Deng WW, Mao L, Yu GT, Bu LL, Ma SR, Liu B, Gutkind JS, Kulkarni AB, Zhang WF, Sun ZJ.

Oncoimmunology. 2016 Oct 7;5(11):e1239005. doi: 10.1080/2162402X.2016.1239005. eCollection 2016.


Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components.

Sakurai A, Doçi CL, Gutkind JS.

Methods Mol Biol. 2017;1493:163-170.


Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer.

Nohata N, Goto Y, Gutkind JS.

J Hum Genet. 2017 Jan;62(1):87-96. doi: 10.1038/jhg.2016.124. Epub 2016 Oct 13. Review.


mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.

Callejas-Valera JL, Iglesias-Bartolome R, Amornphimoltham P, Palacios-Garcia J, Martin D, Califano JA, Molinolo AA, Gutkind JS.

Carcinogenesis. 2016 Oct;37(10):1014-25. doi: 10.1093/carcin/bgw086. Epub 2016 Aug 18.


WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.

Arthofer E, Hot B, Petersen J, Strakova K, Jäger S, Grundmann M, Kostenis E, Gutkind JS, Schulte G.

Mol Pharmacol. 2016 Oct;90(4):447-59. doi: 10.1124/mol.116.104919. Epub 2016 Jul 25.


Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection.

Nohata N, Abba MC, Gutkind JS.

Oral Oncol. 2016 Aug;59:58-66. doi: 10.1016/j.oraloncology.2016.05.014. Review.


Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo.

Porat-Shliom N, Tietgens AJ, Van Itallie CM, Vitale-Cross L, Jarnik M, Harding OJ, Anderson JM, Gutkind JS, Weigert R, Arias IM.

Hepatology. 2016 Oct;64(4):1317-29. doi: 10.1002/hep.28724. Epub 2016 Jul 28.


Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.

Andradas C, Blasco-Benito S, Castillo-Lluva S, Dillenburg-Pilla P, Diez-Alarcia R, Juanes-García A, García-Taboada E, Hernando-Llorente R, Soriano J, Hamann S, Wenners A, Alkatout I, Klapper W, Rocken C, Bauer M, Arnold N, Quintanilla M, Megías D, Vicente-Manzanares M, Urigüen L, Gutkind JS, Guzmán M, Pérez-Gómez E, Sánchez C.

Oncotarget. 2016 Jul 26;7(30):47565-47575. doi: 10.18632/oncotarget.10206.


PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells.

Alonso N, Diaz Nebreda A, Monczor F, Gutkind JS, Davio C, Fernandez N, Shayo C.

Biochim Biophys Acta. 2016 Sep;1860(9):1998-2007. doi: 10.1016/j.bbagen.2016.06.016. Epub 2016 Jun 15.


Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma.

Geiger JL, Bauman JE, Gibson MK, Gooding WE, Varadarajan P, Kotsakis A, Martin D, Gutkind JS, Hedberg ML, Grandis JR, Argiris A.

Head Neck. 2016 Dec;38(12):1759-1764. doi: 10.1002/hed.24501. Epub 2016 May 27.


NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell.

Zhao ZL, Zhang L, Huang CF, Ma SR, Bu LL, Liu JF, Yu GT, Liu B, Gutkind JS, Kulkarni AB, Zhang WF, Sun ZJ.

Sci Rep. 2016 Apr 25;6:24704. doi: 10.1038/srep24704.


Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.

Fadlullah MZ, Chiang IK, Dionne KR, Yee PS, Gan CP, Sam KK, Tiong KH, Ng AK, Martin D, Lim KP, Kallarakkal TG, Mustafa WM, Lau SH, Abraham MT, Zain RB, Rahman ZA, Molinolo A, Patel V, Gutkind JS, Tan AC, Cheong SC.

Oncotarget. 2016 May 10;7(19):27802-18. doi: 10.18632/oncotarget.8533.


Signals and Receptors.

Heldin CH, Lu B, Evans R, Gutkind JS.

Cold Spring Harb Perspect Biol. 2016 Apr 1;8(4):a005900. doi: 10.1101/cshperspect.a005900. Review.


Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands.

Zhu Z, Pang B, Iglesias-Bartolome R, Wu X, Hu L, Zhang C, Wang J, Gutkind JS, Wang S.

Oncotarget. 2016 Apr 12;7(15):20271-81. doi: 10.18632/oncotarget.7941.


A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers.

Yamaguchi K, Iglesias-Bartolomé R, Wang Z, Callejas-Valera JL, Amornphimoltham P, Molinolo AA, Cohen EE, Califano JA, Lippman SM, Luo J, Gutkind JS.

Oncotarget. 2016 Mar 8;7(10):10696-709. doi: 10.18632/oncotarget.7372.


Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis.

Nohata N, Uchida Y, Stratman AN, Adams RH, Zheng Y, Weinstein BM, Mukouyama YS, Gutkind JS.

Dev Biol. 2016 Mar 15;411(2):183-194. doi: 10.1016/j.ydbio.2016.02.005. Epub 2016 Feb 10.


Combined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter.

Wang F, Yang K, Wang Z, Ma Y, Gutkind JS, Hida N, Niu G, Tian J.

Nanoscale. 2016 Feb 21;8(7):3991-4000. doi: 10.1039/c5nr07308a.


MKP1 mediates chemosensitizer effects of E1a in response to cisplatin in non-small cell lung carcinoma cells.

Cimas FJ, Callejas-Valera JL, Pascual-Serra R, García-Cano J, Garcia-Gil E, De la Cruz-Morcillo MA, Ortega-Muelas M, Serrano-Oviedo L, Gutkind JS, Sánchez-Prieto R.

Oncotarget. 2015 Dec 29;6(42):44095-107. doi: 10.18632/oncotarget.6574.


Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.

O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind JS.

Oncogene. 2016 Jul 21;35(29):3771-80. doi: 10.1038/onc.2015.442. Epub 2015 Nov 30.


PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma.

Yu GT, Bu LL, Huang CF, Zhang WF, Chen WJ, Gutkind JS, Kulkarni AB, Sun ZJ.

Oncotarget. 2015 Dec 8;6(39):42067-80. doi: 10.18632/oncotarget.5955.


Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial.

William WN Jr, Papadimitrakopoulou V, Lee JJ, Mao L, Cohen EE, Lin HY, Gillenwater AM, Martin JW, Lingen MW, Boyle JO, Shin DM, Vigneswaran N, Shinn N, Heymach JV, Wistuba II, Tang X, Kim ES, Saintigny P, Blair EA, Meiller T, Gutkind JS, Myers J, El-Naggar A, Lippman SM.

JAMA Oncol. 2016 Feb;2(2):209-16. doi: 10.1001/jamaoncol.2015.4364.


Sonic Hedgehog in SCLC.

Laukkanen MO, Gutkind JS, Castellone MD.

Aging (Albany NY). 2015 Sep;7(9):605-6. No abstract available.


Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling.

House CD, Wang BD, Ceniccola K, Williams R, Simaan M, Olender J, Patel V, Baptista-Hon DT, Annunziata CM, Gutkind JS, Hales TG, Lee NH.

Sci Rep. 2015 Jun 22;5:11541. doi: 10.1038/srep11541.


Polymeric Nanovehicle Regulated Spatiotemporal Real-Time Imaging of the Differentiation Dynamics of Transplanted Neural Stem Cells after Traumatic Brain Injury.

Wang Z, Wang Y, Wang Z, Zhao J, Gutkind JS, Srivatsan A, Zhang G, Liao HS, Fu X, Jin A, Tong X, Niu G, Chen X.

ACS Nano. 2015 Jul 28;9(7):6683-95. doi: 10.1021/acsnano.5b00690. Epub 2015 Jun 2.


Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.

Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS.

Nat Cell Biol. 2015 Jun;17(6):793-803. doi: 10.1038/ncb3164. Epub 2015 May 11.


Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma.

Doçi CL, Mikelis CM, Lionakis MS, Molinolo AA, Gutkind JS.

Cancer Res. 2015 Jul 15;75(14):2937-48. doi: 10.1158/0008-5472.CAN-14-3121. Epub 2015 May 7.


RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.

Mikelis CM, Simaan M, Ando K, Fukuhara S, Sakurai A, Amornphimoltham P, Masedunskas A, Weigert R, Chavakis T, Adams RH, Offermanns S, Mochizuki N, Zheng Y, Gutkind JS.

Nat Commun. 2015 Apr 10;6:6725. doi: 10.1038/ncomms7725.


Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application.

Nudelman Z, Findler M, Barasch D, Nemirovski A, Pikovsky A, Kirmayer D, Basheer M, Gutkind JS, Friedman M, Czerninski R.

Cancer Chemother Pharmacol. 2015 May;75(5):969-74. doi: 10.1007/s00280-015-2721-z. Epub 2015 Mar 11.


Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3.

Madera D, Vitale-Cross L, Martin D, Schneider A, Molinolo AA, Gangane N, Carey TE, McHugh JB, Komarck CM, Walline HM, William WN Jr, Seethala RR, Ferris RL, Gutkind JS.

Cancer Prev Res (Phila). 2015 Mar;8(3):197-207. doi: 10.1158/1940-6207.CAPR-14-0348. Epub 2015 Feb 13.


Fluorescent, bioactive protein nanoparticles (prodots) for rapid, improved cellular uptake.

Deshapriya IK, Stromer BS, Pattammattel A, Kim CS, Iglesias-Bartolome R, Gonzalez-Fajardo L, Patel V, Gutkind JS, Lu X, Kumar CV.

Bioconjug Chem. 2015 Mar 18;26(3):396-404. doi: 10.1021/bc500621h. Epub 2015 Feb 2.


An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation.

Degese MS, Tanos T, Naipauer J, Gingerich T, Chiappe D, Echeverria P, LaMarre J, Gutkind JS, Coso OA.

Biochem J. 2015 Apr 1;467(1):77-90. doi: 10.1042/BJ20141100.


Oncotargeting G proteins: The Hippo in the room.

Feng X, Chen Q, Gutkind JS.

Oncotarget. 2014 Nov 30;5(22):10997-9.


SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis.

Dillenburg-Pilla P, Patel V, Mikelis CM, Zárate-Bladés CR, Doçi CL, Amornphimoltham P, Wang Z, Martin D, Leelahavanichkul K, Dorsam RT, Masedunskas A, Weigert R, Molinolo AA, Gutkind JS.

FASEB J. 2015 Mar;29(3):1056-68. doi: 10.1096/fj.14-260083. Epub 2014 Dec 2.


A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.

Williams KA, Lee M, Hu Y, Andreas J, Patel SJ, Zhang S, Chines P, Elkahloun A, Chandrasekharappa S, Gutkind JS, Molinolo AA, Crawford NP.

PLoS Genet. 2014 Nov 20;10(11):e1004809. doi: 10.1371/journal.pgen.1004809. eCollection 2014 Nov. Erratum in: PLoS Genet. 2015 May;11(5):e1005127.


Engineered mesenchymal stem cells with enhanced tropism and paracrine secretion of cytokines and growth factors to treat traumatic brain injury.

Wang Z, Wang Y, Wang Z, Gutkind JS, Wang Z, Wang F, Lu J, Niu G, Teng G, Chen X.

Stem Cells. 2015 Feb;33(2):456-67. doi: 10.1002/stem.1878.


Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.

Gan CP, Patel V, Mikelis CM, Zain RB, Molinolo AA, Abraham MT, Teo SH, Abdul Rahman ZA, Gutkind JS, Cheong SC.

Oncotarget. 2014 Oct 30;5(20):9626-40.


The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.

Martin D, Abba MC, Molinolo AA, Vitale-Cross L, Wang Z, Zaida M, Delic NC, Samuels Y, Lyons JG, Gutkind JS.

Oncotarget. 2014 Oct 15;5(19):8906-23.

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